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The map label for this gene is adhA [H]

Identifier: 73538535

GI number: 73538535

Start: 1407367

End: 1408362

Strand: Direct

Name: adhA [H]

Synonym: Reut_B4710

Alternate gene names: 73538535

Gene position: 1407367-1408362 (Clockwise)

Preceding gene: 73538529

Following gene: 73538537

Centisome position: 51.62

GC content: 65.86

Gene sequence:

>996_bases
ATGAACGCGACGATGCGTGCAATGGTTTTCGACGGCGGGAGTCCAATCCTAGCTGACCGCCGGGTGCCAGTGCCGGTCCC
GGGAGCCGGTGAAGTGCGAATCCGCGTGGCGGCGTGCGGCGTGTGCCGTACGGACCTGCATGTGGTGGATGGAGACCTCT
CCTCGCCCAAGCCCGCGCTGATCCCGGGCCATGAAATCGTTGGTCGCGTCGATGCGCTCGGCGCCGGTGTCGTTGGACTG
TCAATCGGCGCGCGGGTCGGCGTGCCATGGCTGGGGCACACCTGCGGGCAGTGCCGCTTCTGCCTGAGCGGGCGGGAGAA
CCTTTGCGATGCACCCCAGTTCCACGGCTATACCCGTGACGGCGGATATGCCGAGTACGTGGTCGCCGATGCCAGCTATT
GCTTTCGCATTCCCGAAACGTATGACGACGAGCATGCAGCGCCGCTGCTCTGCGCCGGCCTCATCGGCTTCCGGACACTG
CGCTCGGCTGGGGATGCACAACGTATCGGCATCTACGGATTTGGCGCCGCCGCACATATCGTGACGCAAATCGCGGTGGC
GCAAGGCCGGACCGTCTACGCCTTCACGCGGCCCGGGGACCAAGCCGCCCAGACTTTGGCCACGGATGTCGGGGCTGCCT
GGGCGGGCAGCAGTCAGGACAAGGCACCCGCCACGTTGGACGCTGCCTTGATCTTTGCCCCCGACGGCGCCCTCGTGCCT
GCAGCGCTGGCGGCTGTCGACAAGGGTGGCACTGTGGTCTGCGGGGGCATTCACATGAGCGACATTCCTTCCTTCCCGTA
TCGACTGTTATGGGAGGAACGGCGGATCGTCTCCGTAGCGAACCTGACGCGTGCCGACGGCCACGGCCTAATGGAAGCGG
CAGCCACGTGGCCATTGCATATTCGTACCACGTCCTATCCTCTTTCCAGTGCCAATGCGGCGTTGGATGACCTGCGCGCT
GGCCGTCTGGCCGGGGCGGCGGTGCTCCGCGTGTGA

Upstream 100 bases:

>100_bases
GCGATGACCACGGCCTCTATGTCTGTCACGCCTGCGACGGTTTCACGGCTGCATTCCGGCGGCCGCGCTTTGTTTTTGAA
AACCTGACGAAGGAGGCATC

Downstream 100 bases:

>100_bases
CGGCTTCTTCCGACTGGATTGGCCGCGGCTTTCAGGTACTCGGGTGGGGATCCCCGACCATCGCCGCCTGGCCATGCGCT
TGGCGCGGCATGATCGTGTT

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MNATMRAMVFDGGSPILADRRVPVPVPGAGEVRIRVAACGVCRTDLHVVDGDLSSPKPALIPGHEIVGRVDALGAGVVGL
SIGARVGVPWLGHTCGQCRFCLSGRENLCDAPQFHGYTRDGGYAEYVVADASYCFRIPETYDDEHAAPLLCAGLIGFRTL
RSAGDAQRIGIYGFGAAAHIVTQIAVAQGRTVYAFTRPGDQAAQTLATDVGAAWAGSSQDKAPATLDAALIFAPDGALVP
AALAAVDKGGTVVCGGIHMSDIPSFPYRLLWEERRIVSVANLTRADGHGLMEAAATWPLHIRTTSYPLSSANAALDDLRA
GRLAGAAVLRV

Sequences:

>Translated_331_residues
MNATMRAMVFDGGSPILADRRVPVPVPGAGEVRIRVAACGVCRTDLHVVDGDLSSPKPALIPGHEIVGRVDALGAGVVGL
SIGARVGVPWLGHTCGQCRFCLSGRENLCDAPQFHGYTRDGGYAEYVVADASYCFRIPETYDDEHAAPLLCAGLIGFRTL
RSAGDAQRIGIYGFGAAAHIVTQIAVAQGRTVYAFTRPGDQAAQTLATDVGAAWAGSSQDKAPATLDAALIFAPDGALVP
AALAAVDKGGTVVCGGIHMSDIPSFPYRLLWEERRIVSVANLTRADGHGLMEAAATWPLHIRTTSYPLSSANAALDDLRA
GRLAGAAVLRV
>Mature_331_residues
MNATMRAMVFDGGSPILADRRVPVPVPGAGEVRIRVAACGVCRTDLHVVDGDLSSPKPALIPGHEIVGRVDALGAGVVGL
SIGARVGVPWLGHTCGQCRFCLSGRENLCDAPQFHGYTRDGGYAEYVVADASYCFRIPETYDDEHAAPLLCAGLIGFRTL
RSAGDAQRIGIYGFGAAAHIVTQIAVAQGRTVYAFTRPGDQAAQTLATDVGAAWAGSSQDKAPATLDAALIFAPDGALVP
AALAAVDKGGTVVCGGIHMSDIPSFPYRLLWEERRIVSVANLTRADGHGLMEAAATWPLHIRTTSYPLSSANAALDDLRA
GRLAGAAVLRV

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=158, Percent_Identity=32.9113924050633, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI34577061, Length=103, Percent_Identity=40.7766990291262, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4501929, Length=158, Percent_Identity=32.2784810126582, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI156627571, Length=335, Percent_Identity=24.7761194029851, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI71743840, Length=160, Percent_Identity=29.375, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI262073058, Length=173, Percent_Identity=28.3236994219653, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI71565152, Length=103, Percent_Identity=37.8640776699029, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI71565154, Length=118, Percent_Identity=36.4406779661017, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081918, Length=319, Percent_Identity=31.6614420062696, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87082401, Length=316, Percent_Identity=29.746835443038, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1786518, Length=197, Percent_Identity=37.5634517766497, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787863, Length=217, Percent_Identity=29.9539170506912, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790045, Length=130, Percent_Identity=40.7692307692308, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1788407, Length=230, Percent_Identity=30, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI226510992, Length=129, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082125, Length=158, Percent_Identity=31.6455696202532, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788073, Length=130, Percent_Identity=32.3076923076923, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=165, Percent_Identity=35.7575757575758, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17562584, Length=163, Percent_Identity=32.5153374233129, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71988145, Length=161, Percent_Identity=29.8136645962733, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=221, Percent_Identity=29.8642533936652, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=220, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=254, Percent_Identity=27.9527559055118, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=161, Percent_Identity=39.7515527950311, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6324486, Length=161, Percent_Identity=39.1304347826087, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6323729, Length=161, Percent_Identity=37.888198757764, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319621, Length=211, Percent_Identity=34.5971563981043, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319949, Length=185, Percent_Identity=36.2162162162162, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6323980, Length=242, Percent_Identity=31.8181818181818, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=368, Percent_Identity=26.6304347826087, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17737897, Length=161, Percent_Identity=32.9192546583851, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17137530, Length=132, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 34499; Mature: 34499

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATMRAMVFDGGSPILADRRVPVPVPGAGEVRIRVAACGVCRTDLHVVDGDLSSPKPAL
CCCEEEEEEEECCCCEEECCCCCCCCCCCCCEEEEEEECCEECCCCEEEECCCCCCCCCE
IPGHEIVGRVDALGAGVVGLSIGARVGVPWLGHTCGQCRFCLSGRENLCDAPQFHGYTRD
ECCHHHHHHHHHHCCCEEEEECCCCCCCCHHCCCCCCEEEEECCCCCCCCCCHHCCCCCC
GGYAEYVVADASYCFRIPETYDDEHAAPLLCAGLIGFRTLRSAGDAQRIGIYGFGAAAHI
CCEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHH
VTQIAVAQGRTVYAFTRPGDQAAQTLATDVGAAWAGSSQDKAPATLDAALIFAPDGALVP
HHHHHHHCCCEEEEEECCCHHHHHHHHHHHCHHCCCCCCCCCCCEEEEEEEECCCCCHHH
AALAAVDKGGTVVCGGIHMSDIPSFPYRLLWEERRIVSVANLTRADGHGLMEAAATWPLH
HHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHCCCEEEEHHCCCCCCCCHHHHHCCCEEE
IRTTSYPLSSANAALDDLRAGRLAGAAVLRV
EEECCCCCCCCHHHHHHHHCCHHHCEEEECC
>Mature Secondary Structure
MNATMRAMVFDGGSPILADRRVPVPVPGAGEVRIRVAACGVCRTDLHVVDGDLSSPKPAL
CCCEEEEEEEECCCCEEECCCCCCCCCCCCCEEEEEEECCEECCCCEEEECCCCCCCCCE
IPGHEIVGRVDALGAGVVGLSIGARVGVPWLGHTCGQCRFCLSGRENLCDAPQFHGYTRD
ECCHHHHHHHHHHCCCEEEEECCCCCCCCHHCCCCCCEEEEECCCCCCCCCCHHCCCCCC
GGYAEYVVADASYCFRIPETYDDEHAAPLLCAGLIGFRTLRSAGDAQRIGIYGFGAAAHI
CCEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHH
VTQIAVAQGRTVYAFTRPGDQAAQTLATDVGAAWAGSSQDKAPATLDAALIFAPDGALVP
HHHHHHHCCCEEEEEECCCHHHHHHHHHHHCHHCCCCCCCCCCCEEEEEEEECCCCCHHH
AALAAVDKGGTVVCGGIHMSDIPSFPYRLLWEERRIVSVANLTRADGHGLMEAAATWPLH
HHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHCCCEEEEHHCCCCCCCCHHHHHCCCEEE
IRTTSYPLSSANAALDDLRAGRLAGAAVLRV
EEECCCCCCCCHHHHHHHHCCHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]