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The map label for this gene is cobS [H]

Identifier: 73537590

GI number: 73537590

Start: 352305

End: 353273

Strand: Direct

Name: cobS [H]

Synonym: Reut_B3755

Alternate gene names: 73537590

Gene position: 352305-353273 (Clockwise)

Preceding gene: 73537589

Following gene: 73537591

Centisome position: 12.92

GC content: 65.74

Gene sequence:

>969_bases
ATGGTGCCGGTGCGCAGCCTGTTCGGTATCGATTCCGGCCTGATGGTGCCGGCGTTCAGCGAACGCGATGACCATGTGCC
GGAGATCGATCCGGCCTACCGTTTCCAGCCCGAGGTGACGCTGGCCATCCTGTCGGGCTTCATGCGCGACCGGCGCGTGA
TGGTGCAGGGCCTGCACGGCACCGGTAAATCGACGCATATCGAGCAGGTTGCGGCGCGCCTGAACTGGCCGTGCGTGCGC
GTGAACCTCGACGGGCACATCAGCCGGCTCGACCTGGTCGGCAAGGATGCAATCGTCATCCGTGACGGGCAGCAGATCAC
CGAGTTCCAGGAAGGTATCGTGCCGTGGGCGCTGCAGCGGCCCGTCGCGCTGATCTTCGACGAGTACGATGCGGGCCGGC
CCGACGTGATGTTCGTGATCCAGCGAATCCTCGAACGCGACGGCAAGTTCACGCTGCTGGACCAGAATCGCGTGATTCGT
CCGCATCCATCGTTCCGTCTGTTTGCGACGTCCAACACGGTAGGCCTCGGCAATCTCAACGGGCTGTACCACGGCACCCA
GCTCCTGAATCACGCGCAGATCGACCGCTGGAACGTGGTCGCCACGCTCGACTACCTGCCGCATGCGGAAGAGACAGGCA
TCGTGCTGGCGCGCGTGCCGGAACTCGACAACACCGACGGCCGCGAACTGGTCGATGCCATGGTGGCACTGGCCGCGCTC
ACGCGGCGCGGGTTTGCCGCGGGCGATGTGTCAGCCCTGATGTCGCCGCGTACCGTGATCAGCTGGGCGGAGAACTGCCA
GATCTTCCGCGATCCTGCACTCGCGTTCCGCCTGACCTTCCTGAACAAGTGCGACGAGGCCGAACGGCCGGTGGTGGCGG
AGTACTACCAGCGCTGCTTCGGCAACCTGCCCGGTGAAGCGGCGGGGCAGGCGGCCAGCAACGCGACCCGACCGGAGCCG
GCGCAATGA

Upstream 100 bases:

>100_bases
AGGCTCCCGGCTTGTCTGCTGTCCGCCACAAGAAGGACACAAGCAAGGCAAGCAAGAGGAGCAAGACGTGACGCAGAAGG
AGTTTGGCAGACCGGACCGC

Downstream 100 bases:

>100_bases
GCGCGGCGGCGGCCGCGCAACGGCTGCGCCGGCGACAGCGGCAGGATGCGCTGTCGGGTGCCGCCGTGCGTGCGCTCACC
GGAGATGCGGCGCTGCATTT

Product: hydrogenobyrinic acid a,c-diamide cobaltochelatase

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobS [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MVPVRSLFGIDSGLMVPAFSERDDHVPEIDPAYRFQPEVTLAILSGFMRDRRVMVQGLHGTGKSTHIEQVAARLNWPCVR
VNLDGHISRLDLVGKDAIVIRDGQQITEFQEGIVPWALQRPVALIFDEYDAGRPDVMFVIQRILERDGKFTLLDQNRVIR
PHPSFRLFATSNTVGLGNLNGLYHGTQLLNHAQIDRWNVVATLDYLPHAEETGIVLARVPELDNTDGRELVDAMVALAAL
TRRGFAAGDVSALMSPRTVISWAENCQIFRDPALAFRLTFLNKCDEAERPVVAEYYQRCFGNLPGEAAGQAASNATRPEP
AQ

Sequences:

