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The map label for this gene is trxB [H]

Identifier: 73538281

GI number: 73538281

Start: 1116521

End: 1118254

Strand: Reverse

Name: trxB [H]

Synonym: Reut_B4454

Alternate gene names: 73538281

Gene position: 1118254-1116521 (Counterclockwise)

Preceding gene: 73538283

Following gene: 73538279

Centisome position: 41.02

GC content: 69.03

Gene sequence:

>1734_bases
ATGGCGCAGGCGGACCGGACGGAGAGCGTTGAGGGGCAGGGCACCGAGGCCACGGCAAGCCTCGATGCACCGTATTCGAC
GCTGGAAAGCCGATGGCACCAGATGTTTCCGACGCTCACTGGCGACGAAGTCGAACGGATGCGGCACTTTGGCACGCCGC
AGCGCTGGCAAGCCGGCGAACAACTGTTTTCGGTCGGGCAGGTGGGCCGCGGCATGTGCGTGGTGGTCAGCGGCTGTATC
CAGATCATCCGCCGCGACGGGCTCGGGCATGAGCACCGCATTACCGACCTCGGGCCGGGCATGTTTTCGGCGGAAGTGGG
CACGCTGACCGGGCGCCCGTCGCTCGTGGACGGCCGCGCGGTGACCGATTCCGAAGGCTTCGCGATCCCGCCCGACAGGC
TTCGCGCCTTGCTGGTGGCGGAGGCTGATCTTGGCGAGCGCATCATGCGCGCGCTGATCCTGCGCCGCGTCGGGCTGATC
GAGTCCGGCAGCGGCCCGGTACTGGTCGGTCATGGCGCCGAACCGCTGCTGCTGGCGCTGCAGGCGTTCCTGCGCCGCAA
CGGTCACCCGTACACGGTGATCGACATGGACGTCGAGCGCGACTGTTCCTGCCTGAGCGAGTTCGCGAACGCGCCGGCTT
CGGACTTCCCGCTCGTGATCTGCCCGGACGGCCGCGTGCTGCGCGCGCCCGATGAAGGGCAACTGGCCTCGTGCCTCGGC
TTGCTGCCCGAATTCGATCCGACCCACGTCTACGACGTGGTCGTGGTGGGCGCAGGTCCCGCCGGCCTGGCCACGGCCGT
ATATGCCGCGTCCGAAGGGTTGTCGGTGGCGGTGATCGACTGCCGCTCGCCGGGCGGCCAGGCCGGAGCCAGCGCGCGCA
TCGAGAACTACCTCGGGTTTCCCACCGGTATCTCGGGCCAGGCGCTGGCCGGGCGCGCGTTTGTGCAGGCCCTCAAATTC
GGCGCCCACATTGCGATCCCGCTGGAAGTGAAGGCCCTGCATTGCGGTTCGGATCCGATCCGGCTCGAACTGGCCGATGG
CCGCATGATTTCGACGCATACGGTGGTGATCGCCACAGGCGCCCAGTACCGCCGGCCGGCCATCGACGCGCTCGAACGCT
TCGAGGGGCGGGGCGTGTACTACTGGGCCTCGCCGGTGGAAGCCAAGCTGTGCAAGAACGAGCCGGTGATGCTGGTCGGC
GGTGGCAACTCGGCCGGACAGGCGGCGGTATTCCTGGCCACGCATGCGGCGCATGTCCACATGCTGGTGCGCGGGCAGGG
GCTGGCGGCCACCATGTCGCGCTATCTGGTCGACCGTATCGGCGGGCTGCCCAACGTGCAACTACACACCCGTGCCGAAA
TCCATGCGCTCGAAGGGGACGGGTGGCTGTCCGATGTCCGCTACCAGGCGCCCACCGAGAGCGACGGGCTGGTATCGCTG
CCGGTGCGCCACCTGTTCCTGTTCATCGGCGCCGATCCCAATGCCTCGTGGCTGCGCACGTGCAACGTGGAGACCGACGA
CAAGGGCTTCGTGCGCACGGGCGGTGGGACGCTGGGCTGCGCGTCGGCCGTGCCGTATCCGCTGCAGACCAGCGTGCCGG
GCGTGTTCGCGATTGGCGACGTGCGCTCGGGCTCGACCAAGCGCGTGGCCGCTGCAGTGGGGGAAGGGGCCTCGGTCGTC
GCGCAGATCCACAGCTACCTCGCCGGCCTGACGACGGCGGCACAGGCCGCCTGA

Upstream 100 bases:

>100_bases
CGCGCCGACTACTATCGATGAGGTGCAACGACCGGTTGGGCGTTGATGCGCCGGAGTGCGCGAAAGCCGACAAATTCTTT
TTTGCTACGGGGAGGCCAGT

Downstream 100 bases:

>100_bases
GCCGCTGCCGCGCGCGGTGTGGCACGGCTTGCCGGCATGCCTTGCTTTACTGCATCTTCCCGAGGTTCCCGATCCTCACC
ATCATCTCGGTGAACATCTG

Product: cyclic nucleotide-regulated FAD-dependent pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MAQADRTESVEGQGTEATASLDAPYSTLESRWHQMFPTLTGDEVERMRHFGTPQRWQAGEQLFSVGQVGRGMCVVVSGCI
QIIRRDGLGHEHRITDLGPGMFSAEVGTLTGRPSLVDGRAVTDSEGFAIPPDRLRALLVAEADLGERIMRALILRRVGLI
ESGSGPVLVGHGAEPLLLALQAFLRRNGHPYTVIDMDVERDCSCLSEFANAPASDFPLVICPDGRVLRAPDEGQLASCLG
LLPEFDPTHVYDVVVVGAGPAGLATAVYAASEGLSVAVIDCRSPGGQAGASARIENYLGFPTGISGQALAGRAFVQALKF
GAHIAIPLEVKALHCGSDPIRLELADGRMISTHTVVIATGAQYRRPAIDALERFEGRGVYYWASPVEAKLCKNEPVMLVG
GGNSAGQAAVFLATHAAHVHMLVRGQGLAATMSRYLVDRIGGLPNVQLHTRAEIHALEGDGWLSDVRYQAPTESDGLVSL
PVRHLFLFIGADPNASWLRTCNVETDDKGFVRTGGGTLGCASAVPYPLQTSVPGVFAIGDVRSGSTKRVAAAVGEGASVV
AQIHSYLAGLTTAAQAA

Sequences:

>Translated_577_residues
MAQADRTESVEGQGTEATASLDAPYSTLESRWHQMFPTLTGDEVERMRHFGTPQRWQAGEQLFSVGQVGRGMCVVVSGCI
QIIRRDGLGHEHRITDLGPGMFSAEVGTLTGRPSLVDGRAVTDSEGFAIPPDRLRALLVAEADLGERIMRALILRRVGLI
ESGSGPVLVGHGAEPLLLALQAFLRRNGHPYTVIDMDVERDCSCLSEFANAPASDFPLVICPDGRVLRAPDEGQLASCLG
LLPEFDPTHVYDVVVVGAGPAGLATAVYAASEGLSVAVIDCRSPGGQAGASARIENYLGFPTGISGQALAGRAFVQALKF
GAHIAIPLEVKALHCGSDPIRLELADGRMISTHTVVIATGAQYRRPAIDALERFEGRGVYYWASPVEAKLCKNEPVMLVG
GGNSAGQAAVFLATHAAHVHMLVRGQGLAATMSRYLVDRIGGLPNVQLHTRAEIHALEGDGWLSDVRYQAPTESDGLVSL
PVRHLFLFIGADPNASWLRTCNVETDDKGFVRTGGGTLGCASAVPYPLQTSVPGVFAIGDVRSGSTKRVAAAVGEGASVV
AQIHSYLAGLTTAAQAA
>Mature_576_residues
AQADRTESVEGQGTEATASLDAPYSTLESRWHQMFPTLTGDEVERMRHFGTPQRWQAGEQLFSVGQVGRGMCVVVSGCIQ
IIRRDGLGHEHRITDLGPGMFSAEVGTLTGRPSLVDGRAVTDSEGFAIPPDRLRALLVAEADLGERIMRALILRRVGLIE
SGSGPVLVGHGAEPLLLALQAFLRRNGHPYTVIDMDVERDCSCLSEFANAPASDFPLVICPDGRVLRAPDEGQLASCLGL
LPEFDPTHVYDVVVVGAGPAGLATAVYAASEGLSVAVIDCRSPGGQAGASARIENYLGFPTGISGQALAGRAFVQALKFG
AHIAIPLEVKALHCGSDPIRLELADGRMISTHTVVIATGAQYRRPAIDALERFEGRGVYYWASPVEAKLCKNEPVMLVGG
GNSAGQAAVFLATHAAHVHMLVRGQGLAATMSRYLVDRIGGLPNVQLHTRAEIHALEGDGWLSDVRYQAPTESDGLVSLP
VRHLFLFIGADPNASWLRTCNVETDDKGFVRTGGGTLGCASAVPYPLQTSVPGVFAIGDVRSGSTKRVAAAVGEGASVVA
QIHSYLAGLTTAAQAA

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=324, Percent_Identity=31.4814814814815, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI87081763, Length=340, Percent_Identity=29.7058823529412, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320560, Length=333, Percent_Identity=30.9309309309309, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6321898, Length=327, Percent_Identity=29.3577981651376, Blast_Score=120, Evalue=5e-28,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 60864; Mature: 60733

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50042 CNMP_BINDING_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQADRTESVEGQGTEATASLDAPYSTLESRWHQMFPTLTGDEVERMRHFGTPQRWQAGE
CCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHH
QLFSVGQVGRGMCVVVSGCIQIIRRDGLGHEHRITDLGPGMFSAEVGTLTGRPSLVDGRA
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCCEECCCCCCCCCCCCCCCCE
VTDSEGFAIPPDRLRALLVAEADLGERIMRALILRRVGLIESGSGPVLVGHGAEPLLLAL
EECCCCCCCCHHHHHEEEEECCCHHHHHHHHHHHHHHCCEECCCCCEEEECCCCHHHHHH
QAFLRRNGHPYTVIDMDVERDCSCLSEFANAPASDFPLVICPDGRVLRAPDEGQLASCLG
HHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCEEECCCCCEEECCCCCHHHHHHH
LLPEFDPTHVYDVVVVGAGPAGLATAVYAASEGLSVAVIDCRSPGGQAGASARIENYLGF
CCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHCCC
PTGISGQALAGRAFVQALKFGAHIAIPLEVKALHCGSDPIRLELADGRMISTHTVVIATG
CCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCEEEEECCCEEEEEEEEEEECC
AQYRRPAIDALERFEGRGVYYWASPVEAKLCKNEPVMLVGGGNSAGQAAVFLATHAAHVH
CCCCCHHHHHHHHHCCCEEEEECCCCHHHHCCCCCEEEEECCCCCCCEEEEEEECCEEEE
MLVRGQGLAATMSRYLVDRIGGLPNVQLHTRAEIHALEGDGWLSDVRYQAPTESDGLVSL
EEEECCCHHHHHHHHHHHHHCCCCCCEEEECEEEEEECCCCCHHCCEECCCCCCCCEEEE
PVRHLFLFIGADPNASWLRTCNVETDDKGFVRTGGGTLGCASAVPYPLQTSVPGVFAIGD
CCCEEEEEEECCCCCCEEEEECCCCCCCCEEEECCCCEEHHCCCCCCCCCCCCCEEEEEC
VRSGSTKRVAAAVGEGASVVAQIHSYLAGLTTAAQAA
CCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQADRTESVEGQGTEATASLDAPYSTLESRWHQMFPTLTGDEVERMRHFGTPQRWQAGE
CCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHH
QLFSVGQVGRGMCVVVSGCIQIIRRDGLGHEHRITDLGPGMFSAEVGTLTGRPSLVDGRA
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCCEECCCCCCCCCCCCCCCCE
VTDSEGFAIPPDRLRALLVAEADLGERIMRALILRRVGLIESGSGPVLVGHGAEPLLLAL
EECCCCCCCCHHHHHEEEEECCCHHHHHHHHHHHHHHCCEECCCCCEEEECCCCHHHHHH
QAFLRRNGHPYTVIDMDVERDCSCLSEFANAPASDFPLVICPDGRVLRAPDEGQLASCLG
HHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCEEECCCCCEEECCCCCHHHHHHH
LLPEFDPTHVYDVVVVGAGPAGLATAVYAASEGLSVAVIDCRSPGGQAGASARIENYLGF
CCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHCCC
PTGISGQALAGRAFVQALKFGAHIAIPLEVKALHCGSDPIRLELADGRMISTHTVVIATG
CCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCEEEEECCCEEEEEEEEEEECC
AQYRRPAIDALERFEGRGVYYWASPVEAKLCKNEPVMLVGGGNSAGQAAVFLATHAAHVH
CCCCCHHHHHHHHHCCCEEEEECCCCHHHHCCCCCEEEEECCCCCCCEEEEEEECCEEEE
MLVRGQGLAATMSRYLVDRIGGLPNVQLHTRAEIHALEGDGWLSDVRYQAPTESDGLVSL
EEEECCCHHHHHHHHHHHHHCCCCCCEEEECEEEEEECCCCCHHCCEECCCCCCCCEEEE
PVRHLFLFIGADPNASWLRTCNVETDDKGFVRTGGGTLGCASAVPYPLQTSVPGVFAIGD
CCCEEEEEEECCCCCCEEEEECCCCCCCCEEEECCCCEEHHCCCCCCCCCCCCCEEEEEC
VRSGSTKRVAAAVGEGASVVAQIHSYLAGLTTAAQAA
CCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11353084 [H]