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The map label for this gene is uhpB [C]

Identifier: 73539274

GI number: 73539274

Start: 2243720

End: 2245390

Strand: Reverse

Name: uhpB [C]

Synonym: Reut_B5452

Alternate gene names: 73539274

Gene position: 2245390-2243720 (Counterclockwise)

Preceding gene: 73539277

Following gene: 73539273

Centisome position: 82.36

GC content: 62.72

Gene sequence:

>1671_bases
ATGGTCAGCTTTCCGCACAAGTCGAGGCTCAGCATCCTCGTGCAGACCGGAGCTGTCGGACTGACGTATTTCGCCGGTGC
AAAGCTGGGGCTCACGTACGCCGTCGTGGGCGGCGCAGTGTCGCTGGTGTGGCCTTCCAGCGGAATCGCACTCGCGGCGC
TGCTCACAATGGGCTACGTTGTCGCGCCGGGCATTGCCATCGGTTCCGTGCTGGCCAATGTGTCGGTGGGCGTACCTCTG
CATATCGCGGTGGTGATCGGTCTTGGCGCAACGGCTGCGGCTTTGGCAGCCACATGGTTGTTGACGCGCGCGGCCCGGTT
CCATATCGCCTTGGACCGCATCAGGGATGTGCTGGCTTTCCTGATCGTGGCTGCGATATTCAGCACGGCAGTAAGCGCCC
TGGTCGGTGCGACCGTACTGAGAGGCGGTGGGCTGCTGGCAGGCAGCCAGTACGGACGCGCGATGCTCGAATGGTGGCTC
GGTGACATGATGGGAGTGCTGGTAGTGGCGCCGCCATTGCTCACCCTGTTCACGTATCGCAGCGCTCTCGGCTCCGCACC
GCAAGCTGTGGAAGCATGCGCACTGGCGGTGGCAACCCTTTCGGCAAGTTATCTGATTTTCGGCGCGCCCCAGCTTGCCG
GGCATGGCTACTATCCTGCGGCCCTGGCGATTTTTCCCTTTGTCGTCTGGGCAGCGCTGCGCTTCGATCATCCGGGCGCC
AGCCTCTCGACCCTGATGGTCTCGATCATGGCCATCTGGGGTACCACTCAGGGTACCGGGCCGTTTGCTTCCGACCATCC
TGTGGACAGCCTCGTGAGATGGTGTGCTTTCGCCAATGTCGTCGCAATCACCGGCTTGCTGCTTGCGGCTGCGCGTGCGC
AGGAAAGGCGCATCCACGGGATCCTGCTGGCATCCCAGGCCGAACTGGAGCGCCGCGTGCAAGAGCGAACCCAGGATCTG
CAGCAGGCGAATACCGAGCTGAAGCAAGAGATGGCGAGGCGTCGCCAACTGGAAGCGGAACTGATCCGGATCGGCGATCG
TCAGCAGAGGCTTATCGGCCGGGAACTCCATGATGGCCTTGGGCAACACCTTACCAGCCTGGGCTTCTATTGCGCCTCGC
TCAGCCAGGAACTGCAGAAGCATCGCCATCCGGCTGCCGCTGACGCGGCAACGATCGTCGAGCTGGTCAGGCAGGCGTCC
CTGATGGCTCGCAAGATCGCCCATGGCCTGGATCCGATCGCCCTGGAATCTGGCGGTCTTTCCGCCGCCCTGGAAACCCT
GGCGCAGACTACCGGCACGCTGAACGGCATAGACTGCCGGCTTCGCATCGGGTCAGAGGTGGGACAGATGGATTCGCCAG
TGCAGATCAACCTTTACCGGGCCGCACAGGAAGCCGTCAATAACGCGCTGAAATACAGTCATGGCCAGCACATCTGGATC
GATCTGGAATTCGAAGCCGGCGTGCAGAGGCTTTCCGTCAGCGACGACGGCGTGGGGATGGATCCGGCACAGATGGGGCA
TACGTCGGGACTCGGATTTTACAACCTGCGTCACCGTGCGAGCCTGCTCGGTGGTGCATGCGCGGTGACCCGCAACGCCA
CGGGCGGAACCACGGTTATCATCAGCTATCCAGTCGCGCAAGGTCCCGGCCATGCCAGGGAAATCATGTAG

