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The map label for this gene is guaD [H]

Identifier: 73539205

GI number: 73539205

Start: 2168299

End: 2168757

Strand: Reverse

Name: guaD [H]

Synonym: Reut_B5383

Alternate gene names: 73539205

Gene position: 2168757-2168299 (Counterclockwise)

Preceding gene: 73539208

Following gene: 73539204

Centisome position: 79.55

GC content: 70.37

Gene sequence:

>459_bases
ATGGCAACCCACGAACATCTGATGCGCGAGGCGGTCGAACTCGCCGTGACCAATCTGCGCCGCGGCGGCCGGCCTTTCGG
CGCGGTACTGGCCATCGACGGCGAAGCCGTGGCCACCGGCGTGAATGACATCGTCCACAGCCACGACCCCACCACGCATG
CCGAGATGGAGGCCGTGCGTGCGGCCGCCCGCAAGCTGGGCCGGCCCGACCTCAGCGGCAGCGTGGTCTACGCCAGCGGC
CATCCGTGCCCGATGTGCCTGGCGGCGATGACCATGGCCGGCGTGCAGGCGGTGTACTACGCCTTCGACAACAACGACGC
CGCACCCTATGGGCTGTCGAGCGAAGCCGCCTACCAGGCGCTGCGCCTGCCGCTGATACCGCCGCCGCTTCCACTGCAGC
GCGTGCCGGTCGATATCTCCGCCGCGCAGCTCTACGGCACGCGCCAGCCCCGTGGCTGA

Upstream 100 bases:

>100_bases
AAGGCCGGGCGTAGATTGGCGACTGTCCCTGTCACGCCTATTGCCGCATGGTACGTGCGCTGCACGCCATACGGTGAGCC
GGCGCTTACTTAGCTACGCT

Downstream 100 bases:

>100_bases
GCGCATGGCGGTCGGCGCGCATGAGGCGGATCGGGCGCCGGCACGCTGGCTGGTCCTGGCCGCGGTCGTGGCGATTGGCC
TGAACCTGCGTCCGTTCCTG

Product: cytidine/deoxycytidylate deaminase zinc-binding subunit

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MATHEHLMREAVELAVTNLRRGGRPFGAVLAIDGEAVATGVNDIVHSHDPTTHAEMEAVRAAARKLGRPDLSGSVVYASG
HPCPMCLAAMTMAGVQAVYYAFDNNDAAPYGLSSEAAYQALRLPLIPPPLPLQRVPVDISAAQLYGTRQPRG

Sequences:

>Translated_152_residues
MATHEHLMREAVELAVTNLRRGGRPFGAVLAIDGEAVATGVNDIVHSHDPTTHAEMEAVRAAARKLGRPDLSGSVVYASG
HPCPMCLAAMTMAGVQAVYYAFDNNDAAPYGLSSEAAYQALRLPLIPPPLPLQRVPVDISAAQLYGTRQPRG
>Mature_151_residues
ATHEHLMREAVELAVTNLRRGGRPFGAVLAIDGEAVATGVNDIVHSHDPTTHAEMEAVRAAARKLGRPDLSGSVVYASGH
PCPMCLAAMTMAGVQAVYYAFDNNDAAPYGLSSEAAYQALRLPLIPPPLPLQRVPVDISAAQLYGTRQPRG

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17554608, Length=149, Percent_Identity=33.5570469798658, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17555996, Length=123, Percent_Identity=40.650406504065, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 16128; Mature: 15996

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATHEHLMREAVELAVTNLRRGGRPFGAVLAIDGEAVATGVNDIVHSHDPTTHAEMEAVR
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHH
AAARKLGRPDLSGSVVYASGHPCPMCLAAMTMAGVQAVYYAFDNNDAAPYGLSSEAAYQA
HHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHH
LRLPLIPPPLPLQRVPVDISAAQLYGTRQPRG
HCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
ATHEHLMREAVELAVTNLRRGGRPFGAVLAIDGEAVATGVNDIVHSHDPTTHAEMEAVR
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHH
AAARKLGRPDLSGSVVYASGHPCPMCLAAMTMAGVQAVYYAFDNNDAAPYGLSSEAAYQA
HHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHH
LRLPLIPPPLPLQRVPVDISAAQLYGTRQPRG
HCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]