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The map label for this gene is folE1 [H]

Identifier: 77457118

GI number: 77457118

Start: 1036912

End: 1037472

Strand: Reverse

Name: folE1 [H]

Synonym: Pfl01_0891

Alternate gene names: 77457118

Gene position: 1037472-1036912 (Counterclockwise)

Preceding gene: 77457119

Following gene: 77457117

Centisome position: 16.11

GC content: 60.61

Gene sequence:

>561_bases
ATGACCCGTTCCCTGCCCGAGAATTACCGCGAGATCCTGATCGGCCTCGGTGAAGATCCCGACCGTGAAGGCTTGCTCGA
CACACCGGTGCGCGCGGCCAAGGCCATGCAGTATCTGTGTCACGGCTACGAACAGAGCGTCGACGAGATCGTCAATGGCG
CGCTGTTTGCCTCCGACAGCGACGAGATGATCATCGTCGCCGACATCGAGCTCTATTCGTTGTGCGAACATCACCTGCTG
CCCTTCATCGGCAAGGCCCATGTGGCTTATATTCCGACGGGCAAGGTGCTGGGGCTGTCGAAGATCGCGCGGCTGGTGGA
CATGTTCGCCCGCCGCCTGCAGATCCAGGAAAACCTCACCCGCCAGATCGCCGAGGCGGTCCGGCAAGTCACCGATGCCG
CCGGTGTCGCGGTGGTCATCGAAGCCCGGCACATGTGCATGATGATGCGCGGTGTCGAGAAACAGAATTCGACCATGAAC
ACCTCGGTCATGCTCGGCGCCTTCCGCGAGTCGAGCAACACCCGTCAGGAGTTCCTGCAATTGATTGGACGGAGCAAGTA
A

Upstream 100 bases:

>100_bases
AGCCTGCGTTATCTGCTCGACAACCCGTATGTCACCGGCACCACCCTGACCGTCAACGGCGGGCGGCACGTCAAGTAATA
CGCCCCCGCGAGGATGCTCC

Downstream 100 bases:

>100_bases
ATGCCACAACTTCAACCGGGAATGGCGCGCATCCGGGTCAAGGATCTGCGCCTGCGCACCTTTATCGGGATCAACGAGGA
CGAAATCCTCAACAAGCAGG

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I 1; GTP-CH-I 1 [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MTRSLPENYREILIGLGEDPDREGLLDTPVRAAKAMQYLCHGYEQSVDEIVNGALFASDSDEMIIVADIELYSLCEHHLL
PFIGKAHVAYIPTGKVLGLSKIARLVDMFARRLQIQENLTRQIAEAVRQVTDAAGVAVVIEARHMCMMMRGVEKQNSTMN
TSVMLGAFRESSNTRQEFLQLIGRSK

Sequences:

>Translated_186_residues
MTRSLPENYREILIGLGEDPDREGLLDTPVRAAKAMQYLCHGYEQSVDEIVNGALFASDSDEMIIVADIELYSLCEHHLL
PFIGKAHVAYIPTGKVLGLSKIARLVDMFARRLQIQENLTRQIAEAVRQVTDAAGVAVVIEARHMCMMMRGVEKQNSTMN
TSVMLGAFRESSNTRQEFLQLIGRSK
>Mature_185_residues
TRSLPENYREILIGLGEDPDREGLLDTPVRAAKAMQYLCHGYEQSVDEIVNGALFASDSDEMIIVADIELYSLCEHHLLP
FIGKAHVAYIPTGKVLGLSKIARLVDMFARRLQIQENLTRQIAEAVRQVTDAAGVAVVIEARHMCMMMRGVEKQNSTMNT
SVMLGAFRESSNTRQEFLQLIGRSK

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=174, Percent_Identity=56.8965517241379, Blast_Score=228, Evalue=3e-60,
Organism=Homo sapiens, GI4503949, Length=174, Percent_Identity=56.8965517241379, Blast_Score=228, Evalue=3e-60,
Organism=Homo sapiens, GI66932970, Length=144, Percent_Identity=51.3888888888889, Blast_Score=174, Evalue=5e-44,
Organism=Homo sapiens, GI66932972, Length=134, Percent_Identity=54.4776119402985, Blast_Score=173, Evalue=7e-44,
Organism=Escherichia coli, GI1788476, Length=183, Percent_Identity=40.9836065573771, Blast_Score=119, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560486, Length=182, Percent_Identity=58.2417582417582, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6321706, Length=176, Percent_Identity=58.5227272727273, Blast_Score=217, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24656791, Length=176, Percent_Identity=59.0909090909091, Blast_Score=218, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24656782, Length=175, Percent_Identity=59.4285714285714, Blast_Score=218, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24656796, Length=176, Percent_Identity=59.0909090909091, Blast_Score=218, Evalue=2e-57,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 20797; Mature: 20666

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSLPENYREILIGLGEDPDREGLLDTPVRAAKAMQYLCHGYEQSVDEIVNGALFASDS
CCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
DEMIIVADIELYSLCEHHLLPFIGKAHVAYIPTGKVLGLSKIARLVDMFARRLQIQENLT
CCEEEEECHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RQIAEAVRQVTDAAGVAVVIEARHMCMMMRGVEKQNSTMNTSVMLGAFRESSNTRQEFLQ
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHH
LIGRSK
HHCCCC
>Mature Secondary Structure 
TRSLPENYREILIGLGEDPDREGLLDTPVRAAKAMQYLCHGYEQSVDEIVNGALFASDS
CCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
DEMIIVADIELYSLCEHHLLPFIGKAHVAYIPTGKVLGLSKIARLVDMFARRLQIQENLT
CCEEEEECHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RQIAEAVRQVTDAAGVAVVIEARHMCMMMRGVEKQNSTMNTSVMLGAFRESSNTRQEFLQ
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHH
LIGRSK
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]