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The map label for this gene is yngE [H]

Identifier: 73538290

GI number: 73538290

Start: 1129160

End: 1130815

Strand: Reverse

Name: yngE [H]

Synonym: Reut_B4463

Alternate gene names: 73538290

Gene position: 1130815-1129160 (Counterclockwise)

Preceding gene: 73538294

Following gene: 73538289

Centisome position: 41.48

GC content: 68.54

Gene sequence:

>1656_bases
TTGCAATCCTCCCATCACGCCAACCAAGCCAGCGCCATGATTCCCATCGAGACACGCATCGACCCGTCCTCCGACTCGTT
TGCCAGCCAGCGCGCCGGCATGCAGGCCCTGATCGACCGCCTGCACAGCCTGGAGCAGCGTGCCGTGGCCGCCTCCGAGC
GCGCGCGCCCGGCCTTCGCCAAGCGCGGCGCGCTGCTGCCGCGCGAGCGCATCGGCCGCCTGCTCGACGCCGGCGCGCCG
TTCCTGCCCATTGCCACGCTGGCCGGCTTCGGCATGGACGACCCGAACCATGAGACGTCGATTCCCGGCGGCTCGCTCGT
GGCCGGCATCGGCATCGTCTGCGGCGTGCGCTGCATGGTGCTGGCGACGGATTCGGGCATCGATGCCGGCGCCATGACCG
AGGCCGGCAATATGAAGCTCATGCGCTGCCAGGAGATCGCGCTGGAAAACCGGCTGCCGTTCATCCACCTGGTCGAATCG
GCCGGCGCCAACCTGCGCAAGTACCGCGTCGACAAGTTCATCCGCGGCGGCAGCATCTTCTACAACCTGGCACGGCTGTC
GGCGGCCGGCCTGCCGGTGATCACCGTCGTGCACGGTTCGTCCACCGCCGGCGGCGCCTACATGCCGGGCCTGTCGGACT
ACGTGGTCATGGTGCGCAATCGCGCGCGTGCGTTCCTGGCCGGCCCGCCGCTGCTCAAGGCTGCTACCGGCGAGATTGCG
ACCGACGAAGAACTCGGCGGCGCCGACCTGCACGCCACCGTCAGCGGCCTGGCCGAATACCTGGCCGAAGACGACGAGCA
TGCGATTGCCACCGCGCGCGACATCGTGGCGAGCCTCGACTGGCCTGACGTGGCACCCGCTCCGGGACAGCCGGCCCGTG
CGCCACGCCTGGACCCGGCCGAACTCGACGGCGTAATGACGCTCGACATGAAGCGCCCCGTGGACATGCGCGAAGTCATC
GCGCGCATCGTCGACGATTCCGCATGGCTGCCGTTCAAGCCCGACTACGGTCCCGGCACCGTCTGCGGCCATGCGCGCAT
CGAAGGCCACGCGGTCGGCTTCATTACCAACAACGGCCCGATCGATCCGGCCGGCGCGACCAAGGCCGCGCAGTTCATCC
AGCTCTGCAACCAGTCGGGCACGCCCATCGTGTTCCTGCAGAACACCACGGGCTTTATCGTGGGCCGCGCGTCGGAAGAG
GCGGGCATGATCAAGCACGGCTCGAAGATGATCCAGGCGCTGTCCAACTCGACCGTTCCGCAGATCACGATCTACTGCGG
ATCGTCCTTCGGCGCCGGCAATTTTGGCATGTGCGGCCGGGGCTTCCATCCGCGCTTCTGCTTTTCGTGGCCCAATGCGC
GCACCGCGGTAATGGGCGGCGAGCAGGCCGCCATGACGCTGGAGATCGTGGCGCGCCAGCAGGCCGAGCGCAAAGGCAAG
GCCGTGGACGAAGCGCAGCTCGCGGCGCAGACCGCCGAGATCGTCGCCAACTTCGAACGACAGGCCAGCGCTTTCGTGAC
CAGCGGCCTGCTGCTGGACGATGGCGTGATCGATCCGCGCGACACGCGTGCCGTGCTGGCCTTCGTGCTGGCGACCGCCC
GCGAAGCAAACCGGCGCGAACCGCGTGCCGTGCAGTTTGGCGTGGCGCGCCTCTGA

