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The map label for this gene is yngJ [H]

Identifier: 73539142

GI number: 73539142

Start: 2083793

End: 2084950

Strand: Reverse

Name: yngJ [H]

Synonym: Reut_B5319

Alternate gene names: 73539142

Gene position: 2084950-2083793 (Counterclockwise)

Preceding gene: 73539143

Following gene: 73539141

Centisome position: 76.48

GC content: 64.08

Gene sequence:

>1158_bases
ATGGCCCTTGACCAAGAATCCTTTGCCCTGCTGCGCGCGTCGGTGCAGCGTTTCATCGACGAACGCCTGAAGCCGGCCGA
AGACACGCTCGAAGAGCTTGACGACGTGCCGGCCGACATCGTCGCCGACATGAAGGAAATGGGCCTGTTCGGCATCTCCA
TCCCCGAAAACTACGGCGGTATCGGCCTGTCGATGTCGCAGGAATGCGACGTGGTGTACGACCTCGGCCACACCGCATTC
GCGTTCCGTTCGGTGTTCGGCACCAACGTCGGCATCGGTTCGCAGGGCATCCTGATGGATGGCACTGAAGAGCAGAAGCA
GGCCTACCTGCCGAAGATCGCCAGCGGCGAGCTGATCATCTCGTTCGCGCTGACCGAGCCGAACGCCGGTTCCGACGCGG
CTTCGCTGCAGACGAAGGCCGAACTCGATGGTGACCACTACGTCATCAACGGTACCAAGCGCTTCATCACCAATGCGCCG
CGCGCGGGAGCCTTCACGCTGATGGCGCGCACGGGCGGGCCCGGTGCGTCGGGCATCTCGTCGTTCATCGTGCCGGCCGA
TACCCCGGGCATCTCGCTGGGCAAGCCGGACAAGAAGATGGGCCAGCGCGGCACCAAGACCTGCGACGTCGTGCTGGAGA
ACGCGCGCGTGCCGGCCGCCAATATCATCGGCGGCGTACCGGGCGTGGGGTTCAAGACCGCCATGAAAGTGCTCGACCGC
GGCCGCCTGCACCTGTCGGCGCTGGCCTGCGGCATGGCGCATCGCCTGATTACCGATGCCGTGGCCTATGCCAAGGAGCG
CAAACAGTTCGGCAAGCCGATCGGCGACTTCCAGCTGATTCAGGGCATGCTGGCCGACAGCCAGGCCGAGTTGTACGCGG
GTCTGTCGATGATGCGCGACTGCGCGCAGCGCTATGACGCCAAGCCGGCCGGCAAGAGCGACCCTGAAGTCAGCATGCTG
GCCTCGTGCACCAAGATGTTCTGTACCGAAATGGTGGGCCGCATTGCGGACCGCGCGGTGCAGATTCACGGCGGCGCCGG
CTATATCGCCGAATACAAGGCAGAACGCTTCTACCGCGATGTGCGTCTGCTGCGCCTGTATGAAGGCACCACGCAGATCC
AGCAGGTCATCATCGCCAAGCATCTGCTGCGCGACTGA

Upstream 100 bases:

>100_bases
TTTATTGACGCTTCTGTCCAATGTGGGATGGATTGTCAAATCAGATGGCGCGCGTACCATTGCGCCAAGACTGTCGAACT
GGCTTGACTGGAGAAACGCC

Downstream 100 bases:

>100_bases
TGGCGGCCTCGGCAGCAGGGCGCGATAAGGGCAGTCTTCCGGAGAGCCGCGGCGTGCACCGCCTGCGTGCCGTGGTGGCT
ACCTACCGGCCGGAGTTCCC

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MALDQESFALLRASVQRFIDERLKPAEDTLEELDDVPADIVADMKEMGLFGISIPENYGGIGLSMSQECDVVYDLGHTAF
AFRSVFGTNVGIGSQGILMDGTEEQKQAYLPKIASGELIISFALTEPNAGSDAASLQTKAELDGDHYVINGTKRFITNAP
RAGAFTLMARTGGPGASGISSFIVPADTPGISLGKPDKKMGQRGTKTCDVVLENARVPAANIIGGVPGVGFKTAMKVLDR
GRLHLSALACGMAHRLITDAVAYAKERKQFGKPIGDFQLIQGMLADSQAELYAGLSMMRDCAQRYDAKPAGKSDPEVSML
ASCTKMFCTEMVGRIADRAVQIHGGAGYIAEYKAERFYRDVRLLRLYEGTTQIQQVIIAKHLLRD

Sequences:

>Translated_385_residues
MALDQESFALLRASVQRFIDERLKPAEDTLEELDDVPADIVADMKEMGLFGISIPENYGGIGLSMSQECDVVYDLGHTAF
AFRSVFGTNVGIGSQGILMDGTEEQKQAYLPKIASGELIISFALTEPNAGSDAASLQTKAELDGDHYVINGTKRFITNAP
RAGAFTLMARTGGPGASGISSFIVPADTPGISLGKPDKKMGQRGTKTCDVVLENARVPAANIIGGVPGVGFKTAMKVLDR
GRLHLSALACGMAHRLITDAVAYAKERKQFGKPIGDFQLIQGMLADSQAELYAGLSMMRDCAQRYDAKPAGKSDPEVSML
ASCTKMFCTEMVGRIADRAVQIHGGAGYIAEYKAERFYRDVRLLRLYEGTTQIQQVIIAKHLLRD
>Mature_384_residues
ALDQESFALLRASVQRFIDERLKPAEDTLEELDDVPADIVADMKEMGLFGISIPENYGGIGLSMSQECDVVYDLGHTAFA
FRSVFGTNVGIGSQGILMDGTEEQKQAYLPKIASGELIISFALTEPNAGSDAASLQTKAELDGDHYVINGTKRFITNAPR
AGAFTLMARTGGPGASGISSFIVPADTPGISLGKPDKKMGQRGTKTCDVVLENARVPAANIIGGVPGVGFKTAMKVLDRG
RLHLSALACGMAHRLITDAVAYAKERKQFGKPIGDFQLIQGMLADSQAELYAGLSMMRDCAQRYDAKPAGKSDPEVSMLA
SCTKMFCTEMVGRIADRAVQIHGGAGYIAEYKAERFYRDVRLLRLYEGTTQIQQVIIAKHLLRD

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=381, Percent_Identity=39.6325459317585, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI4557233, Length=382, Percent_Identity=37.434554973822, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=35.2, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=35.7333333333333, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=35.7333333333333, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI76496475, Length=388, Percent_Identity=36.340206185567, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI4557235, Length=388, Percent_Identity=36.340206185567, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI7656849, Length=390, Percent_Identity=32.8205128205128, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=32, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI226958414, Length=377, Percent_Identity=32.3607427055703, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI4501857, Length=379, Percent_Identity=29.8153034300792, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI4503943, Length=376, Percent_Identity=30.8510638297872, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI7669494, Length=364, Percent_Identity=30.7692307692308, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI211971008, Length=392, Percent_Identity=28.3163265306122, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI48976061, Length=392, Percent_Identity=28.3163265306122, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI38505218, Length=395, Percent_Identity=27.8481012658228, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1786223, Length=349, Percent_Identity=28.080229226361, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI87081958, Length=386, Percent_Identity=29.0155440414508, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI87081702, Length=373, Percent_Identity=30.2949061662198, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI87082384, Length=263, Percent_Identity=26.2357414448669, Blast_Score=88, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17570075, Length=387, Percent_Identity=34.1085271317829, Blast_Score=237, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI17569725, Length=374, Percent_Identity=36.8983957219251, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17534899, Length=376, Percent_Identity=35.9042553191489, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71985184, Length=356, Percent_Identity=36.5168539325843, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17538396, Length=386, Percent_Identity=34.1968911917098, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17508101, Length=368, Percent_Identity=34.2391304347826, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17506239, Length=368, Percent_Identity=33.695652173913, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI17533517, Length=372, Percent_Identity=31.4516129032258, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71985192, Length=283, Percent_Identity=38.1625441696113, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=35.1351351351351, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17505929, Length=386, Percent_Identity=29.5336787564767, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=37.2294372294372, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17551932, Length=384, Percent_Identity=28.3854166666667, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=382, Percent_Identity=28.0104712041885, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=268, Percent_Identity=32.4626865671642, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17531909, Length=249, Percent_Identity=31.7269076305221, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17562446, Length=351, Percent_Identity=28.4900284900285, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24660351, Length=386, Percent_Identity=34.4559585492228, Blast_Score=227, Evalue=8e-60,
Organism=Drosophila melanogaster, GI24646207, Length=389, Percent_Identity=35.2185089974293, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI21356377, Length=382, Percent_Identity=35.3403141361257, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI281363737, Length=373, Percent_Identity=35.1206434316354, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24666513, Length=378, Percent_Identity=35.1851851851852, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=34.0369393139842, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI19920834, Length=382, Percent_Identity=29.3193717277487, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24652780, Length=360, Percent_Identity=22.7777777777778, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41485; Mature: 41354

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDQESFALLRASVQRFIDERLKPAEDTLEELDDVPADIVADMKEMGLFGISIPENYGG
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCEEEEECCCCCCC
IGLSMSQECDVVYDLGHTAFAFRSVFGTNVGIGSQGILMDGTEEQKQAYLPKIASGELII
CCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHCCCCCCCCEEE
SFALTEPNAGSDAASLQTKAELDGDHYVINGTKRFITNAPRAGAFTLMARTGGPGASGIS
EEEECCCCCCCCHHHHHHHHCCCCCEEEECCHHHHHCCCCCCCEEEEEEECCCCCCCCHH
SFIVPADTPGISLGKPDKKMGQRGTKTCDVVLENARVPAANIIGGVPGVGFKTAMKVLDR
CEEECCCCCCCCCCCCHHHHHCCCCCHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHC
GRLHLSALACGMAHRLITDAVAYAKERKQFGKPIGDFQLIQGMLADSQAELYAGLSMMRD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
CAQRYDAKPAGKSDPEVSMLASCTKMFCTEMVGRIADRAVQIHGGAGYIAEYKAERFYRD
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHH
VRLLRLYEGTTQIQQVIIAKHLLRD
HHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALDQESFALLRASVQRFIDERLKPAEDTLEELDDVPADIVADMKEMGLFGISIPENYGG
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCEEEEECCCCCCC
IGLSMSQECDVVYDLGHTAFAFRSVFGTNVGIGSQGILMDGTEEQKQAYLPKIASGELII
CCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHCCCCCCCCEEE
SFALTEPNAGSDAASLQTKAELDGDHYVINGTKRFITNAPRAGAFTLMARTGGPGASGIS
EEEECCCCCCCCHHHHHHHHCCCCCEEEECCHHHHHCCCCCCCEEEEEEECCCCCCCCHH
SFIVPADTPGISLGKPDKKMGQRGTKTCDVVLENARVPAANIIGGVPGVGFKTAMKVLDR
CEEECCCCCCCCCCCCHHHHHCCCCCHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHC
GRLHLSALACGMAHRLITDAVAYAKERKQFGKPIGDFQLIQGMLADSQAELYAGLSMMRD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
CAQRYDAKPAGKSDPEVSMLASCTKMFCTEMVGRIADRAVQIHGGAGYIAEYKAERFYRD
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHH
VRLLRLYEGTTQIQQVIIAKHLLRD
HHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]