>Translated_322_residues
MVPVRSLFGIDSGLMVPAFSERDDHVPEIDPAYRFQPEVTLAILSGFMRDRRVMVQGLHGTGKSTHIEQVAARLNWPCVR
VNLDGHISRLDLVGKDAIVIRDGQQITEFQEGIVPWALQRPVALIFDEYDAGRPDVMFVIQRILERDGKFTLLDQNRVIR
PHPSFRLFATSNTVGLGNLNGLYHGTQLLNHAQIDRWNVVATLDYLPHAEETGIVLARVPELDNTDGRELVDAMVALAAL
TRRGFAAGDVSALMSPRTVISWAENCQIFRDPALAFRLTFLNKCDEAERPVVAEYYQRCFGNLPGEAAGQAASNATRPEP
AQ
>Mature_322_residues
MVPVRSLFGIDSGLMVPAFSERDDHVPEIDPAYRFQPEVTLAILSGFMRDRRVMVQGLHGTGKSTHIEQVAARLNWPCVR
VNLDGHISRLDLVGKDAIVIRDGQQITEFQEGIVPWALQRPVALIFDEYDAGRPDVMFVIQRILERDGKFTLLDQNRVIR
PHPSFRLFATSNTVGLGNLNGLYHGTQLLNHAQIDRWNVVATLDYLPHAEETGIVLARVPELDNTDGRELVDAMVALAAL
TRRGFAAGDVSALMSPRTVISWAENCQIFRDPALAFRLTFLNKCDEAERPVVAEYYQRCFGNLPGEAAGQAASNATRPEP
AQ

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG0714

COG function: function code R; MoxR-like ATPases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24415404, Length=246, Percent_Identity=27.6422764227642, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323135, Length=186, Percent_Identity=25.2688172043011, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161076562, Length=185, Percent_Identity=27.5675675675676, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161076560, Length=185, Percent_Identity=27.5675675675676, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011704
- InterPro:   IPR006537 [H]

Pfam domain/function: PF07728 AAA_5 [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 35839; Mature: 35839

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPVRSLFGIDSGLMVPAFSERDDHVPEIDPAYRFQPEVTLAILSGFMRDRRVMVQGLHG
CCCCHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCC
TGKSTHIEQVAARLNWPCVRVNLDGHISRLDLVGKDAIVIRDGQQITEFQEGIVPWALQR
CCCCHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCEEEEECCHHHHHHHHCCCCHHHHC
PVALIFDEYDAGRPDVMFVIQRILERDGKFTLLDQNRVIRPHPSFRLFATSNTVGLGNLN
CEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCEECCCCCEEEEEECCEECCCCCC
GLYHGTQLLNHAQIDRWNVVATLDYLPHAEETGIVLARVPELDNTDGRELVDAMVALAAL
CHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
TRRGFAAGDVSALMSPRTVISWAENCQIFRDPALAFRLTFLNKCDEAERPVVAEYYQRCF
HHCCCCCCCHHHHHCCHHHHHHHHCCEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
GNLPGEAAGQAASNATRPEPAQ
CCCCCHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MVPVRSLFGIDSGLMVPAFSERDDHVPEIDPAYRFQPEVTLAILSGFMRDRRVMVQGLHG
CCCCHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCC
TGKSTHIEQVAARLNWPCVRVNLDGHISRLDLVGKDAIVIRDGQQITEFQEGIVPWALQR
CCCCHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCEEEEECCHHHHHHHHCCCCHHHHC
PVALIFDEYDAGRPDVMFVIQRILERDGKFTLLDQNRVIRPHPSFRLFATSNTVGLGNLN
CEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCEECCCCCEEEEEECCEECCCCCC
GLYHGTQLLNHAQIDRWNVVATLDYLPHAEETGIVLARVPELDNTDGRELVDAMVALAAL
CHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
TRRGFAAGDVSALMSPRTVISWAENCQIFRDPALAFRLTFLNKCDEAERPVVAEYYQRCF
HHCCCCCCCHHHHHCCHHHHHHHHCCEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
GNLPGEAAGQAASNATRPEPAQ
CCCCCHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]