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The map label for this gene is nuoC [H]

Identifier: 77459827

GI number: 77459827

Start: 4074136

End: 4075920

Strand: Direct

Name: nuoC [H]

Synonym: Pfl01_3605

Alternate gene names: 77459827

Gene position: 4074136-4075920 (Clockwise)

Preceding gene: 77459826

Following gene: 77459828

Centisome position: 63.28

GC content: 60.62

Gene sequence:

>1785_bases
ATGACTACAGGCAGTGCTCTGTACATCCCGCCTTATAAGGCAGACGACCAGGATGTGGTCGTCGAACTCAACAACCGTTT
TGGCGCCGAAGCGTTCACCGCCCAGCCGACCCGCACCGGCATGCCGGTGCTGTGGGTGGCTCGCGCCAAGCTCGTCGAAG
TCCTGACCTTCCTGCGCAATTTGCCCAAACCGTACGTCATGCTCTATGACCTGCACGGCGTGGACGAGCGTCTGCGCACC
AAGCGTCAAGGGCTGCCGAGCGGTGCCGATTTCACCGTGTTCTATCACCTCATGTCGCTGGAACGTAATAGTGACGTGAT
GATCAAGGTCGCCTTGTCCGAAAGCGACCTCAGCTTGCCGACCGTCACCAGCATCTGGCCGAACGCCAACTGGTACGAGC
GTGAAGTCTGGGACATGTACGGCATCGACTTCAAAGGTCACCCGCACCTGTCGCGCATCATGATGCCGCCGACCTGGGAA
GGTCACCCGCTGCGCAAGGACTTCCCGGCGCGCGCCACCGAATTCGATCCGTTCAGCCTGAACCTGGCCAAGCAACAGCT
TGAGGAAGAAGCCGCGCGCTTCCGTCCTGAAGACTGGGGCATGAAGCGTTCCGGTGCGAACGAGGACTACATGTTCCTCA
ACCTGGGTCCGAACCACCCTTCGGCGCACGGTGCGTTCCGCATCATCCTGCAGCTGGACGGTGAAGAGATCGTCGATTGC
GTTCCGGACATCGGTTACCACCACCGTGGCGCCGAGAAGATGGCTGAGCGTCAGTCCTGGCACAGTTTCATTCCGTACAC
CGACCGTATCGACTACCTCGGCGGCGTGATGAACAACCTGCCGTACGTGCTCTCGGTCGAGAAGCTGGCCGGCATCAAGG
TGCCAGAGAAAGTCGACGTCATCCGCATCATGATGGCCGAGTTCTTCCGGATCACCAGCCACCTGCTGTTCCTGGGTACC
TACATCCAGGACGTCGGCGCCATGACTCCGGTGTTCTTCACCTTCACCGACCGCCAGAAGGCCTACACGGTGATCGAAGC
CATCACCGGTTTCCGTCTGCACCCGGCCTGGTACCGCATCGGCGGCGTCGCCCACGACCTGCCGCGCGGCTGGGAAAAAC
TGGTGAAAGATTTCGTTGAATGGCTGCCAAAGCGCCTCGACGAATACACCAAGGCCGCCCTGCAGAACAGCATCCTCAAG
GGGCGTACCATCGGCGTTGCCCAGTACAACACCAAAGAGGCCCTGGAATGGGGCGTTACCGGTGCTGGCCTGCGTTCCAC
CGGTTGCGACTTCGACCTGCGTAAGGCGCGCCCATACTCCGGTTACGAGAACTTCGAGTTCGAAGTGCCGCTGGCTGCCA
ACGGCGATGCCTACGACCGCTGCATGGTTCGCGTCGAAGAGATGCGCCAGAGCGTCAAGATCATCGACCAGTGCCTGCGC
AACATGCCGGAAGGCCCGTACAAGGCGGATCACCCGCTGACCACGCCGCCGCCGAAAGAGCGCACGCTGCAGCACATCGA
AACCCTGATCACGCACTTCCTGCAAGTTTCGTGGGGCCCGGTCATGCCGGCCAACGAATCCTTCCAGATGATCGAAGCGA
CCAAGGGCATCAACAGTTATTACCTGACGAGCGACGGCGGCACCATGAGCTACCGTACCCGGATCCGTACTCCGAGCTTC
GCCCACCTGCAGCAGATCCCTTCGGTGATCAAAGGCAGCATGGTCGCGGACCTGATTGCGTACCTGGGTAGTATCGACTT
CGTTATGGCCGACGTGGACCGCTAA

Upstream 100 bases:

>100_bases
CACCAACCTGCGCAGCCCTGACGAAGTCTGATCCAGTCTGTTTCAAAGAAACGAGAAGCTGGCTTCATTCTTTACGTTGA
CCGAAAGCGAAAAAATAACC

Downstream 100 bases:

>100_bases
GCATGAACAGCACGCTTATCCAGACAGACCGTTTCACCTTGAGTGAAACCGAGCGCTCGGCCATCGAGCACGAGCTGCAT
CACTACGAAGACCCGCGCGC

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D [H]

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MTTGSALYIPPYKADDQDVVVELNNRFGAEAFTAQPTRTGMPVLWVARAKLVEVLTFLRNLPKPYVMLYDLHGVDERLRT
KRQGLPSGADFTVFYHLMSLERNSDVMIKVALSESDLSLPTVTSIWPNANWYEREVWDMYGIDFKGHPHLSRIMMPPTWE
GHPLRKDFPARATEFDPFSLNLAKQQLEEEAARFRPEDWGMKRSGANEDYMFLNLGPNHPSAHGAFRIILQLDGEEIVDC
VPDIGYHHRGAEKMAERQSWHSFIPYTDRIDYLGGVMNNLPYVLSVEKLAGIKVPEKVDVIRIMMAEFFRITSHLLFLGT
YIQDVGAMTPVFFTFTDRQKAYTVIEAITGFRLHPAWYRIGGVAHDLPRGWEKLVKDFVEWLPKRLDEYTKAALQNSILK
GRTIGVAQYNTKEALEWGVTGAGLRSTGCDFDLRKARPYSGYENFEFEVPLAANGDAYDRCMVRVEEMRQSVKIIDQCLR
NMPEGPYKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGGTMSYRTRIRTPSF
AHLQQIPSVIKGSMVADLIAYLGSIDFVMADVDR

Sequences:

>Translated_594_residues
MTTGSALYIPPYKADDQDVVVELNNRFGAEAFTAQPTRTGMPVLWVARAKLVEVLTFLRNLPKPYVMLYDLHGVDERLRT
KRQGLPSGADFTVFYHLMSLERNSDVMIKVALSESDLSLPTVTSIWPNANWYEREVWDMYGIDFKGHPHLSRIMMPPTWE
GHPLRKDFPARATEFDPFSLNLAKQQLEEEAARFRPEDWGMKRSGANEDYMFLNLGPNHPSAHGAFRIILQLDGEEIVDC
VPDIGYHHRGAEKMAERQSWHSFIPYTDRIDYLGGVMNNLPYVLSVEKLAGIKVPEKVDVIRIMMAEFFRITSHLLFLGT
YIQDVGAMTPVFFTFTDRQKAYTVIEAITGFRLHPAWYRIGGVAHDLPRGWEKLVKDFVEWLPKRLDEYTKAALQNSILK
GRTIGVAQYNTKEALEWGVTGAGLRSTGCDFDLRKARPYSGYENFEFEVPLAANGDAYDRCMVRVEEMRQSVKIIDQCLR
NMPEGPYKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGGTMSYRTRIRTPSF
AHLQQIPSVIKGSMVADLIAYLGSIDFVMADVDR
>Mature_593_residues
TTGSALYIPPYKADDQDVVVELNNRFGAEAFTAQPTRTGMPVLWVARAKLVEVLTFLRNLPKPYVMLYDLHGVDERLRTK
RQGLPSGADFTVFYHLMSLERNSDVMIKVALSESDLSLPTVTSIWPNANWYEREVWDMYGIDFKGHPHLSRIMMPPTWEG
HPLRKDFPARATEFDPFSLNLAKQQLEEEAARFRPEDWGMKRSGANEDYMFLNLGPNHPSAHGAFRIILQLDGEEIVDCV
PDIGYHHRGAEKMAERQSWHSFIPYTDRIDYLGGVMNNLPYVLSVEKLAGIKVPEKVDVIRIMMAEFFRITSHLLFLGTY
IQDVGAMTPVFFTFTDRQKAYTVIEAITGFRLHPAWYRIGGVAHDLPRGWEKLVKDFVEWLPKRLDEYTKAALQNSILKG
RTIGVAQYNTKEALEWGVTGAGLRSTGCDFDLRKARPYSGYENFEFEVPLAANGDAYDRCMVRVEEMRQSVKIIDQCLRN
MPEGPYKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGGTMSYRTRIRTPSFA
HLQQIPSVIKGSMVADLIAYLGSIDFVMADVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=382, Percent_Identity=41.3612565445026, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI260898743, Length=372, Percent_Identity=41.1290322580645, Blast_Score=306, Evalue=5e-83,
Organism=Homo sapiens, GI4758788, Length=120, Percent_Identity=40.8333333333333, Blast_Score=89, Evalue=2e-17,
Organism=Escherichia coli, GI145693162, Length=580, Percent_Identity=75.1724137931034, Blast_Score=959, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=513, Percent_Identity=26.3157894736842, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1788832, Length=515, Percent_Identity=26.9902912621359, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17568379, Length=424, Percent_Identity=39.1509433962264, Blast_Score=332, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17555284, Length=424, Percent_Identity=39.1509433962264, Blast_Score=332, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI71990788, Length=159, Percent_Identity=32.7044025157233, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32563621, Length=159, Percent_Identity=32.7044025157233, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221459469, Length=383, Percent_Identity=40.4699738903394, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24638644, Length=384, Percent_Identity=41.40625, Blast_Score=325, Evalue=7e-89,
Organism=Drosophila melanogaster, GI24656494, Length=127, Percent_Identity=39.3700787401575, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR022885
- ProDom:   PD001581 [H]

