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The map label for this gene is aslA [H]

Identifier: 73538396

GI number: 73538396

Start: 1248703

End: 1250331

Strand: Reverse

Name: aslA [H]

Synonym: Reut_B4569

Alternate gene names: 73538396

Gene position: 1250331-1248703 (Counterclockwise)

Preceding gene: 73538397

Following gene: 73538395

Centisome position: 45.86

GC content: 61.02

Gene sequence:

>1629_bases
ATGATGCACACATTGAAGCGGCTGGTGGCCGTTACGGCCACCGTCGCCGCCATGAGTCCGTTCGCCGCCGGGGCACAGCA
GACGCGGCCAAATATCCTCGTCATCTGGGGCGACGACATCGGCTGGGAGAACGTCAGCGCCTACGGCATGGGCGTGATGG
GCTACACGACACCGAATATCGACAGCATCGGCATGGAGGGCATCCGCTTTACCGACCAGTACGCCCAGCCTTCCTGCACG
GCGGGCCGCGCGGCGTTCATTACCGGCCAGTATCCGATCCGCTCGGGCATGACCACCGTTGGCCAGCCCGGCGACAAACT
TGGCTGGCAGCCGGCATCGCCAAGCCTTGGCGAAGTGATGAAGCAAGCCGGCTACCGCACCGGTTTCTTTGGAAAGAGCC
ATATGGGCGACCGCAACTCGCACCTGCCCACGGTCCACGGCTTTGACGAGTTCTTTGGCAACCTCTACCACCTGAATACC
GAAGAGCTTCCCGAGAACCACGACTACCAGGCTTATGCGAACGGCTACCCCGGTGGTGACAAGGCCTTCGCGCAGAAATT
CGCACCGCGCGGCGTACTGCACACCTATGCCACGGACAACGACGATCCGACCGACATGCCCCGCTTCGGTCCCGTCGGCA
AACAGAAGATCGAGGACACCGGCCCGCTGACGAAAAAGCGGATGGAGGACTTCGACGCCGCCGAGGTCATTCCCAAAGCC
ATCGACTTCATGCAGGGCGCGAAGCAGAAGGACAAGCCTTTCTTTGTCTGGCTCAACACCAGCCGCATGCACCTCTATAC
CCACCTGAACGACAAGTGGCGGTACGCGGCGGCCAAGTACACGCATGAAGACGACATGCAGGGCAGCGGCATGCTGCAGC
ATGACCACGACATCGGCCTCGTGCTGGAATACCTCAAGCGCAGCGGCCTCGACAAAAACACCATCGTCTGGTACTCGACC
GACAACGGGCCGGAACATGTCTCATGGCCACACGGATCGACCACGCCGTTCCGCGGCGAAAAGATGACGACCTATGAAGG
CGGCGTGCGCGTGGTCTCCATGCTGCGCTGGCCCGGTGTCATCAAGCCGGGCCAGATCAAGAACGGCATCCAGGCGCACC
AGGACATGTTCACGACATTCGCTGCGATTGCGGGCGTGCCGGACGTCGTCGGGCAGATGAAGCGCGAGAAGCATCAGTAC
ATCGACGGCATCAACAACCTCGACTACTGGACGGGAAAGACCGCTGACAGTGCACGCAAGGACTTCCTGTACTACTACGA
GAACAAGCTCACGGCCGTGCGCATGGGCCCATGGAAGCTGCACTTCTCGCTCAAGGAGGATTACTACGGCACGCTCCAGC
CGCGCAGCGTCACGATGCTCTTCAACCTGCGCAGCGACCCGTTCGAAAGCTATGACAGCAAGGACGCCTATGGTCACCTG
CTGCAAAAGGCCCAGTGGATCTCCGGCCCGATGAATGAACTGATCGCCAGTCACCTCAAGACCATCGCGGACTATCCGCC
GGTGCAGCCTGCCAAGTCGTTCGACCGTTCAAACATGGTCCAGGACTTTCTGCAGCAGCAACAGCAGTTGCGGCAGCGGC
AGCAGCAACAGGCGGCGATCAGGGAGTAA

Upstream 100 bases:

>100_bases
CCTCAGCAACTGGCTGCGGCGCTCGCGCATGCCGACAGTATCGGCACGCTGGCCCTCGGCTGACCGGCGGGAAATTCCTT
CTCTGCAGGAGCAACTATCC

Downstream 100 bases:

>100_bases
GGCGTGATCCAGCGCAGAACAGCGACGCGGGCGCTTCTCGTGATCCTGGCGGGCAGCGCGGTTGCGGTCGCGACTGGCTA
TGCCCGCTGGGGCGTGAGTG

Product: arylsulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MMHTLKRLVAVTATVAAMSPFAAGAQQTRPNILVIWGDDIGWENVSAYGMGVMGYTTPNIDSIGMEGIRFTDQYAQPSCT
AGRAAFITGQYPIRSGMTTVGQPGDKLGWQPASPSLGEVMKQAGYRTGFFGKSHMGDRNSHLPTVHGFDEFFGNLYHLNT
EELPENHDYQAYANGYPGGDKAFAQKFAPRGVLHTYATDNDDPTDMPRFGPVGKQKIEDTGPLTKKRMEDFDAAEVIPKA
IDFMQGAKQKDKPFFVWLNTSRMHLYTHLNDKWRYAAAKYTHEDDMQGSGMLQHDHDIGLVLEYLKRSGLDKNTIVWYST
DNGPEHVSWPHGSTTPFRGEKMTTYEGGVRVVSMLRWPGVIKPGQIKNGIQAHQDMFTTFAAIAGVPDVVGQMKREKHQY
IDGINNLDYWTGKTADSARKDFLYYYENKLTAVRMGPWKLHFSLKEDYYGTLQPRSVTMLFNLRSDPFESYDSKDAYGHL
LQKAQWISGPMNELIASHLKTIADYPPVQPAKSFDRSNMVQDFLQQQQQLRQRQQQQAAIRE

Sequences:

>Translated_542_residues
MMHTLKRLVAVTATVAAMSPFAAGAQQTRPNILVIWGDDIGWENVSAYGMGVMGYTTPNIDSIGMEGIRFTDQYAQPSCT
AGRAAFITGQYPIRSGMTTVGQPGDKLGWQPASPSLGEVMKQAGYRTGFFGKSHMGDRNSHLPTVHGFDEFFGNLYHLNT
EELPENHDYQAYANGYPGGDKAFAQKFAPRGVLHTYATDNDDPTDMPRFGPVGKQKIEDTGPLTKKRMEDFDAAEVIPKA
IDFMQGAKQKDKPFFVWLNTSRMHLYTHLNDKWRYAAAKYTHEDDMQGSGMLQHDHDIGLVLEYLKRSGLDKNTIVWYST
DNGPEHVSWPHGSTTPFRGEKMTTYEGGVRVVSMLRWPGVIKPGQIKNGIQAHQDMFTTFAAIAGVPDVVGQMKREKHQY
IDGINNLDYWTGKTADSARKDFLYYYENKLTAVRMGPWKLHFSLKEDYYGTLQPRSVTMLFNLRSDPFESYDSKDAYGHL
LQKAQWISGPMNELIASHLKTIADYPPVQPAKSFDRSNMVQDFLQQQQQLRQRQQQQAAIRE
>Mature_542_residues
MMHTLKRLVAVTATVAAMSPFAAGAQQTRPNILVIWGDDIGWENVSAYGMGVMGYTTPNIDSIGMEGIRFTDQYAQPSCT
AGRAAFITGQYPIRSGMTTVGQPGDKLGWQPASPSLGEVMKQAGYRTGFFGKSHMGDRNSHLPTVHGFDEFFGNLYHLNT
EELPENHDYQAYANGYPGGDKAFAQKFAPRGVLHTYATDNDDPTDMPRFGPVGKQKIEDTGPLTKKRMEDFDAAEVIPKA
IDFMQGAKQKDKPFFVWLNTSRMHLYTHLNDKWRYAAAKYTHEDDMQGSGMLQHDHDIGLVLEYLKRSGLDKNTIVWYST
DNGPEHVSWPHGSTTPFRGEKMTTYEGGVRVVSMLRWPGVIKPGQIKNGIQAHQDMFTTFAAIAGVPDVVGQMKREKHQY
IDGINNLDYWTGKTADSARKDFLYYYENKLTAVRMGPWKLHFSLKEDYYGTLQPRSVTMLFNLRSDPFESYDSKDAYGHL
LQKAQWISGPMNELIASHLKTIADYPPVQPAKSFDRSNMVQDFLQQQQQLRQRQQQQAAIRE

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4503899, Length=438, Percent_Identity=30.5936073059361, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI146229331, Length=470, Percent_Identity=27.8723404255319, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI146229329, Length=470, Percent_Identity=27.8723404255319, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI6005990, Length=470, Percent_Identity=27.8723404255319, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI146229324, Length=470, Percent_Identity=27.8723404255319, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI53831991, Length=465, Percent_Identity=26.2365591397849, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI58743319, Length=557, Percent_Identity=25.673249551167, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI45430057, Length=514, Percent_Identity=25.0972762645914, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI71852584, Length=562, Percent_Identity=24.3772241992883, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI38569405, Length=542, Percent_Identity=25.6457564575646, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI38569407, Length=380, Percent_Identity=28.4210526315789, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI109389362, Length=497, Percent_Identity=22.9376257545272, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI157266309, Length=167, Percent_Identity=37.125748502994, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI146229327, Length=383, Percent_Identity=25.065274151436, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI59797060, Length=493, Percent_Identity=24.3407707910751, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI71852586, Length=154, Percent_Identity=37.6623376623377, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI31742482, Length=178, Percent_Identity=32.0224719101124, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1790233, Length=500, Percent_Identity=30, Blast_Score=194, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI115533416, Length=458, Percent_Identity=27.5109170305677, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI115533418, Length=450, Percent_Identity=27.1111111111111, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17559078, Length=141, Percent_Identity=36.1702127659575, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281366397, Length=384, Percent_Identity=27.6041666666667, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281366395, Length=384, Percent_Identity=27.6041666666667, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24666163, Length=384, Percent_Identity=27.6041666666667, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24666175, Length=392, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24666109, Length=439, Percent_Identity=26.4236902050114, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281363223, Length=433, Percent_Identity=24.9422632794457, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 61177; Mature: 61177

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMHTLKRLVAVTATVAAMSPFAAGAQQTRPNILVIWGDDIGWENVSAYGMGVMGYTTPNI
CHHHHHHHHHHHHHHHHHCHHHCCHHHCCCCEEEEECCCCCCCCCHHHCEEEECCCCCCC
DSIGMEGIRFTDQYAQPSCTAGRAAFITGQYPIRSGMTTVGQPGDKLGWQPASPSLGEVM
CCCCCCCCEECHHHCCCCCCCCCEEEEECCCCHHCCCCCCCCCCHHCCCCCCCCCHHHHH
KQAGYRTGFFGKSHMGDRNSHLPTVHGFDEFFGNLYHLNTEELPENHDYQAYANGYPGGD
HHCCCCCCCCCCCCCCCCCCCCCEECCHHHHCCCEEECCHHHCCCCCCCCEEECCCCCCH
KAFAQKFAPRGVLHTYATDNDDPTDMPRFGPVGKQKIEDTGPLTKKRMEDFDAAEVIPKA
HHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHCCCHHHHHHHH
IDFMQGAKQKDKPFFVWLNTSRMHLYTHLNDKWRYAAAKYTHEDDMQGSGMLQHDHDIGL
HHHHHCCCCCCCCEEEEEECCEEEEEEECCCCEEEHHHCCCCCCCCCCCCCCCCCCCHHH
VLEYLKRSGLDKNTIVWYSTDNGPEHVSWPHGSTTPFRGEKMTTYEGGVRVVSMLRWPGV
HHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCC
IKPGQIKNGIQAHQDMFTTFAAIAGVPDVVGQMKREKHQYIDGINNLDYWTGKTADSARK
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
DFLYYYENKLTAVRMGPWKLHFSLKEDYYGTLQPRSVTMLFNLRSDPFESYDSKDAYGHL
HEEEEECCCEEEEEECCEEEEEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHH
LQKAQWISGPMNELIASHLKTIADYPPVQPAKSFDRSNMVQDFLQQQQQLRQRQQQQAAI
HHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
RE
CC
>Mature Secondary Structure
MMHTLKRLVAVTATVAAMSPFAAGAQQTRPNILVIWGDDIGWENVSAYGMGVMGYTTPNI
CHHHHHHHHHHHHHHHHHCHHHCCHHHCCCCEEEEECCCCCCCCCHHHCEEEECCCCCCC
DSIGMEGIRFTDQYAQPSCTAGRAAFITGQYPIRSGMTTVGQPGDKLGWQPASPSLGEVM
CCCCCCCCEECHHHCCCCCCCCCEEEEECCCCHHCCCCCCCCCCHHCCCCCCCCCHHHHH
KQAGYRTGFFGKSHMGDRNSHLPTVHGFDEFFGNLYHLNTEELPENHDYQAYANGYPGGD
HHCCCCCCCCCCCCCCCCCCCCCEECCHHHHCCCEEECCHHHCCCCCCCCEEECCCCCCH
KAFAQKFAPRGVLHTYATDNDDPTDMPRFGPVGKQKIEDTGPLTKKRMEDFDAAEVIPKA
HHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHCCCHHHHHHHH
IDFMQGAKQKDKPFFVWLNTSRMHLYTHLNDKWRYAAAKYTHEDDMQGSGMLQHDHDIGL
HHHHHCCCCCCCCEEEEEECCEEEEEEECCCCEEEHHHCCCCCCCCCCCCCCCCCCCHHH
VLEYLKRSGLDKNTIVWYSTDNGPEHVSWPHGSTTPFRGEKMTTYEGGVRVVSMLRWPGV
HHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCC
IKPGQIKNGIQAHQDMFTTFAAIAGVPDVVGQMKREKHQYIDGINNLDYWTGKTADSARK
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
DFLYYYENKLTAVRMGPWKLHFSLKEDYYGTLQPRSVTMLFNLRSDPFESYDSKDAYGHL
HEEEEECCCEEEEEECCEEEEEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHH
LQKAQWISGPMNELIASHLKTIADYPPVQPAKSFDRSNMVQDFLQQQQQLRQRQQQQAAI
HHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
RE
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]