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The map label for this gene is deoA [C]

Identifier: 73538529

GI number: 73538529

Start: 1401569

End: 1403107

Strand: Direct

Name: deoA [C]

Synonym: Reut_B4704

Alternate gene names: 73538529

Gene position: 1401569-1403107 (Clockwise)

Preceding gene: 73538526

Following gene: 73538535

Centisome position: 51.41

GC content: 66.86

Gene sequence:

>1539_bases
ATGCAGGCAAACGAGCTGAAACTTGCTGCCGGGGAAGGTCAGGGATCCGAGCCGCTGATTTTCAAACCCCTCGGCATCGA
TACCTGGCAGGAGCATGTCATCTATCTACACCCGGACTGCCCCGTGTGCCGCGCCGAAGGCTTTACCGCGCAAGCACGGG
TGCAGGTGCGGATCGGCGAGGCAAGCCTCATTGCCACGCTGAACCTGGTCGGTGCGCCATTGCTCGATACCGGAGAGGCA
AGCCTTTCCGCCAGCGCTGCACAGGCACTGGAGGCTCGCGCCGGCGATGTCGTGGCCATCAGTCACGCGCCGGCCCTGGA
ATCCGTACGCGCCTTGCGTGCGAAGATCTACGGCCGCCGGCTCGACGGCGCCCAGATCGATTCCATCATCAGCGATATCT
CGGCGGGGCGGTACCCGGATGTGTATATCTCCGCGTTCCTTGCCGCATGTGCAGATGGCCGCATGAACCGGCGGGAAACC
GTGGACCTCACACGTGCCATGGTGCACTCGGGCGAGCGGCTGTCATGGAGCCACGCCGTCGTTGCCGACAAGCACTGCGT
CGGCGGCCTGCCCGGCAACCGGACCACACCCATTGTCGTGGCAATAGCGGCGGCAGGAGGCCTGGTCTTGCCGAAGACGT
CTTCCCGGGCGATCACCTCTCCAGCCGGTACCGCAGACACGATGGAGACATTGACCCGCGTGGCGCTCAGTGCGGCGGAA
CTGCGCCACGTCGTGGAGCGAGTCGGGGCGTCGCTGGTCTGGGGTGGCGCACTGAACCTGAGTCCCGCCGACGATATCCT
GATCCGCGTGGAACGCGCGCTTGATATCGACAGCGACGCGCAGCTTGTTGCCTCCATCCTGTCCAAGAAGGTTGCGGCAG
GCTCGACGCACATCCTGATCGATGTGCCGGTTGGCCCCACAGCCAAGGTGCGCGAGGACAGGGACCTGGAGCGGCTCGAA
GCCGCGATGCGGCATGTGGCGGGGGCGTTCGGCCTGCACATCCTCATGGTTCGGACCGACGGCACCCAGCCGCTTGGCAG
GGGCATTGGCCCCGCGCTGGAGGCGCGAGACATCCTGGCGGTACTCCAGCGCACGGTGGCGGCGCCGCCCGACCTGCGCG
AGCGCTCGGTCATGCTCGCCGGCGCGCTGCTGGAGTTCTGTGGCGCGGCACCCAGGGGCGCTGGCGAAAAAGCCGCTGGC
CAGCTACTCGACAGTGGCGCGGCCTGGCGCAAGTTCCAGGCGATTTGCGAAGCGCAGGGCGGCTTGCGCGTGCCGGGCGA
AGCCATTTTTCGCCGCGACATCGTCGCTCCCCACGCGGGGAAGGTAATCGCCATCGACAACCGCCACATTGCCCGCACCG
CAAAGCTGGCCGGCGCCCCGATGCGGCAGGTCGCGGGCCTTGAGATGCGGGTACGGGTCAACGACGAAGTCCGGGCCGGT
CAACCACTGTTCACGGTCCATGCCCAGGCCTCCGGCGAACTGGACTACTCGTGCAGCTACGCGCTGGCGCACCCTGCGGT
CTCTATCGAGCCGCACTGA

Upstream 100 bases:

