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The map label for this gene is gyaR [H]

Identifier: 75674236

GI number: 75674236

Start: 41197

End: 42198

Strand: Direct

Name: gyaR [H]

Synonym: Nwi_0037

Alternate gene names: 75674236

Gene position: 41197-42198 (Clockwise)

Preceding gene: 75674234

Following gene: 75674238

Centisome position: 1.21

GC content: 65.57

Gene sequence:

>1002_bases
ATGTCGATCAAGAAGAAGCCTCTGGTTGTCGTCACGCGCAAGCTGCCCGACTCGGTCGAGACCCGAATGCGCGAACTGTT
CGATGCGCGACTCAACCTCGACGACCGGCCGATGACGCCCGACGAGCTGATCGACGCCGTCCGTACCGCCGACATCCTGG
TTACGACGGTGACCGACCATATCAACGCGGCGGTGTTGAAACAGCCCGACTGCAAGCTGAAGCTGATCGCGCAGTTCGGC
AACGGCGTCGACAACATCGATGTCGTCGCCGCGCACGAGCACGGCGTCACCGTTACCAATACGCCGAACGTTCTCACCGA
AGACACCGCCGACATGACCATGGCGCTGATCCTCGCGGTGCCGCGCCGTTTCATCGAAGGCGCGGCGCTGCTGACCGCGG
GCGGTGACTGGCCGGGCTGGTCGCCGACCTGGATGCTCGGCCGGCGTCTTGGCGGCAAGCGGCTCGGCATCATCGGCATG
GGCCGCATCGGTCAGGCCGTGGCGCGCCGGGCCCACGCCTTCGGGCTGCAGATCCACTACCATAACCGCAAGCCCGTGGC
GCCGAAGATCGCCGACGAGCTCGGCGCCACCTATTGGGATTCGCTCGACCAGATGCTGGCGCGGATGGACATCATCTCGG
TGAACTGTCCGCACACCCCGGCCACCTTCCATCTGCTGTCGGCGCGCCGGCTCAAGCTGATCCGCAAGGACGCCTATATC
GTCAACACCGCGCGCGGCACGGTGATCGACGAGGACACGCTGACCAAGCTGATCGAGGCCGGCGAGATCGCTGGCGCGGC
GCTTGACGTGTTCGAGCACGAACCAGCGGTCAACCCCAGGCTGGTCCGCCTCGCCAAGGCCGGCAAGGTGGTGCTGCTGC
CGCATATGGGGTCCGCCACCATCGAGGGCCGCGTCGAGATGGGCGAGAAGGTCATCATCAACATCCGCACCTTCCTCGAC
AACCACAAGCCGCCGGACCGCGTGCTGCCGAGCATGTTGTAA

Upstream 100 bases:

>100_bases
GATTCGAACGCACCCTGGCGTAGCGGCGTCACTTCGTTTCTCATCAAGGGGTTGACGCAGCGGTCTGCGAACTTCGAAAC
CGGAAACTAGAGAGCACCCA

Downstream 100 bases:

>100_bases
GCGATGCGTTCGGCATGACGCGATGGAGCCTGCGTGCTCCTTCCTTTTTTCCCTCTCCCCTTGCGGGAGAGGGAAGAAGA
AACCGCCTCAGCAATAGCCG

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSIKKKPLVVVTRKLPDSVETRMRELFDARLNLDDRPMTPDELIDAVRTADILVTTVTDHINAAVLKQPDCKLKLIAQFG
NGVDNIDVVAAHEHGVTVTNTPNVLTEDTADMTMALILAVPRRFIEGAALLTAGGDWPGWSPTWMLGRRLGGKRLGIIGM
GRIGQAVARRAHAFGLQIHYHNRKPVAPKIADELGATYWDSLDQMLARMDIISVNCPHTPATFHLLSARRLKLIRKDAYI
VNTARGTVIDEDTLTKLIEAGEIAGAALDVFEHEPAVNPRLVRLAKAGKVVLLPHMGSATIEGRVEMGEKVIINIRTFLD
NHKPPDRVLPSML

Sequences:

>Translated_333_residues
MSIKKKPLVVVTRKLPDSVETRMRELFDARLNLDDRPMTPDELIDAVRTADILVTTVTDHINAAVLKQPDCKLKLIAQFG
NGVDNIDVVAAHEHGVTVTNTPNVLTEDTADMTMALILAVPRRFIEGAALLTAGGDWPGWSPTWMLGRRLGGKRLGIIGM
GRIGQAVARRAHAFGLQIHYHNRKPVAPKIADELGATYWDSLDQMLARMDIISVNCPHTPATFHLLSARRLKLIRKDAYI
VNTARGTVIDEDTLTKLIEAGEIAGAALDVFEHEPAVNPRLVRLAKAGKVVLLPHMGSATIEGRVEMGEKVIINIRTFLD
NHKPPDRVLPSML
>Mature_332_residues
SIKKKPLVVVTRKLPDSVETRMRELFDARLNLDDRPMTPDELIDAVRTADILVTTVTDHINAAVLKQPDCKLKLIAQFGN
GVDNIDVVAAHEHGVTVTNTPNVLTEDTADMTMALILAVPRRFIEGAALLTAGGDWPGWSPTWMLGRRLGGKRLGIIGMG
RIGQAVARRAHAFGLQIHYHNRKPVAPKIADELGATYWDSLDQMLARMDIISVNCPHTPATFHLLSARRLKLIRKDAYIV
NTARGTVIDEDTLTKLIEAGEIAGAALDVFEHEPAVNPRLVRLAKAGKVVLLPHMGSATIEGRVEMGEKVIINIRTFLDN
HKPPDRVLPSML

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=303, Percent_Identity=34.983498349835, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI23308577, Length=306, Percent_Identity=31.0457516339869, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4557497, Length=262, Percent_Identity=33.206106870229, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI61743967, Length=262, Percent_Identity=33.206106870229, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI145580578, Length=258, Percent_Identity=33.7209302325581, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4557499, Length=258, Percent_Identity=33.7209302325581, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI145580575, Length=265, Percent_Identity=33.5849056603774, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI87082289, Length=314, Percent_Identity=37.2611464968153, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI1789279, Length=292, Percent_Identity=29.4520547945205, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1787645, Length=336, Percent_Identity=25, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081824, Length=289, Percent_Identity=24.2214532871972, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=280, Percent_Identity=33.2142857142857, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=206, Percent_Identity=35.9223300970874, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=247, Percent_Identity=36.0323886639676, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6320925, Length=291, Percent_Identity=28.5223367697594, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322116, Length=291, Percent_Identity=28.1786941580756, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=219, Percent_Identity=29.2237442922374, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=152, Percent_Identity=34.8684210526316, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=266, Percent_Identity=27.0676691729323, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=149, Percent_Identity=28.8590604026846, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28571528, Length=288, Percent_Identity=38.5416666666667, Blast_Score=157, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24646446, Length=308, Percent_Identity=33.1168831168831, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646448, Length=308, Percent_Identity=33.1168831168831, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646452, Length=308, Percent_Identity=33.1168831168831, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646450, Length=308, Percent_Identity=33.1168831168831, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI62472511, Length=248, Percent_Identity=36.2903225806452, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI45552429, Length=273, Percent_Identity=31.5018315018315, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI45551003, Length=272, Percent_Identity=31.6176470588235, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574284, Length=272, Percent_Identity=31.6176470588235, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24585514, Length=272, Percent_Identity=31.6176470588235, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574282, Length=272, Percent_Identity=31.6176470588235, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574286, Length=302, Percent_Identity=29.8013245033113, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI19921140, Length=271, Percent_Identity=32.4723247232472, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24585516, Length=273, Percent_Identity=27.8388278388278, Blast_Score=117, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36627; Mature: 36496

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKKKPLVVVTRKLPDSVETRMRELFDARLNLDDRPMTPDELIDAVRTADILVTTVTDH
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEEEEEEHHH
INAAVLKQPDCKLKLIAQFGNGVDNIDVVAAHEHGVTVTNTPNVLTEDTADMTMALILAV
CCEEEECCCCCCEEEEEHHCCCCCCEEEEEEECCCEEEECCCCCCCCCHHHHHHHHHHHH
PRRFIEGAALLTAGGDWPGWSPTWMLGRRLGGKRLGIIGMGRIGQAVARRAHAFGLQIHY
HHHHHCCCEEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHEEEEEEE
HNRKPVAPKIADELGATYWDSLDQMLARMDIISVNCPHTPATFHLLSARRLKLIRKDAYI
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCEEE
VNTARGTVIDEDTLTKLIEAGEIAGAALDVFEHEPAVNPRLVRLAKAGKVVLLPHMGSAT
EECCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEECCCCEEEEECCCCCE
IEGRVEMGEKVIINIRTFLDNHKPPDRVLPSML
ECCHHCCCCEEEEEEEHHHCCCCCHHHHCCCCC
>Mature Secondary Structure 
SIKKKPLVVVTRKLPDSVETRMRELFDARLNLDDRPMTPDELIDAVRTADILVTTVTDH
CCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEEEEEEHHH
INAAVLKQPDCKLKLIAQFGNGVDNIDVVAAHEHGVTVTNTPNVLTEDTADMTMALILAV
CCEEEECCCCCCEEEEEHHCCCCCCEEEEEEECCCEEEECCCCCCCCCHHHHHHHHHHHH
PRRFIEGAALLTAGGDWPGWSPTWMLGRRLGGKRLGIIGMGRIGQAVARRAHAFGLQIHY
HHHHHCCCEEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHEEEEEEE
HNRKPVAPKIADELGATYWDSLDQMLARMDIISVNCPHTPATFHLLSARRLKLIRKDAYI
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCEEE
VNTARGTVIDEDTLTKLIEAGEIAGAALDVFEHEPAVNPRLVRLAKAGKVVLLPHMGSAT
EECCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEECCCCEEEEECCCCCE
IEGRVEMGEKVIINIRTFLDNHKPPDRVLPSML
ECCHHCCCCEEEEEEEHHHCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA