Click here to switch to the map view.

The map label for this gene is fabG [H]

Identifier: 77456883

GI number: 77456883

Start: 767463

End: 768815

Strand: Reverse

Name: fabG [H]

Synonym: Pfl01_0655

Alternate gene names: 77456883

Gene position: 768815-767463 (Counterclockwise)

Preceding gene: 77456885

Following gene: 77456882

Centisome position: 11.94

GC content: 66.3

Gene sequence:

>1353_bases
ATGTCTGACCGCTATATCGACTTCGCCAACTCGTCCATCGGCCACCGTCTGGTCGGAGCTCTGGGCCTGCCGTCGCCGGT
GCGGCTGGAACGCTGGCAGGCCGGGCGCCTGCGGCCAGTGGAGGGTGCGCTGCTGATCGGCGGCGGGCCGCTGGCCGAGC
GGGTCAGTGCATTCGCCAATCGGCTGACCGATGCCATTTATCGCTACGGCGATCAGCCTGCGTCTGCCACTCAATGGATT
CCCGGACATGGCCCGAAACTCAAGGCCGTGGTGTTCGACGCCAGCGATCTGCAGCACACCGACCAGCTCAAGCAACTGCG
TGAATTTTTCCAGCCGTTGATGAAGAACCTCGACAGCAGCGCGCATCTGGTAATCCTCGGTCGCGCCCCGGAAACCCTGC
GTGACCCGTTTTCTGCCAGCGTACAACGGGCGCTTGAAGGCTTCTCGCGCTCGCTGGCCAAGGAGCTGCGCAGCGGCGGC
ACGCTGCAACTGATCTACGTCGGCGAAGGTGCCGAGGATCAGCTCGAAGGGCCGCTGCGTTTTTTCCTCTCGCCGAAAAG
CGCCTTCGTCTCCGGGCAAGTGATTCGCCTGAACCCTTGCGCCACGCCAGTGACCGACTGGACGCGCCCACTGGCCGGGC
GCAAGGCGCTGGTCACCGGTGCGGCTCGCGGCATCGGCGCCTCGATTGCCGAAACTCTGGCTCGCGACGGCGCCGAGGTG
ATCCTGCTCGACGTACCGCCAGCCAAGACCGATCTCGAAGCCCTGGCGGCTCGCCTCGGCGGTCGCGCCATTACCCTCGA
CATCTGCGCCGAAGACGCCGCTGCGCAACTGATCGAACAGCTGCCGGACGGCCTCGACATTCTGGTGCACAACGCCGGCA
TCACCCGCGACAAGACCCTTGCCAACATGACCCCGGAATTCTGGGACGCGGTGCTGGCGGTCAATCTCAACGCCCCGCAA
GTACTGACCAAGGCCCTGCTCGACAGCGGCACCTTGCGCGATAACGCCCGGGTGATTCTGCTGGCGTCGATCAGCGGCAT
CGCCGGTAATCGCGGGCAGACCAATTACGCGGCGAGCAAGGCCGGACTGATCGGGCTGGCCCAGGCCTGGGCGCCGACGT
TGCTGGAACGTGGCATCAGCATCAACGCCGTGGCGCCGGGGTTCATCGAGACCCAGATGACTGCGCACATTCCGTTCGGC
CTGCGTGAAGCCGGGCGGCGCATGAGTTCGCTGGGCCAGGGCGGCCTGCCGCAAGACGTCGCCGAAGCCGTGGCCTGGCT
GGCCCAACCGGGCACCGGCGCGTTCACCGGACAAGCGCTGCGGGTGTGCGGCCAAAGCGTTCTGGGAGCCTGA

Upstream 100 bases:

>100_bases
AACTACTCTGCTGTTCTAGCGTAGGCCTTATTGCGTGGATCGAACGATTGATTGCCCTTCGCAGTCCACACTTTGAACCC
CATCTTCTGGAGAGCGTTCC

Downstream 100 bases:

>100_bases
CCATGACCATCGAATGGCATACGCTGCACCACGAGCCGAGTCTGCCGGGGCTGTATGCCCGGGCGGCGACCCGACGCAAA
ATCACCGGCACCACCCTGCC

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSDRYIDFANSSIGHRLVGALGLPSPVRLERWQAGRLRPVEGALLIGGGPLAERVSAFANRLTDAIYRYGDQPASATQWI
PGHGPKLKAVVFDASDLQHTDQLKQLREFFQPLMKNLDSSAHLVILGRAPETLRDPFSASVQRALEGFSRSLAKELRSGG
TLQLIYVGEGAEDQLEGPLRFFLSPKSAFVSGQVIRLNPCATPVTDWTRPLAGRKALVTGAARGIGASIAETLARDGAEV
ILLDVPPAKTDLEALAARLGGRAITLDICAEDAAAQLIEQLPDGLDILVHNAGITRDKTLANMTPEFWDAVLAVNLNAPQ
VLTKALLDSGTLRDNARVILLASISGIAGNRGQTNYAASKAGLIGLAQAWAPTLLERGISINAVAPGFIETQMTAHIPFG
LREAGRRMSSLGQGGLPQDVAEAVAWLAQPGTGAFTGQALRVCGQSVLGA

Sequences:

>Translated_450_residues
MSDRYIDFANSSIGHRLVGALGLPSPVRLERWQAGRLRPVEGALLIGGGPLAERVSAFANRLTDAIYRYGDQPASATQWI
PGHGPKLKAVVFDASDLQHTDQLKQLREFFQPLMKNLDSSAHLVILGRAPETLRDPFSASVQRALEGFSRSLAKELRSGG
TLQLIYVGEGAEDQLEGPLRFFLSPKSAFVSGQVIRLNPCATPVTDWTRPLAGRKALVTGAARGIGASIAETLARDGAEV
ILLDVPPAKTDLEALAARLGGRAITLDICAEDAAAQLIEQLPDGLDILVHNAGITRDKTLANMTPEFWDAVLAVNLNAPQ
VLTKALLDSGTLRDNARVILLASISGIAGNRGQTNYAASKAGLIGLAQAWAPTLLERGISINAVAPGFIETQMTAHIPFG
LREAGRRMSSLGQGGLPQDVAEAVAWLAQPGTGAFTGQALRVCGQSVLGA
>Mature_449_residues
SDRYIDFANSSIGHRLVGALGLPSPVRLERWQAGRLRPVEGALLIGGGPLAERVSAFANRLTDAIYRYGDQPASATQWIP
GHGPKLKAVVFDASDLQHTDQLKQLREFFQPLMKNLDSSAHLVILGRAPETLRDPFSASVQRALEGFSRSLAKELRSGGT
LQLIYVGEGAEDQLEGPLRFFLSPKSAFVSGQVIRLNPCATPVTDWTRPLAGRKALVTGAARGIGASIAETLARDGAEVI
LLDVPPAKTDLEALAARLGGRAITLDICAEDAAAQLIEQLPDGLDILVHNAGITRDKTLANMTPEFWDAVLAVNLNAPQV
LTKALLDSGTLRDNARVILLASISGIAGNRGQTNYAASKAGLIGLAQAWAPTLLERGISINAVAPGFIETQMTAHIPFGL
REAGRRMSSLGQGGLPQDVAEAVAWLAQPGTGAFTGQALRVCGQSVLGA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=38.9763779527559, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=32.2448979591837, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI40254992, Length=234, Percent_Identity=33.7606837606838, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI4504505, Length=226, Percent_Identity=31.858407079646, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI5031737, Length=269, Percent_Identity=30.8550185873606, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI126723191, Length=183, Percent_Identity=33.879781420765, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI33667109, Length=201, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI40807363, Length=195, Percent_Identity=28.2051282051282, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI7657478, Length=242, Percent_Identity=28.099173553719, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI31542939, Length=198, Percent_Identity=30.8080808080808, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI126723750, Length=270, Percent_Identity=28.5185185185185, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI66933014, Length=213, Percent_Identity=24.8826291079812, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI19923817, Length=250, Percent_Identity=28, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI20149619, Length=221, Percent_Identity=27.6018099547511, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=237, Percent_Identity=40.084388185654, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=31.7647058823529, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1790717, Length=190, Percent_Identity=32.1052631578947, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI2367365, Length=239, Percent_Identity=30.9623430962343, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789208, Length=242, Percent_Identity=26.4462809917355, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082160, Length=241, Percent_Identity=26.1410788381743, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1789378, Length=256, Percent_Identity=30.078125, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=30.8943089430894, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787526, Length=197, Percent_Identity=34.5177664974619, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788459, Length=244, Percent_Identity=27.4590163934426, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=26.6409266409266, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787905, Length=259, Percent_Identity=31.6602316602317, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1789057, Length=255, Percent_Identity=24.7058823529412, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=240, Percent_Identity=36.25, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17555706, Length=241, Percent_Identity=35.2697095435685, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17564282, Length=197, Percent_Identity=33.502538071066, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17560676, Length=247, Percent_Identity=29.1497975708502, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17561402, Length=251, Percent_Identity=29.4820717131474, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17568967, Length=187, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193203117, Length=191, Percent_Identity=29.8429319371728, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193203115, Length=195, Percent_Identity=28.7179487179487, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=196, Percent_Identity=25.5102040816327, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=205, Percent_Identity=30.7317073170732, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=28.1368821292776, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=27.4193548387097, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=27.6, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=25.4752851711027, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=234, Percent_Identity=28.2051282051282, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639444, Length=244, Percent_Identity=34.0163934426229, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI23397609, Length=240, Percent_Identity=34.5833333333333, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI18859837, Length=186, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21355319, Length=243, Percent_Identity=28.8065843621399, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17737361, Length=204, Percent_Identity=31.8627450980392, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24643142, Length=191, Percent_Identity=34.5549738219895, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358495, Length=250, Percent_Identity=26.4, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644339, Length=247, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357041, Length=243, Percent_Identity=27.1604938271605, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 47616; Mature: 47485

