Click here to switch to the map view.

The map label for this gene is sdaC [H]

Identifier: 77457146

GI number: 77457146

Start: 1068665

End: 1069966

Strand: Reverse

Name: sdaC [H]

Synonym: Pfl01_0919

Alternate gene names: 77457146

Gene position: 1069966-1068665 (Counterclockwise)

Preceding gene: 77457147

Following gene: 77457145

Centisome position: 16.62

GC content: 61.67

Gene sequence:

>1302_bases
ATGACCGATGTACGCACACCTGCTGCCGAAAATCCCGCTGTAGACCGCACACGCAATAACGAAACCGCCCACAAGGGCTG
GAGCAAGTTCGACACCACCTGGATGCTCGGCCTGTATGGCACCGCCATTGGCGCCGGCACCCTGTTCCTGCCGATCAACG
CCGGTGTCGGCGGCTTCTGGCCGTTGCTGATCCTGGCGTTGCTGGCTTTCCCGATGACCTTCTTCGCGCACCGTGGCCTC
ACCCGCTTCGTGCTCTCGGGCCGCTCCGGTGACATCACCGAAGTGGTGGAGGAACACTTCGGCATCGGCGCCGGCAAACT
GATTACGCTGCTGTATTTCTTCGCAATCTTCCCGATCCTGCTGGTGTACAGCGTGGCGCTGACCAACACTCTCGGCAGCT
TCCTCGAACACCAGTTGCACATCGCCCCGCCACCGCGCGCGGTGCTGTCGCTGGCGCTGATCCTCGGTCTGATGGCCATC
GTCCGTTGCGGTCAGAACGTGATCGTCAAAGCCATGAGTGTGCTGGTGTATCCGTTCGTCGCCGCGTTGCTGTTGCTCGG
CATCAGCCTGATTCCGAACTGGAACGGCGCATTCTTCGCCAGCGCTCAAGAACCGATGGAAATGTCGGTGTTCCTCAAGA
CCCTGTGGCTGGCGATCCCGGTGATGGTGTTCTCGTTCAACCATTCACCCATCATCTCTGCGTTCGCCGTCGAGCAGAAA
CAGCGCTACGGCGAGCAGGCCGAACGCAAGAGCAGCGGCATCCTCGCCATGGCCCACGGCATGATGGTCGTCACGGTGAT
GTTCTTCTGCTTCAGCTGCGTGCTGGCGCTGTCGCCGACGGATCTGGCAGCGGCCAAGGCGCAGAACATCTCGATCCTGT
CGTATCTGGCCAACCACTTCCAGACCCCGGTCATCGCTTACGCCGCGCCATTGATTGCGCTGGTGGCGATCACCAAATCC
TTCCTCGGCCACTACATCGGCGCCAGCGAAGGCTTCCAGGGCATGATCGTCAAAAGCCTGCGCAGCCGTGGCCGGGTGAT
GTCGGCGAGCTGGCTGAACCGTGCGACCGCGCTGTTCATGATCCTCAGCTGCTGGGCCGTGGCGACCTTCAACCCGAGCA
TCCTCGGCATGATCGAAACCCTCGGCGGGCCGGTGATTGCCTGCCTGCTGTTCCTGATGCCGATGTACGCGATCCGCCGC
GTGCCAGCCTTGCGCCAGTATTCGGGCCAGGTGTCGAACGTGTTCGTGGTGCTGATCGGCCTGATTGCACTGTCAGCGAT
CATCTACTCGGTTCTGCCCTGA

Upstream 100 bases:

>100_bases
ACGGGGCGGCTTGGCCGTGAGCTGGGTGGAGTGCTGAGGAGCGCTCCCTGACCGCCCGTAACACGTGAGCCCGAGCAAGA
ATAATAACGAGGCAAAAACG

Downstream 100 bases:

>100_bases
AACGGGCCGCAAACGAAGAAGGCGAGCCATGAGCTCGCCTTCTTTTTGGCCGGTTTCATTGTTCGACAATATTCCCGGCA
TGTCCCTTGCTACATCACTG

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MTDVRTPAAENPAVDRTRNNETAHKGWSKFDTTWMLGLYGTAIGAGTLFLPINAGVGGFWPLLILALLAFPMTFFAHRGL
TRFVLSGRSGDITEVVEEHFGIGAGKLITLLYFFAIFPILLVYSVALTNTLGSFLEHQLHIAPPPRAVLSLALILGLMAI
VRCGQNVIVKAMSVLVYPFVAALLLLGISLIPNWNGAFFASAQEPMEMSVFLKTLWLAIPVMVFSFNHSPIISAFAVEQK
QRYGEQAERKSSGILAMAHGMMVVTVMFFCFSCVLALSPTDLAAAKAQNISILSYLANHFQTPVIAYAAPLIALVAITKS
FLGHYIGASEGFQGMIVKSLRSRGRVMSASWLNRATALFMILSCWAVATFNPSILGMIETLGGPVIACLLFLMPMYAIRR
VPALRQYSGQVSNVFVVLIGLIALSAIIYSVLP

Sequences:

>Translated_433_residues
MTDVRTPAAENPAVDRTRNNETAHKGWSKFDTTWMLGLYGTAIGAGTLFLPINAGVGGFWPLLILALLAFPMTFFAHRGL
TRFVLSGRSGDITEVVEEHFGIGAGKLITLLYFFAIFPILLVYSVALTNTLGSFLEHQLHIAPPPRAVLSLALILGLMAI
VRCGQNVIVKAMSVLVYPFVAALLLLGISLIPNWNGAFFASAQEPMEMSVFLKTLWLAIPVMVFSFNHSPIISAFAVEQK
QRYGEQAERKSSGILAMAHGMMVVTVMFFCFSCVLALSPTDLAAAKAQNISILSYLANHFQTPVIAYAAPLIALVAITKS
FLGHYIGASEGFQGMIVKSLRSRGRVMSASWLNRATALFMILSCWAVATFNPSILGMIETLGGPVIACLLFLMPMYAIRR
VPALRQYSGQVSNVFVVLIGLIALSAIIYSVLP
>Mature_432_residues
TDVRTPAAENPAVDRTRNNETAHKGWSKFDTTWMLGLYGTAIGAGTLFLPINAGVGGFWPLLILALLAFPMTFFAHRGLT
RFVLSGRSGDITEVVEEHFGIGAGKLITLLYFFAIFPILLVYSVALTNTLGSFLEHQLHIAPPPRAVLSLALILGLMAIV
RCGQNVIVKAMSVLVYPFVAALLLLGISLIPNWNGAFFASAQEPMEMSVFLKTLWLAIPVMVFSFNHSPIISAFAVEQKQ
RYGEQAERKSSGILAMAHGMMVVTVMFFCFSCVLALSPTDLAAAKAQNISILSYLANHFQTPVIAYAAPLIALVAITKSF
LGHYIGASEGFQGMIVKSLRSRGRVMSASWLNRATALFMILSCWAVATFNPSILGMIETLGGPVIACLLFLMPMYAIRRV
PALRQYSGQVSNVFVVLIGLIALSAIIYSVLP

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=424, Percent_Identity=68.8679245283019, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI1789504, Length=439, Percent_Identity=46.9248291571754, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1789211, Length=409, Percent_Identity=36.919315403423, Blast_Score=272, Evalue=4e-74,
Organism=Escherichia coli, GI145693183, Length=436, Percent_Identity=26.1467889908257, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789961, Length=403, Percent_Identity=25.0620347394541, Blast_Score=122, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46973; Mature: 46841

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVRTPAAENPAVDRTRNNETAHKGWSKFDTTWMLGLYGTAIGAGTLFLPINAGVGGFW
CCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHH
PLLILALLAFPMTFFAHRGLTRFVLSGRSGDITEVVEEHFGIGAGKLITLLYFFAIFPIL
HHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LVYSVALTNTLGSFLEHQLHIAPPPRAVLSLALILGLMAIVRCGQNVIVKAMSVLVYPFV
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AALLLLGISLIPNWNGAFFASAQEPMEMSVFLKTLWLAIPVMVFSFNHSPIISAFAVEQK
HHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
QRYGEQAERKSSGILAMAHGMMVVTVMFFCFSCVLALSPTDLAAAKAQNISILSYLANHF
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHH
QTPVIAYAAPLIALVAITKSFLGHYIGASEGFQGMIVKSLRSRGRVMSASWLNRATALFM
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHH
ILSCWAVATFNPSILGMIETLGGPVIACLLFLMPMYAIRRVPALRQYSGQVSNVFVVLIG
HHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHH
LIALSAIIYSVLP
HHHHHHHHHHHCC
>Mature Secondary Structure 
TDVRTPAAENPAVDRTRNNETAHKGWSKFDTTWMLGLYGTAIGAGTLFLPINAGVGGFW
CCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHH
PLLILALLAFPMTFFAHRGLTRFVLSGRSGDITEVVEEHFGIGAGKLITLLYFFAIFPIL
HHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LVYSVALTNTLGSFLEHQLHIAPPPRAVLSLALILGLMAIVRCGQNVIVKAMSVLVYPFV
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AALLLLGISLIPNWNGAFFASAQEPMEMSVFLKTLWLAIPVMVFSFNHSPIISAFAVEQK
HHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
QRYGEQAERKSSGILAMAHGMMVVTVMFFCFSCVLALSPTDLAAAKAQNISILSYLANHF
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHH
QTPVIAYAAPLIALVAITKSFLGHYIGASEGFQGMIVKSLRSRGRVMSASWLNRATALFM
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHH
ILSCWAVATFNPSILGMIETLGGPVIACLLFLMPMYAIRRVPALRQYSGQVSNVFVVLIG
HHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHH
LIALSAIIYSVLP
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]