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The map label for this gene is aprA [H]

Identifier: 77458903

GI number: 77458903

Start: 3078274

End: 3079734

Strand: Direct

Name: aprA [H]

Synonym: Pfl01_2678

Alternate gene names: 77458903

Gene position: 3078274-3079734 (Clockwise)

Preceding gene: 77458902

Following gene: 77458904

Centisome position: 47.81

GC content: 61.6

Gene sequence:

>1461_bases
ATGTCGAAAGTAAAAGCTAATGCTGTTGATACCGCCGAGCAGGCTTTCCAGCTGAACGCGGCTCCCCTGGCTGCGTCGAG
CTCGGCGTTCAACCAGATCAACAGCTTCAGCCATCAGTACGATCGTGGCGGCAACCTCACGGTCAATGGCAAACCCTCCT
TTTCCGTCGACCAGGCCGCCACCCAGTTGCTGCGCGACGGCGCTGCCTACCAGGACAAGGATGGCAGCGGCAAGATCGAA
CTCACCTACACGTTCCTGACTTCGGCATCGTCCAGCACGATGTACAAACACGGGATCAGCGGGTTCAGTCAGTTCAGTAC
CCAACAAAAAGCCCAGGCCGTGCTCGCCATGCAATCCTGGGCCGATGTGGCCAATGTGACCTTCACCGAGAAAGCCTCGG
GCGGTGACGGCCACATGACCTTCGGCAACTACAGCGGCGGCCAGGACGGCGCGGCAGCGTTCGCTTATCTGCCAGGCACC
GGCGCCGGTTACGACGGCACGTCGTGGTACCTGATCAACAGTGGCTACACGCAAAACAAAAACCCGGATCTGAACAACTA
CGGTCGTCAGACCCTGACCCACGAAATCGGCCACACCCTTGGCCTGGCGCACCCGGGCGACTACAACGCCGGCAACGGCA
ACCCGACCTACAACGACGCCACCTACGGGCAAGACACCCGCGGCTACAGCGTCATGAGCTACTGGAGCGAAAGCAACACC
AGTCAGAACTTCAGCAAGGGTGGCGTGGAAGCTTATTCCTCCGGCCCGCTGATGGATGACATCGCGGCGATCCAGAAGCT
CTACGGCGCCAACCTGACCACCCGTACCGGTGACACCACCTACGGCTTCAACTCCAACGCCGGTCGCGATTTCCTCAGCG
CCTCGTCGTCGGCCGACAAGCTGGTGTTCTCGGTATGGGATGCGGGCGGCAAGGACACCTTCGACTTCTCGGGTTTCACC
CAGAACCAGAAGATCAACCTCAATGAAGCCTCGTTCTCCGACGTTGGCGGCCTGGTGGGCAACGTGTCCATCGCCAAGGG
CGTCACCATCGAGAACGCCATCGGCGGTTCGGGCAACGACCTGCTGATCGGCAACAGCGCGGCCAACGAGCTCAAGGGCG
GTGCCGGCAACGACATCATCTGGGGCGCAGGCGGTGCTGACAAGCTGTGGGGCGGCGCGGGTTCGGACACCTTTGTGTTC
GCGGCCAGCTCCGACTCCAAACCGGGTGCGATCGATCAGATCCTCGATTTCGTCAGCGGTCTGGACAAAATCGACCTGAC
CGGCATCACCAACGGTGCAGGCCTGCACTTCGTCAGTGCCTTCACCGGCGCAGCGGGTGACGCGGTTCTGACGTCATCGG
GCGGCAACAGCCTGTTGTCGGTGGACTTCTCCGGACACGGCGTGGCTGATTTCCAGGTCAGCACCGTTGGCCAGGCAGCC
ACCAGCGACATCGTGGCGTGA

Upstream 100 bases:

>100_bases
GGTTTCTTACGCCTTCATTGGGCGAGTGATAGGACAATCTCGCCAGAGGTTGTCGCTATCGGACAAAAACTGTTCCATTG
CTAAACAAGGAAGTGTGTTT

Downstream 100 bases:

>100_bases
TGTAACACGGGAAGCGGCGCGTGATGCGCCGCTTTCTTCACTTGCATCGCCATGGCCGGTAAGCAAGGCTACGTGCCGGA
GTGAAATTTCCTATGATCCA

Product: epralysin

Products: NA

Alternate protein names: AP [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSKVKANAVDTAEQAFQLNAAPLAASSSAFNQINSFSHQYDRGGNLTVNGKPSFSVDQAATQLLRDGAAYQDKDGSGKIE
LTYTFLTSASSSTMYKHGISGFSQFSTQQKAQAVLAMQSWADVANVTFTEKASGGDGHMTFGNYSGGQDGAAAFAYLPGT
GAGYDGTSWYLINSGYTQNKNPDLNNYGRQTLTHEIGHTLGLAHPGDYNAGNGNPTYNDATYGQDTRGYSVMSYWSESNT
SQNFSKGGVEAYSSGPLMDDIAAIQKLYGANLTTRTGDTTYGFNSNAGRDFLSASSSADKLVFSVWDAGGKDTFDFSGFT
QNQKINLNEASFSDVGGLVGNVSIAKGVTIENAIGGSGNDLLIGNSAANELKGGAGNDIIWGAGGADKLWGGAGSDTFVF
AASSDSKPGAIDQILDFVSGLDKIDLTGITNGAGLHFVSAFTGAAGDAVLTSSGGNSLLSVDFSGHGVADFQVSTVGQAA
TSDIVA

Sequences:

>Translated_486_residues
MSKVKANAVDTAEQAFQLNAAPLAASSSAFNQINSFSHQYDRGGNLTVNGKPSFSVDQAATQLLRDGAAYQDKDGSGKIE
LTYTFLTSASSSTMYKHGISGFSQFSTQQKAQAVLAMQSWADVANVTFTEKASGGDGHMTFGNYSGGQDGAAAFAYLPGT
GAGYDGTSWYLINSGYTQNKNPDLNNYGRQTLTHEIGHTLGLAHPGDYNAGNGNPTYNDATYGQDTRGYSVMSYWSESNT
SQNFSKGGVEAYSSGPLMDDIAAIQKLYGANLTTRTGDTTYGFNSNAGRDFLSASSSADKLVFSVWDAGGKDTFDFSGFT
QNQKINLNEASFSDVGGLVGNVSIAKGVTIENAIGGSGNDLLIGNSAANELKGGAGNDIIWGAGGADKLWGGAGSDTFVF
AASSDSKPGAIDQILDFVSGLDKIDLTGITNGAGLHFVSAFTGAAGDAVLTSSGGNSLLSVDFSGHGVADFQVSTVGQAA
TSDIVA
>Mature_485_residues
SKVKANAVDTAEQAFQLNAAPLAASSSAFNQINSFSHQYDRGGNLTVNGKPSFSVDQAATQLLRDGAAYQDKDGSGKIEL
TYTFLTSASSSTMYKHGISGFSQFSTQQKAQAVLAMQSWADVANVTFTEKASGGDGHMTFGNYSGGQDGAAAFAYLPGTG
AGYDGTSWYLINSGYTQNKNPDLNNYGRQTLTHEIGHTLGLAHPGDYNAGNGNPTYNDATYGQDTRGYSVMSYWSESNTS
QNFSKGGVEAYSSGPLMDDIAAIQKLYGANLTTRTGDTTYGFNSNAGRDFLSASSSADKLVFSVWDAGGKDTFDFSGFTQ
NQKINLNEASFSDVGGLVGNVSIAKGVTIENAIGGSGNDLLIGNSAANELKGGAGNDIIWGAGGADKLWGGAGSDTFVFA
ASSDSKPGAIDQILDFVSGLDKIDLTGITNGAGLHFVSAFTGAAGDAVLTSSGGNSLLSVDFSGHGVADFQVSTVGQAAT
SDIVA

Specific function: Unknown

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR016294
- InterPro:   IPR013858
- InterPro:   IPR006026
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF08548 Peptidase_M10_C [H]

EC number: NA

Molecular weight: Translated: 50170; Mature: 50038

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS00142 ZINC_PROTEASE ; PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVKANAVDTAEQAFQLNAAPLAASSSAFNQINSFSHQYDRGGNLTVNGKPSFSVDQAA
CCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHH
TQLLRDGAAYQDKDGSGKIELTYTFLTSASSSTMYKHGISGFSQFSTQQKAQAVLAMQSW
HHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
ADVANVTFTEKASGGDGHMTFGNYSGGQDGAAAFAYLPGTGAGYDGTSWYLINSGYTQNK
HHHHCEEEEECCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCC
NPDLNNYGRQTLTHEIGHTLGLAHPGDYNAGNGNPTYNDATYGQDTRGYSVMSYWSESNT
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
SQNFSKGGVEAYSSGPLMDDIAAIQKLYGANLTTRTGDTTYGFNSNAGRDFLSASSSADK
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHHCCCCCCE
LVFSVWDAGGKDTFDFSGFTQNQKINLNEASFSDVGGLVGNVSIAKGVTIENAIGGSGND
EEEEEECCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCEEHHCCCEEECCCCCCCCE
LLIGNSAANELKGGAGNDIIWGAGGADKLWGGAGSDTFVFAASSDSKPGAIDQILDFVSG
EEEECCCHHHCCCCCCCCEEECCCCCHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHC
LDKIDLTGITNGAGLHFVSAFTGAAGDAVLTSSGGNSLLSVDFSGHGVADFQVSTVGQAA
CCCEEEEECCCCCCCEEHHHHCCCCCCEEEECCCCCEEEEEECCCCCEEEEEEECCCCHH
TSDIVA
HHHCCC
>Mature Secondary Structure 
SKVKANAVDTAEQAFQLNAAPLAASSSAFNQINSFSHQYDRGGNLTVNGKPSFSVDQAA
CCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHH
TQLLRDGAAYQDKDGSGKIELTYTFLTSASSSTMYKHGISGFSQFSTQQKAQAVLAMQSW
HHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
ADVANVTFTEKASGGDGHMTFGNYSGGQDGAAAFAYLPGTGAGYDGTSWYLINSGYTQNK
HHHHCEEEEECCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCC
NPDLNNYGRQTLTHEIGHTLGLAHPGDYNAGNGNPTYNDATYGQDTRGYSVMSYWSESNT
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
SQNFSKGGVEAYSSGPLMDDIAAIQKLYGANLTTRTGDTTYGFNSNAGRDFLSASSSADK
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHHCCCCCCE
LVFSVWDAGGKDTFDFSGFTQNQKINLNEASFSDVGGLVGNVSIAKGVTIENAIGGSGND
EEEEEECCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCEEHHCCCEEECCCCCCCCE
LLIGNSAANELKGGAGNDIIWGAGGADKLWGGAGSDTFVFAASSDSKPGAIDQILDFVSG
EEEECCCHHHCCCCCCCCEEECCCCCHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHC
LDKIDLTGITNGAGLHFVSAFTGAAGDAVLTSSGGNSLLSVDFSGHGVADFQVSTVGQAA
CCCEEEEECCCCCCCEEHHHHCCCCCCEEEECCCCCEEEEEECCCCCEEEEEEECCCCHH
TSDIVA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1427098; 2123832; 10984043; 8253063; 8690704 [H]