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The map label for this gene is pepP [H]

Identifier: 73539294

GI number: 73539294

Start: 2263599

End: 2265017

Strand: Reverse

Name: pepP [H]

Synonym: Reut_B5472

Alternate gene names: 73539294

Gene position: 2265017-2263599 (Counterclockwise)

Preceding gene: 73539295

Following gene: 73539293

Centisome position: 83.08

GC content: 66.31

Gene sequence:

>1419_bases
ATGGGCTGCGCCATCGAACCTATCGGCGTTCCCATGTTTGACAAGGGCGTCTACCGGGCACGCCGTCGCCAGCTGCGCGA
GCGCGTCGGCACGGGTCTGCTGCTATTTCCCGGCAATGACCACTGCGCCATCAACTTCGCGCATAACCCGTATCCGTTCA
GGCAAGACTCGACCTTCACCTACCTGTTCGGCATTCGCCGCCCCGGCCTGGCCGCATTGATCGATGCCGATAGCGGTGCG
GAAACGCTGTTCGGCGACGACGCCACCGCTGACGATGAGCTGTGGCTCGGTGCACAGCCTCGCCTCCATGCGCAGGCCGA
ACGTGCGGGCATTGCCAGTGTACGGCCGTTGTCGGAGATCGAAGCCGTGATCAGCACTGCCCGCAGTCAGGGGCGCACCG
TGCACTACCTGCCTTCTTACCGGCACCAAACGACGCTCGATCTCGCCCGACGGCTTGAGCTGCCGGCGGCATCCGTCGCG
GCAAAGTCGTCCGTCGCACTGATCCGCGCAGTGGTCGCACTGCGCGAGATCAAGAGCGCGGGCGAGGTATCCGAAGTCGA
GAAGGCACTCACCGTGACGCACGCCATGCACCTTGCCGCCATGCGCATGAGCCGCCCCGGCGTGGTCGAGCGCGAGGTGG
TCGCGGAGATGCGCCGCATTGCGCAATGCCACGACGTGCAGGAAGCCTATGCACCTATCTTCACGCGGCGCAAGGAAGGG
CTGCATGCGCAGGTCTATGACATGCAGCTTGCAGCGGGCGACCTCGTCATCAACGACGCGGGCGCCTGCAGCGCCATGGA
CTACGCCAGCGATGTCACGCGCACGCTGCCTGTTGGCGGCCGCTTCAGCGCCAGGCAGCGCGAACTGTACGAACTGCTGC
TGGCGGCCCAGCTTGCCGGTATCGCCGCCATGCGTCCCGGCTTGCGCTATCTCGACCTGCACAAGGCGGTCAGCGCGGCG
ATCGTGCGCGGCATGTGCGAGATGGGCTTCTTTCGCGGCGCGCCGGAGGAGATCGTCGCGGCCGGCGCCCATGCCATTTG
CTTTCCGCATGGGCTGGGTCACCAGCTCGGCCTTGATGTCCATGACATGGAGGCGCTGGGCGAAGACCACGTCGGCTACG
ACGACGAAGTATCGCGCAGCGGCCAGTTCGGGCTGCGCTACCTGCGCATGGGCAAGCGCCTGCGCGAAGGCATGGTCATG
ACGATCGAGCCGGGCATCTATTTCATGCCGGCCCTGATCGACCGCTGGCGCGCCGAGCAACGGCACGCCGCACACATCTG
TTACGCGCGCTTCGACGCCTACCGCGATTTCGGCGGCATGCGCGTCGAGGATGTGGTGCATGTCGGCGGAAAGAGCGCGC
GCGTGCTCGGCCCGCACATCCCGAAGACGGTGGCCGAGGTCGAGGCGGCCATGCCGTAG

Upstream 100 bases:

>100_bases
GCCCCTGCCAGTCGTTCGCCCGAGGCCGTGCGCGACGACGTGCGCAACGGCTACCTGAGCGCGGCGCAGGCCCGTGAAAT
CTACGGCGTCACGGTCTGAC

Downstream 100 bases:

>100_bases
TCATTCCGTTCGTCGCAGCATCCTGCGGCCGCCCGGCCAATCCGCATGCCGCAGCGCTTTCCTACCACTGAGAGAGAGAT
CTTGAAGGCATCTTATTTGC

Product: Xaa-Pro dipeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MGCAIEPIGVPMFDKGVYRARRRQLRERVGTGLLLFPGNDHCAINFAHNPYPFRQDSTFTYLFGIRRPGLAALIDADSGA
ETLFGDDATADDELWLGAQPRLHAQAERAGIASVRPLSEIEAVISTARSQGRTVHYLPSYRHQTTLDLARRLELPAASVA
AKSSVALIRAVVALREIKSAGEVSEVEKALTVTHAMHLAAMRMSRPGVVEREVVAEMRRIAQCHDVQEAYAPIFTRRKEG
LHAQVYDMQLAAGDLVINDAGACSAMDYASDVTRTLPVGGRFSARQRELYELLLAAQLAGIAAMRPGLRYLDLHKAVSAA
IVRGMCEMGFFRGAPEEIVAAGAHAICFPHGLGHQLGLDVHDMEALGEDHVGYDDEVSRSGQFGLRYLRMGKRLREGMVM
TIEPGIYFMPALIDRWRAEQRHAAHICYARFDAYRDFGGMRVEDVVHVGGKSARVLGPHIPKTVAEVEAAMP

Sequences:

