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The map label for this gene is pntB [H]

Identifier: 73538492

GI number: 73538492

Start: 1359954

End: 1361351

Strand: Reverse

Name: pntB [H]

Synonym: Reut_B4666

Alternate gene names: 73538492

Gene position: 1361351-1359954 (Counterclockwise)

Preceding gene: 73538493

Following gene: 73538491

Centisome position: 49.94

GC content: 66.02

Gene sequence:

>1398_bases
ATGCCTTCGGGAATCAGCAGTATTGCTTACCTGGGCGCGAGCGCGCTCTTCATCCTCAGCCTGAGCGGGCTGAGCCATCC
GGCCAGCGCGAAGCGCGGCAACCTGCTCGGCATCGCGGGTATGGTGATCGCCGTGCTGACCACGGTGCTGGCCGGCAGCC
CGGACGGGGTGCCCATCATCATCGGCGCGATGGTGCTCGGCGCGGCGGCCGGCGCGGTGCTGGCCCGACGCGTGGAAATG
ACGCAGATGCCGGAGCTGGTTGCGGTGCTGCACAGCTTCGTCGGCCTGGCTGCGGTGCTGGTGGGCTATGCGAACTATCT
GGACGCGCATGCGCTGACCGGTGCGGAGAAGGCCATCCACGAGATCGAAACCTACCTTGGCATCCTGATCGGCGCGGTGA
CGTTCACGGGTTCGGTGATCGCGTTCCTCAAGCTGCGCGGCACGCTCGGCGGCAAGCCGACGCTGCTGCCGGGCCGTCAC
GTGCTCAACGCGCTGGCGCTGATCGTGTGCGTGGTGCTGGCCTACCAGTTCCTCAATGCGCCATCGGTGCAGGACGGGCT
GGTGCCGCTGGGCGTGATGACGGTGATCGCGCTGCTGGTGGGTGCACACCTGGTCGCGGCGATCGGTGGTGCCGACATGC
CGGTGGTGGTGTCGATGCTTAACAGCTACTCGGGCTGGGCCGCCGCGGCGACTGGCTTCATGCTCGGCAACGACCTGCTC
ATCATCACCGGTGCGTTGGTTGGCTCGAGCGGCGCGATCCTCAGCTACATCATGTGCAAGGCCATGAACCGCAAATTCCT
GTCGGTGATCCTGGGCGGGTTCGGCGTCACGCAGGCCAAGGGCGCGGCGACAGAGCAGGGCGAGGTGTTGCCGGTATCGA
GCGACGAGGTCAGCGCGCTGCTGAAGGACGCGAACGAGGTCATCATCGTGCCCGGCTACGGCATGGCGGTGGCGCAGGCG
CAGGGCACCATCAGCGAGATCGCAAAGCGGCTGCGTGCGCAGGGCGTCAATGTGCGCTTCGGTATCCATCCGGTCGCCGG
CCGTTTGCCCGGGCATATGAACGTGCTGCTGGCTGAGGCGCGCGTGCCGTATGACATCGTGCTCGAGATGGAGGAGATCA
ACGACGATTTTGAGCACGCCGACGTCGTTCTGGTGGTTGGCGCCAACGATATCGTTAACCCGGGGGCGCTCGAAGACCCC
GCCAGCCCCATCGCCGGCATGCCGGTGCTCGAAGTCTGGAAAGCGCGCACCGTGGTGGTGTCCAAGCGCAGCATGGCCGC
CGGCTATGCGGGCGTCGACAACCCCTTGTTTTACAAGGAAAACACGCGGATGTGGTTCGGCGATGCCAAGGGCAGCGTAG
ACGCGTTGTTGCGCCAGCTCGAGGAGGTTCCCGCGTGA

Upstream 100 bases:

>100_bases
GCCGGCGCGGCGGTGCTGATCGCCACCATCAACATCGCAGGCGGCTTCCTCGTGACGCAGCGCATGCTGAAGATGTTCCA
GCGGGACTGAGGAGACAGAC

Downstream 100 bases:

>100_bases
TTGGCCGCGTTCGTCCGCCGCAAAGCATGACTACGACTTATGTATTAACTTGCAGTCATGCGGCGGATGGCGGCCCAATT
GATGCGGAATTCGCAATATA

Product: NAD(P) transhydrogenase subunit beta

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Pyridine nucleotide transhydrogenase subunit beta [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MPSGISSIAYLGASALFILSLSGLSHPASAKRGNLLGIAGMVIAVLTTVLAGSPDGVPIIIGAMVLGAAAGAVLARRVEM
TQMPELVAVLHSFVGLAAVLVGYANYLDAHALTGAEKAIHEIETYLGILIGAVTFTGSVIAFLKLRGTLGGKPTLLPGRH
VLNALALIVCVVLAYQFLNAPSVQDGLVPLGVMTVIALLVGAHLVAAIGGADMPVVVSMLNSYSGWAAAATGFMLGNDLL
IITGALVGSSGAILSYIMCKAMNRKFLSVILGGFGVTQAKGAATEQGEVLPVSSDEVSALLKDANEVIIVPGYGMAVAQA
QGTISEIAKRLRAQGVNVRFGIHPVAGRLPGHMNVLLAEARVPYDIVLEMEEINDDFEHADVVLVVGANDIVNPGALEDP
ASPIAGMPVLEVWKARTVVVSKRSMAAGYAGVDNPLFYKENTRMWFGDAKGSVDALLRQLEEVPA

Sequences:

>Translated_465_residues
MPSGISSIAYLGASALFILSLSGLSHPASAKRGNLLGIAGMVIAVLTTVLAGSPDGVPIIIGAMVLGAAAGAVLARRVEM
TQMPELVAVLHSFVGLAAVLVGYANYLDAHALTGAEKAIHEIETYLGILIGAVTFTGSVIAFLKLRGTLGGKPTLLPGRH
VLNALALIVCVVLAYQFLNAPSVQDGLVPLGVMTVIALLVGAHLVAAIGGADMPVVVSMLNSYSGWAAAATGFMLGNDLL
IITGALVGSSGAILSYIMCKAMNRKFLSVILGGFGVTQAKGAATEQGEVLPVSSDEVSALLKDANEVIIVPGYGMAVAQA
QGTISEIAKRLRAQGVNVRFGIHPVAGRLPGHMNVLLAEARVPYDIVLEMEEINDDFEHADVVLVVGANDIVNPGALEDP
ASPIAGMPVLEVWKARTVVVSKRSMAAGYAGVDNPLFYKENTRMWFGDAKGSVDALLRQLEEVPA
>Mature_464_residues
PSGISSIAYLGASALFILSLSGLSHPASAKRGNLLGIAGMVIAVLTTVLAGSPDGVPIIIGAMVLGAAAGAVLARRVEMT
QMPELVAVLHSFVGLAAVLVGYANYLDAHALTGAEKAIHEIETYLGILIGAVTFTGSVIAFLKLRGTLGGKPTLLPGRHV
LNALALIVCVVLAYQFLNAPSVQDGLVPLGVMTVIALLVGAHLVAAIGGADMPVVVSMLNSYSGWAAAATGFMLGNDLLI
ITGALVGSSGAILSYIMCKAMNRKFLSVILGGFGVTQAKGAATEQGEVLPVSSDEVSALLKDANEVIIVPGYGMAVAQAQ
GTISEIAKRLRAQGVNVRFGIHPVAGRLPGHMNVLLAEARVPYDIVLEMEEINDDFEHADVVLVVGANDIVNPGALEDPA
SPIAGMPVLEVWKARTVVVSKRSMAAGYAGVDNPLFYKENTRMWFGDAKGSVDALLRQLEEVPA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=464, Percent_Identity=51.7241379310345, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI122939153, Length=464, Percent_Identity=51.7241379310345, Blast_Score=446, Evalue=1e-125,
Organism=Escherichia coli, GI1787886, Length=462, Percent_Identity=63.4199134199134, Blast_Score=567, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17550456, Length=468, Percent_Identity=48.5042735042735, Blast_Score=408, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 48043; Mature: 47912

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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ECHHHHCCCCCCCCCEEEECCCEEEECCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
PSGISSIAYLGASALFILSLSGLSHPASAKRGNLLGIAGMVIAVLTTVLAGSPDGVPII
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH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ECHHHHCCCCCCCCCEEEECCCEEEECCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]