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The map label for this gene is nadC [H]

Identifier: 77457012

GI number: 77457012

Start: 921240

End: 922088

Strand: Reverse

Name: nadC [H]

Synonym: Pfl01_0785

Alternate gene names: 77457012

Gene position: 922088-921240 (Counterclockwise)

Preceding gene: 77457018

Following gene: 77456997

Centisome position: 14.32

GC content: 62.9

Gene sequence:

>849_bases
ATGCCGAATCTACGTCTCGCCGATTTGACCGCCGAAATCGAAGCCAACGTGCGCCGTGCGTTGCTCGAAGACATCGGCAG
CGGCGACATCACCGCGCAACTGATCCCGGCCGAACGCCTGGCCAAAGCCACCATCATCACCCGCGACGCCGCCGTCATCA
GTGGCACAGCCTGGGTCGATGCGGTGTTCCGCCAGCTCGATCCGCGGGTGGCGGTGCACTGGCAGGTGCGCGATGGCGAA
CGGGTTTCGCCCAATCAGCCGCTGTTTCATCTGGAAGGCCCGGCCCGTTCGCTGCTGACCGGCGAGCGCAGCGCCCTGAA
CTTCCTGCAATTGCTGTCGGGCGTGGCGACCCGCGCGCAATACCTGGCGGACTTCGTCGCCGAGACCTCGGTAAAACTGC
TCGACACCCGCAAGACCCTGCCGGGCCTGCGTCTGGCGCAGAAATACGCGGTCACCTGCGGCGGTTGCCATAACCATCGC
ATCGGCCTGTACGACGCGTTCCTGATCAAGGAAAACCACATCGCCGCCAGCGGTGGCATCCCACAAGCCATTGCCGCTGC
GCACAAGATTGCCCCGGGCAAGCCGGTGGAAATCGAAGTGGAAAGTCTGGAGGAACTGAAAGAAGCGCTGGCCGCCGGTG
CCGATATCATCATGCTCGACGAACTGAGCCTTGATGACATGCGCGAAGCCGTGCGCCTGAACGCCGGCAAGGCAAAACTG
GAAGCCAGTGGCGGCATCAACGAAAGCACGCTGCTGCCGATCGCACAGACCGGGGTGGATTACATTTCGATCGGCGCGAT
GACCAAGGATGTGAAGGCTGTGGACCTGTCGATGCGCCTGAGCATCTGA

Upstream 100 bases:

>100_bases
AAAGAAAATCGACCGGATGCAGCGCTGCCTGGCTGTTCTCGCCTTGGGTTGGCCGACGCCATGCCCCTATAATCGGGCCA
CTTAGTTTGTGGAGCCCGTT

Downstream 100 bases:

>100_bases
GTCGATCACGCAATAAAAAACGCCAGCCCTTTCGAGGCTGGCGTTTTTGTTTCAGACCACCAGATTGTTCATCTCGCAGT
ACTCTTCCCACTCGACACCC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MPNLRLADLTAEIEANVRRALLEDIGSGDITAQLIPAERLAKATIITRDAAVISGTAWVDAVFRQLDPRVAVHWQVRDGE
RVSPNQPLFHLEGPARSLLTGERSALNFLQLLSGVATRAQYLADFVAETSVKLLDTRKTLPGLRLAQKYAVTCGGCHNHR
IGLYDAFLIKENHIAASGGIPQAIAAAHKIAPGKPVEIEVESLEELKEALAAGADIIMLDELSLDDMREAVRLNAGKAKL
EASGGINESTLLPIAQTGVDYISIGAMTKDVKAVDLSMRLSI

Sequences:

>Translated_282_residues
MPNLRLADLTAEIEANVRRALLEDIGSGDITAQLIPAERLAKATIITRDAAVISGTAWVDAVFRQLDPRVAVHWQVRDGE
RVSPNQPLFHLEGPARSLLTGERSALNFLQLLSGVATRAQYLADFVAETSVKLLDTRKTLPGLRLAQKYAVTCGGCHNHR
IGLYDAFLIKENHIAASGGIPQAIAAAHKIAPGKPVEIEVESLEELKEALAAGADIIMLDELSLDDMREAVRLNAGKAKL
EASGGINESTLLPIAQTGVDYISIGAMTKDVKAVDLSMRLSI
>Mature_281_residues
PNLRLADLTAEIEANVRRALLEDIGSGDITAQLIPAERLAKATIITRDAAVISGTAWVDAVFRQLDPRVAVHWQVRDGER
VSPNQPLFHLEGPARSLLTGERSALNFLQLLSGVATRAQYLADFVAETSVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRI
GLYDAFLIKENHIAASGGIPQAIAAAHKIAPGKPVEIEVESLEELKEALAAGADIIMLDELSLDDMREAVRLNAGKAKLE
ASGGINESTLLPIAQTGVDYISIGAMTKDVKAVDLSMRLSI

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=255, Percent_Identity=32.9411764705882, Blast_Score=132, Evalue=4e-31,
Organism=Escherichia coli, GI1786299, Length=281, Percent_Identity=54.8042704626335, Blast_Score=274, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6321162, Length=282, Percent_Identity=31.9148936170213, Blast_Score=136, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30298; Mature: 30167

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNLRLADLTAEIEANVRRALLEDIGSGDITAQLIPAERLAKATIITRDAAVISGTAWVD
CCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHEEECCCCEEECHHHHH
AVFRQLDPRVAVHWQVRDGERVSPNQPLFHLEGPARSLLTGERSALNFLQLLSGVATRAQ
HHHHHCCCCEEEEEEECCCCCCCCCCCEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHH
YLADFVAETSVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAASGGI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCCCCCEEEEEEEECCCEECCCCC
PQAIAAAHKIAPGKPVEIEVESLEELKEALAAGADIIMLDELSLDDMREAVRLNAGKAKL
CHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCEEE
EASGGINESTLLPIAQTGVDYISIGAMTKDVKAVDLSMRLSI
EECCCCCCCEECCHHHCCCCEEEECCCCCCCEEEEEEEEECC
>Mature Secondary Structure 
PNLRLADLTAEIEANVRRALLEDIGSGDITAQLIPAERLAKATIITRDAAVISGTAWVD
CCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHEEECCCCEEECHHHHH
AVFRQLDPRVAVHWQVRDGERVSPNQPLFHLEGPARSLLTGERSALNFLQLLSGVATRAQ
HHHHHCCCCEEEEEEECCCCCCCCCCCEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHH
YLADFVAETSVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAASGGI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCCCCCEEEEEEEECCCEECCCCC
PQAIAAAHKIAPGKPVEIEVESLEELKEALAAGADIIMLDELSLDDMREAVRLNAGKAKL
CHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCEEE
EASGGINESTLLPIAQTGVDYISIGAMTKDVKAVDLSMRLSI
EECCCCCCCEECCHHHCCCCEEEECCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]