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The map label for this gene is cusR [H]

Identifier: 77459741

GI number: 77459741

Start: 3998706

End: 3999389

Strand: Direct

Name: cusR [H]

Synonym: Pfl01_3519

Alternate gene names: 77459741

Gene position: 3998706-3999389 (Clockwise)

Preceding gene: 77459735

Following gene: 77459742

Centisome position: 62.11

GC content: 63.74

Gene sequence:

>684_bases
ATGACTCGCATCCTCACCATCGAAGACGACGCCGTGACCGCCCGGGAAATTGTCGCCGAACTGAGCAGCCACGGCCTCGA
CGTGGACTGGGTCGACAACGGCCGTGAAGGCCTGGACCGCGCCGTCAGCGGCAACTACGACCTGATCACCCTCGACCGCA
TGCTGCCGGAACTCGATGGCCTGGCCATCGTCACCACCCTGCGCACCATGGGCGTGGCCACGCCGATCCTGATGATCAGC
GCCCTTTCCGATGTCGACGAGCGCGTGCGCGGCTTGCGCGCCGGCGGCGATGATTACCTGACCAAACCGTTCGCCACCGA
TGAAATGGCCGCCCGGGTCGAAGTGTTGCTGCGTCGGCAGAACAGCAACGGCGCCCAGCCGACCACGTTGCAGGTGGCGG
ATCTGCAACTCGACCTGATCAGCCACGAAGCCCGTCGCGCCGAGCAAGTGCTGACGCTGCTGCCGACCGAGTACAAGTTG
CTGGAATTCCTGATGCGCAACAGCGGTCAGATCCTGTCGCGGATGATGATTTTCGAGGAAGTCTGGGGCTACCACTTCGA
CCCCGGCACCAACCTGATCGACGTGCACATCGGCCGTCTGCGCAAGAAGATCGACCCGCCGGGCAATGTCCCGCTGATCC
GTACGGTGCGAGGCTCGGGTTATGTCATTGCCGAACCCGTCTGA

Upstream 100 bases:

>100_bases
GCGACTAATGACGGCTAAAACATGAAAGTTAATTTAAAGCGCCCGCGCAAAATCTTGGCAAAATGCTGCCATTGCGTTTG
AACAGACCAGCAGGCCCACC

Downstream 100 bases:

>100_bases
CGGTTGGCGCTCTTCCAGCAGCCGCTTGCTGGCGCTGTACAGTTCGTTGTTCGTGGCCTGGAGCGCGATCCTCATGGGGG
TCATGTACTTCGAGGTTTCC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MTRILTIEDDAVTAREIVAELSSHGLDVDWVDNGREGLDRAVSGNYDLITLDRMLPELDGLAIVTTLRTMGVATPILMIS
ALSDVDERVRGLRAGGDDYLTKPFATDEMAARVEVLLRRQNSNGAQPTTLQVADLQLDLISHEARRAEQVLTLLPTEYKL
LEFLMRNSGQILSRMMIFEEVWGYHFDPGTNLIDVHIGRLRKKIDPPGNVPLIRTVRGSGYVIAEPV

Sequences:

>Translated_227_residues
MTRILTIEDDAVTAREIVAELSSHGLDVDWVDNGREGLDRAVSGNYDLITLDRMLPELDGLAIVTTLRTMGVATPILMIS
ALSDVDERVRGLRAGGDDYLTKPFATDEMAARVEVLLRRQNSNGAQPTTLQVADLQLDLISHEARRAEQVLTLLPTEYKL
LEFLMRNSGQILSRMMIFEEVWGYHFDPGTNLIDVHIGRLRKKIDPPGNVPLIRTVRGSGYVIAEPV
>Mature_226_residues
TRILTIEDDAVTAREIVAELSSHGLDVDWVDNGREGLDRAVSGNYDLITLDRMLPELDGLAIVTTLRTMGVATPILMISA
LSDVDERVRGLRAGGDDYLTKPFATDEMAARVEVLLRRQNSNGAQPTTLQVADLQLDLISHEARRAEQVLTLLPTEYKLL
EFLMRNSGQILSRMMIFEEVWGYHFDPGTNLIDVHIGRLRKKIDPPGNVPLIRTVRGSGYVIAEPV

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=44.1964285714286, Blast_Score=184, Evalue=4e-48,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=43.37899543379, Blast_Score=170, Evalue=6e-44,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=42.152466367713, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=34.3891402714932, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=33.9366515837104, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=32.4324324324324, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=32.8828828828829, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=30.7692307692308, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=35.4978354978355, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=31.25, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=30.8695652173913, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=30.2127659574468, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=27.4336283185841, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788550, Length=121, Percent_Identity=28.9256198347107, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1790437, Length=123, Percent_Identity=30.8943089430894, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790299, Length=137, Percent_Identity=29.1970802919708, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25263; Mature: 25132

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRILTIEDDAVTAREIVAELSSHGLDVDWVDNGREGLDRAVSGNYDLITLDRMLPELDG
CCEEEEECCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCCCCEEEHHHHCCHHCC
LAIVTTLRTMGVATPILMISALSDVDERVRGLRAGGDDYLTKPFATDEMAARVEVLLRRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHC
NSNGAQPTTLQVADLQLDLISHEARRAEQVLTLLPTEYKLLEFLMRNSGQILSRMMIFEE
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHH
VWGYHFDPGTNLIDVHIGRLRKKIDPPGNVPLIRTVRGSGYVIAEPV
HCCEECCCCCCEEEHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCC
>Mature Secondary Structure 
TRILTIEDDAVTAREIVAELSSHGLDVDWVDNGREGLDRAVSGNYDLITLDRMLPELDG
CEEEEECCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCCCCEEEHHHHCCHHCC
LAIVTTLRTMGVATPILMISALSDVDERVRGLRAGGDDYLTKPFATDEMAARVEVLLRRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHC
NSNGAQPTTLQVADLQLDLISHEARRAEQVLTLLPTEYKLLEFLMRNSGQILSRMMIFEE
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHH
VWGYHFDPGTNLIDVHIGRLRKKIDPPGNVPLIRTVRGSGYVIAEPV
HCCEECCCCCCEEEHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]