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The map label for this gene is 73537725

Identifier: 73537725

GI number: 73537725

Start: 514356

End: 515957

Strand: Direct

Name: 73537725

Synonym: Reut_B3891

Alternate gene names: NA

Gene position: 514356-515957 (Clockwise)

Preceding gene: 73537716

Following gene: 73537726

Centisome position: 18.87

GC content: 67.54

Gene sequence:

>1602_bases
ATGGCTTGTGCGGTACTGGATCCGATGCACGAACGAGAACTCCGGAGACACACCGTGACCTGGCAGCCCGAAATTGACGA
ACTCGCCTACCGCCGCCGCCTGGCCGAGCGCATGGGCGGCGAAGAGAAAGTGGCGCGCCACCGCGAGGCCGGCAAGCTGA
CCGTGCGCGATCGCGTCGCCGGCATTGCCGACCCGGGATCGTTCCGCGAGGTCGGTGGCCTGAGCGGCAGCGGCCGCTAT
GACAGCAATGGCCGGCTGGTGGACCTGGTGCCGTCGAACCTCGTGATGGGCCGCGCGAAGATGGGCGGGCGGCCCGTGGT
GCTGGTGGGCGACGATTTCACGGTGCGTGGCGGCGCCAACGATGGCGCGGTTGGCGACAAGCTCGTCCACGCCGAGAAGA
TGGCGCACGATCTGCGCCTGCCGATGGTGCGGCTTGTCGACGGCACCGGCGGTGGTGGTTCGGTGCGCAATATCGAGATC
AAGGGCCACACGCTGATTCCCACCATGAAGGTCTGGCAGCACGTGGTCGAGAACATGTCGGTGGTGCCCGTGGTGTCGCT
GGCGCTCGGGTCCGTCGCGGGCATGGGCGCTGCACGCGTGGCAGCCAGCCATTACTCGGTGATGGTCAAGGAAACCTCGC
AACTGTTCACCGAAGGCCCGCCCGTGGTCGCGCACATCGGCCAGCAACTGAGCAAGAACGAACTGGGTGGCAGCCACATC
CACACGCGCAATGGCGTGGTCGACGACGAAGTCGCCACGGAGCGGGACGCGTTCGAGCATGCCCGCCGCTTCCTGTCCTA
CTTGCCGGCGTCGGTCCACGAACTCCCGCCGCGCACCGAGCCGTCCGATGATCCCGCCCGCCGCGACGAATGGCTGCTCT
CTGCGATTCCGCGTGACAGCCGCGCGGTCTACAAGATCCGCCCGATCGTGCAGGCGCTCGTGGACGACGGTTCGTTCTTC
GAGATCGGCCGGCAATGGGGTTGCGCCATCGTCACCGGGCTGGCCCGGCTCGATGGCTGGCCTGTGGCCGTGATCGCCAG
CGACCCGTACTTCCATGGTGGCGGCTGGGACAGCGCGACCGCCGAGAAATTCACGCGCTTCGTCGACCTGGCGCAGACCT
TCCACCTGCCCGTGGTCAATCTTGTCGACACGGCTGGCTTCCTGATCGGCCAGGAGGCCGAGCAGGCCGCGACCATGCGC
CACGGCGTGCGCGCGCTCGCAGCGGTCTACCAGGCGACCGTGCCGTGGTGCTCGGTCATCCTGCGCCGCGCGTATGGCAT
GTCCGCGGCCGCGCACCAGCATATGGGCCGCTTCAATTGCCGCTATGCATGGCCTTCGGCGAACTGGGGCGCGATGCCGA
TTGAAGGCGGGCTCGAAGTCGCCTACAAGGCCGAGATCGAAGGCGCGGATGATCCGGTGCAGAAGCGCGCCGAGATCGAA
CAGCGCGTGCGCAGCCTGACCTCGCCATTCCGCAGCGCCGAAGCCTTCGTCATCGAAGACATCATCGACCCGCGCGAGAC
CCGCACGCTGCTGTGCGAATTTGCCAACCTGGCGGCGCCGCTGCGCGAAGCGGGCATCAGCCGCTTCGGCATCCGTCCCT
GA

Upstream 100 bases:

>100_bases
CCTCTGTGTGGACACATCCTGTCGTTATCGCGGACATCATAGCTGCGCAAAAAAGAATCCTCAATGAAATCAACGGCTCG
CGGGGTGTCGCCGGGTTGGC

Downstream 100 bases:

>100_bases
GCGGGCCGCAGCAACAAGCACGCAATACCAGTCACTGGCCGCAGAAGCCGCAATCTGAACGAGGAGACAAAATTGAACAA
GCTGTTGATCGCCAATCGGG

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MACAVLDPMHERELRRHTVTWQPEIDELAYRRRLAERMGGEEKVARHREAGKLTVRDRVAGIADPGSFREVGGLSGSGRY
DSNGRLVDLVPSNLVMGRAKMGGRPVVLVGDDFTVRGGANDGAVGDKLVHAEKMAHDLRLPMVRLVDGTGGGGSVRNIEI
KGHTLIPTMKVWQHVVENMSVVPVVSLALGSVAGMGAARVAASHYSVMVKETSQLFTEGPPVVAHIGQQLSKNELGGSHI
HTRNGVVDDEVATERDAFEHARRFLSYLPASVHELPPRTEPSDDPARRDEWLLSAIPRDSRAVYKIRPIVQALVDDGSFF
EIGRQWGCAIVTGLARLDGWPVAVIASDPYFHGGGWDSATAEKFTRFVDLAQTFHLPVVNLVDTAGFLIGQEAEQAATMR
HGVRALAAVYQATVPWCSVILRRAYGMSAAAHQHMGRFNCRYAWPSANWGAMPIEGGLEVAYKAEIEGADDPVQKRAEIE
QRVRSLTSPFRSAEAFVIEDIIDPRETRTLLCEFANLAAPLREAGISRFGIRP

Sequences:

>Translated_533_residues
MACAVLDPMHERELRRHTVTWQPEIDELAYRRRLAERMGGEEKVARHREAGKLTVRDRVAGIADPGSFREVGGLSGSGRY
DSNGRLVDLVPSNLVMGRAKMGGRPVVLVGDDFTVRGGANDGAVGDKLVHAEKMAHDLRLPMVRLVDGTGGGGSVRNIEI
KGHTLIPTMKVWQHVVENMSVVPVVSLALGSVAGMGAARVAASHYSVMVKETSQLFTEGPPVVAHIGQQLSKNELGGSHI
HTRNGVVDDEVATERDAFEHARRFLSYLPASVHELPPRTEPSDDPARRDEWLLSAIPRDSRAVYKIRPIVQALVDDGSFF
EIGRQWGCAIVTGLARLDGWPVAVIASDPYFHGGGWDSATAEKFTRFVDLAQTFHLPVVNLVDTAGFLIGQEAEQAATMR
HGVRALAAVYQATVPWCSVILRRAYGMSAAAHQHMGRFNCRYAWPSANWGAMPIEGGLEVAYKAEIEGADDPVQKRAEIE
QRVRSLTSPFRSAEAFVIEDIIDPRETRTLLCEFANLAAPLREAGISRFGIRP
>Mature_532_residues
ACAVLDPMHERELRRHTVTWQPEIDELAYRRRLAERMGGEEKVARHREAGKLTVRDRVAGIADPGSFREVGGLSGSGRYD
SNGRLVDLVPSNLVMGRAKMGGRPVVLVGDDFTVRGGANDGAVGDKLVHAEKMAHDLRLPMVRLVDGTGGGGSVRNIEIK
GHTLIPTMKVWQHVVENMSVVPVVSLALGSVAGMGAARVAASHYSVMVKETSQLFTEGPPVVAHIGQQLSKNELGGSHIH
TRNGVVDDEVATERDAFEHARRFLSYLPASVHELPPRTEPSDDPARRDEWLLSAIPRDSRAVYKIRPIVQALVDDGSFFE
IGRQWGCAIVTGLARLDGWPVAVIASDPYFHGGGWDSATAEKFTRFVDLAQTFHLPVVNLVDTAGFLIGQEAEQAATMRH
GVRALAAVYQATVPWCSVILRRAYGMSAAAHQHMGRFNCRYAWPSANWGAMPIEGGLEVAYKAEIEGADDPVQKRAEIEQ
RVRSLTSPFRSAEAFVIEDIIDPRETRTLLCEFANLAAPLREAGISRFGIRP

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=489, Percent_Identity=31.4928425357873, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI295821216, Length=511, Percent_Identity=31.1154598825832, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI11545863, Length=524, Percent_Identity=27.0992366412214, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI38679974, Length=174, Percent_Identity=29.8850574712644, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI38679971, Length=174, Percent_Identity=29.8850574712644, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI38679960, Length=174, Percent_Identity=29.8850574712644, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI38679977, Length=174, Percent_Identity=29.8850574712644, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI38679967, Length=174, Percent_Identity=29.8850574712644, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI134142062, Length=214, Percent_Identity=28.9719626168224, Blast_Score=71, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25147359, Length=517, Percent_Identity=31.5280464216634, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25147362, Length=505, Percent_Identity=31.6831683168317, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=28.3302063789869, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71997163, Length=260, Percent_Identity=25.7692307692308, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586065, Length=528, Percent_Identity=27.8409090909091, Blast_Score=165, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 58276; Mature: 58145

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACAVLDPMHERELRRHTVTWQPEIDELAYRRRLAERMGGEEKVARHREAGKLTVRDRVA
CCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEHHHHC
GIADPGSFREVGGLSGSGRYDSNGRLVDLVPSNLVMGRAKMGGRPVVLVGDDFTVRGGAN
CCCCCCCHHHHCCCCCCCCCCCCCCEEEECCCCHHEEHHHCCCCEEEEECCCEEEECCCC
DGAVGDKLVHAEKMAHDLRLPMVRLVDGTGGGGSVRNIEIKGHTLIPTMKVWQHVVENMS
CCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCEECCHHHHHHHHHHCCC
VVPVVSLALGSVAGMGAARVAASHYSVMVKETSQLFTEGPPVVAHIGQQLSKNELGGSHI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEE
HTRNGVVDDEVATERDAFEHARRFLSYLPASVHELPPRTEPSDDPARRDEWLLSAIPRDS
ECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCC
RAVYKIRPIVQALVDDGSFFEIGRQWGCAIVTGLARLDGWPVAVIASDPYFHGGGWDSAT
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEECCCCCCCHH
AEKFTRFVDLAQTFHLPVVNLVDTAGFLIGQEAEQAATMRHGVRALAAVYQATVPWCSVI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRRAYGMSAAAHQHMGRFNCRYAWPSANWGAMPIEGGLEVAYKAEIEGADDPVQKRAEIE
HHHHHCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHH
QRVRSLTSPFRSAEAFVIEDIIDPRETRTLLCEFANLAAPLREAGISRFGIRP
HHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ACAVLDPMHERELRRHTVTWQPEIDELAYRRRLAERMGGEEKVARHREAGKLTVRDRVA
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEHHHHC
GIADPGSFREVGGLSGSGRYDSNGRLVDLVPSNLVMGRAKMGGRPVVLVGDDFTVRGGAN
CCCCCCCHHHHCCCCCCCCCCCCCCEEEECCCCHHEEHHHCCCCEEEEECCCEEEECCCC
DGAVGDKLVHAEKMAHDLRLPMVRLVDGTGGGGSVRNIEIKGHTLIPTMKVWQHVVENMS
CCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCEECCHHHHHHHHHHCCC
VVPVVSLALGSVAGMGAARVAASHYSVMVKETSQLFTEGPPVVAHIGQQLSKNELGGSHI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEE
HTRNGVVDDEVATERDAFEHARRFLSYLPASVHELPPRTEPSDDPARRDEWLLSAIPRDS
ECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCC
RAVYKIRPIVQALVDDGSFFEIGRQWGCAIVTGLARLDGWPVAVIASDPYFHGGGWDSAT
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEECCCCCCCHH
AEKFTRFVDLAQTFHLPVVNLVDTAGFLIGQEAEQAATMRHGVRALAAVYQATVPWCSVI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRRAYGMSAAAHQHMGRFNCRYAWPSANWGAMPIEGGLEVAYKAEIEGADDPVQKRAEIE
HHHHHCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHH
QRVRSLTSPFRSAEAFVIEDIIDPRETRTLLCEFANLAAPLREAGISRFGIRP
HHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]