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The map label for this gene is yxnA [H]

Identifier: 77459574

GI number: 77459574

Start: 3826693

End: 3827481

Strand: Direct

Name: yxnA [H]

Synonym: Pfl01_3352

Alternate gene names: 77459574

Gene position: 3826693-3827481 (Clockwise)

Preceding gene: 77459573

Following gene: 77459575

Centisome position: 59.44

GC content: 63.37

Gene sequence:

>789_bases
GTGGTGTTGACCGGTGCCAGCGGCGGCATCGGGATAGCGATCACGCGTGCCTTGTGCGCTGCCGGTGCGCAGGTCCTGGC
GGTCGCGCGGCATCAGGAATCGCTGCGCCTGTTGCTCGACCTTTACCCGCAGAACCTGTGCTGGGTCGCCGCCGATCTGA
CGTTCCTCAGCGACCGGCGCAAGGTGTTGGCCGCCGCCGAGGCCATCGGCGGCATCAACCTGCTGATCAACGCCGCCGGG
GTCAATCACTTCGCAATGCTGGAACAGCTCGACGACAGCGACATCAACGCCATGCTGGCGGTGAACATCAGTGCGCCGAT
CTGCCTGACCAAACTGTTGCTGCCGCTGCTCAAGCAGGCCGACAGTGCCATGGTGGTCAACGTCGGCTCGACCTATGGTT
CGATCGGTTATCCCGGTTATGCCAGTTACTGCGCGACCAAGTTTGCCTTGCGCGGATTTTCCGAGGCCTTGCGCCGAGAG
TTGGCGGATACCCGGGTCGGTGTGTTGTACGTGGCGCCCCGCGCCACACGCACCGCCATGAACAGCCCCGCCGCCCAGGC
ATTGAACGACGCACTCAAATCCAGCGTCGACGACCCGCAAGCCGTCGCGAATGCCGTAATCCATGCGATTGCCGGCGATC
GCCGCGACCTCTATCTGGGCTGGCCGGAGCGCTTCTTCGTACGCCTCAACAGCCTGCTGCCCAATCTGGTGGATCGCGGT
CTGCGCAAGCAATTGCCGTTGATCCGTCGCCTGAGTGAAAAACCCGAGAACGAGACGCCGAAACCATGA

Upstream 100 bases:

>100_bases
GTGATCCATGCCTCGAAAGTCGTCTATCGGCTCTACGCCGACATGTTCCGCGGCCTGCCCCGTGACGCGGAGGCTCAACA
TGCAGCTGCATGAAGCCCGT

Downstream 100 bases:

>100_bases
AAAAACTTCTCGCCTGTGTGCTGCTGGGCGCCCTCAGTCAAAGTGTCTGGGCGCTGGACGCTGCCGATCAACAACGCCTC
AACAGCATCCAGCAGAGCTG

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MVLTGASGGIGIAITRALCAAGAQVLAVARHQESLRLLLDLYPQNLCWVAADLTFLSDRRKVLAAAEAIGGINLLINAAG
VNHFAMLEQLDDSDINAMLAVNISAPICLTKLLLPLLKQADSAMVVNVGSTYGSIGYPGYASYCATKFALRGFSEALRRE
LADTRVGVLYVAPRATRTAMNSPAAQALNDALKSSVDDPQAVANAVIHAIAGDRRDLYLGWPERFFVRLNSLLPNLVDRG
LRKQLPLIRRLSEKPENETPKP

Sequences:

>Translated_262_residues
MVLTGASGGIGIAITRALCAAGAQVLAVARHQESLRLLLDLYPQNLCWVAADLTFLSDRRKVLAAAEAIGGINLLINAAG
VNHFAMLEQLDDSDINAMLAVNISAPICLTKLLLPLLKQADSAMVVNVGSTYGSIGYPGYASYCATKFALRGFSEALRRE
LADTRVGVLYVAPRATRTAMNSPAAQALNDALKSSVDDPQAVANAVIHAIAGDRRDLYLGWPERFFVRLNSLLPNLVDRG
LRKQLPLIRRLSEKPENETPKP
>Mature_262_residues
MVLTGASGGIGIAITRALCAAGAQVLAVARHQESLRLLLDLYPQNLCWVAADLTFLSDRRKVLAAAEAIGGINLLINAAG
VNHFAMLEQLDDSDINAMLAVNISAPICLTKLLLPLLKQADSAMVVNVGSTYGSIGYPGYASYCATKFALRGFSEALRRE
LADTRVGVLYVAPRATRTAMNSPAAQALNDALKSSVDDPQAVANAVIHAIAGDRRDLYLGWPERFFVRLNSLLPNLVDRG
LRKQLPLIRRLSEKPENETPKP