Upstream 100 bases:

>100_bases
GCAGGCATGCGCGGGCGGCGTCCGGTCGGGGAGCATTGGGTTTGGCGTGCACATTATGCACAATCTGAGCGATTAATGTT
GTCCCGCGGGGCGCGGTGGT

Downstream 100 bases:

>100_bases
GCCATCAACGAACATCCTAGCCTGTAGCTAACAAGAATTCCTGGAGCCCAGCATGCTGTACACCGAAGACCACCGCAATA
TCATGGGCAGCATCCGCCGC

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MQSSHHANQASAMIPIETRIDPSSDSFASQRAGMQALIDRLHSLEQRAVAASERARPAFAKRGALLPRERIGRLLDAGAP
FLPIATLAGFGMDDPNHETSIPGGSLVAGIGIVCGVRCMVLATDSGIDAGAMTEAGNMKLMRCQEIALENRLPFIHLVES
AGANLRKYRVDKFIRGGSIFYNLARLSAAGLPVITVVHGSSTAGGAYMPGLSDYVVMVRNRARAFLAGPPLLKAATGEIA
TDEELGGADLHATVSGLAEYLAEDDEHAIATARDIVASLDWPDVAPAPGQPARAPRLDPAELDGVMTLDMKRPVDMREVI
ARIVDDSAWLPFKPDYGPGTVCGHARIEGHAVGFITNNGPIDPAGATKAAQFIQLCNQSGTPIVFLQNTTGFIVGRASEE
AGMIKHGSKMIQALSNSTVPQITIYCGSSFGAGNFGMCGRGFHPRFCFSWPNARTAVMGGEQAAMTLEIVARQQAERKGK
AVDEAQLAAQTAEIVANFERQASAFVTSGLLLDDGVIDPRDTRAVLAFVLATAREANRREPRAVQFGVARL

Sequences:

>Translated_551_residues
MQSSHHANQASAMIPIETRIDPSSDSFASQRAGMQALIDRLHSLEQRAVAASERARPAFAKRGALLPRERIGRLLDAGAP
FLPIATLAGFGMDDPNHETSIPGGSLVAGIGIVCGVRCMVLATDSGIDAGAMTEAGNMKLMRCQEIALENRLPFIHLVES
AGANLRKYRVDKFIRGGSIFYNLARLSAAGLPVITVVHGSSTAGGAYMPGLSDYVVMVRNRARAFLAGPPLLKAATGEIA
TDEELGGADLHATVSGLAEYLAEDDEHAIATARDIVASLDWPDVAPAPGQPARAPRLDPAELDGVMTLDMKRPVDMREVI
ARIVDDSAWLPFKPDYGPGTVCGHARIEGHAVGFITNNGPIDPAGATKAAQFIQLCNQSGTPIVFLQNTTGFIVGRASEE
AGMIKHGSKMIQALSNSTVPQITIYCGSSFGAGNFGMCGRGFHPRFCFSWPNARTAVMGGEQAAMTLEIVARQQAERKGK
AVDEAQLAAQTAEIVANFERQASAFVTSGLLLDDGVIDPRDTRAVLAFVLATAREANRREPRAVQFGVARL
>Mature_551_residues
MQSSHHANQASAMIPIETRIDPSSDSFASQRAGMQALIDRLHSLEQRAVAASERARPAFAKRGALLPRERIGRLLDAGAP
FLPIATLAGFGMDDPNHETSIPGGSLVAGIGIVCGVRCMVLATDSGIDAGAMTEAGNMKLMRCQEIALENRLPFIHLVES
AGANLRKYRVDKFIRGGSIFYNLARLSAAGLPVITVVHGSSTAGGAYMPGLSDYVVMVRNRARAFLAGPPLLKAATGEIA
TDEELGGADLHATVSGLAEYLAEDDEHAIATARDIVASLDWPDVAPAPGQPARAPRLDPAELDGVMTLDMKRPVDMREVI
ARIVDDSAWLPFKPDYGPGTVCGHARIEGHAVGFITNNGPIDPAGATKAAQFIQLCNQSGTPIVFLQNTTGFIVGRASEE
AGMIKHGSKMIQALSNSTVPQITIYCGSSFGAGNFGMCGRGFHPRFCFSWPNARTAVMGGEQAAMTLEIVARQQAERKGK
AVDEAQLAAQTAEIVANFERQASAFVTSGLLLDDGVIDPRDTRAVLAFVLATAREANRREPRAVQFGVARL

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=551, Percent_Identity=43.1941923774955, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI119943100, Length=515, Percent_Identity=30.2912621359223, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI295821216, Length=535, Percent_Identity=29.3457943925234, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI310133460, Length=144, Percent_Identity=41.6666666666667, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17552936, Length=555, Percent_Identity=41.981981981982, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI25147359, Length=474, Percent_Identity=30.5907172995781, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI25147362, Length=474, Percent_Identity=30.5907172995781, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24586065, Length=556, Percent_Identity=41.9064748201439, Blast_Score=433, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 58448; Mature: 58448

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSSHHANQASAMIPIETRIDPSSDSFASQRAGMQALIDRLHSLEQRAVAASERARPAFA
CCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KRGALLPRERIGRLLDAGAPFLPIATLAGFGMDDPNHETSIPGGSLVAGIGIVCGVRCMV
HCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEE
LATDSGIDAGAMTEAGNMKLMRCQEIALENRLPFIHLVESAGANLRKYRVDKFIRGGSIF
EEECCCCCCCCCCCCCCEEEHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCHHH
YNLARLSAAGLPVITVVHGSSTAGGAYMPGLSDYVVMVRNRARAFLAGPPLLKAATGEIA
HHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCEEECCCCCHHHCCCCCC
TDEELGGADLHATVSGLAEYLAEDDEHAIATARDIVASLDWPDVAPAPGQPARAPRLDPA
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHH
ELDGVMTLDMKRPVDMREVIARIVDDSAWLPFKPDYGPGTVCGHARIEGHAVGFITNNGP
HCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEECEEECCEEEEEEECCCC
IDPAGATKAAQFIQLCNQSGTPIVFLQNTTGFIVGRASEEAGMIKHGSKMIQALSNSTVP
CCCCCHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCC
QITIYCGSSFGAGNFGMCGRGFHPRFCFSWPNARTAVMGGEQAAMTLEIVARQQAERKGK
EEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHCC
AVDEAQLAAQTAEIVANFERQASAFVTSGLLLDDGVIDPRDTRAVLAFVLATAREANRRE
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCC
PRAVQFGVARL
CCEECCCCCCC
>Mature Secondary Structure
MQSSHHANQASAMIPIETRIDPSSDSFASQRAGMQALIDRLHSLEQRAVAASERARPAFA
CCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KRGALLPRERIGRLLDAGAPFLPIATLAGFGMDDPNHETSIPGGSLVAGIGIVCGVRCMV
HCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEE
LATDSGIDAGAMTEAGNMKLMRCQEIALENRLPFIHLVESAGANLRKYRVDKFIRGGSIF
EEECCCCCCCCCCCCCCEEEHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCHHH
YNLARLSAAGLPVITVVHGSSTAGGAYMPGLSDYVVMVRNRARAFLAGPPLLKAATGEIA
HHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCEEECCCCCHHHCCCCCC
TDEELGGADLHATVSGLAEYLAEDDEHAIATARDIVASLDWPDVAPAPGQPARAPRLDPA
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHH
ELDGVMTLDMKRPVDMREVIARIVDDSAWLPFKPDYGPGTVCGHARIEGHAVGFITNNGP
HCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEECEEECCEEEEEEECCCC
IDPAGATKAAQFIQLCNQSGTPIVFLQNTTGFIVGRASEEAGMIKHGSKMIQALSNSTVP
CCCCCHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCC
QITIYCGSSFGAGNFGMCGRGFHPRFCFSWPNARTAVMGGEQAAMTLEIVARQQAERKGK
EEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHCC
AVDEAQLAAQTAEIVANFERQASAFVTSGLLLDDGVIDPRDTRAVLAFVLATAREANRRE
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCC
PRAVQFGVARL
CCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]