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The map label for this gene is copA [H]

Identifier: 77460032

GI number: 77460032

Start: 4310828

End: 4312546

Strand: Direct

Name: copA [H]

Synonym: Pfl01_3810

Alternate gene names: 77460032

Gene position: 4310828-4312546 (Clockwise)

Preceding gene: 77460031

Following gene: 77460033

Centisome position: 66.95

GC content: 64.05

Gene sequence:

>1719_bases
ATGCCTTCCACCACCTCAAGACGCACCTTCGTCAAAGGCCTCGCCGCCGGCAGTCTGCTCGGCGGCCTCGGCCTGTGGCG
CACGCCGGTCTGGGCCTTGAACAGCCCCGGCCAGGTGAACGAGTTAAGCGGCACCGACTTCGAGCTGTTCATCGGCGAAA
CCCCGGTCAACTTCACCGGCCAGCCCCGCACCGCCCTGACCATCAACGGCAGCCTGCCCGGCCCGCTGCTGCGCTGGCGC
GAAGGCGACACCGTGACGCTGCGGGTGCGCAACCGGCTCAAGGACAGCACGTCGATCCACTGGCACGGCATCCTGCTGCC
GGCCAACATGGACGGCGTGCCGGGCCTGAGTTTCAAGGGCATCGAGCCGGGTGGCGTGTACGTTTACCAGTTCAAGGTTC
GCCAGCACGGCACCTACTGGTATCACAGCCATTCCGGCTTGCAGGAGCAGGCCGGGGTCTACGGGCCGCTGGTGATCGAT
GCGCGGGAACCAGAGCCGTTCCAGTACGACCGCGACTACGTGGTGATGCTCAGTGACTGGACCGACGAAGACCCGGCCAG
CCTGATGAAGACCCTGAAAAAACAGTCCGACTACTACAACTTCCACAAGCGCACCGTCGGCGACTTCGTCCACGACGTCG
GCGAAAAAGGCTGGGGCGCCACCGTCGCCGATCGCACGATGTGGGCGCAGATGAAGATGAATCCCACCGACATCGCTGAC
GTCAGCGGTGCGACCTACACCTTCCTGATGAACGGCCACGCCCCAGATGACAACTGGACCGGCCTGTTCCGCCCCGGTGA
AAAGCTGCGTCTGCGGCTGATCAACGGCTCGGCCATGAGCTACTTCGACGTGCGCATTCCCGGATTGAAAATGACCGTGG
TCGCCGCCGATGGCTTGCACGTCAAACCGGTCAGCGTCGACGAGTTGCGCATCGCCGTGGCGGAAACCTATGACGTGATC
GTCGAACCCGCCGCCGACGCCTACACCCTGTTCGCCCAAGCCATGGACCGCACCGGTTACGCCCGAGGCACCCTCGCCGC
CCGCGCCGGTTTGTCGGCCCCGGTGCCGGCGCTGGATCCGCGACCGCTGGTGACCATGGACGACATGGGTATGGGCGGCA
TGGGCTCTGGTGGAATGAATCATGGTTCCATGGACATGAGCGGCATGGATCACTCAAGCATGAACATGGGCCCGATGCAG
TCGCACCCCGACAGCGAAAAGGACAACCCGCTGGTGGACATGCAAGCCATGACCACCGCCGCGAAACTCGACGACCCCGG
CCTCGGCCTGCGCAACAACGGTCGCCGGGTGCTGACCTACGCCGACCTGCGCAGCACGTTCGAAGACCCGGACGGCCGCG
ACCCGAGTCGCACCCTCGAGCTGCACCTCACCGGCCACATGGAGAAATTCGCCTGGTCGTTCAACGGCATCAAGTTCTCC
GACGCCGAGCCTCTGCTGTTGAAGTACGGCGAGCGGATTCGCCTGGTGCTGGTCAACGACACGATGATGACTCACCCCAT
CCACCTGCACGGCATGTGGAGCGATCTGGAAGACGAAAACGGCAATTTCCAGGTGCGCAAACACACCATCGACATGCCGC
CCGGCACCCGCCGCACTTACCGCGTGACCGCCGACGCGCTCGGCCATTGGGCCTATCACTGCCATCTCCTGTACCACATG
GAAATGGGCATGTTCCGCGAAGTGCGGGTGGAAGAATGA

Upstream 100 bases:

>100_bases
GCCGAACTGAACCTGACACAACTGTAATCCGCGCCTCAGCCAGCTGAAAGCTGCCGCTGGTTAGCCTCCCCGTCATTGGT
CAAACGGGGACTTCCAGCGC

Downstream 100 bases:

