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The map label for this gene is oxc [H]

Identifier: 73538490

GI number: 73538490

Start: 1356027

End: 1357760

Strand: Reverse

Name: oxc [H]

Synonym: Reut_B4664

Alternate gene names: 73538490

Gene position: 1357760-1356027 (Counterclockwise)

Preceding gene: 73538491

Following gene: 73538489

Centisome position: 49.8

GC content: 64.19

Gene sequence:

>1734_bases
ATGGCAGAAGTCGGAAACGAGCTGCAGCGTCACGCCGCGGAAGAACAGCAGGCACAAACCGATGGTTTCCATCTGGTCAT
CGACGCGCTGAAGCTGAACGGCATCGAAAACATCTACGGCCTGCCCGGCATTCCGGTCACCGATCTGGCTCGTCTGGCGC
AGGCCAACGGCATGCGCGTCATCAGCTTCCGTCACGAGCAGAACGCAGGCAACGCCGCAGCGATTGCCGGCTTTATCTCG
CAGAAGCCGGGCGTTTGCCTGACCGTGTCGGCCCCTGGCTTCCTGAACGGCCTGACGGCGCTGGCGCATGCCACCACCAA
CTGCTTCCCGATGATCCTGATCAGCGGCTCGAGCGAGCGCGAGATCGTCGACCTGCAGCAGGGTGACTACGAAGAGATGG
ACCAGCTGGCCATTGCCCGTCCGCACGCGAAGGCTGCCTTCCGCGTGCTGCACGCCGAAGACATTGGCGTGGGTATCGCG
CGTGCCATTCGTGCCGCCGTATCGGGCCGCCCGGGCGGTGTGTATCTCGATCTGCCGGCCAAGCTGCTGGGCCAGTCGCT
GGAAGCAGAGAAGGGCAAGAAGTCGCTGATCAAGGTAGTGGATCCGGCCCCGCGCCAGCTGCCCGCACCGGACTCGGTCG
ACCGCGCCGTCGCATTGCTGAAGAACGCCAAGCGCCCGCTGATCCTGCTGGGCAAGGGTGCCGCTTACGCACGCGCCGAC
GAGGATATCCGTGCGCTGGTCGAGAAGACCGGCATTCCGTATCTGCCGATGTCGATGGCCAAAGGCCTGCTGCCCGATAC
GCATCCGCAATCGGCCTCGGCGGCACGCTCGTACGTGCTGGCTGAAGCCGATGTGGTGATGCTGGTCGGCGCCCGCCTGA
ACTGGCTGCTGTCGCACGGCAAGGGCAAGACCTGGGGCGGCCCGAAGCAGTTCATCCAGATCGACATCTCGCCGACCGAG
ATGGACAGCAACGTCGCCATCGCCGCGCCGGTGGTGGGTGACATCGGTTCGTGCGTGTCGGCGATCCTTGGCAAGGTAGG
CAACGACTTTGCCAAGCCGCCCGCCGAGTGGTTGAACGCTGTGTACGAACGCAAGGACAAGAACCTGGCGAAGATGGGCG
AGCTGCTGAACAAGGAAGTCTCGCCGATGAACTTCCACACCGGGCTGCGCGTGCTGAAGGACGTCATCAAGGCCAATCCG
GGCATCTCGTTCGTCAACGAAGGCGCCAACACATTGGACTACGCCCGCGCCGTGATCGACATGTACGAGCCGCGCAAGCG
CCTCGACGTCGGCACCTGGGGCGTGATGGGCGTGGGCATGGGCTACGCGGTCGCCGCAGCGGTCGAGACCAATAAGCCGG
TGCTGGCGCTGTGCGGTGACAGTGCATTCGGTTTCTCGGGCATGGAAGTCGAGACGATCTGCCGCTACAACCTGCCGGTG
TGCATCGTCATCTTCAACAACAACGGCATTTACAAGGGCATCGACAAGAACCCCACCGGCGGCGCGGACCCGGCGGTCAC
CACCTTCGTGCCGGGTGCCCGCTACGACAAGATGATGGAAGCATTCGGCGGCGTCGGTGCCAACGTGACCACGCCGGCGG
AACTCGAGGCTGCCGTGAACGAAGCGCTGCGCTCGGGCAGGCCCACGCTGGTCAATGCTGTGATCGACCCGTCTGCCGGC
ACCGAAAGCGGCCGCCTGACCAACCTGAATCCGCAAAGCTCGGCCAAGAAGTAA

Upstream 100 bases:

>100_bases
GCATGTCCGAAGTCGTAGCCAAGCAGCCCGATAGCACCACCGCGGCAGCCACGAAATAACACATTCCCACCCCAGTCAAT
TTGCATAGAAGGAAGCAACC

Downstream 100 bases:

