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The map label for this gene is mmgC [H]

Identifier: 73537716

GI number: 73537716

Start: 503107

End: 504294

Strand: Direct

Name: mmgC [H]

Synonym: Reut_B3882

Alternate gene names: 73537716

Gene position: 503107-504294 (Clockwise)

Preceding gene: 73537715

Following gene: 73537725

Centisome position: 18.45

GC content: 63.72

Gene sequence:

>1188_bases
ATGATCCGTGACACCGCTCGCCTCGAGAAAATACTGGCTGACATCCGCCGGTTCGTTGCCGAAACCTGCATCCCGCTGGA
AGCCTCCATCGATGCTGACGATGCCATCCCGGCAGACGTCGTCGATGCCATGCGAAGACTTGGCCTGTTCGGTCATAGCA
TTCCGGAAGCCTTCGGAGGTGCCGGACTGACTTCGGAAGAGCTTACGCTGGTCAATATCGAAGTCTCGCAAGCTGCTACG
ACGTTTCGTGCACGCTTCGGTGGCAATACCGGCATTGCGTCGGAGTCGCTGGTGGTGGACGGTACCGAGGCCCAGAAAGA
TCGCTACCTGCCCCGCCTTGCCTCCGGGGAACTCACCGGCTGCTTCGCGCTGACCGAGCCGGATGCCGGTTCCGACGCCA
CGTCACTGCGTACCACCGCACGGCGCGAGGGCGACCACTATGTACTCGACGGCACCAAGTGCTTCATCACCAATGCGCCG
ATTGCCGATCTGTTCACGGTCTTCGCGCGTAGCGAGCCTGGCGTCGCCGGCGCGCCCGGCATCAGCGCGTTCCTGATCGA
GCGCGGCACTCCCGGTCTGACCACTGGCCCGGCCGAGCGCAAGATGGGGCAGCACGGCTCGCCAGTGGGCGACGTCTACC
TTGAGAATTGCCGCGTGCCTGCCAGCGCCATCGTCGGCGGCAAGCCAGGCACCGGTTTCAAGACTGCAATGAAGGCGCTC
AACAAGCAACGGATCAACCTGGCGGGGCTCTGCATCGGTCCGGCCGTACGCCTGGTCGACGAAATGGTTCGCTACGCGAC
ACGGCGCAGTCAGTTCGGCAAGCCGATTGCCGACTACCAGCTCGTGCAGCAGATGATCGCCGACAGTAACACCGAACTGC
ATGCGGCGCGTGCGTTGGTGCTGGAAACGGCGCGCCGCCGCGACAATGGCGAGGATGTCACGATGGAAGCGTCGATGTGC
AAGATGTTTGCCTCCGAGATGGCCGGCCGTGTGGCCGACCGCGCGGTGCAAGTATTTGGCGGCAGTGGCTACATGGCCCG
CACCGTGGCGGAGCGGTTCTATCGCGACGTCCGCGTGTTCCGTTTGTATGAAGGCACGACGCAGATCCACCAGCTCAATA
TCGCCCGCCGCACTCTTGCTGCGCGGACAGAGGCTCTGGGTATCGCCGCGGAGCCTGTGGGGGACTGA

Upstream 100 bases:

>100_bases
ACGCGGGCATGGGCGGAAGCTGAGCCCCGGATGTGTTGTACCGCGCCGGCTCGCCGGCGCCTCGCCCAAGTTATCTTTAT
CGACAGGAAACAGATACACC

Downstream 100 bases:

>100_bases
TTCATGCGAGCGCGACGGTTACCCGGGAGCGCGGCGGCATTGCACGCATGATCTGTTGAATCAGGCCAGGCACGCCGACG
CATTCGAAGACCACATCGGC

Product: butyryl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MIRDTARLEKILADIRRFVAETCIPLEASIDADDAIPADVVDAMRRLGLFGHSIPEAFGGAGLTSEELTLVNIEVSQAAT
TFRARFGGNTGIASESLVVDGTEAQKDRYLPRLASGELTGCFALTEPDAGSDATSLRTTARREGDHYVLDGTKCFITNAP
IADLFTVFARSEPGVAGAPGISAFLIERGTPGLTTGPAERKMGQHGSPVGDVYLENCRVPASAIVGGKPGTGFKTAMKAL
NKQRINLAGLCIGPAVRLVDEMVRYATRRSQFGKPIADYQLVQQMIADSNTELHAARALVLETARRRDNGEDVTMEASMC
KMFASEMAGRVADRAVQVFGGSGYMARTVAERFYRDVRVFRLYEGTTQIHQLNIARRTLAARTEALGIAAEPVGD

Sequences:

>Translated_395_residues
MIRDTARLEKILADIRRFVAETCIPLEASIDADDAIPADVVDAMRRLGLFGHSIPEAFGGAGLTSEELTLVNIEVSQAAT
TFRARFGGNTGIASESLVVDGTEAQKDRYLPRLASGELTGCFALTEPDAGSDATSLRTTARREGDHYVLDGTKCFITNAP
IADLFTVFARSEPGVAGAPGISAFLIERGTPGLTTGPAERKMGQHGSPVGDVYLENCRVPASAIVGGKPGTGFKTAMKAL
NKQRINLAGLCIGPAVRLVDEMVRYATRRSQFGKPIADYQLVQQMIADSNTELHAARALVLETARRRDNGEDVTMEASMC
KMFASEMAGRVADRAVQVFGGSGYMARTVAERFYRDVRVFRLYEGTTQIHQLNIARRTLAARTEALGIAAEPVGD
>Mature_395_residues
MIRDTARLEKILADIRRFVAETCIPLEASIDADDAIPADVVDAMRRLGLFGHSIPEAFGGAGLTSEELTLVNIEVSQAAT
TFRARFGGNTGIASESLVVDGTEAQKDRYLPRLASGELTGCFALTEPDAGSDATSLRTTARREGDHYVLDGTKCFITNAP
IADLFTVFARSEPGVAGAPGISAFLIERGTPGLTTGPAERKMGQHGSPVGDVYLENCRVPASAIVGGKPGTGFKTAMKAL
NKQRINLAGLCIGPAVRLVDEMVRYATRRSQFGKPIADYQLVQQMIADSNTELHAARALVLETARRRDNGEDVTMEASMC
KMFASEMAGRVADRAVQVFGGSGYMARTVAERFYRDVRVFRLYEGTTQIHQLNIARRTLAARTEALGIAAEPVGD

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=38.8140161725067, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI4557235, Length=381, Percent_Identity=36.4829396325459, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI76496475, Length=381, Percent_Identity=36.4829396325459, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI226958412, Length=363, Percent_Identity=34.1597796143251, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI226958414, Length=374, Percent_Identity=33.6898395721925, Blast_Score=231, Evalue=6e-61,
Organism=Homo sapiens, GI21361497, Length=382, Percent_Identity=35.0785340314136, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=34.8773841961853, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=32.8912466843501, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=32.8912466843501, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI7656849, Length=365, Percent_Identity=33.972602739726, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4501857, Length=371, Percent_Identity=31.8059299191375, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=30.4232804232804, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI7669494, Length=345, Percent_Identity=30.7246376811594, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI48976061, Length=402, Percent_Identity=31.592039800995, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI211971008, Length=402, Percent_Identity=31.592039800995, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI38505218, Length=420, Percent_Identity=26.4285714285714, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1786223, Length=378, Percent_Identity=28.8359788359788, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI87081958, Length=378, Percent_Identity=29.8941798941799, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87081702, Length=334, Percent_Identity=27.8443113772455, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082384, Length=288, Percent_Identity=26.0416666666667, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17569725, Length=365, Percent_Identity=35.6164383561644, Blast_Score=240, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=35.978835978836, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71985184, Length=376, Percent_Identity=36.968085106383, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17506239, Length=369, Percent_Identity=36.8563685636856, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17508101, Length=366, Percent_Identity=35.2459016393443, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17534899, Length=371, Percent_Identity=34.7708894878706, Blast_Score=231, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17538396, Length=369, Percent_Identity=33.0623306233062, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17533517, Length=374, Percent_Identity=33.4224598930481, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI71990804, Length=286, Percent_Identity=38.1118881118881, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI71985192, Length=323, Percent_Identity=34.984520123839, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17505929, Length=361, Percent_Identity=29.9168975069252, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17534353, Length=368, Percent_Identity=28.5326086956522, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI32563615, Length=235, Percent_Identity=37.0212765957447, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17551932, Length=376, Percent_Identity=28.1914893617021, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71982178, Length=271, Percent_Identity=31.3653136531365, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=34.0248962655602, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17562446, Length=342, Percent_Identity=30.4093567251462, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17531913, Length=175, Percent_Identity=33.7142857142857, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=291, Percent_Identity=28.1786941580756, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=291, Percent_Identity=28.1786941580756, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356377, Length=352, Percent_Identity=38.3522727272727, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI281363737, Length=352, Percent_Identity=36.0795454545455, Blast_Score=234, Evalue=7e-62,
Organism=Drosophila melanogaster, GI24660351, Length=383, Percent_Identity=33.9425587467363, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24666513, Length=369, Percent_Identity=36.0433604336043, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24646207, Length=364, Percent_Identity=35.4395604395604, Blast_Score=207, Evalue=7e-54,
Organism=Drosophila melanogaster, GI21355753, Length=364, Percent_Identity=32.4175824175824, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI19920834, Length=342, Percent_Identity=30.7017543859649, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24652780, Length=370, Percent_Identity=24.8648648648649, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42422; Mature: 42422

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRDTARLEKILADIRRFVAETCIPLEASIDADDAIPADVVDAMRRLGLFGHSIPEAFGG
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHCC
AGLTSEELTLVNIEVSQAATTFRARFGGNTGIASESLVVDGTEAQKDRYLPRLASGELTG
CCCCCCCEEEEEEEHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHCCCCCCCCCCEE
CFALTEPDAGSDATSLRTTARREGDHYVLDGTKCFITNAPIADLFTVFARSEPGVAGAPG
EEEECCCCCCCCHHHHHHHHHHCCCEEEECCCEEEEECCCHHHHHHHHHCCCCCCCCCCC
ISAFLIERGTPGLTTGPAERKMGQHGSPVGDVYLENCRVPASAIVGGKPGTGFKTAMKAL
CEEEEEECCCCCCCCCCHHHHCCCCCCCHHHHHHHCCCCCHHHEECCCCCCCHHHHHHHH
NKQRINLAGLCIGPAVRLVDEMVRYATRRSQFGKPIADYQLVQQMIADSNTELHAARALV
HHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
LETARRRDNGEDVTMEASMCKMFASEMAGRVADRAVQVFGGSGYMARTVAERFYRDVRVF
HHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHE
RLYEGTTQIHQLNIARRTLAARTEALGIAAEPVGD
EEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIRDTARLEKILADIRRFVAETCIPLEASIDADDAIPADVVDAMRRLGLFGHSIPEAFGG
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHCC
AGLTSEELTLVNIEVSQAATTFRARFGGNTGIASESLVVDGTEAQKDRYLPRLASGELTG
CCCCCCCEEEEEEEHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHCCCCCCCCCCEE
CFALTEPDAGSDATSLRTTARREGDHYVLDGTKCFITNAPIADLFTVFARSEPGVAGAPG
EEEECCCCCCCCHHHHHHHHHHCCCEEEECCCEEEEECCCHHHHHHHHHCCCCCCCCCCC
ISAFLIERGTPGLTTGPAERKMGQHGSPVGDVYLENCRVPASAIVGGKPGTGFKTAMKAL
CEEEEEECCCCCCCCCCHHHHCCCCCCCHHHHHHHCCCCCHHHEECCCCCCCHHHHHHHH
NKQRINLAGLCIGPAVRLVDEMVRYATRRSQFGKPIADYQLVQQMIADSNTELHAARALV
HHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
LETARRRDNGEDVTMEASMCKMFASEMAGRVADRAVQVFGGSGYMARTVAERFYRDVRVF
HHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHE
RLYEGTTQIHQLNIARRTLAARTEALGIAAEPVGD
EEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]