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The map label for this gene is phoQ [H]

Identifier: 73537880

GI number: 73537880

Start: 689338

End: 690291

Strand: Reverse

Name: phoQ [H]

Synonym: Reut_B4047

Alternate gene names: 73537880

Gene position: 690291-689338 (Counterclockwise)

Preceding gene: 73537881

Following gene: 73537878

Centisome position: 25.32

GC content: 70.34

Gene sequence:

>954_bases
GTGGTGTCGCGCAGCATCGTGCTGGCTTCGTCCGACACGCCAGTGAGCGTTTCCGTGGCGCTGGATCGCACCGAACTGCG
CGCCGCACGGCGCGCGTTCAACACCATGCTGGGCTGGTCGCTCGGAGCGCTTGGCATGGGCCTGATGCTGGCCGTGGCCG
CTCAGGTGCGCTTCGGGCTGGCGCCACTCAAGCGCCTGCGGCAAGCACTGGGCGCGATGCAGGCACGGCGCGAGAGTCGC
TTGGGCGGCAATTGGCCTACTGAAGTCGAGCCATTGATCAGCCAAATCAACACGCTGCTGGACCACAACGCGCAGGCGCT
CGAGCGGTCGCGGCAACAGGCGGCGGACCTGGCGCACGCGGTAAAGACACCGCTCGCCGTGCTCGCCAATGAGGCGTCCA
GCTTGCCGAGCCCGGCTGCCGATGCCGTGTCCCGCCAGGTCGACGCCATGCGCCGGCAGGTCGACCGCCACCTGGCCCGC
GCGCGCGCAGCAGGCGCCGCGGCGGCACGTGGCCAGCGCATCGAGGCCGGCCCCGCGGTACGCGAGCTGACGCGCGCCCT
GACGCGCCTTCATGGCGCGCGGCAGCTCGACATCGGCGTGGAAAGCGAAGGACACTTCGCCGGCGACCGTCAGGATCTGG
TGGAGATGCTCGGCAATCTGCTCGACAACGCCTGCCAGTGGGCACGCTCGCAGGTACGCATCCACTTGCGCGAAGACACT
GCCGCAGCGTTGCTGGAGGTGCTCGTGGAAGATGACGGCCCGGGCATGCCGCCCGAGGCGCGCGAACTGGCCACCACCCG
GTTCGGGCGGCTCGACGAAGCCGCCGCCGGCAGCGGTCTCGGCCTGGCCATCGTCACAGAGATTGCGGCGATGTATGAGG
GATCACTGGAGCTGGGTAACAGCGCGCTCGGCGGCCTGGCAGCGCACCTGCGGCTGCCGGCCGGCATGGCCTGA

Upstream 100 bases:

>100_bases
GCGCTCGTTGTGGGACACAGAAATGCCGGAAAAGGCTGCGCACAAGGTAGCGGGAACGCCTGCCTAAGTTCGTCAGGGAC
CCAACCAGCAGTCGCTGCTG

Downstream 100 bases:

>100_bases
TCGCTGCCGCATCAGGACACGCGCGCCATCATTGCATCGCGGGTGCCGGCTGCCAGACCGCAGGCAAAGGCGGTCTCCGC
CACGAGGAACAGCGGGCCGA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MVSRSIVLASSDTPVSVSVALDRTELRAARRAFNTMLGWSLGALGMGLMLAVAAQVRFGLAPLKRLRQALGAMQARRESR
LGGNWPTEVEPLISQINTLLDHNAQALERSRQQAADLAHAVKTPLAVLANEASSLPSPAADAVSRQVDAMRRQVDRHLAR
ARAAGAAAARGQRIEAGPAVRELTRALTRLHGARQLDIGVESEGHFAGDRQDLVEMLGNLLDNACQWARSQVRIHLREDT
AAALLEVLVEDDGPGMPPEARELATTRFGRLDEAAAGSGLGLAIVTEIAAMYEGSLELGNSALGGLAAHLRLPAGMA

Sequences:

>Translated_317_residues
MVSRSIVLASSDTPVSVSVALDRTELRAARRAFNTMLGWSLGALGMGLMLAVAAQVRFGLAPLKRLRQALGAMQARRESR
LGGNWPTEVEPLISQINTLLDHNAQALERSRQQAADLAHAVKTPLAVLANEASSLPSPAADAVSRQVDAMRRQVDRHLAR
ARAAGAAAARGQRIEAGPAVRELTRALTRLHGARQLDIGVESEGHFAGDRQDLVEMLGNLLDNACQWARSQVRIHLREDT
AAALLEVLVEDDGPGMPPEARELATTRFGRLDEAAAGSGLGLAIVTEIAAMYEGSLELGNSALGGLAAHLRLPAGMA
>Mature_317_residues
MVSRSIVLASSDTPVSVSVALDRTELRAARRAFNTMLGWSLGALGMGLMLAVAAQVRFGLAPLKRLRQALGAMQARRESR
LGGNWPTEVEPLISQINTLLDHNAQALERSRQQAADLAHAVKTPLAVLANEASSLPSPAADAVSRQVDAMRRQVDRHLAR
ARAAGAAAARGQRIEAGPAVRELTRALTRLHGARQLDIGVESEGHFAGDRQDLVEMLGNLLDNACQWARSQVRIHLREDT
AAALLEVLVEDDGPGMPPEARELATTRFGRLDEAAAGSGLGLAIVTEIAAMYEGSLELGNSALGGLAAHLRLPAGMA

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=317, Percent_Identity=29.3375394321767, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1790551, Length=298, Percent_Identity=29.1946308724832, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787894, Length=215, Percent_Identity=31.6279069767442, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789403, Length=270, Percent_Identity=29.6296296296296, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=24.2753623188406, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1786783, Length=283, Percent_Identity=25.4416961130742, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788279, Length=304, Percent_Identity=25.6578947368421, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=230, Percent_Identity=30, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 33622; Mature: 33622

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSRSIVLASSDTPVSVSVALDRTELRAARRAFNTMLGWSLGALGMGLMLAVAAQVRFGL
CCCCCEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APLKRLRQALGAMQARRESRLGGNWPTEVEPLISQINTLLDHNAQALERSRQQAADLAHA
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VKTPLAVLANEASSLPSPAADAVSRQVDAMRRQVDRHLARARAAGAAAARGQRIEAGPAV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
RELTRALTRLHGARQLDIGVESEGHFAGDRQDLVEMLGNLLDNACQWARSQVRIHLREDT
HHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECHHH
AAALLEVLVEDDGPGMPPEARELATTRFGRLDEAAAGSGLGLAIVTEIAAMYEGSLELGN
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCCHHHCC
SALGGLAAHLRLPAGMA
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVSRSIVLASSDTPVSVSVALDRTELRAARRAFNTMLGWSLGALGMGLMLAVAAQVRFGL
CCCCCEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APLKRLRQALGAMQARRESRLGGNWPTEVEPLISQINTLLDHNAQALERSRQQAADLAHA
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VKTPLAVLANEASSLPSPAADAVSRQVDAMRRQVDRHLARARAAGAAAARGQRIEAGPAV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
RELTRALTRLHGARQLDIGVESEGHFAGDRQDLVEMLGNLLDNACQWARSQVRIHLREDT
HHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECHHH
AAALLEVLVEDDGPGMPPEARELATTRFGRLDEAAAGSGLGLAIVTEIAAMYEGSLELGN
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCCHHHCC
SALGGLAAHLRLPAGMA
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]