>100_bases
TTCAACCGAATTTCAATCCCGAATTTCACCCGCTTATCCAATAGGAGAACGAAAGTGACCCTCCCACTCAACGGCATCAA
GATCATCGACTTCACGCACG

Product: putative oxalyl-CoA decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MAEVGNELQRHAAEEQQAQTDGFHLVIDALKLNGIENIYGLPGIPVTDLARLAQANGMRVISFRHEQNAGNAAAIAGFIS
QKPGVCLTVSAPGFLNGLTALAHATTNCFPMILISGSSEREIVDLQQGDYEEMDQLAIARPHAKAAFRVLHAEDIGVGIA
RAIRAAVSGRPGGVYLDLPAKLLGQSLEAEKGKKSLIKVVDPAPRQLPAPDSVDRAVALLKNAKRPLILLGKGAAYARAD
EDIRALVEKTGIPYLPMSMAKGLLPDTHPQSASAARSYVLAEADVVMLVGARLNWLLSHGKGKTWGGPKQFIQIDISPTE
MDSNVAIAAPVVGDIGSCVSAILGKVGNDFAKPPAEWLNAVYERKDKNLAKMGELLNKEVSPMNFHTGLRVLKDVIKANP
GISFVNEGANTLDYARAVIDMYEPRKRLDVGTWGVMGVGMGYAVAAAVETNKPVLALCGDSAFGFSGMEVETICRYNLPV
CIVIFNNNGIYKGIDKNPTGGADPAVTTFVPGARYDKMMEAFGGVGANVTTPAELEAAVNEALRSGRPTLVNAVIDPSAG
TESGRLTNLNPQSSAKK

Sequences:

>Translated_577_residues
MAEVGNELQRHAAEEQQAQTDGFHLVIDALKLNGIENIYGLPGIPVTDLARLAQANGMRVISFRHEQNAGNAAAIAGFIS
QKPGVCLTVSAPGFLNGLTALAHATTNCFPMILISGSSEREIVDLQQGDYEEMDQLAIARPHAKAAFRVLHAEDIGVGIA
RAIRAAVSGRPGGVYLDLPAKLLGQSLEAEKGKKSLIKVVDPAPRQLPAPDSVDRAVALLKNAKRPLILLGKGAAYARAD
EDIRALVEKTGIPYLPMSMAKGLLPDTHPQSASAARSYVLAEADVVMLVGARLNWLLSHGKGKTWGGPKQFIQIDISPTE
MDSNVAIAAPVVGDIGSCVSAILGKVGNDFAKPPAEWLNAVYERKDKNLAKMGELLNKEVSPMNFHTGLRVLKDVIKANP
GISFVNEGANTLDYARAVIDMYEPRKRLDVGTWGVMGVGMGYAVAAAVETNKPVLALCGDSAFGFSGMEVETICRYNLPV
CIVIFNNNGIYKGIDKNPTGGADPAVTTFVPGARYDKMMEAFGGVGANVTTPAELEAAVNEALRSGRPTLVNAVIDPSAG
TESGRLTNLNPQSSAKK
>Mature_576_residues
AEVGNELQRHAAEEQQAQTDGFHLVIDALKLNGIENIYGLPGIPVTDLARLAQANGMRVISFRHEQNAGNAAAIAGFISQ
KPGVCLTVSAPGFLNGLTALAHATTNCFPMILISGSSEREIVDLQQGDYEEMDQLAIARPHAKAAFRVLHAEDIGVGIAR
AIRAAVSGRPGGVYLDLPAKLLGQSLEAEKGKKSLIKVVDPAPRQLPAPDSVDRAVALLKNAKRPLILLGKGAAYARADE
DIRALVEKTGIPYLPMSMAKGLLPDTHPQSASAARSYVLAEADVVMLVGARLNWLLSHGKGKTWGGPKQFIQIDISPTEM
DSNVAIAAPVVGDIGSCVSAILGKVGNDFAKPPAEWLNAVYERKDKNLAKMGELLNKEVSPMNFHTGLRVLKDVIKANPG
ISFVNEGANTLDYARAVIDMYEPRKRLDVGTWGVMGVGMGYAVAAAVETNKPVLALCGDSAFGFSGMEVETICRYNLPVC
IVIFNNNGIYKGIDKNPTGGADPAVTTFVPGARYDKMMEAFGGVGANVTTPAELEAAVNEALRSGRPTLVNAVIDPSAGT
ESGRLTNLNPQSSAKK

Specific function: Oxalic acid catabolism; second step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=566, Percent_Identity=39.7526501766784, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI21361361, Length=574, Percent_Identity=29.2682926829268, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1788716, Length=561, Percent_Identity=59.5365418894831, Blast_Score=671, Evalue=0.0,
Organism=Escherichia coli, GI87081685, Length=560, Percent_Identity=25.5357142857143, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1790104, Length=547, Percent_Identity=27.0566727605119, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1786717, Length=479, Percent_Identity=26.3048016701461, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1787096, Length=545, Percent_Identity=23.302752293578, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17531301, Length=549, Percent_Identity=37.8870673952641, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17531299, Length=552, Percent_Identity=37.6811594202899, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17542570, Length=592, Percent_Identity=26.8581081081081, Blast_Score=185, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6320816, Length=549, Percent_Identity=34.9726775956284, Blast_Score=282, Evalue=9e-77,
Organism=Saccharomyces cerevisiae, GI6323755, Length=566, Percent_Identity=23.8515901060071, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI19922626, Length=561, Percent_Identity=39.3939393939394, Blast_Score=382, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017660
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.8 [H]

Molecular weight: Translated: 61102; Mature: 60971

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVGNELQRHAAEEQQAQTDGFHLVIDALKLNGIENIYGLPGIPVTDLARLAQANGMRV
CCCCHHHHHHHHHHHHHHHCCCEEEEEEEHHHCCCHHHCCCCCCCHHHHHHHHHCCCEEE
ISFRHEQNAGNAAAIAGFISQKPGVCLTVSAPGFLNGLTALAHATTNCFPMILISGSSER
EEEECCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCC
EIVDLQQGDYEEMDQLAIARPHAKAAFRVLHAEDIGVGIARAIRAAVSGRPGGVYLDLPA
EEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECCH
KLLGQSLEAEKGKKSLIKVVDPAPRQLPAPDSVDRAVALLKNAKRPLILLGKGAAYARAD
HHHCCHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCC
EDIRALVEKTGIPYLPMSMAKGLLPDTHPQSASAARSYVLAEADVVMLVGARLNWLLSHG
HHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHCCC
KGKTWGGPKQFIQIDISPTEMDSNVAIAAPVVGDIGSCVSAILGKVGNDFAKPPAEWLNA
CCCCCCCCCCEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VYERKDKNLAKMGELLNKEVSPMNFHTGLRVLKDVIKANPGISFVNEGANTLDYARAVID
HHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHH
MYEPRKRLDVGTWGVMGVGMGYAVAAAVETNKPVLALCGDSAFGFSGMEVETICRYNLPV
HHCCHHHCCCCCCHHHHHCCHHHEEEEEECCCCEEEEECCCCCCCCCCCHHHHEECCCCE
CIVIFNNNGIYKGIDKNPTGGADPAVTTFVPGARYDKMMEAFGGVGANVTTPAELEAAVN
EEEEECCCCEEECCCCCCCCCCCCCCEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHH
EALRSGRPTLVNAVIDPSAGTESGRLTNLNPQSSAKK
HHHHCCCCEEEEEEECCCCCCCCCCEECCCCCCCCCC
>Mature Secondary Structure 
AEVGNELQRHAAEEQQAQTDGFHLVIDALKLNGIENIYGLPGIPVTDLARLAQANGMRV
CCCHHHHHHHHHHHHHHHCCCEEEEEEEHHHCCCHHHCCCCCCCHHHHHHHHHCCCEEE
ISFRHEQNAGNAAAIAGFISQKPGVCLTVSAPGFLNGLTALAHATTNCFPMILISGSSER
EEEECCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCC
EIVDLQQGDYEEMDQLAIARPHAKAAFRVLHAEDIGVGIARAIRAAVSGRPGGVYLDLPA
EEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECCH
KLLGQSLEAEKGKKSLIKVVDPAPRQLPAPDSVDRAVALLKNAKRPLILLGKGAAYARAD
HHHCCHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCC
EDIRALVEKTGIPYLPMSMAKGLLPDTHPQSASAARSYVLAEADVVMLVGARLNWLLSHG
HHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHCCC
KGKTWGGPKQFIQIDISPTEMDSNVAIAAPVVGDIGSCVSAILGKVGNDFAKPPAEWLNA
CCCCCCCCCCEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VYERKDKNLAKMGELLNKEVSPMNFHTGLRVLKDVIKANPGISFVNEGANTLDYARAVID
HHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHH
MYEPRKRLDVGTWGVMGVGMGYAVAAAVETNKPVLALCGDSAFGFSGMEVETICRYNLPV
HHCCHHHCCCCCCHHHHHCCHHHEEEEEECCCCEEEEECCCCCCCCCCCHHHHEECCCCE
CIVIFNNNGIYKGIDKNPTGGADPAVTTFVPGARYDKMMEAFGGVGANVTTPAELEAAVN
EEEEECCCCEEECCCCCCCCCCCCCCEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHH
EALRSGRPTLVNAVIDPSAGTESGRLTNLNPQSSAKK
HHHHCCCCEEEEEEECCCCCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8157618 [H]