>100_bases
GGACGCCGACCATGACTCGATTTGCCGCGTTTTCGTTGTCGCTCCTGTCGATGGCTCCGGCCTTCGCCGCCAGCGACATG
CAGGGTATGGATCACAGCCG

Product: copper-resistance protein CopA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MPSTTSRRTFVKGLAAGSLLGGLGLWRTPVWALNSPGQVNELSGTDFELFIGETPVNFTGQPRTALTINGSLPGPLLRWR
EGDTVTLRVRNRLKDSTSIHWHGILLPANMDGVPGLSFKGIEPGGVYVYQFKVRQHGTYWYHSHSGLQEQAGVYGPLVID
AREPEPFQYDRDYVVMLSDWTDEDPASLMKTLKKQSDYYNFHKRTVGDFVHDVGEKGWGATVADRTMWAQMKMNPTDIAD
VSGATYTFLMNGHAPDDNWTGLFRPGEKLRLRLINGSAMSYFDVRIPGLKMTVVAADGLHVKPVSVDELRIAVAETYDVI
VEPAADAYTLFAQAMDRTGYARGTLAARAGLSAPVPALDPRPLVTMDDMGMGGMGSGGMNHGSMDMSGMDHSSMNMGPMQ
SHPDSEKDNPLVDMQAMTTAAKLDDPGLGLRNNGRRVLTYADLRSTFEDPDGRDPSRTLELHLTGHMEKFAWSFNGIKFS
DAEPLLLKYGERIRLVLVNDTMMTHPIHLHGMWSDLEDENGNFQVRKHTIDMPPGTRRTYRVTADALGHWAYHCHLLYHM
EMGMFREVRVEE

Sequences:

>Translated_572_residues
MPSTTSRRTFVKGLAAGSLLGGLGLWRTPVWALNSPGQVNELSGTDFELFIGETPVNFTGQPRTALTINGSLPGPLLRWR
EGDTVTLRVRNRLKDSTSIHWHGILLPANMDGVPGLSFKGIEPGGVYVYQFKVRQHGTYWYHSHSGLQEQAGVYGPLVID
AREPEPFQYDRDYVVMLSDWTDEDPASLMKTLKKQSDYYNFHKRTVGDFVHDVGEKGWGATVADRTMWAQMKMNPTDIAD
VSGATYTFLMNGHAPDDNWTGLFRPGEKLRLRLINGSAMSYFDVRIPGLKMTVVAADGLHVKPVSVDELRIAVAETYDVI
VEPAADAYTLFAQAMDRTGYARGTLAARAGLSAPVPALDPRPLVTMDDMGMGGMGSGGMNHGSMDMSGMDHSSMNMGPMQ
SHPDSEKDNPLVDMQAMTTAAKLDDPGLGLRNNGRRVLTYADLRSTFEDPDGRDPSRTLELHLTGHMEKFAWSFNGIKFS
DAEPLLLKYGERIRLVLVNDTMMTHPIHLHGMWSDLEDENGNFQVRKHTIDMPPGTRRTYRVTADALGHWAYHCHLLYHM
EMGMFREVRVEE
>Mature_571_residues
PSTTSRRTFVKGLAAGSLLGGLGLWRTPVWALNSPGQVNELSGTDFELFIGETPVNFTGQPRTALTINGSLPGPLLRWRE
GDTVTLRVRNRLKDSTSIHWHGILLPANMDGVPGLSFKGIEPGGVYVYQFKVRQHGTYWYHSHSGLQEQAGVYGPLVIDA
REPEPFQYDRDYVVMLSDWTDEDPASLMKTLKKQSDYYNFHKRTVGDFVHDVGEKGWGATVADRTMWAQMKMNPTDIADV
SGATYTFLMNGHAPDDNWTGLFRPGEKLRLRLINGSAMSYFDVRIPGLKMTVVAADGLHVKPVSVDELRIAVAETYDVIV
EPAADAYTLFAQAMDRTGYARGTLAARAGLSAPVPALDPRPLVTMDDMGMGGMGSGGMNHGSMDMSGMDHSSMNMGPMQS
HPDSEKDNPLVDMQAMTTAAKLDDPGLGLRNNGRRVLTYADLRSTFEDPDGRDPSRTLELHLTGHMEKFAWSFNGIKFSD
AEPLLLKYGERIRLVLVNDTMMTHPIHLHGMWSDLEDENGNFQVRKHTIDMPPGTRRTYRVTADALGHWAYHCHLLYHME
MGMFREVRVEE

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=600, Percent_Identity=25.8333333333333, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17539950, Length=299, Percent_Identity=26.4214046822742, Blast_Score=79, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320714, Length=565, Percent_Identity=23.0088495575221, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323703, Length=286, Percent_Identity=29.7202797202797, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321067, Length=269, Percent_Identity=26.7657992565056, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574104, Length=614, Percent_Identity=22.4755700325733, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI18859919, Length=559, Percent_Identity=23.4347048300537, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24650186, Length=581, Percent_Identity=23.2358003442341, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281360167, Length=300, Percent_Identity=27.6666666666667, Blast_Score=96, Evalue=9e-20,
Organism=Drosophila melanogaster, GI221330000, Length=300, Percent_Identity=27.6666666666667, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585842, Length=300, Percent_Identity=27.6666666666667, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221329998, Length=300, Percent_Identity=27.6666666666667, Blast_Score=95, Evalue=2e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 63696; Mature: 63565

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSTTSRRTFVKGLAAGSLLGGLGLWRTPVWALNSPGQVNELSGTDFELFIGETPVNFTG
CCCCCCHHHHHHHHHHHHHHHCCCHHCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCC
QPRTALTINGSLPGPLLRWREGDTVTLRVRNRLKDSTSIHWHGILLPANMDGVPGLSFKG
CCCEEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCEECC
IEPGGVYVYQFKVRQHGTYWYHSHSGLQEQAGVYGPLVIDAREPEPFQYDRDYVVMLSDW
CCCCCEEEEEEEEEECCEEEEECCCCCHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECC
TDEDPASLMKTLKKQSDYYNFHKRTVGDFVHDVGEKGWGATVADRTMWAQMKMNPTDIAD
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHCCEEEEEEECCCCCHHC
VSGATYTFLMNGHAPDDNWTGLFRPGEKLRLRLINGSAMSYFDVRIPGLKMTVVAADGLH
CCCCEEEEEEECCCCCCCCCEEECCCCEEEEEEEECCCEEEEEEECCCEEEEEEEECCEE
VKPVSVDELRIAVAETYDVIVEPAADAYTLFAQAMDRTGYARGTLAARAGLSAPVPALDP
ECCCCHHHEEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCC
RPLVTMDDMGMGGMGSGGMNHGSMDMSGMDHSSMNMGPMQSHPDSEKDNPLVDMQAMTTA
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHH
AKLDDPGLGLRNNGRRVLTYADLRSTFEDPDGRDPSRTLELHLTGHMEKFAWSFNGIKFS
HHCCCCCCCCCCCCCEEEEEHHHHHHCCCCCCCCCCCEEEEEEECCCEEHEEEECCEEEC
DAEPLLLKYGERIRLVLVNDTMMTHPIHLHGMWSDLEDENGNFQVRKHTIDMPPGTRRTY
CCCCHHEECCCEEEEEEEECCEEECCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCEEE
RVTADALGHWAYHCHLLYHMEMGMFREVRVEE
EEEHHHHHCCEEEEEEEEEECCCCEEEEEECC
>Mature Secondary Structure 
PSTTSRRTFVKGLAAGSLLGGLGLWRTPVWALNSPGQVNELSGTDFELFIGETPVNFTG
CCCCCHHHHHHHHHHHHHHHCCCHHCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCC
QPRTALTINGSLPGPLLRWREGDTVTLRVRNRLKDSTSIHWHGILLPANMDGVPGLSFKG
CCCEEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCEECC
IEPGGVYVYQFKVRQHGTYWYHSHSGLQEQAGVYGPLVIDAREPEPFQYDRDYVVMLSDW
CCCCCEEEEEEEEEECCEEEEECCCCCHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECC
TDEDPASLMKTLKKQSDYYNFHKRTVGDFVHDVGEKGWGATVADRTMWAQMKMNPTDIAD
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHCCEEEEEEECCCCCHHC
VSGATYTFLMNGHAPDDNWTGLFRPGEKLRLRLINGSAMSYFDVRIPGLKMTVVAADGLH
CCCCEEEEEEECCCCCCCCCEEECCCCEEEEEEEECCCEEEEEEECCCEEEEEEEECCEE
VKPVSVDELRIAVAETYDVIVEPAADAYTLFAQAMDRTGYARGTLAARAGLSAPVPALDP
ECCCCHHHEEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCC
RPLVTMDDMGMGGMGSGGMNHGSMDMSGMDHSSMNMGPMQSHPDSEKDNPLVDMQAMTTA
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHH
AKLDDPGLGLRNNGRRVLTYADLRSTFEDPDGRDPSRTLELHLTGHMEKFAWSFNGIKFS
HHCCCCCCCCCCCCCEEEEEHHHHHHCCCCCCCCCCCEEEEEEECCCEEHEEEECCEEEC
DAEPLLLKYGERIRLVLVNDTMMTHPIHLHGMWSDLEDENGNFQVRKHTIDMPPGTRRTY
CCCCHHEECCCEEEEEEEECCEEECCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCEEE
RVTADALGHWAYHCHLLYHMEMGMFREVRVEE
EEEHHHHHCCEEEEEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]