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The map label for this gene is mmgC [H]

Identifier: 73538386

GI number: 73538386

Start: 1237588

End: 1238736

Strand: Reverse

Name: mmgC [H]

Synonym: Reut_B4559

Alternate gene names: 73538386

Gene position: 1238736-1237588 (Counterclockwise)

Preceding gene: 73538387

Following gene: 73538385

Centisome position: 45.44

GC content: 65.8

Gene sequence:

>1149_bases
ATGGACCTGTTCTACTCCGACGAACACAAGGCGTTCCGGCAGGAAGTGCGCGATTTCATCGCCGCCAACCTGCCTGACGA
CATGCGCGAGCGCCTGCGCGCCGGTGGCTTCGCCTCCAAGACCGACACCGAACGCTGGCAGCGCGCGCTGAACCGGCGCG
GCTGGGGCGCGCCCGCCTGGCCGACGGCCTTCGGCGGCGCTGGCTGGGACGCGGCGAAACAGCAGATTTTTGCCGATGAA
TGCGCCGCCGCACCGGCGCCTCCCCCGCACATCTTCAACATCACGATGCTCGGCCCGGTGATCATCCACTTCGGCTCCGA
TGCCCAGCGTGAGTATTTCCTGCCGAAGCTGTTGAATGCCGATATCCAGGTGTGCCAGGGCTTCTCCGAGCCGGGCTCGG
GCTCCGATCTGGCGTCGCTGAAGACCTCTGCCGTGCGCGAAGGCGACGAGTACGTCGTCAACGGCCAGAAGATCTGGACC
AGCCAGGCGCATTACTCCGACTGGGTGTTCGCGCTCGTACGCACCGATCCGGAAGCCGTGCGCAAGCAGGCCGGCATTTC
GTTCCTGCTGATCGACCTGAAATCGCCGGGCATCACCGTGCGCCCGATCATCAGCATCGACGGCCGCCACAGCCTCAACG
AAGTCTTCTTCGACAACGCCCGCGTGCCGGTGACCAACCTCGTCGGCGAGGAAAACAAGGGCTGGGACTACGCGAAGTTC
CTGCTCGGACACGAGCGCGCGTACATCGCCGGTATCGGCCGCAACAAGGAACGCGTGGCCTGCGCGAAGGCGCTGCTGAC
GAAGCTGGCAAGCGAAGGCCATCCGGAGCGTGAGTTGGCCGGCTGGCGCGGCCGCATCGCGCTGATCGAGGCCGATCTGC
ACGCGCTCGAGGTGACCCAGTTCCGCATGCACGGCGGCCACGCCGACATGAAGCTGTCGCCGATGTTGAAGGCGCGCGGC
AGCGAGATCTTCCAGGCCATTACCGATGTGATCTGCCGCATGAGCGGCCCCGCGGCGCTGCGCGCCGATGGCATCGGCGG
CCCCACGCTGACCAAGTCATACCTGTACTCGCGCGCCGTATCAATCTTCGGCGGCAGTACCGAGGTGCAGAAGAACATCC
TGTCGGCCACCGTGCTGAGCCTGCCATGA

Upstream 100 bases:

>100_bases
CAACCACCAGCGCTCCCATGACATGAAAGAAGGCCTGACAGCCTTCGCCGAAAAGCGGCAGCCGGTCTTCAAGGGCTGCT
GACGCGAGACGAGGAATCCG

Downstream 100 bases:

>100_bases
ATCTCCAATGGAACGATGTCCAGCAGCAACTGAAAGACAGCCTGTCCCGGCTGCTGGCGAATGAATACGACTTCGAACAC
CGGCAACGCTACGTGGCCGC

Product: acyl-CoA dehydrogenase

Products: 6-carboxyhex-2-enoyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MDLFYSDEHKAFRQEVRDFIAANLPDDMRERLRAGGFASKTDTERWQRALNRRGWGAPAWPTAFGGAGWDAAKQQIFADE
CAAAPAPPPHIFNITMLGPVIIHFGSDAQREYFLPKLLNADIQVCQGFSEPGSGSDLASLKTSAVREGDEYVVNGQKIWT
SQAHYSDWVFALVRTDPEAVRKQAGISFLLIDLKSPGITVRPIISIDGRHSLNEVFFDNARVPVTNLVGEENKGWDYAKF
LLGHERAYIAGIGRNKERVACAKALLTKLASEGHPERELAGWRGRIALIEADLHALEVTQFRMHGGHADMKLSPMLKARG
SEIFQAITDVICRMSGPAALRADGIGGPTLTKSYLYSRAVSIFGGSTEVQKNILSATVLSLP

Sequences:

>Translated_382_residues
MDLFYSDEHKAFRQEVRDFIAANLPDDMRERLRAGGFASKTDTERWQRALNRRGWGAPAWPTAFGGAGWDAAKQQIFADE
CAAAPAPPPHIFNITMLGPVIIHFGSDAQREYFLPKLLNADIQVCQGFSEPGSGSDLASLKTSAVREGDEYVVNGQKIWT
SQAHYSDWVFALVRTDPEAVRKQAGISFLLIDLKSPGITVRPIISIDGRHSLNEVFFDNARVPVTNLVGEENKGWDYAKF
LLGHERAYIAGIGRNKERVACAKALLTKLASEGHPERELAGWRGRIALIEADLHALEVTQFRMHGGHADMKLSPMLKARG
SEIFQAITDVICRMSGPAALRADGIGGPTLTKSYLYSRAVSIFGGSTEVQKNILSATVLSLP
>Mature_382_residues
MDLFYSDEHKAFRQEVRDFIAANLPDDMRERLRAGGFASKTDTERWQRALNRRGWGAPAWPTAFGGAGWDAAKQQIFADE
CAAAPAPPPHIFNITMLGPVIIHFGSDAQREYFLPKLLNADIQVCQGFSEPGSGSDLASLKTSAVREGDEYVVNGQKIWT
SQAHYSDWVFALVRTDPEAVRKQAGISFLLIDLKSPGITVRPIISIDGRHSLNEVFFDNARVPVTNLVGEENKGWDYAKF
LLGHERAYIAGIGRNKERVACAKALLTKLASEGHPERELAGWRGRIALIEADLHALEVTQFRMHGGHADMKLSPMLKARG
SEIFQAITDVICRMSGPAALRADGIGGPTLTKSYLYSRAVSIFGGSTEVQKNILSATVLSLP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=397, Percent_Identity=25.6926952141058, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI226958412, Length=250, Percent_Identity=27.6, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI226958414, Length=220, Percent_Identity=27.2727272727273, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4557233, Length=393, Percent_Identity=25.6997455470738, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4501859, Length=399, Percent_Identity=24.812030075188, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI7656849, Length=248, Percent_Identity=30.241935483871, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4557231, Length=252, Percent_Identity=25.3968253968254, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI187960098, Length=252, Percent_Identity=25.3968253968254, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI76496475, Length=172, Percent_Identity=34.8837209302326, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4557235, Length=172, Percent_Identity=34.8837209302326, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI38505218, Length=296, Percent_Identity=25.3378378378378, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI211971008, Length=288, Percent_Identity=26.3888888888889, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI48976061, Length=288, Percent_Identity=26.3888888888889, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI21361497, Length=308, Percent_Identity=24.6753246753247, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081958, Length=249, Percent_Identity=28.1124497991968, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17570075, Length=260, Percent_Identity=28.8461538461538, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17505929, Length=334, Percent_Identity=27.8443113772455, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17551932, Length=395, Percent_Identity=24.8101265822785, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17538396, Length=268, Percent_Identity=27.2388059701493, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71990804, Length=189, Percent_Identity=30.6878306878307, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17508101, Length=183, Percent_Identity=32.2404371584699, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17534899, Length=152, Percent_Identity=32.2368421052632, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17506239, Length=183, Percent_Identity=30.6010928961749, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI32563615, Length=183, Percent_Identity=30.6010928961749, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17569725, Length=146, Percent_Identity=33.5616438356164, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71982178, Length=249, Percent_Identity=25.7028112449799, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71985192, Length=209, Percent_Identity=29.6650717703349, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71985184, Length=209, Percent_Identity=29.6650717703349, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562446, Length=196, Percent_Identity=29.0816326530612, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17533517, Length=206, Percent_Identity=27.1844660194175, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21356377, Length=391, Percent_Identity=24.2966751918159, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24666513, Length=392, Percent_Identity=24.4897959183673, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24660351, Length=202, Percent_Identity=29.2079207920792, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355753, Length=197, Percent_Identity=27.9187817258883, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281363737, Length=153, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646207, Length=395, Percent_Identity=25.0632911392405, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.1.62

Molecular weight: Translated: 41978; Mature: 41978

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLFYSDEHKAFRQEVRDFIAANLPDDMRERLRAGGFASKTDTERWQRALNRRGWGAPAW
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC
PTAFGGAGWDAAKQQIFADECAAAPAPPPHIFNITMLGPVIIHFGSDAQREYFLPKLLNA
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECEEEEECCCCCCHHHHHHHHHCC
DIQVCQGFSEPGSGSDLASLKTSAVREGDEYVVNGQKIWTSQAHYSDWVFALVRTDPEAV
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCEEEECCCCCCCEEEEEEECCHHHH
RKQAGISFLLIDLKSPGITVRPIISIDGRHSLNEVFFDNARVPVTNLVGEENKGWDYAKF
HHHCCCEEEEEEECCCCEEEEEEEEECCCCHHHHHHHCCCCCCHHHHCCCCCCCCHHHHH
LLGHERAYIAGIGRNKERVACAKALLTKLASEGHPERELAGWRGRIALIEADLHALEVTQ
HHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCHHHHHHH
FRMHGGHADMKLSPMLKARGSEIFQAITDVICRMSGPAALRADGIGGPTLTKSYLYSRAV
HHCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHH
SIFGGSTEVQKNILSATVLSLP
HHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLFYSDEHKAFRQEVRDFIAANLPDDMRERLRAGGFASKTDTERWQRALNRRGWGAPAW
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC
PTAFGGAGWDAAKQQIFADECAAAPAPPPHIFNITMLGPVIIHFGSDAQREYFLPKLLNA
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECEEEEECCCCCCHHHHHHHHHCC
DIQVCQGFSEPGSGSDLASLKTSAVREGDEYVVNGQKIWTSQAHYSDWVFALVRTDPEAV
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCEEEECCCCCCCEEEEEEECCHHHH
RKQAGISFLLIDLKSPGITVRPIISIDGRHSLNEVFFDNARVPVTNLVGEENKGWDYAKF
HHHCCCEEEEEEECCCCEEEEEEEEECCCCHHHHHHHCCCCCCHHHHCCCCCCCCHHHHH
LLGHERAYIAGIGRNKERVACAKALLTKLASEGHPERELAGWRGRIALIEADLHALEVTQ
HHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCHHHHHHH
FRMHGGHADMKLSPMLKARGSEIFQAITDVICRMSGPAALRADGIGGPTLTKSYLYSRAV
HHCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHH
SIFGGSTEVQKNILSATVLSLP
HHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pimeloyl-CoA; NAD+

Specific reaction: pimeloyl-CoA + NAD+ = 6-carboxyhex-2-enoyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]