Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 73538289

GI number: 73538289

Start: 1127947

End: 1129107

Strand: Reverse

Name: acdA [H]

Synonym: Reut_B4462

Alternate gene names: 73538289

Gene position: 1129107-1127947 (Counterclockwise)

Preceding gene: 73538290

Following gene: 73538288

Centisome position: 41.42

GC content: 62.96

Gene sequence:

>1161_bases
ATGCTGTACACCGAAGACCACCGCAATATCATGGGCAGCATCCGCCGCTTCGTGTCGGCGGAGATCGATCCGCACGTCGA
TGAGTGGGAAGCCGCCGAAATTTTCCCGGCGCACGAACTGTTCAAGAAGATGGGCGACCTCGGCTTCCTGGGCATCACCA
AGCCGGTCGAATACGGCGGCCTTGGCCTTGATTTCTCGTACGCCATCGCTGCGGCGGAAGCACTGGGCTATGCACGTGCA
CAAGGCATCGGCATGGGCGTTGGCGTGCAGTGCGACATGGCTACGCCGGCGCTGACCGCATTCGGTTCCGACGCGCTCAA
GCGAGAGTTTCTTGCGCCCGCCATTGCCGGCGACATGGTGTGCTCGATCGGCGTCTCGGAAGCGGGGGCGGGCTCCGACG
TGGCATCGCTCAAGACGCGCGCACGCCGTGACGGCGACGACTACGTCATCACCGGTTCCAAGATGTGGATCACCAACGGC
ACGCAGGCCGACTGGATCTGCCTGCTGTGCAACACGTCCGACGGCCCCGTGCACAAGAACAAGTCGCTGATCGTGGTGCC
GCTCAAGGAGAACGGCAAGCGCGTGAAAGGCGTGGAAATCCAGAAGATCAAGAAATTCGGCATGTGGTGCTCCGACACCG
CGCAGATCTTCTTCGACGAAGTGCGCGTGCCGGTGCGCAACCGCATCGGCGAAGAAGGCATGGGCTTTATCTACCAGATG
AAGCAGTTCCAGGAAGAGCGCCTGAACGGTGCCGCGCGCCGCCTGGCCTGTACGGCGCTGATCGAAGAAACCGCCGAGTA
CCTGCGCCAGCGCATCGCGTTCGGCAAGCCGCTGCTCGACAACCAGTTCATCCAGTTCAAGCTGGCCGAACTGAAGACCG
AAATGGAAGCGCTGCGCGCGCTGGTGTATGTGGCCACGCAGACCTACATCAACGGCGGCGAAGTGACCGAGCTCGCTTCC
ATGGCCAAGCTCAAGGCCGGTCGGCTGTCGCGCGACGTAGCCGACTGGTGCATGCAGTTCCAGGGCGGCATGGGCTACAC
GTGGGACAACCATGCATCGCGCGCGTATCGCGATTTCCGCCTCGGTTCGATCGGCGGCGGCGCGGACGAGGTGATGCTGC
AGGTCATCGCCAAGCAGATGGGCCTGATGTCGCGCGGCTGA

Upstream 100 bases:

>100_bases
AACCGGCGCGAACCGCGTGCCGTGCAGTTTGGCGTGGCGCGCCTCTGAGCCATCAACGAACATCCTAGCCTGTAGCTAAC
AAGAATTCCTGGAGCCCAGC

Downstream 100 bases:

>100_bases
GCGCGTGTCCTTCCACATTTGACGAGACACACTGCCATGCCCGACACCTCGCAGAACGACGGCGTAATCGTTCGCCGCTC
CGGCGGCGTGCTGTTCGCCA

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MLYTEDHRNIMGSIRRFVSAEIDPHVDEWEAAEIFPAHELFKKMGDLGFLGITKPVEYGGLGLDFSYAIAAAEALGYARA
QGIGMGVGVQCDMATPALTAFGSDALKREFLAPAIAGDMVCSIGVSEAGAGSDVASLKTRARRDGDDYVITGSKMWITNG
TQADWICLLCNTSDGPVHKNKSLIVVPLKENGKRVKGVEIQKIKKFGMWCSDTAQIFFDEVRVPVRNRIGEEGMGFIYQM
KQFQEERLNGAARRLACTALIEETAEYLRQRIAFGKPLLDNQFIQFKLAELKTEMEALRALVYVATQTYINGGEVTELAS
MAKLKAGRLSRDVADWCMQFQGGMGYTWDNHASRAYRDFRLGSIGGGADEVMLQVIAKQMGLMSRG

Sequences:

>Translated_386_residues
MLYTEDHRNIMGSIRRFVSAEIDPHVDEWEAAEIFPAHELFKKMGDLGFLGITKPVEYGGLGLDFSYAIAAAEALGYARA
QGIGMGVGVQCDMATPALTAFGSDALKREFLAPAIAGDMVCSIGVSEAGAGSDVASLKTRARRDGDDYVITGSKMWITNG
TQADWICLLCNTSDGPVHKNKSLIVVPLKENGKRVKGVEIQKIKKFGMWCSDTAQIFFDEVRVPVRNRIGEEGMGFIYQM
KQFQEERLNGAARRLACTALIEETAEYLRQRIAFGKPLLDNQFIQFKLAELKTEMEALRALVYVATQTYINGGEVTELAS
MAKLKAGRLSRDVADWCMQFQGGMGYTWDNHASRAYRDFRLGSIGGGADEVMLQVIAKQMGLMSRG
>Mature_386_residues
MLYTEDHRNIMGSIRRFVSAEIDPHVDEWEAAEIFPAHELFKKMGDLGFLGITKPVEYGGLGLDFSYAIAAAEALGYARA
QGIGMGVGVQCDMATPALTAFGSDALKREFLAPAIAGDMVCSIGVSEAGAGSDVASLKTRARRDGDDYVITGSKMWITNG
TQADWICLLCNTSDGPVHKNKSLIVVPLKENGKRVKGVEIQKIKKFGMWCSDTAQIFFDEVRVPVRNRIGEEGMGFIYQM
KQFQEERLNGAARRLACTALIEETAEYLRQRIAFGKPLLDNQFIQFKLAELKTEMEALRALVYVATQTYINGGEVTELAS
MAKLKAGRLSRDVADWCMQFQGGMGYTWDNHASRAYRDFRLGSIGGGADEVMLQVIAKQMGLMSRG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=386, Percent_Identity=34.7150259067358, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI4557233, Length=379, Percent_Identity=34.5646437994723, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI4501859, Length=382, Percent_Identity=31.6753926701571, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI226958412, Length=379, Percent_Identity=30.6068601583113, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI187960098, Length=381, Percent_Identity=31.496062992126, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI4557231, Length=381, Percent_Identity=31.496062992126, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI7656849, Length=367, Percent_Identity=32.1525885558583, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI226958414, Length=344, Percent_Identity=31.9767441860465, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI76496475, Length=394, Percent_Identity=28.6802030456853, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI4557235, Length=394, Percent_Identity=28.6802030456853, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI21361497, Length=376, Percent_Identity=27.9255319148936, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI38505218, Length=293, Percent_Identity=30.0341296928328, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI4503943, Length=362, Percent_Identity=27.9005524861878, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=27.9005524861878, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI48976061, Length=311, Percent_Identity=26.6881028938907, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI211971008, Length=311, Percent_Identity=26.6881028938907, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI87081958, Length=380, Percent_Identity=29.4736842105263, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1786223, Length=379, Percent_Identity=26.3852242744063, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI87082384, Length=308, Percent_Identity=24.6753246753247, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551932, Length=380, Percent_Identity=51.3157894736842, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17505929, Length=380, Percent_Identity=51.5789473684211, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17508101, Length=376, Percent_Identity=32.4468085106383, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17506239, Length=381, Percent_Identity=31.758530183727, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=32.2834645669291, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17538396, Length=375, Percent_Identity=31.2, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17534899, Length=386, Percent_Identity=29.7927461139896, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=29.1338582677165, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI71990804, Length=281, Percent_Identity=35.2313167259786, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71985184, Length=379, Percent_Identity=29.5514511873351, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=29.5514511873351, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI32563615, Length=236, Percent_Identity=33.0508474576271, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71985192, Length=305, Percent_Identity=29.1803278688525, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71982178, Length=279, Percent_Identity=27.2401433691756, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17531909, Length=242, Percent_Identity=28.099173553719, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17534353, Length=310, Percent_Identity=29.6774193548387, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17562446, Length=292, Percent_Identity=27.3972602739726, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17531913, Length=173, Percent_Identity=29.4797687861272, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=34.1269841269841, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=34.1269841269841, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI21355753, Length=380, Percent_Identity=31.3157894736842, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=30.3191489361702, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24660351, Length=385, Percent_Identity=29.3506493506493, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI281363737, Length=344, Percent_Identity=29.6511627906977, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19920834, Length=307, Percent_Identity=32.5732899022801, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 42492; Mature: 42492

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYTEDHRNIMGSIRRFVSAEIDPHVDEWEAAEIFPAHELFKKMGDLGFLGITKPVEYGG
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHCCCCEEECCCCCCCCC
LGLDFSYAIAAAEALGYARAQGIGMGVGVQCDMATPALTAFGSDALKREFLAPAIAGDMV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHH
CSIGVSEAGAGSDVASLKTRARRDGDDYVITGSKMWITNGTQADWICLLCNTSDGPVHKN
EECCCCCCCCCCHHHHHHHHHHCCCCCEEEECCEEEEECCCCCCEEEEEEECCCCCCCCC
KSLIVVPLKENGKRVKGVEIQKIKKFGMWCSDTAQIFFDEVRVPVRNRIGEEGMGFIYQM
CCEEEEEECCCCCEECCCHHHHHHHHCCCCCHHHHHHHHHHCCCHHHCCCCCCHHHHHHH
KQFQEERLNGAARRLACTALIEETAEYLRQRIAFGKPLLDNQFIQFKLAELKTEMEALRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
LVYVATQTYINGGEVTELASMAKLKAGRLSRDVADWCMQFQGGMGYTWDNHASRAYRDFR
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
LGSIGGGADEVMLQVIAKQMGLMSRG
CCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLYTEDHRNIMGSIRRFVSAEIDPHVDEWEAAEIFPAHELFKKMGDLGFLGITKPVEYGG
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHCCCCEEECCCCCCCCC
LGLDFSYAIAAAEALGYARAQGIGMGVGVQCDMATPALTAFGSDALKREFLAPAIAGDMV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHH
CSIGVSEAGAGSDVASLKTRARRDGDDYVITGSKMWITNGTQADWICLLCNTSDGPVHKN
EECCCCCCCCCCHHHHHHHHHHCCCCCEEEECCEEEEECCCCCCEEEEEEECCCCCCCCC
KSLIVVPLKENGKRVKGVEIQKIKKFGMWCSDTAQIFFDEVRVPVRNRIGEEGMGFIYQM
CCEEEEEECCCCCEECCCHHHHHHHHCCCCCHHHHHHHHHHCCCHHHCCCCCCHHHHHHH
KQFQEERLNGAARRLACTALIEETAEYLRQRIAFGKPLLDNQFIQFKLAELKTEMEALRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
LVYVATQTYINGGEVTELASMAKLKAGRLSRDVADWCMQFQGGMGYTWDNHASRAYRDFR
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
LGSIGGGADEVMLQVIAKQMGLMSRG
CCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]