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The map label for this gene is folD1 [H]

Identifier: 77459921

GI number: 77459921

Start: 4188961

End: 4189815

Strand: Direct

Name: folD1 [H]

Synonym: Pfl01_3699

Alternate gene names: 77459921

Gene position: 4188961-4189815 (Clockwise)

Preceding gene: 77459914

Following gene: 77459922

Centisome position: 65.06

GC content: 63.16

Gene sequence:

>855_bases
ATGACTGCACAACTAATCGACGGCAAATCGATCGCCGCCAGCCTGCGCCAGCAGATCGCCCAACGGGTTGCCGAACGTCG
CCAGCAAGGTCTGCGCACGCCAGGCCTCGCGGTGATCCTGGTCGGCAGCGATCCTGCCTCTCAGGTTTATGTCTCGCACA
AGCGTAAAGACTGTGAAGAGGTCGGCTTCCTCTCTCAAGCGTACGACCTGCCTTCCGAAACCACTCAAGAAGCGCTGACC
GATCTGATCGATCGACTGAACGACGACCCGGCAATCGACGGCGTTCTGCTTCAACTTCCTCTGCCAGAGCACCTGGACGC
TTCCAAACTGCTGGAACGCATCCGCCCGGACAAGGACGTCGACGGTTTCCATCCTTATAACGTCGGCCGTCTGGCCCAGC
GCATTCCATTGCTGCGCCCGTGCACCCCGAAGGGCATCATGACCCTGCTGGAAAGCACGGGCGCCGATCTGTACGGGATG
GACGCCGTGGTCGTCGGCGCGTCCAACATCGTCGGTCGCCCGATGGCGATGGAACTGTTGCTGGCCGGTTGCACCGTGAC
CGTCACCCACCGCTTCACCAAGGATCTGGCCGGCCATGTCGGTCGTGCCGACCTGGTGGTCGTGGCCGCCGGCAAGCCGG
GCCTGGTCAAGGGCGAATGGATCAAGGAAGGCGCGATCGTGATCGACGTCGGCATCAACCGACAGGAAGACGGCAAACTG
GTCGGTGACGTCGTGTACGAAACCGCCCTGCCCCGCGCCGGCTGGATCACTCCGGTGCCGGGTGGCGTCGGTCCGATGAC
CCGTGCCTGCCTGCTGGAAAACACCCTCTACGCGGCAGAAACCCTGCACGCCTGA

Upstream 100 bases:

>100_bases
GGGCTTAGGGGAATTTGCTGACCAAGCGCCTTTGCCCTCACCGTTTGACATGCGAGAATGCGTTCTCTTTTTTTCCCCTC
TCGATGGTTAATCACGCGCA

Downstream 100 bases:

>100_bases
GTCGCGTTTTCCGTACGCCGAGAACCCCGCCTTGTGCGGGGTTTTTCATGCCCTCGAAAAAACCTTTACCGTTCGCCGGA
AACCCCTATTTTTACAGGGC

Product: bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MTAQLIDGKSIAASLRQQIAQRVAERRQQGLRTPGLAVILVGSDPASQVYVSHKRKDCEEVGFLSQAYDLPSETTQEALT
DLIDRLNDDPAIDGVLLQLPLPEHLDASKLLERIRPDKDVDGFHPYNVGRLAQRIPLLRPCTPKGIMTLLESTGADLYGM
DAVVVGASNIVGRPMAMELLLAGCTVTVTHRFTKDLAGHVGRADLVVVAAGKPGLVKGEWIKEGAIVIDVGINRQEDGKL
VGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAETLHA

Sequences:

>Translated_284_residues
MTAQLIDGKSIAASLRQQIAQRVAERRQQGLRTPGLAVILVGSDPASQVYVSHKRKDCEEVGFLSQAYDLPSETTQEALT
DLIDRLNDDPAIDGVLLQLPLPEHLDASKLLERIRPDKDVDGFHPYNVGRLAQRIPLLRPCTPKGIMTLLESTGADLYGM
DAVVVGASNIVGRPMAMELLLAGCTVTVTHRFTKDLAGHVGRADLVVVAAGKPGLVKGEWIKEGAIVIDVGINRQEDGKL
VGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAETLHA
>Mature_283_residues
TAQLIDGKSIAASLRQQIAQRVAERRQQGLRTPGLAVILVGSDPASQVYVSHKRKDCEEVGFLSQAYDLPSETTQEALTD
LIDRLNDDPAIDGVLLQLPLPEHLDASKLLERIRPDKDVDGFHPYNVGRLAQRIPLLRPCTPKGIMTLLESTGADLYGMD
AVVVGASNIVGRPMAMELLLAGCTVTVTHRFTKDLAGHVGRADLVVVAAGKPGLVKGEWIKEGAIVIDVGINRQEDGKLV
GDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAETLHA

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate [H]

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI222418558, Length=295, Percent_Identity=43.728813559322, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI94721354, Length=295, Percent_Identity=44.7457627118644, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI222136639, Length=290, Percent_Identity=43.1034482758621, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI36796743, Length=198, Percent_Identity=28.7878787878788, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786741, Length=283, Percent_Identity=67.4911660777385, Blast_Score=400, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17568735, Length=292, Percent_Identity=40.4109589041096, Blast_Score=184, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6321643, Length=299, Percent_Identity=42.809364548495, Blast_Score=229, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6319558, Length=286, Percent_Identity=43.7062937062937, Blast_Score=223, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6322933, Length=311, Percent_Identity=27.6527331189711, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17136818, Length=292, Percent_Identity=47.945205479452, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI17136816, Length=292, Percent_Identity=47.945205479452, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI62472483, Length=287, Percent_Identity=42.5087108013937, Blast_Score=205, Evalue=2e-53,
Organism=Drosophila melanogaster, GI45551871, Length=287, Percent_Identity=42.5087108013937, Blast_Score=205, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24645718, Length=287, Percent_Identity=42.5087108013937, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI17137370, Length=287, Percent_Identity=42.5087108013937, Blast_Score=205, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020631 [H]

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C [H]

EC number: =1.5.1.5; =3.5.4.9 [H]

Molecular weight: Translated: 30508; Mature: 30376

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQLIDGKSIAASLRQQIAQRVAERRQQGLRTPGLAVILVGSDPASQVYVSHKRKDCEE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHCCHHH
VGFLSQAYDLPSETTQEALTDLIDRLNDDPAIDGVLLQLPLPEHLDASKLLERIRPDKDV
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCC
DGFHPYNVGRLAQRIPLLRPCTPKGIMTLLESTGADLYGMDAVVVGASNIVGRPMAMELL
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEECCCEEEEECHHHCCCHHHHHHH
LAGCTVTVTHRFTKDLAGHVGRADLVVVAAGKPGLVKGEWIKEGAIVIDVGINRQEDGKL
HHCCEEEEHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEECCCCEEEEECCCCCCCCCH
VGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAETLHA
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAQLIDGKSIAASLRQQIAQRVAERRQQGLRTPGLAVILVGSDPASQVYVSHKRKDCEE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHCCHHH
VGFLSQAYDLPSETTQEALTDLIDRLNDDPAIDGVLLQLPLPEHLDASKLLERIRPDKDV
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCC
DGFHPYNVGRLAQRIPLLRPCTPKGIMTLLESTGADLYGMDAVVVGASNIVGRPMAMELL
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEECCCEEEEECHHHCCCHHHHHHH
LAGCTVTVTHRFTKDLAGHVGRADLVVVAAGKPGLVKGEWIKEGAIVIDVGINRQEDGKL
HHCCEEEEHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEECCCCEEEEECCCCCCCCCH
VGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAETLHA
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA