Click here to switch to the map view.

The map label for this gene is fur [H]

Identifier: 75674212

GI number: 75674212

Start: 13439

End: 13909

Strand: Direct

Name: fur [H]

Synonym: Nwi_0013

Alternate gene names: 75674212

Gene position: 13439-13909 (Clockwise)

Preceding gene: 75674211

Following gene: 75674213

Centisome position: 0.4

GC content: 61.57

Gene sequence:

>471_bases
ATGCGCCATCGGAACCGGACACTAGAGATGATGGCCCTAAAATCGACGCCTGTGCAGAAGCCCACCACGATCGAGGCGCG
TTGCGCGGCCGCCGGAATGCGCATGACCGAACAGCGCCGGGTTATCGCGCGCGTGCTCGCGGAGGCGTCCGATCATCCCG
ACGTCGAGGAGCTTTACCGGCGCTGCGCCGGGGTGGATGACAAGATCTCGATCTCGACGGTCTATCGCACGGTGAAGCTG
TTCGAGGATGCCGGCATCATCGAGCGGCACGATTTCCGCGAAGGCCGCGCGCGCTATGAGACGATGCGCGACAGCCACCA
CGATCATCTGATCAACCTGCGCGACGGCCAGGTTATCGAATTCACTTCGGATGAGATCGAGAAACTGCAAGCCGAGGTCG
CGCGCAAGCTCGGCTACCGGCTGGTCGATCATCGGCTCGAACTCTATTGCGTGCCGATGGATGACGAATAA

Upstream 100 bases:

>100_bases
GAGCCAGGGAGAACCACCGGCAACGGTGCATCGGTTTTTTCGTCCGGTCGCACTCCTTATATCGTTCGCGCGCATTATCT
TACGCACATATGAGCGGATC

Downstream 100 bases:

>100_bases
GTCGCGGGTGCCTGTCGAAATGCCGGAAAGCCGCATGCCGCCGCGCAAGCTGCACATCAAATCCTACGGTTGCCAGATGA
ACGTCTACGACGCCCAGCGC

Product: ferric-uptake regulator

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MRHRNRTLEMMALKSTPVQKPTTIEARCAAAGMRMTEQRRVIARVLAEASDHPDVEELYRRCAGVDDKISISTVYRTVKL
FEDAGIIERHDFREGRARYETMRDSHHDHLINLRDGQVIEFTSDEIEKLQAEVARKLGYRLVDHRLELYCVPMDDE

Sequences:

>Translated_156_residues
MRHRNRTLEMMALKSTPVQKPTTIEARCAAAGMRMTEQRRVIARVLAEASDHPDVEELYRRCAGVDDKISISTVYRTVKL
FEDAGIIERHDFREGRARYETMRDSHHDHLINLRDGQVIEFTSDEIEKLQAEVARKLGYRLVDHRLELYCVPMDDE
>Mature_156_residues
MRHRNRTLEMMALKSTPVQKPTTIEARCAAAGMRMTEQRRVIARVLAEASDHPDVEELYRRCAGVDDKISISTVYRTVKL
FEDAGIIERHDFREGRARYETMRDSHHDHLINLRDGQVIEFTSDEIEKLQAEVARKLGYRLVDHRLELYCVPMDDE

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=120, Percent_Identity=45, Blast_Score=104, Evalue=3e-24,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 18213; Mature: 18213

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHRNRTLEMMALKSTPVQKPTTIEARCAAAGMRMTEQRRVIARVLAEASDHPDVEELYR
CCCCCCHHEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHH
RCAGVDDKISISTVYRTVKLFEDAGIIERHDFREGRARYETMRDSHHDHLINLRDGQVIE
HHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEE
FTSDEIEKLQAEVARKLGYRLVDHRLELYCVPMDDE
ECHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
>Mature Secondary Structure
MRHRNRTLEMMALKSTPVQKPTTIEARCAAAGMRMTEQRRVIARVLAEASDHPDVEELYR
CCCCCCHHEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHH
RCAGVDDKISISTVYRTVKLFEDAGIIERHDFREGRARYETMRDSHHDHLINLRDGQVIE
HHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEE
FTSDEIEKLQAEVARKLGYRLVDHRLELYCVPMDDE
ECHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9835040 [H]