>100_bases
CGGGTACAGGGCAAACATATCGAACGCCTGGATCGAGCTGCCCTATCTGCGATAGGTACATGCCTTCACACGTCCGATGC
CGATCGGAGGGGAAAGCGCA

Downstream 100 bases:

>100_bases
ACGCCGCAGCCGGCTTCGTCCGACATGTACATGCTCTCGTTTCCGCTGTAAGTCGATATCAACGTCGTGCCTTCACCTTG
GATCCATGAAGCTTGCGGGG

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase 2

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MQANELKLAAGEGQGSEPLIFKPLGIDTWQEHVIYLHPDCPVCRAEGFTAQARVQVRIGEASLIATLNLVGAPLLDTGEA
SLSASAAQALEARAGDVVAISHAPALESVRALRAKIYGRRLDGAQIDSIISDISAGRYPDVYISAFLAACADGRMNRRET
VDLTRAMVHSGERLSWSHAVVADKHCVGGLPGNRTTPIVVAIAAAGGLVLPKTSSRAITSPAGTADTMETLTRVALSAAE
LRHVVERVGASLVWGGALNLSPADDILIRVERALDIDSDAQLVASILSKKVAAGSTHILIDVPVGPTAKVREDRDLERLE
AAMRHVAGAFGLHILMVRTDGTQPLGRGIGPALEARDILAVLQRTVAAPPDLRERSVMLAGALLEFCGAAPRGAGEKAAG
QLLDSGAAWRKFQAICEAQGGLRVPGEAIFRRDIVAPHAGKVIAIDNRHIARTAKLAGAPMRQVAGLEMRVRVNDEVRAG
QPLFTVHAQASGELDYSCSYALAHPAVSIEPH

Sequences:

>Translated_512_residues
MQANELKLAAGEGQGSEPLIFKPLGIDTWQEHVIYLHPDCPVCRAEGFTAQARVQVRIGEASLIATLNLVGAPLLDTGEA
SLSASAAQALEARAGDVVAISHAPALESVRALRAKIYGRRLDGAQIDSIISDISAGRYPDVYISAFLAACADGRMNRRET
VDLTRAMVHSGERLSWSHAVVADKHCVGGLPGNRTTPIVVAIAAAGGLVLPKTSSRAITSPAGTADTMETLTRVALSAAE
LRHVVERVGASLVWGGALNLSPADDILIRVERALDIDSDAQLVASILSKKVAAGSTHILIDVPVGPTAKVREDRDLERLE
AAMRHVAGAFGLHILMVRTDGTQPLGRGIGPALEARDILAVLQRTVAAPPDLRERSVMLAGALLEFCGAAPRGAGEKAAG
QLLDSGAAWRKFQAICEAQGGLRVPGEAIFRRDIVAPHAGKVIAIDNRHIARTAKLAGAPMRQVAGLEMRVRVNDEVRAG
QPLFTVHAQASGELDYSCSYALAHPAVSIEPH
>Mature_512_residues
MQANELKLAAGEGQGSEPLIFKPLGIDTWQEHVIYLHPDCPVCRAEGFTAQARVQVRIGEASLIATLNLVGAPLLDTGEA
SLSASAAQALEARAGDVVAISHAPALESVRALRAKIYGRRLDGAQIDSIISDISAGRYPDVYISAFLAACADGRMNRRET
VDLTRAMVHSGERLSWSHAVVADKHCVGGLPGNRTTPIVVAIAAAGGLVLPKTSSRAITSPAGTADTMETLTRVALSAAE
LRHVVERVGASLVWGGALNLSPADDILIRVERALDIDSDAQLVASILSKKVAAGSTHILIDVPVGPTAKVREDRDLERLE
AAMRHVAGAFGLHILMVRTDGTQPLGRGIGPALEARDILAVLQRTVAAPPDLRERSVMLAGALLEFCGAAPRGAGEKAAG
QLLDSGAAWRKFQAICEAQGGLRVPGEAIFRRDIVAPHAGKVIAIDNRHIARTAKLAGAPMRQVAGLEMRVRVNDEVRAG
QPLFTVHAQASGELDYSCSYALAHPAVSIEPH

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI166158925, Length=406, Percent_Identity=30.5418719211823, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI4503445, Length=406, Percent_Identity=30.5418719211823, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI166158922, Length=406, Percent_Identity=30.5418719211823, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=27.4752475247525, Blast_Score=89, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH2_CUPPJ (Q46S32)

Other databases:

- EMBL:   CP000091
- RefSeq:   YP_298896.1
- ProteinModelPortal:   Q46S32
- SMR:   Q46S32
- GeneID:   3613942
- GenomeReviews:   CP000091_GR
- KEGG:   reu:Reut_B4704
- NMPDR:   fig|264198.3.peg.5374
- HOGENOM:   HBG460532
- OMA:   ACADGRM
- ProtClustDB:   PRK04350
- BioCyc:   REUT264198:REUT_B4704-MONOMER
- HAMAP:   MF_00703
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02645

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 53922; Mature: 53922

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQANELKLAAGEGQGSEPLIFKPLGIDTWQEHVIYLHPDCPVCRAEGFTAQARVQVRIGE
CCCCCEEEEECCCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEEEECC
ASLIATLNLVGAPLLDTGEASLSASAAQALEARAGDVVAISHAPALESVRALRAKIYGRR
HHEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCC
LDGAQIDSIISDISAGRYPDVYISAFLAACADGRMNRRETVDLTRAMVHSGERLSWSHAV
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCE
VADKHCVGGLPGNRTTPIVVAIAAAGGLVLPKTSSRAITSPAGTADTMETLTRVALSAAE
EECCHHCCCCCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LRHVVERVGASLVWGGALNLSPADDILIRVERALDIDSDAQLVASILSKKVAAGSTHILI
HHHHHHHHCCEEEECCCCCCCCHHHHHEEEHHHCCCCCHHHHHHHHHHHHHCCCCEEEEE
DVPVGPTAKVREDRDLERLEAAMRHVAGAFGLHILMVRTDGTQPLGRGIGPALEARDILA
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHCCCCCHHHHHHHHH
VLQRTVAAPPDLRERSVMLAGALLEFCGAAPRGAGEKAAGQLLDSGAAWRKFQAICEAQG
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCC
GLRVPGEAIFRRDIVAPHAGKVIAIDNRHIARTAKLAGAPMRQVAGLEMRVRVNDEVRAG
CCCCCHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHCCCCHHHHCCCEEEEEECCCCCCC
QPLFTVHAQASGELDYSCSYALAHPAVSIEPH
CCEEEEEECCCCCCCCEEEEEECCCEEECCCC
>Mature Secondary Structure
MQANELKLAAGEGQGSEPLIFKPLGIDTWQEHVIYLHPDCPVCRAEGFTAQARVQVRIGE
CCCCCEEEEECCCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEEEECC
ASLIATLNLVGAPLLDTGEASLSASAAQALEARAGDVVAISHAPALESVRALRAKIYGRR
HHEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCC
LDGAQIDSIISDISAGRYPDVYISAFLAACADGRMNRRETVDLTRAMVHSGERLSWSHAV
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCE
VADKHCVGGLPGNRTTPIVVAIAAAGGLVLPKTSSRAITSPAGTADTMETLTRVALSAAE
EECCHHCCCCCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LRHVVERVGASLVWGGALNLSPADDILIRVERALDIDSDAQLVASILSKKVAAGSTHILI
HHHHHHHHCCEEEECCCCCCCCHHHHHEEEHHHCCCCCHHHHHHHHHHHHHCCCCEEEEE
DVPVGPTAKVREDRDLERLEAAMRHVAGAFGLHILMVRTDGTQPLGRGIGPALEARDILA
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHCCCCCHHHHHHHHH
VLQRTVAAPPDLRERSVMLAGALLEFCGAAPRGAGEKAAGQLLDSGAAWRKFQAICEAQG
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCC
GLRVPGEAIFRRDIVAPHAGKVIAIDNRHIARTAKLAGAPMRQVAGLEMRVRVNDEVRAG
CCCCCHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHCCCCHHHHCCCEEEEEECCCCCCC
QPLFTVHAQASGELDYSCSYALAHPAVSIEPH
CCEEEEEECCCCCCCCEEEEEECCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA