Click here to switch to the map view.

The map label for this gene is dapA [H]

Identifier: 77457598

GI number: 77457598

Start: 1544314

End: 1545192

Strand: Direct

Name: dapA [H]

Synonym: Pfl01_1371

Alternate gene names: 77457598

Gene position: 1544314-1545192 (Clockwise)

Preceding gene: 77457595

Following gene: 77457599

Centisome position: 23.99

GC content: 61.32

Gene sequence:

>879_bases
ATGATTGCGGGCAGTATGGTGGCACTGGTCACACCCATGGATGCACAAGGGCGTCTTGACTGGGACAGCCTCAGCAAACT
CGTGGACTTCCATCTCAAGAACGGCACCCATGCCATTGTCGCGGTCGGCACCACCGGCGAGTCGGCAACCCTTGATGTAG
AAGAACACATCGCCGTCATCAAAGCCGTGGTCAAACAGGTTGCCGGTCGTATTCCGGTGATCGCCGGTACCGGCGCCAAC
TCGACCCGCGAAGCTGTCGAGCTGACCCGCAATGCCAAGGAAGCCGGCGCCGATGCCTGCCTGCTGGTAGTCCCGTACTA
CAACAAGCCGACCCAGGAAGGCCTGTACCAGCACTTCAAGCACATCGCCGAAGCGGTCGACATCCCACAGATTCTCTATA
ACGTTCCCGGCCGCACCTCCTGCGACATGCAGGCCGAGACCGTGATCCGCCTGTCCACCGTGCCGAACATCATCGGCATC
AAGGAAGCGACCGGCGACCTGAAACGTGCCAAGGCGATCATCGACGGCGTGAGCAAGGACTTCATCGTGCTGTCCGGCGA
TGATCCGACCGCCGTCGAGCTGATCTTGTTGGGCGGCAAGGGCAACATCTCCGTCACCGCCAACGTCGCGCCACGCGAAA
TGGCCGACCTGTGCGAGGCCGCGCTCAAGGGCGACGCCGAGACCGCACGGGCCATCAACGAAAAACTGATGCCGCTGCAC
AAGGACCTGTTCATCGAAGCCAACCCGATTCCGGTGAAGTGGGCTTTGGTCGAAATGGGCCTGATGCACCAAGGCATCCG
CCTGCCGCTGACCTGGCTGAGCGCTCCTTGTCATGAAACGCTGCGCTCGGCCCTGCGCCAGTGCAACGTCCTGGTTTAA

Upstream 100 bases:

>100_bases
AAAAGCGGCGCCAAGGGGAATGGCGGCACAGTACTTCGCTTGTGCAAGCATCTTGGCGCCAGTACCATTACCGCTCTCTT
TTTCCGGCAGGAGCGGTTTC

Downstream 100 bases:

>100_bases
TTGAGGAAGTACAACGCATGAAGCGAATGGCCGGACTTTCCGCACTTGCCTTGATTATCTCCAGCACCAGTGGCTGCGGA
TGGATCTGGGGCCCGGAAGG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MIAGSMVALVTPMDAQGRLDWDSLSKLVDFHLKNGTHAIVAVGTTGESATLDVEEHIAVIKAVVKQVAGRIPVIAGTGAN
STREAVELTRNAKEAGADACLLVVPYYNKPTQEGLYQHFKHIAEAVDIPQILYNVPGRTSCDMQAETVIRLSTVPNIIGI
KEATGDLKRAKAIIDGVSKDFIVLSGDDPTAVELILLGGKGNISVTANVAPREMADLCEAALKGDAETARAINEKLMPLH
KDLFIEANPIPVKWALVEMGLMHQGIRLPLTWLSAPCHETLRSALRQCNVLV

Sequences:

>Translated_292_residues
MIAGSMVALVTPMDAQGRLDWDSLSKLVDFHLKNGTHAIVAVGTTGESATLDVEEHIAVIKAVVKQVAGRIPVIAGTGAN
STREAVELTRNAKEAGADACLLVVPYYNKPTQEGLYQHFKHIAEAVDIPQILYNVPGRTSCDMQAETVIRLSTVPNIIGI
KEATGDLKRAKAIIDGVSKDFIVLSGDDPTAVELILLGGKGNISVTANVAPREMADLCEAALKGDAETARAINEKLMPLH
KDLFIEANPIPVKWALVEMGLMHQGIRLPLTWLSAPCHETLRSALRQCNVLV
>Mature_292_residues
MIAGSMVALVTPMDAQGRLDWDSLSKLVDFHLKNGTHAIVAVGTTGESATLDVEEHIAVIKAVVKQVAGRIPVIAGTGAN
STREAVELTRNAKEAGADACLLVVPYYNKPTQEGLYQHFKHIAEAVDIPQILYNVPGRTSCDMQAETVIRLSTVPNIIGI
KEATGDLKRAKAIIDGVSKDFIVLSGDDPTAVELILLGGKGNISVTANVAPREMADLCEAALKGDAETARAINEKLMPLH
KDLFIEANPIPVKWALVEMGLMHQGIRLPLTWLSAPCHETLRSALRQCNVLV

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=288, Percent_Identity=29.1666666666667, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI13540533, Length=235, Percent_Identity=28.5106382978723, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=56.8493150684932, Blast_Score=335, Evalue=1e-93,
Organism=Escherichia coli, GI87082415, Length=258, Percent_Identity=33.7209302325581, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786463, Length=241, Percent_Identity=32.7800829875519, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1789620, Length=233, Percent_Identity=30.0429184549356, Blast_Score=118, Evalue=5e-28,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31323; Mature: 31323

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAGSMVALVTPMDAQGRLDWDSLSKLVDFHLKNGTHAIVAVGTTGESATLDVEEHIAVI
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEEECHHHHHHHH
KAVVKQVAGRIPVIAGTGANSTREAVELTRNAKEAGADACLLVVPYYNKPTQEGLYQHFK
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHH
HIAEAVDIPQILYNVPGRTSCDMQAETVIRLSTVPNIIGIKEATGDLKRAKAIIDGVSKD
HHHHHHCHHHHHHCCCCCCCCCCCHHHEEEEECCCCCEECHHHHHHHHHHHHHHHCCCCC
FIVLSGDDPTAVELILLGGKGNISVTANVAPREMADLCEAALKGDAETARAINEKLMPLH
EEEEECCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
KDLFIEANPIPVKWALVEMGLMHQGIRLPLTWLSAPCHETLRSALRQCNVLV
HHEEEECCCCCEEHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIAGSMVALVTPMDAQGRLDWDSLSKLVDFHLKNGTHAIVAVGTTGESATLDVEEHIAVI
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEEECHHHHHHHH
KAVVKQVAGRIPVIAGTGANSTREAVELTRNAKEAGADACLLVVPYYNKPTQEGLYQHFK
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHH
HIAEAVDIPQILYNVPGRTSCDMQAETVIRLSTVPNIIGIKEATGDLKRAKAIIDGVSKD
HHHHHHCHHHHHHCCCCCCCCCCCHHHEEEEECCCCCEECHHHHHHHHHHHHHHHCCCCC
FIVLSGDDPTAVELILLGGKGNISVTANVAPREMADLCEAALKGDAETARAINEKLMPLH
EEEEECCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
KDLFIEANPIPVKWALVEMGLMHQGIRLPLTWLSAPCHETLRSALRQCNVLV
HHEEEECCCCCEEHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA