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The map label for this gene is glyA1 [H]

Identifier: 73538647

GI number: 73538647

Start: 1524595

End: 1525869

Strand: Reverse

Name: glyA1 [H]

Synonym: Reut_B4822

Alternate gene names: 73538647

Gene position: 1525869-1524595 (Counterclockwise)

Preceding gene: 73538649

Following gene: 73538646

Centisome position: 55.97

GC content: 64.08

Gene sequence:

>1275_bases
ATGTCGAACACCCAGTCTTTCTTCTCGCAGCCCCTGGCCGAGCGCGATGCGCTGGTTCGCGGCGCCCTTTCGAAGGAACT
CGAGCGTCAGCAGTCGCAAGTCGAGCTGATCGCCTCGGAAAACATCGTGTCGCGCGCGGTGCTCGAAGCCCAAGGTTCGG
TACTGACCAACAAGTACGCCGAAGGTTACCCGGGCAAGCGCTACTACGGCGGCTGTAAATTTGCGGACGAAGTCGAATCG
CTCGCGATCGAGCGCGTGAAGCAGCTCTTCAACGCCGGCTTTGCCAACGTGCAGCCCCACTCGGGCGCCCAGGCGAACGG
CTCGGTGATGCTCGCGCTGACGAAGCCGGGCGACACCGTGCTCGGCATGTCGCTGGACGCGGGAGGCCACCTGACCCATG
GCGCCAAGCCGGCGTTGTCGGGCAAGTGGTTCAACGCCGTGCAGTATGGCGTGAACCGCGAGTCGATGCTGATCGACTAT
GACCAGGTCGAAGCGCTTGCGAAGGAACACAAGCCGAGCCTGATCATCGCCGGCTTCTCCGCGTATCCACGCCAGCTCGA
TTTCGCCCGCTTCCGCGCGATCGCCGACAGCGTCGGTGCGAAGCTGATGGTCGACATGGCGCACATCGCCGGTGTGATTG
CTGCGGGCCGTCATTCGAACCCGGTCGATTATGCTCACGTCGTCACTTCGACGACGCACAAGACCCTCCGAGGCCCGCGC
GGCGGATTCGTGCTGACCAACCATGAAGAAATCGCCAAGAAGATCAACTCGGCCGTGTTCCCCGGGCTGCAGGGTGGCCC
GTTGATGCACGTGATTGCAGCCAAGGCGGTGGCGTTCGGCGAGGCGATGACGTCGGACTTCAGGACCTATATCGACAACG
TGCTCGCGAACGCCAAGGCCCTCGGCGAAGTGTTGAAGGAAGGCGGCGTCGACCTGGTCACCGGCGGCACCGACAACCAT
CTGCTGCTGGTCGATCTTCGCCCGAAAGGGCTCAAGGGCACGCAGGTCGAGCAGGCGCTCGAACGTGCCGGCATCACCTG
CAACAAGAACGGCATTCCATTCGACACCGAGAAGCCGACCATCACGTCCGGCATCCGGCTCGGCGCGCCGGCCGCCACGA
CGCGCGGCTTCGGTGTTGCGGAGTTCCGCGAGATCGGCCGCCTGATCCTCGAGGTGTTCGAAGCGCTGCGCGCGAATCCG
GAGGGCGACGCTGTCACCGAGCAGCGCGTGCGCCAGCAAATCTTCGCGCTGTGCGATCGCTTCCCGATCTACTGA

Upstream 100 bases:

>100_bases
CGACAAGAATAGATCCGTTGGCAACGCTGTGCCGCTCCGGCAAACAGACCTGGCGCCGCGGGCCTCTCGTCCTCAGCCAT
TTCATCCCACACGGACCTCT

Downstream 100 bases:

>100_bases
CCCGAACGAACGATAAGACTGGAGCCCCCCATGAGCCCGCTGCACCAGGACAGCATCATTATCGACGGCCTGAACATCTC
GAAGTTCGAGCGGTCGGTGT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSNTQSFFSQPLAERDALVRGALSKELERQQSQVELIASENIVSRAVLEAQGSVLTNKYAEGYPGKRYYGGCKFADEVES
LAIERVKQLFNAGFANVQPHSGAQANGSVMLALTKPGDTVLGMSLDAGGHLTHGAKPALSGKWFNAVQYGVNRESMLIDY
DQVEALAKEHKPSLIIAGFSAYPRQLDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHSNPVDYAHVVTSTTHKTLRGPR
GGFVLTNHEEIAKKINSAVFPGLQGGPLMHVIAAKAVAFGEAMTSDFRTYIDNVLANAKALGEVLKEGGVDLVTGGTDNH
LLLVDLRPKGLKGTQVEQALERAGITCNKNGIPFDTEKPTITSGIRLGAPAATTRGFGVAEFREIGRLILEVFEALRANP
EGDAVTEQRVRQQIFALCDRFPIY

Sequences:

>Translated_424_residues
MSNTQSFFSQPLAERDALVRGALSKELERQQSQVELIASENIVSRAVLEAQGSVLTNKYAEGYPGKRYYGGCKFADEVES
LAIERVKQLFNAGFANVQPHSGAQANGSVMLALTKPGDTVLGMSLDAGGHLTHGAKPALSGKWFNAVQYGVNRESMLIDY
DQVEALAKEHKPSLIIAGFSAYPRQLDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHSNPVDYAHVVTSTTHKTLRGPR
GGFVLTNHEEIAKKINSAVFPGLQGGPLMHVIAAKAVAFGEAMTSDFRTYIDNVLANAKALGEVLKEGGVDLVTGGTDNH
LLLVDLRPKGLKGTQVEQALERAGITCNKNGIPFDTEKPTITSGIRLGAPAATTRGFGVAEFREIGRLILEVFEALRANP
EGDAVTEQRVRQQIFALCDRFPIY
>Mature_423_residues
SNTQSFFSQPLAERDALVRGALSKELERQQSQVELIASENIVSRAVLEAQGSVLTNKYAEGYPGKRYYGGCKFADEVESL
AIERVKQLFNAGFANVQPHSGAQANGSVMLALTKPGDTVLGMSLDAGGHLTHGAKPALSGKWFNAVQYGVNRESMLIDYD
QVEALAKEHKPSLIIAGFSAYPRQLDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHSNPVDYAHVVTSTTHKTLRGPRG
GFVLTNHEEIAKKINSAVFPGLQGGPLMHVIAAKAVAFGEAMTSDFRTYIDNVLANAKALGEVLKEGGVDLVTGGTDNHL
LLVDLRPKGLKGTQVEQALERAGITCNKNGIPFDTEKPTITSGIRLGAPAATTRGFGVAEFREIGRLILEVFEALRANPE
GDAVTEQRVRQQIFALCDRFPIY

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=453, Percent_Identity=44.3708609271523, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI261862352, Length=453, Percent_Identity=44.3708609271523, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI261862350, Length=453, Percent_Identity=44.3708609271523, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI261862348, Length=453, Percent_Identity=44.3708609271523, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI22547186, Length=417, Percent_Identity=47.4820143884892, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI261862346, Length=453, Percent_Identity=43.2671081677704, Blast_Score=322, Evalue=4e-88,
Organism=Homo sapiens, GI22547189, Length=400, Percent_Identity=44.75, Blast_Score=300, Evalue=1e-81,
Organism=Escherichia coli, GI1788902, Length=415, Percent_Identity=55.9036144578313, Blast_Score=439, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI25144732, Length=414, Percent_Identity=45.8937198067633, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI25144729, Length=414, Percent_Identity=45.8937198067633, Blast_Score=343, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6319739, Length=411, Percent_Identity=42.8223844282238, Blast_Score=327, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6323087, Length=406, Percent_Identity=44.0886699507389, Blast_Score=319, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24640005, Length=403, Percent_Identity=46.4019851116625, Blast_Score=352, Evalue=2e-97,
Organism=Drosophila melanogaster, GI221329721, Length=407, Percent_Identity=46.1916461916462, Blast_Score=352, Evalue=3e-97,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45618; Mature: 45486

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTQSFFSQPLAERDALVRGALSKELERQQSQVELIASENIVSRAVLEAQGSVLTNKYA
CCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
EGYPGKRYYGGCKFADEVESLAIERVKQLFNAGFANVQPHSGAQANGSVMLALTKPGDTV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEE
LGMSLDAGGHLTHGAKPALSGKWFNAVQYGVNRESMLIDYDQVEALAKEHKPSLIIAGFS
EEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEECHHHHHHHHHHCCCCEEEEECC
AYPRQLDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHSNPVDYAHVVTSTTHKTLRGPR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCC
GGFVLTNHEEIAKKINSAVFPGLQGGPLMHVIAAKAVAFGEAMTSDFRTYIDNVLANAKA
CCEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGEVLKEGGVDLVTGGTDNHLLLVDLRPKGLKGTQVEQALERAGITCNKNGIPFDTEKPT
HHHHHHHCCCEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCC
ITSGIRLGAPAATTRGFGVAEFREIGRLILEVFEALRANPEGDAVTEQRVRQQIFALCDR
HHCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FPIY
CCCC
>Mature Secondary Structure 
SNTQSFFSQPLAERDALVRGALSKELERQQSQVELIASENIVSRAVLEAQGSVLTNKYA
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
EGYPGKRYYGGCKFADEVESLAIERVKQLFNAGFANVQPHSGAQANGSVMLALTKPGDTV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEE
LGMSLDAGGHLTHGAKPALSGKWFNAVQYGVNRESMLIDYDQVEALAKEHKPSLIIAGFS
EEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEECHHHHHHHHHHCCCCEEEEECC
AYPRQLDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHSNPVDYAHVVTSTTHKTLRGPR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCC
GGFVLTNHEEIAKKINSAVFPGLQGGPLMHVIAAKAVAFGEAMTSDFRTYIDNVLANAKA
CCEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGEVLKEGGVDLVTGGTDNHLLLVDLRPKGLKGTQVEQALERAGITCNKNGIPFDTEKPT
HHHHHHHCCCEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCC
ITSGIRLGAPAATTRGFGVAEFREIGRLILEVFEALRANPEGDAVTEQRVRQQIFALCDR
HHCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FPIY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA