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The map label for this gene is folM [H]

Identifier: 77457119

GI number: 77457119

Start: 1037495

End: 1038205

Strand: Reverse

Name: folM [H]

Synonym: Pfl01_0892

Alternate gene names: 77457119

Gene position: 1038205-1037495 (Counterclockwise)

Preceding gene: 77457120

Following gene: 77457118

Centisome position: 16.13

GC content: 61.74

Gene sequence:

>711_bases
ATGACTTCTCCCACCGCTCCCATCCTTATCACCGGCGCCGGCCAGCGGGTCGGCCTGCATTGTGCGCAGCGTCTGCTGGA
AGATGGTCATCGGGTGATCTTCACTTACCGCAGCGAACGGCCGGGTGTGAAGACCTTGCGGGATCTGGGCGCCCTAGGGC
TGCACGCGGACTTTTCCAGCGAAGCTTCGATCCTCGCCTTCATCACCGAGCTGAAGTCACACACCGACAGCCTGCGCGCG
ATCGTGCACAACGCCTCGGAGTGGCTGGCGGAAACCGCTGACGGCGAAGCCGAAGCCTTCAGCCGCATGTTCAACATTCA
CATGCTGGCGCCGTACCTGATCAATCTGCATTGCGCTGAATTGCTGCAACGTTCGAGTCCTGCCGACATCATCCACATCA
GCGATGACGTCACCCGCAAGGGCAGCAGCAAACACATCGGCTATTGCGCCAGCAAGGCCGGGCTCGACAGTCTCACGCTG
TCCTTCGCCGCGCGCTACGCGCCGTCAATCAAGGTCAACGGCATCGCACCGGCCCTGCTATTGTTCAATCCCGACGACGA
CGCGGAGTACCGTGCCAAGGCGCTGGCCAAGTCCGCGCTGGGCATCGAACCCGGCAGCGAAGTGATTTATCAGAGCCTGC
GTTATCTGCTCGACAACCCGTATGTCACCGGCACCACCCTGACCGTCAACGGCGGGCGGCACGTCAAGTAA

Upstream 100 bases:

>100_bases
CTGCACGCCCGCTGCCTGCCGCACCCTCCACGCAAAATCGCTGAAACCGTCGCTCGCGTCGCTGTTATAGTTTTTGCTCT
GACTTCGACGCGAGCCGTAC

Downstream 100 bases:

>100_bases
TACGCCCCCGCGAGGATGCTCCATGACCCGTTCCCTGCCCGAGAATTACCGCGAGATCCTGATCGGCCTCGGTGAAGATC
CCGACCGTGAAGGCTTGCTC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: DHFR [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTSPTAPILITGAGQRVGLHCAQRLLEDGHRVIFTYRSERPGVKTLRDLGALGLHADFSSEASILAFITELKSHTDSLRA
IVHNASEWLAETADGEAEAFSRMFNIHMLAPYLINLHCAELLQRSSPADIIHISDDVTRKGSSKHIGYCASKAGLDSLTL
SFAARYAPSIKVNGIAPALLLFNPDDDAEYRAKALAKSALGIEPGSEVIYQSLRYLLDNPYVTGTTLTVNGGRHVK

Sequences:

>Translated_236_residues
MTSPTAPILITGAGQRVGLHCAQRLLEDGHRVIFTYRSERPGVKTLRDLGALGLHADFSSEASILAFITELKSHTDSLRA
IVHNASEWLAETADGEAEAFSRMFNIHMLAPYLINLHCAELLQRSSPADIIHISDDVTRKGSSKHIGYCASKAGLDSLTL
SFAARYAPSIKVNGIAPALLLFNPDDDAEYRAKALAKSALGIEPGSEVIYQSLRYLLDNPYVTGTTLTVNGGRHVK
>Mature_235_residues
TSPTAPILITGAGQRVGLHCAQRLLEDGHRVIFTYRSERPGVKTLRDLGALGLHADFSSEASILAFITELKSHTDSLRAI
VHNASEWLAETADGEAEAFSRMFNIHMLAPYLINLHCAELLQRSSPADIIHISDDVTRKGSSKHIGYCASKAGLDSLTLS
FAARYAPSIKVNGIAPALLLFNPDDDAEYRAKALAKSALGIEPGSEVIYQSLRYLLDNPYVTGTTLTVNGGRHVK

Specific function: Catalyzes the reduction of dihydrofolate to tetrahydrofolate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787891, Length=234, Percent_Identity=45.2991452991453, Blast_Score=201, Evalue=3e-53,
Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=25.2032520325203, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=27.6859504132231, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.5.1.3 [H]

Molecular weight: Translated: 25570; Mature: 25439

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPTAPILITGAGQRVGLHCAQRLLEDGHRVIFTYRSERPGVKTLRDLGALGLHADFSS
CCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCC
EASILAFITELKSHTDSLRAIVHNASEWLAETADGEAEAFSRMFNIHMLAPYLINLHCAE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLQRSSPADIIHISDDVTRKGSSKHIGYCASKAGLDSLTLSFAARYAPSIKVNGIAPALL
HHHCCCCCCEEEECCCCCCCCCCCCCEEEHHHCCCHHHHHHHHHHHCCCEEECCCCEEEE
LFNPDDDAEYRAKALAKSALGIEPGSEVIYQSLRYLLDNPYVTGTTLTVNGGRHVK
EECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEECCEEEEECCCCCCC
>Mature Secondary Structure 
TSPTAPILITGAGQRVGLHCAQRLLEDGHRVIFTYRSERPGVKTLRDLGALGLHADFSS
CCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCC
EASILAFITELKSHTDSLRAIVHNASEWLAETADGEAEAFSRMFNIHMLAPYLINLHCAE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLQRSSPADIIHISDDVTRKGSSKHIGYCASKAGLDSLTLSFAARYAPSIKVNGIAPALL
HHHCCCCCCEEEECCCCCCCCCCCCCEEEHHHCCCHHHHHHHHHHHCCCEEECCCCEEEE
LFNPDDDAEYRAKALAKSALGIEPGSEVIYQSLRYLLDNPYVTGTTLTVNGGRHVK
EECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEECCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA