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The map label for this gene is moaE [H]

Identifier: 77457193

GI number: 77457193

Start: 1126350

End: 1126802

Strand: Direct

Name: moaE [H]

Synonym: Pfl01_0966

Alternate gene names: 77457193

Gene position: 1126350-1126802 (Clockwise)

Preceding gene: 77457192

Following gene: 77457194

Centisome position: 17.49

GC content: 64.24

Gene sequence:

>453_bases
ATGGGCATTCGGGTGCAGTCCGAACCGTTCGATCCTGGCGCTGAAGTCAACGCGATGCACGCGGCGAATGTCGGCGTCGG
CGCGGTGGTGAGTTTTGTCGGCTACGTGCGCGACTTCAACGATGGCCTCGATGTCGCCGGGATGTTCCTCGAACACTATC
CGGGCATGACCGAAAAGGCCCTCGGCAAGATCGCCTTGGAGGCCGAGCAGCGCTGGCCGCTGTTGAAGCTGGAAGTGCTG
CACCGCATCGGCGCGCTGGAACCGGGTGAACCGATCGTGTTTGTCGCCGCCGCCAGTGCCCACCGCCAGGCGGCGTTCGA
CGCCTGCGCCTTCGTCATGGATTACCTGAAAACCCGCGCGCCGTTCTGGAAGAAAGAGAACACCAGCGACGGCCCGCGCT
GGGTCGAAGGCCGTGACAGCGATCATGCGGCGGCGGATCGCTGGAAGCAGTAA

Upstream 100 bases:

>100_bases
CCTGATGTGCGCACGCAACGAAGACCTCTGCCAGCTCGACGAGCCGGTGGTGGACGGCGACGAAGTGGCGTTTTTTCCCA
CCGTGACCGGAGGCTGAGCC

Downstream 100 bases:

>100_bases
TTCCTCCCCCCGATCAATCTCCCCTCGACTCCCGACCATCGGCTGACGCCGATGGTGTTTGTTCAATTGACGGCTTGTAC
GTAAAAGTCCAGTATGGATT

Product: molybdopterin biosynthesis MoaE

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MGIRVQSEPFDPGAEVNAMHAANVGVGAVVSFVGYVRDFNDGLDVAGMFLEHYPGMTEKALGKIALEAEQRWPLLKLEVL
HRIGALEPGEPIVFVAAASAHRQAAFDACAFVMDYLKTRAPFWKKENTSDGPRWVEGRDSDHAAADRWKQ

Sequences:

>Translated_150_residues
MGIRVQSEPFDPGAEVNAMHAANVGVGAVVSFVGYVRDFNDGLDVAGMFLEHYPGMTEKALGKIALEAEQRWPLLKLEVL
HRIGALEPGEPIVFVAAASAHRQAAFDACAFVMDYLKTRAPFWKKENTSDGPRWVEGRDSDHAAADRWKQ
>Mature_149_residues
GIRVQSEPFDPGAEVNAMHAANVGVGAVVSFVGYVRDFNDGLDVAGMFLEHYPGMTEKALGKIALEAEQRWPLLKLEVLH
RIGALEPGEPIVFVAAASAHRQAAFDACAFVMDYLKTRAPFWKKENTSDGPRWVEGRDSDHAAADRWKQ

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=109, Percent_Identity=34.8623853211009, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1787003, Length=146, Percent_Identity=56.8493150684932, Blast_Score=160, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17509279, Length=108, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356259, Length=122, Percent_Identity=36.8852459016393, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 16511; Mature: 16380

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIRVQSEPFDPGAEVNAMHAANVGVGAVVSFVGYVRDFNDGLDVAGMFLEHYPGMTEKA
CCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHH
LGKIALEAEQRWPLLKLEVLHRIGALEPGEPIVFVAAASAHRQAAFDACAFVMDYLKTRA
HHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCC
PFWKKENTSDGPRWVEGRDSDHAAADRWKQ
CCCCCCCCCCCCCCCCCCCCCCHHHHHCCC
>Mature Secondary Structure 
GIRVQSEPFDPGAEVNAMHAANVGVGAVVSFVGYVRDFNDGLDVAGMFLEHYPGMTEKA
CCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHH
LGKIALEAEQRWPLLKLEVLHRIGALEPGEPIVFVAAASAHRQAAFDACAFVMDYLKTRA
HHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCC
PFWKKENTSDGPRWVEGRDSDHAAADRWKQ
CCCCCCCCCCCCCCCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]