Upstream 100 bases:

>100_bases
CCATAAAAATTTTGGACTTTGACACTTCCAGTAGTATTGTCATTTTGGCTAGCAAAAAAAGTGACGTGCCAAAGCCTGTC
CCAAGAATTCGGGGTGAAAA

Downstream 100 bases:

>100_bases
CAGCAGCCCGGGCCGCCCGGCCAGGGTCCTGATCGTGGATGACCACCCCATCGTCCGCGAGGGCCTGGCCCACCTGCTGA
ATATGCACGAGGAACTTCAG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MVSFPHKSRLSILVQTGAVGLTYFAGAKLGLTYAVVGGAVSLVWPSSGIALAALLTMGYVVAPGIAIGSVLANVSVGVPL
HIAVVIGLGATAAALAATWLLTRAARFHIALDRIRDVLAFLIVAAIFSTAVSALVGATVLRGGGLLAGSQYGRAMLEWWL
GDMMGVLVVAPPLLTLFTYRSALGSAPQAVEACALAVATLSASYLIFGAPQLAGHGYYPAALAIFPFVVWAALRFDHPGA
SLSTLMVSIMAIWGTTQGTGPFASDHPVDSLVRWCAFANVVAITGLLLAAARAQERRIHGILLASQAELERRVQERTQDL
QQANTELKQEMARRRQLEAELIRIGDRQQRLIGRELHDGLGQHLTSLGFYCASLSQELQKHRHPAAADAATIVELVRQAS
LMARKIAHGLDPIALESGGLSAALETLAQTTGTLNGIDCRLRIGSEVGQMDSPVQINLYRAAQEAVNNALKYSHGQHIWI
DLEFEAGVQRLSVSDDGVGMDPAQMGHTSGLGFYNLRHRASLLGGACAVTRNATGGTTVIISYPVAQGPGHAREIM

Sequences:

>Translated_556_residues
MVSFPHKSRLSILVQTGAVGLTYFAGAKLGLTYAVVGGAVSLVWPSSGIALAALLTMGYVVAPGIAIGSVLANVSVGVPL
HIAVVIGLGATAAALAATWLLTRAARFHIALDRIRDVLAFLIVAAIFSTAVSALVGATVLRGGGLLAGSQYGRAMLEWWL
GDMMGVLVVAPPLLTLFTYRSALGSAPQAVEACALAVATLSASYLIFGAPQLAGHGYYPAALAIFPFVVWAALRFDHPGA
SLSTLMVSIMAIWGTTQGTGPFASDHPVDSLVRWCAFANVVAITGLLLAAARAQERRIHGILLASQAELERRVQERTQDL
QQANTELKQEMARRRQLEAELIRIGDRQQRLIGRELHDGLGQHLTSLGFYCASLSQELQKHRHPAAADAATIVELVRQAS
LMARKIAHGLDPIALESGGLSAALETLAQTTGTLNGIDCRLRIGSEVGQMDSPVQINLYRAAQEAVNNALKYSHGQHIWI
DLEFEAGVQRLSVSDDGVGMDPAQMGHTSGLGFYNLRHRASLLGGACAVTRNATGGTTVIISYPVAQGPGHAREIM
>Mature_556_residues
MVSFPHKSRLSILVQTGAVGLTYFAGAKLGLTYAVVGGAVSLVWPSSGIALAALLTMGYVVAPGIAIGSVLANVSVGVPL
HIAVVIGLGATAAALAATWLLTRAARFHIALDRIRDVLAFLIVAAIFSTAVSALVGATVLRGGGLLAGSQYGRAMLEWWL
GDMMGVLVVAPPLLTLFTYRSALGSAPQAVEACALAVATLSASYLIFGAPQLAGHGYYPAALAIFPFVVWAALRFDHPGA
SLSTLMVSIMAIWGTTQGTGPFASDHPVDSLVRWCAFANVVAITGLLLAAARAQERRIHGILLASQAELERRVQERTQDL
QQANTELKQEMARRRQLEAELIRIGDRQQRLIGRELHDGLGQHLTSLGFYCASLSQELQKHRHPAAADAATIVELVRQAS
LMARKIAHGLDPIALESGGLSAALETLAQTTGTLNGIDCRLRIGSEVGQMDSPVQINLYRAAQEAVNNALKYSHGQHIWI
DLEFEAGVQRLSVSDDGVGMDPAQMGHTSGLGFYNLRHRASLLGGACAVTRNATGGTTVIISYPVAQGPGHAREIM

