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The map label for this gene is ykpB [H]

Identifier: 75674362

GI number: 75674362

Start: 190817

End: 191737

Strand: Direct

Name: ykpB [H]

Synonym: Nwi_0163

Alternate gene names: 75674362

Gene position: 190817-191737 (Clockwise)

Preceding gene: 75674361

Following gene: 75674364

Centisome position: 5.61

GC content: 66.78

Gene sequence:

>921_bases
ATGCGCATTCTCGTCGTCGGGGCCGGCGCGACCGGCGGCTATTTCGGCGGCTGCCTGTTGCGGGCCGGTCAGGATGTAAC
CTTCCTGGTGCGCCCCAAACGCGCCACTGAGCTGGCGAGCGCCGGTCTTGTCATCCGTAGCCCGCACGGCGACTTCACGC
TCGATAATCCGCCGACAGTGCAGGCCGATGGCGTGAGCGAGACATTCGATCTCGTTCTGCTGAGCTGCAAGGCGTTCGAT
CTGGAAGACGCGATCGCATCATTCGCGAGGGCCGTGGGACCGACGACAGCGATCGTCCCGCTGCTCAACGGGATGCTGCA
CCTGGAGACGCTCGACGCCGCGTTCAGCCGCGAGCGCGTGCTCGGCGGCCTGTGCTCGCTCGCGGTCACTCTCAACGAGA
AGCGCGAGGTCGTCCATCTCGCGCCGATGCACTCGCTTCGCTTCGGCGAGCGCGACGGCGGTGCGAGCGAGCGCGTCCGG
GCCATCGCCGAAGCTTTCGCCGGCGCAAGGTGTGGCGCGCAGCCGTCCGAAACCATCATCCAGGACATGTGGGAGAAGTG
GGTGTTTCTGGCGGCGCTCGCCGGCGCGACCTGCGTGATGCGTGCATCCATCGGCCAGATCGTCGCCGCGCCCGGCGGCC
GTGATTTCATGCTGGCCTTAACGGACGAGGCCGCCGGTATCGCGAAAGCGGCAGGTTATGCACCGCGCGAAGAATTCCTG
AGCGGCGCGACCGCGATGCTGACGGCGGCGGGCTCGCAGCTCACCGCATCCATGTTCCGCGACATCGAGACCGGCGCCCG
GGTCGAAGCCGACCATATCATGGGCGATCTCATCGCTCGTGCCGAAGCCGCGAAGCTCCCGGTGCCGAAGCTCCGCACCA
TCCATACGCATTTGAAGGCGTATGAGAACCGGCGGGGATGA

Upstream 100 bases:

>100_bases
CAGGCGGCTGATCTGATGAAACAGCACAGGTCTTGCCTTGCGCAAGGATATCCACTTCGCCTGAAAATGCTCCGGACATA
GACAAACAGGGAGCCCATCG

Downstream 100 bases:

>100_bases
TGCGAGGTGCGCGCGCTGCCCGCCGGTGTTCAGACCCGCCGTGTTCAGAAGTCCAGGTCGACATAGGTGCGCGACGCCGG
CACTCCCGCCAGCCATTCGC

Product: 2-dehydropantoate 2-reductase

Products: 2-dehydropantoate; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MRILVVGAGATGGYFGGCLLRAGQDVTFLVRPKRATELASAGLVIRSPHGDFTLDNPPTVQADGVSETFDLVLLSCKAFD
LEDAIASFARAVGPTTAIVPLLNGMLHLETLDAAFSRERVLGGLCSLAVTLNEKREVVHLAPMHSLRFGERDGGASERVR
AIAEAFAGARCGAQPSETIIQDMWEKWVFLAALAGATCVMRASIGQIVAAPGGRDFMLALTDEAAGIAKAAGYAPREEFL
SGATAMLTAAGSQLTASMFRDIETGARVEADHIMGDLIARAEAAKLPVPKLRTIHTHLKAYENRRG

Sequences:

>Translated_306_residues
MRILVVGAGATGGYFGGCLLRAGQDVTFLVRPKRATELASAGLVIRSPHGDFTLDNPPTVQADGVSETFDLVLLSCKAFD
LEDAIASFARAVGPTTAIVPLLNGMLHLETLDAAFSRERVLGGLCSLAVTLNEKREVVHLAPMHSLRFGERDGGASERVR
AIAEAFAGARCGAQPSETIIQDMWEKWVFLAALAGATCVMRASIGQIVAAPGGRDFMLALTDEAAGIAKAAGYAPREEFL
SGATAMLTAAGSQLTASMFRDIETGARVEADHIMGDLIARAEAAKLPVPKLRTIHTHLKAYENRRG
>Mature_306_residues
MRILVVGAGATGGYFGGCLLRAGQDVTFLVRPKRATELASAGLVIRSPHGDFTLDNPPTVQADGVSETFDLVLLSCKAFD
LEDAIASFARAVGPTTAIVPLLNGMLHLETLDAAFSRERVLGGLCSLAVTLNEKREVVHLAPMHSLRFGERDGGASERVR
AIAEAFAGARCGAQPSETIIQDMWEKWVFLAALAGATCVMRASIGQIVAAPGGRDFMLALTDEAAGIAKAAGYAPREEFL
SGATAMLTAAGSQLTASMFRDIETGARVEADHIMGDLIARAEAAKLPVPKLRTIHTHLKAYENRRG

Specific function: Catalyzes The NADPH-Dependent Reduction Of Ketopantoate Into Pantoic Acid. [C]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: 1.1.1.169

Molecular weight: Translated: 32345; Mature: 32345

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVGAGATGGYFGGCLLRAGQDVTFLVRPKRATELASAGLVIRSPHGDFTLDNPPTV
CEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHCCEEEECCCCCEECCCCCCE
QADGVSETFDLVLLSCKAFDLEDAIASFARAVGPTTAIVPLLNGMLHLETLDAAFSRERV
EECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHH
LGGLCSLAVTLNEKREVVHLAPMHSLRFGERDGGASERVRAIAEAFAGARCGAQPSETII
HHHHHHHHEEECCCCCEEEECCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHH
QDMWEKWVFLAALAGATCVMRASIGQIVAAPGGRDFMLALTDEAAGIAKAAGYAPREEFL
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEEECCHHHHHHHCCCCCHHHHH
SGATAMLTAAGSQLTASMFRDIETGARVEADHIMGDLIARAEAAKLPVPKLRTIHTHLKA
CCHHHHHHHCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
YENRRG
HHCCCC
>Mature Secondary Structure
MRILVVGAGATGGYFGGCLLRAGQDVTFLVRPKRATELASAGLVIRSPHGDFTLDNPPTV
CEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHCCEEEECCCCCEECCCCCCE
QADGVSETFDLVLLSCKAFDLEDAIASFARAVGPTTAIVPLLNGMLHLETLDAAFSRERV
EECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHH
LGGLCSLAVTLNEKREVVHLAPMHSLRFGERDGGASERVRAIAEAFAGARCGAQPSETII
HHHHHHHHEEECCCCCEEEECCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHH
QDMWEKWVFLAALAGATCVMRASIGQIVAAPGGRDFMLALTDEAAGIAKAAGYAPREEFL
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEEECCHHHHHHHCCCCCHHHHH
SGATAMLTAAGSQLTASMFRDIETGARVEADHIMGDLIARAEAAKLPVPKLRTIHTHLKA
CCHHHHHHHCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
YENRRG
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 4.0 {NADPH}} [C]

Substrates: (R)-pantoate; NADP+

Specific reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]