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The map label for this gene is purE [H]

Identifier: 77461843

GI number: 77461843

Start: 6295927

End: 6296418

Strand: Reverse

Name: purE [H]

Synonym: Pfl01_5622

Alternate gene names: 77461843

Gene position: 6296418-6295927 (Counterclockwise)

Preceding gene: 77461845

Following gene: 77461842

Centisome position: 97.79

GC content: 63.01

Gene sequence:

>492_bases
ATGAGTGCACTGGTTGGCGTGATCATGGGCTCCAAGTCCGATTGGTCCACCCTTAGCCACACCGCCGATATGCTGGAAAA
GCTCGGCATCCCTTACGAGGTCAAGGTGGTTTCCGCCCACCGCACCCCGGATCTGCTGTTCCAGTACGCCGAAGAGGCTG
AAGGCCGCGGCATCGAGGTGATCATCGCCGGTGCCGGTGGCGCAGCCCACCTGCCAGGCATGTGTGCGGCCAAAACCCAC
CTGCCGGTGCTGGGCGTGCCGGTGCAGTCAGCCATGCTTTCGGGCGTCGACTCGCTGCTTTCGATCGTGCAGATGCCGGC
CGGTATTCCGGTTGCCACTCTGGCCATCGGCAAGGCCGGTGCGATCAACGCAGCCCTGCTGTCGGCGAGCATCCTGGGCG
CCAAGCATCCGCAATTCCACGCGGTACTGAAAACCTTCCGTGCCGAGCAGACAGACAGCGTCCTGGACAATCCAGACCCA
CGTATTGCCTGA

Upstream 100 bases:

>100_bases
GCCGGTTCGTCCGGCCATTTTTCCTACAACAAGCCACGCATCCTGCGTGGCTTGTTGTTTTTGACGCGCCTGCGGGCGCC
CAGAGAGAAGAGGCGCGACG

Downstream 100 bases:

>100_bases
GGTTGTTGAGATGAAAATCGGTGTAATCGGTGGCGGCCAGTTGGGTCGCATGTTGGCCCTGGCGGGCACCCCGCTGGGCA
TGAACTTCGCTTTCCTCGAC

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MSALVGVIMGSKSDWSTLSHTADMLEKLGIPYEVKVVSAHRTPDLLFQYAEEAEGRGIEVIIAGAGGAAHLPGMCAAKTH
LPVLGVPVQSAMLSGVDSLLSIVQMPAGIPVATLAIGKAGAINAALLSASILGAKHPQFHAVLKTFRAEQTDSVLDNPDP
RIA

Sequences:

>Translated_163_residues
MSALVGVIMGSKSDWSTLSHTADMLEKLGIPYEVKVVSAHRTPDLLFQYAEEAEGRGIEVIIAGAGGAAHLPGMCAAKTH
LPVLGVPVQSAMLSGVDSLLSIVQMPAGIPVATLAIGKAGAINAALLSASILGAKHPQFHAVLKTFRAEQTDSVLDNPDP
RIA
>Mature_162_residues
SALVGVIMGSKSDWSTLSHTADMLEKLGIPYEVKVVSAHRTPDLLFQYAEEAEGRGIEVIIAGAGGAAHLPGMCAAKTHL
PVLGVPVQSAMLSGVDSLLSIVQMPAGIPVATLAIGKAGAINAALLSASILGAKHPQFHAVLKTFRAEQTDSVLDNPDPR
IA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=159, Percent_Identity=67.2955974842767, Blast_Score=182, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6324702, Length=152, Percent_Identity=54.6052631578947, Blast_Score=155, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16828; Mature: 16697

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALVGVIMGSKSDWSTLSHTADMLEKLGIPYEVKVVSAHRTPDLLFQYAEEAEGRGIEV
CCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEE
IIAGAGGAAHLPGMCAAKTHLPVLGVPVQSAMLSGVDSLLSIVQMPAGIPVATLAIGKAG
EEECCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEHEECCCCC
AINAALLSASILGAKHPQFHAVLKTFRAEQTDSVLDNPDPRIA
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHCCCCCCCC
>Mature Secondary Structure 
SALVGVIMGSKSDWSTLSHTADMLEKLGIPYEVKVVSAHRTPDLLFQYAEEAEGRGIEV
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEE
IIAGAGGAAHLPGMCAAKTHLPVLGVPVQSAMLSGVDSLLSIVQMPAGIPVATLAIGKAG
EEECCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEHEECCCCC
AINAALLSASILGAKHPQFHAVLKTFRAEQTDSVLDNPDPRIA
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]