Specific function: Member Of The Two-Component Regulatory System Uhpb/Uhpa Involved In The Regulation Of The Uptake Of Hexose Phosphates. Uhpb Functions As A Membrane-Associated Protein Kinase That Phosphorylates Uhpa In Response To Environmental Signals. [C]

COG id: COG4564

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=340, Percent_Identity=26.1764705882353, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787474, Length=222, Percent_Identity=27.027027027027, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1788812, Length=203, Percent_Identity=28.0788177339901, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: 2.7.3.- [C]

Molecular weight: Translated: 58675; Mature: 58675

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSFPHKSRLSILVQTGAVGLTYFAGAKLGLTYAVVGGAVSLVWPSSGIALAALLTMGYV
CCCCCCCCCEEEEEECCCCHHHHHCCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHH
VAPGIAIGSVLANVSVGVPLHIAVVIGLGATAAALAATWLLTRAARFHIALDRIRDVLAF
HHCHHHHHHHHHHCCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIVAAIFSTAVSALVGATVLRGGGLLAGSQYGRAMLEWWLGDMMGVLVVAPPLLTLFTYR
HHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALGSAPQAVEACALAVATLSASYLIFGAPQLAGHGYYPAALAIFPFVVWAALRFDHPGA
HHHCCCHHHHHHHHHHHHHHHCCCEEEECHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCC
SLSTLMVSIMAIWGTTQGTGPFASDHPVDSLVRWCAFANVVAITGLLLAAARAQERRIHG
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILLASQAELERRVQERTQDLQQANTELKQEMARRRQLEAELIRIGDRQQRLIGRELHDGL
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GQHLTSLGFYCASLSQELQKHRHPAAADAATIVELVRQASLMARKIAHGLDPIALESGGL
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCH
SAALETLAQTTGTLNGIDCRLRIGSEVGQMDSPVQINLYRAAQEAVNNALKYSHGQHIWI
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEE
DLEFEAGVQRLSVSDDGVGMDPAQMGHTSGLGFYNLRHRASLLGGACAVTRNATGGTTVI
EEEHHCCCCEEECCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHCCHHEEEECCCCCEEEE
ISYPVAQGPGHAREIM
EEECCCCCCCCHHCCC
>Mature Secondary Structure
MVSFPHKSRLSILVQTGAVGLTYFAGAKLGLTYAVVGGAVSLVWPSSGIALAALLTMGYV
CCCCCCCCCEEEEEECCCCHHHHHCCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHH
VAPGIAIGSVLANVSVGVPLHIAVVIGLGATAAALAATWLLTRAARFHIALDRIRDVLAF
HHCHHHHHHHHHHCCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIVAAIFSTAVSALVGATVLRGGGLLAGSQYGRAMLEWWLGDMMGVLVVAPPLLTLFTYR
HHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALGSAPQAVEACALAVATLSASYLIFGAPQLAGHGYYPAALAIFPFVVWAALRFDHPGA
HHHCCCHHHHHHHHHHHHHHHCCCEEEECHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCC
SLSTLMVSIMAIWGTTQGTGPFASDHPVDSLVRWCAFANVVAITGLLLAAARAQERRIHG
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILLASQAELERRVQERTQDLQQANTELKQEMARRRQLEAELIRIGDRQQRLIGRELHDGL
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GQHLTSLGFYCASLSQELQKHRHPAAADAATIVELVRQASLMARKIAHGLDPIALESGGL
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCH
SAALETLAQTTGTLNGIDCRLRIGSEVGQMDSPVQINLYRAAQEAVNNALKYSHGQHIWI
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEE
DLEFEAGVQRLSVSDDGVGMDPAQMGHTSGLGFYNLRHRASLLGGACAVTRNATGGTTVI
EEEHHCCCCEEECCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHCCHHEEEECCCCCEEEE
ISYPVAQGPGHAREIM
EEECCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with a nitrogenous group as acceptor [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8661927 [H]