>Translated_472_residues
MGCAIEPIGVPMFDKGVYRARRRQLRERVGTGLLLFPGNDHCAINFAHNPYPFRQDSTFTYLFGIRRPGLAALIDADSGA
ETLFGDDATADDELWLGAQPRLHAQAERAGIASVRPLSEIEAVISTARSQGRTVHYLPSYRHQTTLDLARRLELPAASVA
AKSSVALIRAVVALREIKSAGEVSEVEKALTVTHAMHLAAMRMSRPGVVEREVVAEMRRIAQCHDVQEAYAPIFTRRKEG
LHAQVYDMQLAAGDLVINDAGACSAMDYASDVTRTLPVGGRFSARQRELYELLLAAQLAGIAAMRPGLRYLDLHKAVSAA
IVRGMCEMGFFRGAPEEIVAAGAHAICFPHGLGHQLGLDVHDMEALGEDHVGYDDEVSRSGQFGLRYLRMGKRLREGMVM
TIEPGIYFMPALIDRWRAEQRHAAHICYARFDAYRDFGGMRVEDVVHVGGKSARVLGPHIPKTVAEVEAAMP
>Mature_471_residues
GCAIEPIGVPMFDKGVYRARRRQLRERVGTGLLLFPGNDHCAINFAHNPYPFRQDSTFTYLFGIRRPGLAALIDADSGAE
TLFGDDATADDELWLGAQPRLHAQAERAGIASVRPLSEIEAVISTARSQGRTVHYLPSYRHQTTLDLARRLELPAASVAA
KSSVALIRAVVALREIKSAGEVSEVEKALTVTHAMHLAAMRMSRPGVVEREVVAEMRRIAQCHDVQEAYAPIFTRRKEGL
HAQVYDMQLAAGDLVINDAGACSAMDYASDVTRTLPVGGRFSARQRELYELLLAAQLAGIAAMRPGLRYLDLHKAVSAAI
VRGMCEMGFFRGAPEEIVAAGAHAICFPHGLGHQLGLDVHDMEALGEDHVGYDDEVSRSGQFGLRYLRMGKRLREGMVMT
IEPGIYFMPALIDRWRAEQRHAAHICYARFDAYRDFGGMRVEDVVHVGGKSARVLGPHIPKTVAEVEAAMP

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=432, Percent_Identity=29.3981481481481, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI260593663, Length=422, Percent_Identity=29.8578199052133, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI260593665, Length=225, Percent_Identity=36.4444444444444, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI11559925, Length=432, Percent_Identity=27.5462962962963, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1789275, Length=467, Percent_Identity=28.4796573875803, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1790282, Length=439, Percent_Identity=25.7403189066059, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788728, Length=348, Percent_Identity=28.448275862069, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17508215, Length=433, Percent_Identity=29.0993071593533, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71989583, Length=345, Percent_Identity=26.9565217391304, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6321118, Length=417, Percent_Identity=28.537170263789, Blast_Score=142, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6320922, Length=478, Percent_Identity=23.4309623430962, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357079, Length=482, Percent_Identity=28.8381742738589, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI19920384, Length=372, Percent_Identity=27.9569892473118, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 51834; Mature: 51703

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00491 PROLINE_PEPTIDASE ; PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGCAIEPIGVPMFDKGVYRARRRQLRERVGTGLLLFPGNDHCAINFAHNPYPFRQDSTFT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCCCCCCCCEE
YLFGIRRPGLAALIDADSGAETLFGDDATADDELWLGAQPRLHAQAERAGIASVRPLSEI
EEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHCCCCCCCCHHHH
EAVISTARSQGRTVHYLPSYRHQTTLDLARRLELPAASVAAKSSVALIRAVVALREIKSA
HHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GEVSEVEKALTVTHAMHLAAMRMSRPGVVEREVVAEMRRIAQCHDVQEAYAPIFTRRKEG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LHAQVYDMQLAAGDLVINDAGACSAMDYASDVTRTLPVGGRFSARQRELYELLLAAQLAG
CEEEEEEEEEECCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
IAAMRPGLRYLDLHKAVSAAIVRGMCEMGFFRGAPEEIVAAGAHAICFPHGLGHQLGLDV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEECCCCCCHHHCCCH
HDMEALGEDHVGYDDEVSRSGQFGLRYLRMGKRLREGMVMTIEPGIYFMPALIDRWRAEQ
HHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHH
RHAAHICYARFDAYRDFGGMRVEDVVHVGGKSARVLGPHIPKTVAEVEAAMP
HHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEECCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
GCAIEPIGVPMFDKGVYRARRRQLRERVGTGLLLFPGNDHCAINFAHNPYPFRQDSTFT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCCCCCCCCEE
YLFGIRRPGLAALIDADSGAETLFGDDATADDELWLGAQPRLHAQAERAGIASVRPLSEI
EEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHCCCCCCCCHHHH
EAVISTARSQGRTVHYLPSYRHQTTLDLARRLELPAASVAAKSSVALIRAVVALREIKSA
HHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GEVSEVEKALTVTHAMHLAAMRMSRPGVVEREVVAEMRRIAQCHDVQEAYAPIFTRRKEG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LHAQVYDMQLAAGDLVINDAGACSAMDYASDVTRTLPVGGRFSARQRELYELLLAAQLAG
CEEEEEEEEEECCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
IAAMRPGLRYLDLHKAVSAAIVRGMCEMGFFRGAPEEIVAAGAHAICFPHGLGHQLGLDV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEECCCCCCHHHCCCH
HDMEALGEDHVGYDDEVSRSGQFGLRYLRMGKRLREGMVMTIEPGIYFMPALIDRWRAEQ
HHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHH
RHAAHICYARFDAYRDFGGMRVEDVVHVGGKSARVLGPHIPKTVAEVEAAMP
HHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEECCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]