| Definition | Ralstonia eutropha JMP134 chromosome chromosome 2, complete sequence. |
|---|---|
| Accession | NC_007348 |
| Length | 2,726,152 |
Click here to switch to the map view.
The map label for this gene is hdhA [H]
Identifier: 73538151
GI number: 73538151
Start: 978653
End: 979420
Strand: Reverse
Name: hdhA [H]
Synonym: Reut_B4321
Alternate gene names: 73538151
Gene position: 979420-978653 (Counterclockwise)
Preceding gene: 73538154
Following gene: 73538150
Centisome position: 35.93
GC content: 66.28
Gene sequence:
>768_bases ATGCAGAACCTTTTTGATCTTTCCGGCCGCGTGGCCGTCGTGACCGGCTCGACCATGGGCATGGGCTTTGAAATGGCGCG TGCGCTGGGCAGCGCCGGGGCCAGCGTCATCGTTTCCGGACGCAATGGCGACGTCGCCCGTACGGTCGCCGCGCAACTGG AGAGCGACGGTATTCGCGCCGTGGGTATCGCCTGCGATATCGCCGACCTGGCCAGCGTGCACGCATTTGCGGAACAGGGG CTGGCGGCCTTTGGCAGGGTGGACGCCCTGGTGTTGAACGCTGCGGCCGATGGCGCCGCGGGTTCTTTGCTCTCGCAGGG CCCTGAAGTGTTCGATGCGGCGATGGCCGGCAATGTGCGCGGCAACCTGCAGCTGGTCAATGCGCTGGCACCGCAGATGG TGTCGCGCGGCGACGGTTCGATCACCTTCATGTCGAGCATCGCGGCCAAGCGTGGCTCGGCATTCCTCGGCATGTACAGC ATCACCAAGGGTGCGGTCGACCAGGCCGTGCGCAGCCTTGCCCTGGAGCTCGGCGCGAACGGCGTGAACGTGAATGCCAT CAATCCGGGTCCGGTCCGAACGGAATTCTCGCGTGAAGCCCTGTGGGGCGATCCCGCACGCGAGGCGCAACTGGCTTCGC GCATCCCGATGCGGCGCATCGGCGAGGCAAATGACGTGGCCGGGCTTGCAGTGTTGCTGGCCTCGCCTGCCGGACGTTTC ATCAACGGGCAGAGCATCAGCGTGGACGGCGGGCTGTCCGTAGCCTGA
Upstream 100 bases:
>100_bases TGATGGTCATAATTTGTTCAATAGATGTTGATCGCAATTTAAGAGGTCATCCCCATTCATTTGACCTCGCACTTCACCCC AACCGACAGGAGTCCCTGTA
Downstream 100 bases:
>100_bases CGCGTCACGTTGTTCGGATGGCTTCAAATGTGCATACATATGAAGCCGTCTTCAGCGCGTTGAAGAGATTTGCCGTATTG TCTCGGTTGAACCGTGCCGG
Product: NAD-dependent epimerase/dehydratase
Products: NA
Alternate protein names: 7-alpha-HSDH [H]
Number of amino acids: Translated: 255; Mature: 255
Protein sequence:
>255_residues MQNLFDLSGRVAVVTGSTMGMGFEMARALGSAGASVIVSGRNGDVARTVAAQLESDGIRAVGIACDIADLASVHAFAEQG LAAFGRVDALVLNAAADGAAGSLLSQGPEVFDAAMAGNVRGNLQLVNALAPQMVSRGDGSITFMSSIAAKRGSAFLGMYS ITKGAVDQAVRSLALELGANGVNVNAINPGPVRTEFSREALWGDPAREAQLASRIPMRRIGEANDVAGLAVLLASPAGRF INGQSISVDGGLSVA
Sequences:
>Translated_255_residues MQNLFDLSGRVAVVTGSTMGMGFEMARALGSAGASVIVSGRNGDVARTVAAQLESDGIRAVGIACDIADLASVHAFAEQG LAAFGRVDALVLNAAADGAAGSLLSQGPEVFDAAMAGNVRGNLQLVNALAPQMVSRGDGSITFMSSIAAKRGSAFLGMYS ITKGAVDQAVRSLALELGANGVNVNAINPGPVRTEFSREALWGDPAREAQLASRIPMRRIGEANDVAGLAVLLASPAGRF INGQSISVDGGLSVA >Mature_255_residues MQNLFDLSGRVAVVTGSTMGMGFEMARALGSAGASVIVSGRNGDVARTVAAQLESDGIRAVGIACDIADLASVHAFAEQG LAAFGRVDALVLNAAADGAAGSLLSQGPEVFDAAMAGNVRGNLQLVNALAPQMVSRGDGSITFMSSIAAKRGSAFLGMYS ITKGAVDQAVRSLALELGANGVNVNAINPGPVRTEFSREALWGDPAREAQLASRIPMRRIGEANDVAGLAVLLASPAGRF INGQSISVDGGLSVA
Specific function: 7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI5031737, Length=249, Percent_Identity=35.7429718875502, Blast_Score=150, Evalue=1e-36, Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=34.2857142857143, Blast_Score=147, Evalue=6e-36, Organism=Homo sapiens, GI126723750, Length=248, Percent_Identity=30.241935483871, Blast_Score=124, Evalue=6e-29, Organism=Homo sapiens, GI33667109, Length=192, Percent_Identity=35.9375, Blast_Score=117, Evalue=9e-27, Organism=Homo sapiens, GI19923817, Length=266, Percent_Identity=28.5714285714286, Blast_Score=108, Evalue=6e-24, Organism=Homo sapiens, GI7705925, Length=252, Percent_Identity=32.9365079365079, Blast_Score=106, Evalue=3e-23, Organism=Homo sapiens, GI126723191, Length=182, Percent_Identity=32.967032967033, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=30.4878048780488, Blast_Score=91, Evalue=9e-19, Organism=Homo sapiens, GI10190704, Length=254, Percent_Identity=28.3464566929134, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI20149619, Length=207, Percent_Identity=30.9178743961353, Blast_Score=88, Evalue=6e-18, Organism=Homo sapiens, GI4503301, Length=255, Percent_Identity=30.5882352941176, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI59889578, Length=230, Percent_Identity=31.304347826087, Blast_Score=82, Evalue=7e-16, Organism=Homo sapiens, GI66933014, Length=254, Percent_Identity=29.5275590551181, Blast_Score=80, Evalue=1e-15, Organism=Homo sapiens, GI15277342, Length=255, Percent_Identity=27.843137254902, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI209862901, Length=203, Percent_Identity=32.512315270936, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI19923983, Length=203, Percent_Identity=32.512315270936, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI157739938, Length=193, Percent_Identity=26.4248704663212, Blast_Score=71, Evalue=8e-13, Organism=Homo sapiens, GI7706318, Length=208, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI223718074, Length=208, Percent_Identity=30.2884615384615, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI32455239, Length=184, Percent_Identity=30.9782608695652, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI5031765, Length=184, Percent_Identity=30.9782608695652, Blast_Score=66, Evalue=3e-11, Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=5e-31, Organism=Escherichia coli, GI1790717, Length=256, Percent_Identity=32.03125, Blast_Score=125, Evalue=3e-30, Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=33.0708661417323, Blast_Score=116, Evalue=1e-27, Organism=Escherichia coli, GI1789208, Length=248, Percent_Identity=31.8548387096774, Blast_Score=105, Evalue=3e-24, Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=31.640625, Blast_Score=103, Evalue=1e-23, Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=28.2258064516129, Blast_Score=92, Evalue=3e-20, Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=29.0322580645161, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI2367175, Length=253, Percent_Identity=30.4347826086957, Blast_Score=82, Evalue=4e-17, Organism=Escherichia coli, GI1787526, Length=191, Percent_Identity=31.9371727748691, Blast_Score=81, Evalue=8e-17, Organism=Escherichia coli, GI1789378, Length=249, Percent_Identity=28.9156626506024, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI1786812, Length=253, Percent_Identity=30.4347826086957, Blast_Score=76, Evalue=2e-15, Organism=Escherichia coli, GI1786701, Length=195, Percent_Identity=28.2051282051282, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1787545, Length=259, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-12, Organism=Escherichia coli, GI1789057, Length=255, Percent_Identity=28.6274509803922, Blast_Score=64, Evalue=7e-12, Organism=Escherichia coli, GI2367365, Length=248, Percent_Identity=25.8064516129032, Blast_Score=61, Evalue=8e-11, Organism=Caenorhabditis elegans, GI17560676, Length=246, Percent_Identity=32.1138211382114, Blast_Score=135, Evalue=2e-32, Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=30.5882352941176, Blast_Score=119, Evalue=1e-27, Organism=Caenorhabditis elegans, GI71994600, Length=254, Percent_Identity=33.4645669291339, Blast_Score=110, Evalue=5e-25, Organism=Caenorhabditis elegans, GI115534694, Length=252, Percent_Identity=30.952380952381, Blast_Score=110, Evalue=7e-25, Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=32.5757575757576, Blast_Score=107, Evalue=5e-24, Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=33.1983805668016, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=33.3333333333333, Blast_Score=101, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=31.0606060606061, Blast_Score=100, Evalue=9e-22, Organism=Caenorhabditis elegans, GI17531453, Length=264, Percent_Identity=32.1969696969697, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17560220, Length=265, Percent_Identity=30.9433962264151, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=30.6818181818182, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17560150, Length=257, Percent_Identity=29.9610894941634, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17559104, Length=259, Percent_Identity=29.3436293436293, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI17544670, Length=265, Percent_Identity=30.9433962264151, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI25147288, Length=251, Percent_Identity=32.2709163346614, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17562904, Length=265, Percent_Identity=29.0566037735849, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17560332, Length=271, Percent_Identity=30.2583025830258, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17562908, Length=264, Percent_Identity=32.1969696969697, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI193204405, Length=268, Percent_Identity=30.9701492537313, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=27.8625954198473, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=29.5019157088123, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=29.1497975708502, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=28.8973384030418, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=27.8195488721804, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17536025, Length=257, Percent_Identity=26.8482490272374, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17561272, Length=253, Percent_Identity=26.4822134387352, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=26.4591439688716, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI193207620, Length=223, Percent_Identity=27.3542600896861, Blast_Score=73, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17508651, Length=253, Percent_Identity=26.4822134387352, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17567345, Length=195, Percent_Identity=27.6923076923077, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17558006, Length=217, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=5e-12, Organism=Caenorhabditis elegans, GI17564282, Length=192, Percent_Identity=27.0833333333333, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI71992402, Length=222, Percent_Identity=27.4774774774775, Blast_Score=65, Evalue=4e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=254, Percent_Identity=27.5590551181102, Blast_Score=91, Evalue=2e-19, Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=34.0080971659919, Blast_Score=144, Evalue=6e-35, Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=35.4838709677419, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI24643142, Length=252, Percent_Identity=32.9365079365079, Blast_Score=113, Evalue=1e-25, Organism=Drosophila melanogaster, GI21357041, Length=248, Percent_Identity=33.4677419354839, Blast_Score=108, Evalue=2e-24, Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=30.5220883534137, Blast_Score=106, Evalue=2e-23, Organism=Drosophila melanogaster, GI28571526, Length=250, Percent_Identity=32.4, Blast_Score=102, Evalue=2e-22, Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=31.1023622047244, Blast_Score=99, Evalue=2e-21, Organism=Drosophila melanogaster, GI24644337, Length=256, Percent_Identity=32.03125, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI21358495, Length=201, Percent_Identity=30.8457711442786, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI24640492, Length=204, Percent_Identity=25.9803921568627, Blast_Score=72, Evalue=3e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.159 [H]
Molecular weight: Translated: 25772; Mature: 25772
Theoretical pI: Translated: 4.99; Mature: 4.99
Prosite motif: PS00435 PEROXIDASE_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 3.5 %Met (Translated Protein) 3.9 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 3.5 %Met (Mature Protein) 3.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQNLFDLSGRVAVVTGSTMGMGFEMARALGSAGASVIVSGRNGDVARTVAAQLESDGIRA CCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCEE VGIACDIADLASVHAFAEQGLAAFGRVDALVLNAAADGAAGSLLSQGPEVFDAAMAGNVR EEEEECHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHCCHHHHHHHHHCCCC GNLQLVNALAPQMVSRGDGSITFMSSIAAKRGSAFLGMYSITKGAVDQAVRSLALELGAN CCHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCC GVNVNAINPGPVRTEFSREALWGDPAREAQLASRIPMRRIGEANDVAGLAVLLASPAGRF CEEEECCCCCCCCCCCCHHHHCCCCHHHHHHHHHCCHHHCCCCCCHHHHHHHHHCCCCCE INGQSISVDGGLSVA ECCCEEEECCCCCCC >Mature Secondary Structure MQNLFDLSGRVAVVTGSTMGMGFEMARALGSAGASVIVSGRNGDVARTVAAQLESDGIRA CCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCEE VGIACDIADLASVHAFAEQGLAAFGRVDALVLNAAADGAAGSLLSQGPEVFDAAMAGNVR EEEEECHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHCCHHHHHHHHHCCCC GNLQLVNALAPQMVSRGDGSITFMSSIAAKRGSAFLGMYSITKGAVDQAVRSLALELGAN CCHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCC GVNVNAINPGPVRTEFSREALWGDPAREAQLASRIPMRRIGEANDVAGLAVLLASPAGRF CEEEECCCCCCCCCCCCHHHHCCCCHHHHHHHHHCCHHHCCCCCCHHHHHHHHHCCCCCE INGQSISVDGGLSVA ECCCEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]