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRYIDFANSSIGHRLVGALGLPSPVRLERWQAGRLRPVEGALLIGGGPLAERVSAFAN
CCCCEEECCCCCHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHH
RLTDAIYRYGDQPASATQWIPGHGPKLKAVVFDASDLQHTDQLKQLREFFQPLMKNLDSS
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCC
AHLVILGRAPETLRDPFSASVQRALEGFSRSLAKELRSGGTLQLIYVGEGAEDQLEGPLR
CEEEEEECCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCHH
FFLSPKSAFVSGQVIRLNPCATPVTDWTRPLAGRKALVTGAARGIGASIAETLARDGAEV
EEECCCHHHHCCEEEEECCCCCCCCHHHHCCCCCHHHHHHHHHCCCHHHHHHHHCCCCEE
ILLDVPPAKTDLEALAARLGGRAITLDICAEDAAAQLIEQLPDGLDILVHNAGITRDKTL
EEEECCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCCHH
ANMTPEFWDAVLAVNLNAPQVLTKALLDSGTLRDNARVILLASISGIAGNRGQTNYAASK
HHCCHHHHCEEEEEECCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHH
AGLIGLAQAWAPTLLERGISINAVAPGFIETQMTAHIPFGLREAGRRMSSLGQGGLPQDV
CCHHHHHHHHHHHHHHCCCEEEECCCCHHHCCEEEECCCCHHHHHHHHHHCCCCCCCHHH
AEAVAWLAQPGTGAFTGQALRVCGQSVLGA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDRYIDFANSSIGHRLVGALGLPSPVRLERWQAGRLRPVEGALLIGGGPLAERVSAFAN
CCCEEECCCCCHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHH
RLTDAIYRYGDQPASATQWIPGHGPKLKAVVFDASDLQHTDQLKQLREFFQPLMKNLDSS
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCC
AHLVILGRAPETLRDPFSASVQRALEGFSRSLAKELRSGGTLQLIYVGEGAEDQLEGPLR
CEEEEEECCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCHH
FFLSPKSAFVSGQVIRLNPCATPVTDWTRPLAGRKALVTGAARGIGASIAETLARDGAEV
EEECCCHHHHCCEEEEECCCCCCCCHHHHCCCCCHHHHHHHHHCCCHHHHHHHHCCCCEE
ILLDVPPAKTDLEALAARLGGRAITLDICAEDAAAQLIEQLPDGLDILVHNAGITRDKTL
EEEECCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCCHH
ANMTPEFWDAVLAVNLNAPQVLTKALLDSGTLRDNARVILLASISGIAGNRGQTNYAASK
HHCCHHHHCEEEEEECCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHH
AGLIGLAQAWAPTLLERGISINAVAPGFIETQMTAHIPFGLREAGRRMSSLGQGGLPQDV
CCHHHHHHHHHHHHHHCCCEEEECCCCHHHCCEEEECCCCHHHHHHHHHHCCCCCCCHHH
AEAVAWLAQPGTGAFTGQALRVCGQSVLGA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]