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 67726; Mature: 67595

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTGSALYIPPYKADDQDVVVELNNRFGAEAFTAQPTRTGMPVLWVARAKLVEVLTFLRN
CCCCCEEEECCCCCCCCCEEEEECCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHH
LPKPYVMLYDLHGVDERLRTKRQGLPSGADFTVFYHLMSLERNSDVMIKVALSESDLSLP
CCCCEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
TVTSIWPNANWYEREVWDMYGIDFKGHPHLSRIMMPPTWEGHPLRKDFPARATEFDPFSL
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHEECCCCCCCCCCCCCCCCCCCCCCCCCH
NLAKQQLEEEAARFRPEDWGMKRSGANEDYMFLNLGPNHPSAHGAFRIILQLDGEEIVDC
HHHHHHHHHHHHHCCCHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHH
VPDIGYHHRGAEKMAERQSWHSFIPYTDRIDYLGGVMNNLPYVLSVEKLAGIKVPEKVDV
HCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEHHHHHCCCCCCHHHH
IRIMMAEFFRITSHLLFLGTYIQDVGAMTPVFFTFTDRQKAYTVIEAITGFRLHPAWYRI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCEECHHHHHH
GGVAHDLPRGWEKLVKDFVEWLPKRLDEYTKAALQNSILKGRTIGVAQYNTKEALEWGVT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCC
GAGLRSTGCDFDLRKARPYSGYENFEFEVPLAANGDAYDRCMVRVEEMRQSVKIIDQCLR
CCCCCCCCCCCCHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NMPEGPYKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSY
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEE
YLTSDGGTMSYRTRIRTPSFAHLQQIPSVIKGSMVADLIAYLGSIDFVMADVDR
EEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
>Mature Secondary Structure 
TTGSALYIPPYKADDQDVVVELNNRFGAEAFTAQPTRTGMPVLWVARAKLVEVLTFLRN
CCCCEEEECCCCCCCCCEEEEECCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHH
LPKPYVMLYDLHGVDERLRTKRQGLPSGADFTVFYHLMSLERNSDVMIKVALSESDLSLP
CCCCEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
TVTSIWPNANWYEREVWDMYGIDFKGHPHLSRIMMPPTWEGHPLRKDFPARATEFDPFSL
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHEECCCCCCCCCCCCCCCCCCCCCCCCCH
NLAKQQLEEEAARFRPEDWGMKRSGANEDYMFLNLGPNHPSAHGAFRIILQLDGEEIVDC
HHHHHHHHHHHHHCCCHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHH
VPDIGYHHRGAEKMAERQSWHSFIPYTDRIDYLGGVMNNLPYVLSVEKLAGIKVPEKVDV
HCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEHHHHHCCCCCCHHHH
IRIMMAEFFRITSHLLFLGTYIQDVGAMTPVFFTFTDRQKAYTVIEAITGFRLHPAWYRI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCEECHHHHHH
GGVAHDLPRGWEKLVKDFVEWLPKRLDEYTKAALQNSILKGRTIGVAQYNTKEALEWGVT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCC
GAGLRSTGCDFDLRKARPYSGYENFEFEVPLAANGDAYDRCMVRVEEMRQSVKIIDQCLR
CCCCCCCCCCCCHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NMPEGPYKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSY
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEE
YLTSDGGTMSYRTRIRTPSFAHLQQIPSVIKGSMVADLIAYLGSIDFVMADVDR
EEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA