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The map label for this gene is pcaR [H]

Identifier: 77457492

GI number: 77457492

Start: 1438086

End: 1438928

Strand: Direct

Name: pcaR [H]

Synonym: Pfl01_1265

Alternate gene names: 77457492

Gene position: 1438086-1438928 (Clockwise)

Preceding gene: 77457490

Following gene: 77457493

Centisome position: 22.34

GC content: 64.77

Gene sequence:

>843_bases
ATGAACGATCAAATGCGCAATTCCTTCACCTCGGTAGCGCCGCCGATCGTCGCTTCGCCGGCCAAGCGTATCCAGGCCCT
GACTGGTGATCCGGATTTCATGACCTCCCTGGCCCGTGGCCTGGCGGTGGTGCAGGCGTTTCAGGAGCGCAAGCGCCACC
TGACCATCGCCCAGATCAGCCACCGCACGGAAATTCCCCGCGCCGCCGTGCGCCGTTGCCTGCACACACTGATCAAACTC
GGCTACGCCACCACCGACGGGCGCACTTATTCGCTTCTGCCCAAAGTGCTGACCCTCGGTCACGCCTATCTGTCGTCGAC
GCCGCTGGCGGTCTCGGCCCAGCCGTACCTCGACCGCATGAGCGAGCAACTGCACGAGGCCTGCAACATGGCCACGCTGG
AAGGCGACGACATTCTCTACATCGCCCGTTCGGCGACCACTCAGCGTCTGATTTCGGTGGACCTCTCGGTGGGCGGGCGT
TTGCCGGCGTACTGCACGTCCATGGGGCGGATTCTGCTGGCGGCGCTGGACGACACCTCGCTGCGCGAATACCTCGACCA
CGCCGAACTGGTGGCCAAGACCAGCCGCACCATTCACACCGCAGACGCCTTGCTCGAATGTCTGCAGGAAGTCCGGCAGC
AGGGCTGGTGCATCGTCGATCAGGAACTGGAACAGGGTCTGCGCTCGATTGCCGTGCCGGTGTACGACGCGTCCGGCCAG
GTGGTGGCCGCGCTCAACGTCAGCACCCACGCCGGTCGCGTCAGCCGCACCGAGCTGGAGCAGCGCTTTTTGCCCGGTCT
GTTGAGCGCCAGCCGCGACCTCAGTGCGCAATTGTTTGCCTGA

Upstream 100 bases:

>100_bases
CGGTTCGATAATCGCCCGGTGTTGGCGGTCTGTCACTTGTGTATCCGCCAGCGAGCCGCTTGTATAGCCGTTGATCCGAA
CAAGAAAAAGAGGACCTGAC

Downstream 100 bases:

>100_bases
TGAAGCTGTTCGATAAACGCACAGAGTTGCGTTTATCGAATTGACGCTAAAACCCCCGGATCATTAATGTCGCGGCAGCG
TCATCCGGCGCGAATGTGAA

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MNDQMRNSFTSVAPPIVASPAKRIQALTGDPDFMTSLARGLAVVQAFQERKRHLTIAQISHRTEIPRAAVRRCLHTLIKL
GYATTDGRTYSLLPKVLTLGHAYLSSTPLAVSAQPYLDRMSEQLHEACNMATLEGDDILYIARSATTQRLISVDLSVGGR
LPAYCTSMGRILLAALDDTSLREYLDHAELVAKTSRTIHTADALLECLQEVRQQGWCIVDQELEQGLRSIAVPVYDASGQ
VVAALNVSTHAGRVSRTELEQRFLPGLLSASRDLSAQLFA

Sequences:

>Translated_280_residues
MNDQMRNSFTSVAPPIVASPAKRIQALTGDPDFMTSLARGLAVVQAFQERKRHLTIAQISHRTEIPRAAVRRCLHTLIKL
GYATTDGRTYSLLPKVLTLGHAYLSSTPLAVSAQPYLDRMSEQLHEACNMATLEGDDILYIARSATTQRLISVDLSVGGR
LPAYCTSMGRILLAALDDTSLREYLDHAELVAKTSRTIHTADALLECLQEVRQQGWCIVDQELEQGLRSIAVPVYDASGQ
VVAALNVSTHAGRVSRTELEQRFLPGLLSASRDLSAQLFA
>Mature_280_residues
MNDQMRNSFTSVAPPIVASPAKRIQALTGDPDFMTSLARGLAVVQAFQERKRHLTIAQISHRTEIPRAAVRRCLHTLIKL
GYATTDGRTYSLLPKVLTLGHAYLSSTPLAVSAQPYLDRMSEQLHEACNMATLEGDDILYIARSATTQRLISVDLSVGGR
LPAYCTSMGRILLAALDDTSLREYLDHAELVAKTSRTIHTADALLECLQEVRQQGWCIVDQELEQGLRSIAVPVYDASGQ
VVAALNVSTHAGRVSRTELEQRFLPGLLSASRDLSAQLFA

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=256, Percent_Identity=34.765625, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1786468, Length=230, Percent_Identity=29.1304347826087, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1789999, Length=252, Percent_Identity=26.984126984127, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082359, Length=245, Percent_Identity=24.8979591836735, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1786715, Length=231, Percent_Identity=25.1082251082251, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30685; Mature: 30685

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDQMRNSFTSVAPPIVASPAKRIQALTGDPDFMTSLARGLAVVQAFQERKRHLTIAQIS
CCCHHHHHHHHHCCCHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
HRTEIPRAAVRRCLHTLIKLGYATTDGRTYSLLPKVLTLGHAYLSSTPLAVSAQPYLDRM
HHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHH
SEQLHEACNMATLEGDDILYIARSATTQRLISVDLSVGGRLPAYCTSMGRILLAALDDTS
HHHHHHHHCCCEECCCCEEEEECCHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCHH
LREYLDHAELVAKTSRTIHTADALLECLQEVRQQGWCIVDQELEQGLRSIAVPVYDASGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCEEECCCCC
VVAALNVSTHAGRVSRTELEQRFLPGLLSASRDLSAQLFA
EEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure
MNDQMRNSFTSVAPPIVASPAKRIQALTGDPDFMTSLARGLAVVQAFQERKRHLTIAQIS
CCCHHHHHHHHHCCCHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
HRTEIPRAAVRRCLHTLIKLGYATTDGRTYSLLPKVLTLGHAYLSSTPLAVSAQPYLDRM
HHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHH
SEQLHEACNMATLEGDDILYIARSATTQRLISVDLSVGGRLPAYCTSMGRILLAALDDTS
HHHHHHHHCCCEECCCCEEEEECCHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCHH
LREYLDHAELVAKTSRTIHTADALLECLQEVRQQGWCIVDQELEQGLRSIAVPVYDASGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCEEECCCCC
VVAALNVSTHAGRVSRTELEQRFLPGLLSASRDLSAQLFA
EEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]