Click here to switch to the map view.

The map label for this gene is mug [H]

Identifier: 73538309

GI number: 73538309

Start: 1151591

End: 1152184

Strand: Direct

Name: mug [H]

Synonym: Reut_B4482

Alternate gene names: 73538309

Gene position: 1151591-1152184 (Clockwise)

Preceding gene: 73538307

Following gene: 73538310

Centisome position: 42.24

GC content: 64.14

Gene sequence:

>594_bases
ATGAAGCATCCACAGCTAGCGCCAACGCATGGACCGTCCGGCCCGTTGCCGGACATCATGAAGCCGGGGCTCTCGGCAGT
GTTCTGCGGACTCAATCCCGGGCTGCGGGCTGCGGCGAGCGGCCATCACTTCGCAGGACACGGCAACCGGTTCTGGCGCG
TGATTCATCTCGCAGGCATCACCGACCGGGAGCTCGAACCCGTGGACGACCGGCAATTGCTGTCATACGGATACGGTCTG
ACAACTGCGGTAAGCCGGCCAACTGCCAGCGCGGCCGCACTCTCCCACAACGAATATGTCGATGCATCGGTGCGCCTGAT
CATCAAGCTGGAGCGCTTCCATCCTGCCTGCGTTGCGTTCCTCGGCAAGGCTGCCTATGCGGCCATGACGAGCCAGCGTG
TTGTCCCGTGGGGCCCGCAGCGGCGGCGCATGGGCGGCGCAAGGGTCTGGGTGTTGCCCAACCCGAGCGGGCGAAATCGG
GCGTTCAGTCTCGCCGGTCTTGTCGACGCGTATGGCGAGTTCCGTGCGTCCGTGGAAAGTCAGATCCGCTACGGGGAGTC
CCCACAGTGTGCGGAAGTCGATAGCCTGAAATGA

Upstream 100 bases:

>100_bases
CCTATAGTCGGAACACCGCTGCATGCATCTGGTCGATGCCGCAGGCAGCAAGACCTGTCCGGTTACTGGTTGTGCCGGGC
GAGCGCCAAGGACAACAGGA

Downstream 100 bases:

>100_bases
ACAGGAGGTAAGCGGGATGGTATGGACCACCAACGAGATGGTTGAGCGCGCGACGACGCAGATCAACGATGGGGATTTTG
TCTATCTGGGCCCGGGCCTG

Product: G/U mismatch-specific uracil-DNA glycosylase

Products: NA

Alternate protein names: Double-strand-specific uracil glycosylase; Mismatch-specific uracil DNA-glycosylase; MUG [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MKHPQLAPTHGPSGPLPDIMKPGLSAVFCGLNPGLRAAASGHHFAGHGNRFWRVIHLAGITDRELEPVDDRQLLSYGYGL
TTAVSRPTASAAALSHNEYVDASVRLIIKLERFHPACVAFLGKAAYAAMTSQRVVPWGPQRRRMGGARVWVLPNPSGRNR
AFSLAGLVDAYGEFRASVESQIRYGESPQCAEVDSLK

Sequences:

>Translated_197_residues
MKHPQLAPTHGPSGPLPDIMKPGLSAVFCGLNPGLRAAASGHHFAGHGNRFWRVIHLAGITDRELEPVDDRQLLSYGYGL
TTAVSRPTASAAALSHNEYVDASVRLIIKLERFHPACVAFLGKAAYAAMTSQRVVPWGPQRRRMGGARVWVLPNPSGRNR
AFSLAGLVDAYGEFRASVESQIRYGESPQCAEVDSLK
>Mature_197_residues
MKHPQLAPTHGPSGPLPDIMKPGLSAVFCGLNPGLRAAASGHHFAGHGNRFWRVIHLAGITDRELEPVDDRQLLSYGYGL
TTAVSRPTASAAALSHNEYVDASVRLIIKLERFHPACVAFLGKAAYAAMTSQRVVPWGPQRRRMGGARVWVLPNPSGRNR
AFSLAGLVDAYGEFRASVESQIRYGESPQCAEVDSLK

Specific function: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone o

COG id: COG3663

COG function: function code L; G:T/U mismatch-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TDG/mug DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI59853162, Length=159, Percent_Identity=32.7044025157233, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1789449, Length=159, Percent_Identity=47.7987421383648, Blast_Score=150, Evalue=6e-38,
Organism=Drosophila melanogaster, GI21356805, Length=185, Percent_Identity=34.0540540540541, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015637
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.28 [H]

Molecular weight: Translated: 21326; Mature: 21326

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHPQLAPTHGPSGPLPDIMKPGLSAVFCGLNPGLRAAASGHHFAGHGNRFWRVIHLAGI
CCCCCCCCCCCCCCCCCHHHCCCCCEEEECCCCCCHHCCCCCCCCCCCCEEEEEEEECCC
TDRELEPVDDRQLLSYGYGLTTAVSRPTASAAALSHNEYVDASVRLIIKLERFHPACVAF
CCCCCCCCCHHHHHHHCCCHHHHHCCCCCHHHHHCCCCCCCCEEEEEEEECCCCHHHHHH
LGKAAYAAMTSQRVVPWGPQRRRMGGARVWVLPNPSGRNRAFSLAGLVDAYGEFRASVES
HHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHH
QIRYGESPQCAEVDSLK
HHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKHPQLAPTHGPSGPLPDIMKPGLSAVFCGLNPGLRAAASGHHFAGHGNRFWRVIHLAGI
CCCCCCCCCCCCCCCCCHHHCCCCCEEEECCCCCCHHCCCCCCCCCCCCEEEEEEEECCC
TDRELEPVDDRQLLSYGYGLTTAVSRPTASAAALSHNEYVDASVRLIIKLERFHPACVAF
CCCCCCCCCHHHHHHHCCCHHHHHCCCCCHHHHHCCCCCCCCEEEEEEEECCCCHHHHHH
LGKAAYAAMTSQRVVPWGPQRRRMGGARVWVLPNPSGRNRAFSLAGLVDAYGEFRASVES
HHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHH
QIRYGESPQCAEVDSLK
HHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA