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The map label for this gene is hrcA [H]

Identifier: 75674393

GI number: 75674393

Start: 223971

End: 225059

Strand: Direct

Name: hrcA [H]

Synonym: Nwi_0194

Alternate gene names: 75674393

Gene position: 223971-225059 (Clockwise)

Preceding gene: 75674389

Following gene: 75674394

Centisome position: 6.58

GC content: 63.73

Gene sequence:

>1089_bases
TTGGCCCATCACGATCCGATTGGTCTGATTGCACCGAACGCCGGGCTTGCCCAGTTGAACGAGCGCTCGCGCGACATTTT
TCGCCAGATCGTCGAGAGCTATCTTGCAACGGGCGAACCCGTGGGCTCCCGCAACATTTCCCGGCTGATCGCGGTGCCGC
TCTCTCCGGCCTCGGTCCGCAATGTGATGTCCGATCTCGAACAGCTCGGGCTGATTTACGCGCCGCACACCTCGGCCGGG
CGCCTGCCGACCGAGCTCGGCCTGCGTTTTTTTGTCGATGCCCTGATGCAGGTTGGAGATCTCACCGAACCGGAACGCCA
ATCGATCCAGAGCCAGCTCGCGTCGGTCGGCAAGGCGCAATCGGTCGAGGCCGCGCTGGAGGAAGCCTTGACGCGGCTGT
CCGGATTGACCCGGACGGCGGCGGTGGTGCTGACGGCGAAATCAAACGTGCGCTTGAAGCATATCGAGTTTGTCAGGCTG
GAGCCCGACAAGGCGCTGGTGGTGCTGGTCGCAGAAGACGGACAGGTCGAAAATCGCGTGCTGACGCTCCCTTCCGGCGT
TCCGGCCTCAGCGCTGACGGAAGCATCCAATTTTCTGAATGCCCGGATTCGCGGCCGGACGCTCGCCGAGGCCCGGCTCG
AGCTGGAAACCGCGCTGGCGCAAAGCAAGGCGGAGCTCGATCAGCTCACACAAAAAATCGTCGCGGCCGGAATCGCGAGC
TGGTCCGGCGGCGACAGCGACGACCGCCAATTGATCGTGCGAGGCCACGCCAACCTGCTCGAGGACCTGCACGCGATGGA
GGACCTCGAACGGGTGCGGCTATTGTTCGACGACCTTGAAACCAAGCGCGAGGTGATCGATCTGCTTGGCCGCGCCGAGC
GCGCCGACGGCGTGCGGATCTTCATCGGCTCGGAAAACAAGCTGTTCTCGCTGTCCGGATCATCGACGATCATCGCACCC
TACAGCGATGGCGCCGGTCATATCGTTGGCGTTCTCGGCGTGATCGGACCCACCCGGCTGAACTACGCGCGCGTGATCCC
GATGGTGGACTACGCCGCGCGCATCGTCAGCCAGATGCTCGGCAGGTGA

Upstream 100 bases:

>100_bases
AACCGCAATTGCCCAAAGCCTGCTTGTAACTGGTGCGAGGGAGAGACAGATTAGAAGCGGTCTCAGGCACGACGAACATT
ATGCGCGGGAGATAATAGCG

Downstream 100 bases:

>100_bases
GCCGGACCCGCCACGCTTGATTTTTACGCCTGAACCACGATATCCCGCACGACCATTCCTTTCCATTCGAGACAATTGCG
AGAAGGCTGCGTAATGACCG

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MAHHDPIGLIAPNAGLAQLNERSRDIFRQIVESYLATGEPVGSRNISRLIAVPLSPASVRNVMSDLEQLGLIYAPHTSAG
RLPTELGLRFFVDALMQVGDLTEPERQSIQSQLASVGKAQSVEAALEEALTRLSGLTRTAAVVLTAKSNVRLKHIEFVRL
EPDKALVVLVAEDGQVENRVLTLPSGVPASALTEASNFLNARIRGRTLAEARLELETALAQSKAELDQLTQKIVAAGIAS
WSGGDSDDRQLIVRGHANLLEDLHAMEDLERVRLLFDDLETKREVIDLLGRAERADGVRIFIGSENKLFSLSGSSTIIAP
YSDGAGHIVGVLGVIGPTRLNYARVIPMVDYAARIVSQMLGR

