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The map label for this gene is fghA [H]

Identifier: 73537832

GI number: 73537832

Start: 637172

End: 638023

Strand: Reverse

Name: fghA [H]

Synonym: Reut_B3999

Alternate gene names: 73537832

Gene position: 638023-637172 (Counterclockwise)

Preceding gene: 73537833

Following gene: 73537828

Centisome position: 23.4

GC content: 66.9

Gene sequence:

>852_bases
GTGACCCTCGAACTGCTGTCCGAACACGGCTGCCATGGCGGCGTGCAGCGCTTCTACCGGCACGCATCGGCCACCATCGG
GCTGCCAATGCGATTCTCGGTGTACCTGCCGCCACAGGCGCTGGCCGGTGGCGGCAAGCTGCCGGCCCTGTTCTATTTGG
CGGGGCTGACCTGCACCGAGGAAACCTTCATGATCAAGGCCGGTGCGCAGCGCTTTGCCGCCGAGCACGGGCTGGTCCTG
GTGGCCCCCGACACCAGTCCGCGCGGTGCGGGCGTGCCGGGCGAAGCCGATGCGTGGGACTTCGGCGTTGGTGCGGGTTT
CTACGTCGACGCGACCGAAGCGCCGTGGAACACGCACTGGGGCATGGAAAGCTACGTCACGCAGGAGCTGTTCGACCTCG
TGAGCCGTGAGCTGCCGGTCGATCCGGACCGTGTCGGCATTTTCGGGCATTCGATGGGCGGTCACGGGGCACTGGTGCTC
GCGCAGCGGCATCCGCAGCGTTTCCGCTCGGTGTCGGCGTTCGCGCCGATTGCAGCGCCGACGCGATGCCCGTGGGGGCA
GAAGGCGTTCACGGGCTACCTCGGCACCGACCGCAGCCGCTGGGACGAATATGATGCCAGTGCATTGATGGCTGCCCAGA
AGGTCGCGCCCTTCCCGGCCGGCATCCTCGTGGATCAGGGCCTGTCTGACCAGTTCCTGCAAAACCAGCTCCACCCCGAA
GCGTTGGAGGCCGCGTGCGCGGCGGTCGGACAACCGCTGACGCTGCGCCGTCATACGGGCTACGACCACGGCTACTTCTT
CATCAGCACCTTCATCGCGGACCATATCCGGCATCACGCCGGACAACTGTGA

Upstream 100 bases:

>100_bases
ATCACGCACACGCTGCCGCTGGACCGCATCAACGAAGGCTTCGAGCTGATGAGGCGCGGCGAGTCGATCCGCTCGGTGGT
GCTGTACTGAGGAGCGCGCC

Downstream 100 bases:

>100_bases
CGATGCGGAGATGACGGCGATGCGCGGCCCGCGCCGCGCATCGCTCAGATGTAGCGCTCCGCCATGACCTGCGCGCTCAG
GCGGCGCCGTTTCCAGAACA

Product: carboxylesterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTLELLSEHGCHGGVQRFYRHASATIGLPMRFSVYLPPQALAGGGKLPALFYLAGLTCTEETFMIKAGAQRFAAEHGLVL
VAPDTSPRGAGVPGEADAWDFGVGAGFYVDATEAPWNTHWGMESYVTQELFDLVSRELPVDPDRVGIFGHSMGGHGALVL
AQRHPQRFRSVSAFAPIAAPTRCPWGQKAFTGYLGTDRSRWDEYDASALMAAQKVAPFPAGILVDQGLSDQFLQNQLHPE
ALEAACAAVGQPLTLRRHTGYDHGYFFISTFIADHIRHHAGQL

Sequences:

>Translated_283_residues
MTLELLSEHGCHGGVQRFYRHASATIGLPMRFSVYLPPQALAGGGKLPALFYLAGLTCTEETFMIKAGAQRFAAEHGLVL
VAPDTSPRGAGVPGEADAWDFGVGAGFYVDATEAPWNTHWGMESYVTQELFDLVSRELPVDPDRVGIFGHSMGGHGALVL
AQRHPQRFRSVSAFAPIAAPTRCPWGQKAFTGYLGTDRSRWDEYDASALMAAQKVAPFPAGILVDQGLSDQFLQNQLHPE
ALEAACAAVGQPLTLRRHTGYDHGYFFISTFIADHIRHHAGQL
>Mature_282_residues
TLELLSEHGCHGGVQRFYRHASATIGLPMRFSVYLPPQALAGGGKLPALFYLAGLTCTEETFMIKAGAQRFAAEHGLVLV
APDTSPRGAGVPGEADAWDFGVGAGFYVDATEAPWNTHWGMESYVTQELFDLVSRELPVDPDRVGIFGHSMGGHGALVLA
QRHPQRFRSVSAFAPIAAPTRCPWGQKAFTGYLGTDRSRWDEYDASALMAAQKVAPFPAGILVDQGLSDQFLQNQLHPEA
LEAACAAVGQPLTLRRHTGYDHGYFFISTFIADHIRHHAGQL

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=287, Percent_Identity=54.7038327526132, Blast_Score=333, Evalue=8e-92,
Organism=Escherichia coli, GI1786551, Length=282, Percent_Identity=48.936170212766, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1788477, Length=281, Percent_Identity=50.5338078291815, Blast_Score=271, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI17510185, Length=285, Percent_Identity=49.1228070175439, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6322393, Length=297, Percent_Identity=37.3737373737374, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI45551932, Length=285, Percent_Identity=53.6842105263158, Blast_Score=301, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24648347, Length=285, Percent_Identity=53.6842105263158, Blast_Score=301, Evalue=5e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30705; Mature: 30574

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLELLSEHGCHGGVQRFYRHASATIGLPMRFSVYLPPQALAGGGKLPALFYLAGLTCTE
CCHHHHHHCCCCHHHHHHHHHHCCEECCCEEEEEEECHHHHCCCCCCHHHHHHHCCCCCC
ETFMIKAGAQRFAAEHGLVLVAPDTSPRGAGVPGEADAWDFGVGAGFYVDATEAPWNTHW
CEEEEEHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCC
GMESYVTQELFDLVSRELPVDPDRVGIFGHSMGGHGALVLAQRHPQRFRSVSAFAPIAAP
CHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHCCCCCC
TRCPWGQKAFTGYLGTDRSRWDEYDASALMAAQKVAPFPAGILVDQGLSDQFLQNQLHPE
CCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHCCCHH
ALEAACAAVGQPLTLRRHTGYDHGYFFISTFIADHIRHHAGQL
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLELLSEHGCHGGVQRFYRHASATIGLPMRFSVYLPPQALAGGGKLPALFYLAGLTCTE
CHHHHHHCCCCHHHHHHHHHHCCEECCCEEEEEEECHHHHCCCCCCHHHHHHHCCCCCC
ETFMIKAGAQRFAAEHGLVLVAPDTSPRGAGVPGEADAWDFGVGAGFYVDATEAPWNTHW
CEEEEEHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCC
GMESYVTQELFDLVSRELPVDPDRVGIFGHSMGGHGALVLAQRHPQRFRSVSAFAPIAAP
CHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHCCCCCC
TRCPWGQKAFTGYLGTDRSRWDEYDASALMAAQKVAPFPAGILVDQGLSDQFLQNQLHPE
CCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHCCCHH
ALEAACAAVGQPLTLRRHTGYDHGYFFISTFIADHIRHHAGQL
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]