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32455239, Length=175, Percent_Identity=34.2857142857143, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI5031765, Length=175, Percent_Identity=34.2857142857143, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI142976729, Length=186, Percent_Identity=27.4193548387097, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI20149619, Length=255, Percent_Identity=27.0588235294118, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI40254992, Length=178, Percent_Identity=30.8988764044944, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4503817, Length=229, Percent_Identity=27.0742358078603, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI19743808, Length=210, Percent_Identity=30, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI32483357, Length=203, Percent_Identity=27.0935960591133, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI150247226, Length=189, Percent_Identity=32.8042328042328, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI223718074, Length=171, Percent_Identity=31.5789473684211, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI7706318, Length=168, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=215, Percent_Identity=29.7674418604651, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787820, Length=180, Percent_Identity=32.7777777777778, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI87082100, Length=224, Percent_Identity=29.0178571428571, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786701, Length=232, Percent_Identity=26.2931034482759, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI87082160, Length=175, Percent_Identity=25.1428571428571, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=204, Percent_Identity=29.9019607843137, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=234, Percent_Identity=23.5042735042735, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=216, Percent_Identity=27.7777777777778, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=171, Percent_Identity=28.0701754385965, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=191, Percent_Identity=30.3664921465969, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24643142, Length=182, Percent_Identity=36.2637362637363, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21356301, Length=187, Percent_Identity=29.9465240641711, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI116007236, Length=187, Percent_Identity=32.0855614973262, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161076933, Length=189, Percent_Identity=29.6296296296296, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24584748, Length=189, Percent_Identity=29.6296296296296, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571387, Length=227, Percent_Identity=30.8370044052863, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21358495, Length=192, Percent_Identity=30.2083333333333, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007238, Length=180, Percent_Identity=31.6666666666667, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24584744, Length=199, Percent_Identity=27.6381909547739, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28574402, Length=199, Percent_Identity=27.6381909547739, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221510726, Length=110, Percent_Identity=38.1818181818182, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24663911, Length=232, Percent_Identity=32.3275862068966, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI23397609, Length=176, Percent_Identity=35.2272727272727, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24581726, Length=186, Percent_Identity=27.9569892473118, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28161; Mature: 28161

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLTGASGGIGIAITRALCAAGAQVLAVARHQESLRLLLDLYPQNLCWVAADLTFLSDRR
CEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
KVLAAAEAIGGINLLINAAGVNHFAMLEQLDDSDINAMLAVNISAPICLTKLLLPLLKQA
HHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHCC
DSAMVVNVGSTYGSIGYPGYASYCATKFALRGFSEALRRELADTRVGVLYVAPRATRTAM
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHC
NSPAAQALNDALKSSVDDPQAVANAVIHAIAGDRRDLYLGWPERFFVRLNSLLPNLVDRG
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHH
LRKQLPLIRRLSEKPENETPKP
HHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MVLTGASGGIGIAITRALCAAGAQVLAVARHQESLRLLLDLYPQNLCWVAADLTFLSDRR
CEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
KVLAAAEAIGGINLLINAAGVNHFAMLEQLDDSDINAMLAVNISAPICLTKLLLPLLKQA
HHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHCC
DSAMVVNVGSTYGSIGYPGYASYCATKFALRGFSEALRRELADTRVGVLYVAPRATRTAM
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHC
NSPAAQALNDALKSSVDDPQAVANAVIHAIAGDRRDLYLGWPERFFVRLNSLLPNLVDRG
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHH
LRKQLPLIRRLSEKPENETPKP
HHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]