Sequences:

>Translated_362_residues
MAHHDPIGLIAPNAGLAQLNERSRDIFRQIVESYLATGEPVGSRNISRLIAVPLSPASVRNVMSDLEQLGLIYAPHTSAG
RLPTELGLRFFVDALMQVGDLTEPERQSIQSQLASVGKAQSVEAALEEALTRLSGLTRTAAVVLTAKSNVRLKHIEFVRL
EPDKALVVLVAEDGQVENRVLTLPSGVPASALTEASNFLNARIRGRTLAEARLELETALAQSKAELDQLTQKIVAAGIAS
WSGGDSDDRQLIVRGHANLLEDLHAMEDLERVRLLFDDLETKREVIDLLGRAERADGVRIFIGSENKLFSLSGSSTIIAP
YSDGAGHIVGVLGVIGPTRLNYARVIPMVDYAARIVSQMLGR
>Mature_361_residues
AHHDPIGLIAPNAGLAQLNERSRDIFRQIVESYLATGEPVGSRNISRLIAVPLSPASVRNVMSDLEQLGLIYAPHTSAGR
LPTELGLRFFVDALMQVGDLTEPERQSIQSQLASVGKAQSVEAALEEALTRLSGLTRTAAVVLTAKSNVRLKHIEFVRLE
PDKALVVLVAEDGQVENRVLTLPSGVPASALTEASNFLNARIRGRTLAEARLELETALAQSKAELDQLTQKIVAAGIASW
SGGDSDDRQLIVRGHANLLEDLHAMEDLERVRLLFDDLETKREVIDLLGRAERADGVRIFIGSENKLFSLSGSSTIIAPY
SDGAGHIVGVLGVIGPTRLNYARVIPMVDYAARIVSQMLGR

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons [H]

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01628 HrcA [H]

EC number: NA

Molecular weight: Translated: 39127; Mature: 38996

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHHDPIGLIAPNAGLAQLNERSRDIFRQIVESYLATGEPVGSRNISRLIAVPLSPASVR
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHH
NVMSDLEQLGLIYAPHTSAGRLPTELGLRFFVDALMQVGDLTEPERQSIQSQLASVGKAQ
HHHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHH
SVEAALEEALTRLSGLTRTAAVVLTAKSNVRLKHIEFVRLEPDKALVVLVAEDGQVENRV
HHHHHHHHHHHHHHCCHHHEEEEEEECCCCEEEEEEEEEECCCCEEEEEEECCCCCCCEE
LTLPSGVPASALTEASNFLNARIRGRTLAEARLELETALAQSKAELDQLTQKIVAAGIAS
EECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WSGGDSDDRQLIVRGHANLLEDLHAMEDLERVRLLFDDLETKREVIDLLGRAERADGVRI
CCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
FIGSENKLFSLSGSSTIIAPYSDGAGHIVGVLGVIGPTRLNYARVIPMVDYAARIVSQML
EECCCCCEEEECCCCEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
GR
CC
>Mature Secondary Structure 
AHHDPIGLIAPNAGLAQLNERSRDIFRQIVESYLATGEPVGSRNISRLIAVPLSPASVR
CCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHH
NVMSDLEQLGLIYAPHTSAGRLPTELGLRFFVDALMQVGDLTEPERQSIQSQLASVGKAQ
HHHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHH
SVEAALEEALTRLSGLTRTAAVVLTAKSNVRLKHIEFVRLEPDKALVVLVAEDGQVENRV
HHHHHHHHHHHHHHCCHHHEEEEEEECCCCEEEEEEEEEECCCCEEEEEEECCCCCCCEE
LTLPSGVPASALTEASNFLNARIRGRTLAEARLELETALAQSKAELDQLTQKIVAAGIAS
EECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WSGGDSDDRQLIVRGHANLLEDLHAMEDLERVRLLFDDLETKREVIDLLGRAERADGVRI
CCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
FIGSENKLFSLSGSSTIIAPYSDGAGHIVGVLGVIGPTRLNYARVIPMVDYAARIVSQML
EECCCCCEEEECCCCEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
GR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA