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The map label for this gene is grxC [C]

Identifier: 73538279

GI number: 73538279

Start: 1113753

End: 1114484

Strand: Reverse

Name: grxC [C]

Synonym: Reut_B4452

Alternate gene names: 73538279

Gene position: 1114484-1113753 (Counterclockwise)

Preceding gene: 73538281

Following gene: 161611270

Centisome position: 40.88

GC content: 62.7

Gene sequence:

>732_bases
ATGCTGCAATCCCGTGAAGGCCAACGCATTCCCAATGTCGCTTTCCGCATCCGCCAGGACAACGAGTGGAAGACTGTCAC
CTCCGGCGATCTGTTCAACGGCAAGACCGTCGTCGTGTTCTCGCTGCCCGGCGCCTTCACGCCGACCTGCTCGTCGACCC
ACCTGCCGCGCTACAACGAATTGGCGCCGGCATTTGCCAAGCATGGCGTGGACGAGATCCTGTGCGTGTCGGTCAACGAC
ACCTTCGTGATGAACGAATGGGCCAAGGACCAGGAGTCGCAGAACATCACCATGATTCCCGATGGCAACGGCGAATTCAC
CGAAGGCATGGGCATGCTGGTGGACAAGGCCGACCTGGGCTTCGGCAAGCGCAGCTGGCGCTATTCGATGCTCGTCCGTG
ACGGCGTGGTCGAGAAAATGTTCATCGAGCCGAACGAGCCGGGCGACCCGTTCAAGGTCTCCGATGCCGACACCATGCTG
AACCACATCGCCCCCGACGCCAAGCGTCCGGACCAGGTGGTGGTGTTCTCGAAGGCAGGCTGCTCGTTCTGCGCCAAGGC
CAAGCAGCAACTGTCCGACGCCGGCTACGAGTACATCGAGGTGCCGCTCGACAACAAGGTGCGCGGCAAGGTGCTGGGCG
CCGTGTCCGGCGAGATGACCGCGCCGCAGGTCTTCATCAACGGCAAGCTGATTGGCGGCGCCGCCGCGCTCGAGCAGTAC
CTGGGCCAGTAA

Upstream 100 bases:

>100_bases
GTTTAAACGATGAATTGTACAAATCACATTGGGATCGCCAGAATCGGGTCCATCGCTGCAACACGCAGCAAACCACTGAA
ACCACCAAGGAGTGACCCCG

Downstream 100 bases:

>100_bases
TCCCCGTATCACGACCGCCCGCGCGGTCCGGCAGTCGCCGGACCCGATGGCGCCGCGCTGCCCGCGCGGTGCCATCCAGC
CCGCCGATTGATGTCCGATC

Product: glutaredoxin-like region

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MLQSREGQRIPNVAFRIRQDNEWKTVTSGDLFNGKTVVVFSLPGAFTPTCSSTHLPRYNELAPAFAKHGVDEILCVSVND
TFVMNEWAKDQESQNITMIPDGNGEFTEGMGMLVDKADLGFGKRSWRYSMLVRDGVVEKMFIEPNEPGDPFKVSDADTML
NHIAPDAKRPDQVVVFSKAGCSFCAKAKQQLSDAGYEYIEVPLDNKVRGKVLGAVSGEMTAPQVFINGKLIGGAAALEQY
LGQ

Sequences:

>Translated_243_residues
MLQSREGQRIPNVAFRIRQDNEWKTVTSGDLFNGKTVVVFSLPGAFTPTCSSTHLPRYNELAPAFAKHGVDEILCVSVND
TFVMNEWAKDQESQNITMIPDGNGEFTEGMGMLVDKADLGFGKRSWRYSMLVRDGVVEKMFIEPNEPGDPFKVSDADTML
NHIAPDAKRPDQVVVFSKAGCSFCAKAKQQLSDAGYEYIEVPLDNKVRGKVLGAVSGEMTAPQVFINGKLIGGAAALEQY
LGQ
>Mature_243_residues
MLQSREGQRIPNVAFRIRQDNEWKTVTSGDLFNGKTVVVFSLPGAFTPTCSSTHLPRYNELAPAFAKHGVDEILCVSVND
TFVMNEWAKDQESQNITMIPDGNGEFTEGMGMLVDKADLGFGKRSWRYSMLVRDGVVEKMFIEPNEPGDPFKVSDADTML
NHIAPDAKRPDQVVVFSKAGCSFCAKAKQQLSDAGYEYIEVPLDNKVRGKVLGAVSGEMTAPQVFINGKLIGGAAALEQY
LGQ

Specific function: The Disulfide Bond Functions As An Electron Carrier In The Glutathione-Dependent Synthesis Of Deoxyribonucleotides By The Enzyme Ribonucleotide Reductase. In Addition, It Is Also Involved In Reducing Some Disulfides In A Coupled System With Glutathione R

COG id: COG0678

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI6912238, Length=151, Percent_Identity=37.0860927152318, Blast_Score=101, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6323138, Length=152, Percent_Identity=29.6052631578947, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI78706776, Length=146, Percent_Identity=42.4657534246575, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI78709078, Length=146, Percent_Identity=42.4657534246575, Blast_Score=118, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR011906
- InterPro:   IPR014025
- InterPro:   IPR013740
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin; PF08534 Redoxin [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 26675; Mature: 26675

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQSREGQRIPNVAFRIRQDNEWKTVTSGDLFNGKTVVVFSLPGAFTPTCSSTHLPRYNE
CCCCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHH
LAPAFAKHGVDEILCVSVNDTFVMNEWAKDQESQNITMIPDGNGEFTEGMGMLVDKADLG
HHHHHHHCCCCEEEEEECCCEEEECCHHCCCCCCCEEEEECCCCCCCCCCEEEEECCCCC
FGKRSWRYSMLVRDGVVEKMFIEPNEPGDPFKVSDADTMLNHIAPDAKRPDQVVVFSKAG
CCCCCEEEEEEECCCCEEEEEECCCCCCCCEEECHHHHHHHHHCCCCCCCCEEEEECCCC
CSFCAKAKQQLSDAGYEYIEVPLDNKVRGKVLGAVSGEMTAPQVFINGKLIGGAAALEQY
CHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCCCCEEEEECEEECHHHHHHHH
LGQ
HCC
>Mature Secondary Structure
MLQSREGQRIPNVAFRIRQDNEWKTVTSGDLFNGKTVVVFSLPGAFTPTCSSTHLPRYNE
CCCCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHH
LAPAFAKHGVDEILCVSVNDTFVMNEWAKDQESQNITMIPDGNGEFTEGMGMLVDKADLG
HHHHHHHCCCCEEEEEECCCEEEECCHHCCCCCCCEEEEECCCCCCCCCCEEEEECCCCC
FGKRSWRYSMLVRDGVVEKMFIEPNEPGDPFKVSDADTMLNHIAPDAKRPDQVVVFSKAG
CCCCCEEEEEEECCCCEEEEEECCCCCCCCEEECHHHHHHHHHCCCCCCCCEEEEECCCC
CSFCAKAKQQLSDAGYEYIEVPLDNKVRGKVLGAVSGEMTAPQVFINGKLIGGAAALEQY
CHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCCCCEEEEECEEECHHHHHHHH
LGQ
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]