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The map label for this gene is alsR [H]

Identifier: 73537396

GI number: 73537396

Start: 114281

End: 115174

Strand: Direct

Name: alsR [H]

Synonym: Reut_B3561

Alternate gene names: 73537396

Gene position: 114281-115174 (Clockwise)

Preceding gene: 73537390

Following gene: 73537399

Centisome position: 4.19

GC content: 68.12

Gene sequence:

>894_bases
ATGGATCTGCGTCAACTCCAGCAGTTCGTTGCCCTGGCCGAGACCGGCAACTTCCACCGGGCTGCCGAACGCCTGCACAT
GGCGCAGCCGCCGCTGTCCATTTCCATCCGCAAGCTCGAAGAGCAGCTCGGCACCGCGCTGTTCGTGAGAACACCGCGCG
GCGTGAGGCTGACCCAGGCCGGAGAAGCAGCGCTGCAGGATGCGCGGCGCGCGTTGTTCCATGCGGGGCAGGCACGCGCC
GCGGCGATGGCGGCTGCGCAAGGCGAACGCGGCGCGCTGCGGATCGGCTTTGTCGGTTCAGCGACCTATGCGCTGCTGCC
CAAGCTGATCCCCGCCTTCCGCGCCGCTCACCCGGGGATCGAGCTAGTGCTGCATGAATCCACCACCGCGAACATCCTGG
ACCAGCTCGAGAAGCACCGGCTGGATGCCGGGCTGGTGCGCTTCCCGATCCTGAGCAGCGGCGGCTACACGCTGACACCG
CTGGAGAGCGACGTCTTCGTCGCGGCCGTGCCTGCGGACAGCCCGCATGCGAAGGAGGAATCGATTCCGCTGAAGGCGCT
CGCGGCCGAGCCGTTCATCATGCATCCGGCGGCGGCGGTGCCGAACCTGCATGCGGTGTCAATGATGCTGTGCCAGCAAG
CCGGGTTTGTGCCGCGCGTGGCGCAGGAGGCGGTGCAGGTCCAGACCATTATCAGTCTGGTGGAGAGTGGGCTTGGCGTG
GCACTGGTGCCTAGCGTGGCGACGCGGTATGCGAACCGGCGGGTGCGGTTTTTGCCGCTCTCCAGCCCGCGGCCGGCGGG
GCGGATCGGGATTGCGTTCGCGGCGCGGGCCGATGATGCGGATCGGCAGGTGGAGAGGTTTTTGGGGGCGGCGTTGGAGG
CGGTGGGGGGTTAA

Upstream 100 bases:

>100_bases
GTCTGTCTCCGGATCTTTACTGTGGAGCACAGCGTAGATCACCGGGACATGTCTGGTCTAATATTAGTTTTTTAGAAACT
GATATTCACTGGATATCGAG

Downstream 100 bases:

>100_bases
AAGGGGCCTTTGGGTTGGGGTTGGGGTGTCGCTCTTGGCCCGCGAAACAGCAGCGCCGGCCAAGAGCGACAATCCTCACC
TGCTTTTCCCTTGCCTCCCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MDLRQLQQFVALAETGNFHRAAERLHMAQPPLSISIRKLEEQLGTALFVRTPRGVRLTQAGEAALQDARRALFHAGQARA
AAMAAAQGERGALRIGFVGSATYALLPKLIPAFRAAHPGIELVLHESTTANILDQLEKHRLDAGLVRFPILSSGGYTLTP
LESDVFVAAVPADSPHAKEESIPLKALAAEPFIMHPAAAVPNLHAVSMMLCQQAGFVPRVAQEAVQVQTIISLVESGLGV
ALVPSVATRYANRRVRFLPLSSPRPAGRIGIAFAARADDADRQVERFLGAALEAVGG

Sequences:

>Translated_297_residues
MDLRQLQQFVALAETGNFHRAAERLHMAQPPLSISIRKLEEQLGTALFVRTPRGVRLTQAGEAALQDARRALFHAGQARA
AAMAAAQGERGALRIGFVGSATYALLPKLIPAFRAAHPGIELVLHESTTANILDQLEKHRLDAGLVRFPILSSGGYTLTP
LESDVFVAAVPADSPHAKEESIPLKALAAEPFIMHPAAAVPNLHAVSMMLCQQAGFVPRVAQEAVQVQTIISLVESGLGV
ALVPSVATRYANRRVRFLPLSSPRPAGRIGIAFAARADDADRQVERFLGAALEAVGG
>Mature_297_residues
MDLRQLQQFVALAETGNFHRAAERLHMAQPPLSISIRKLEEQLGTALFVRTPRGVRLTQAGEAALQDARRALFHAGQARA
AAMAAAQGERGALRIGFVGSATYALLPKLIPAFRAAHPGIELVLHESTTANILDQLEKHRLDAGLVRFPILSSGGYTLTP
LESDVFVAAVPADSPHAKEESIPLKALAAEPFIMHPAAAVPNLHAVSMMLCQQAGFVPRVAQEAVQVQTIISLVESGLGV
ALVPSVATRYANRRVRFLPLSSPRPAGRIGIAFAARADDADRQVERFLGAALEAVGG

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=265, Percent_Identity=35.0943396226415, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1790399, Length=277, Percent_Identity=34.2960288808664, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1788887, Length=273, Percent_Identity=35.8974358974359, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1787879, Length=279, Percent_Identity=34.7670250896057, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI157672245, Length=248, Percent_Identity=34.2741935483871, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI145693105, Length=253, Percent_Identity=28.4584980237154, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1788297, Length=254, Percent_Identity=30.3149606299213, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790208, Length=257, Percent_Identity=30.7392996108949, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788748, Length=247, Percent_Identity=25.9109311740891, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=25.8964143426295, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI87081904, Length=281, Percent_Identity=29.1814946619217, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=34.4827586206897, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787806, Length=150, Percent_Identity=30, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786401, Length=135, Percent_Identity=34.0740740740741, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787589, Length=142, Percent_Identity=35.9154929577465, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786713, Length=72, Percent_Identity=50, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790262, Length=245, Percent_Identity=26.530612244898, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI48994962, Length=145, Percent_Identity=32.4137931034483, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI145693193, Length=120, Percent_Identity=38.3333333333333, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1788296, Length=230, Percent_Identity=27.3913043478261, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31670; Mature: 31670

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRQLQQFVALAETGNFHRAAERLHMAQPPLSISIRKLEEQLGTALFVRTPRGVRLTQA
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCCCEEEHH
GEAALQDARRALFHAGQARAAAMAAAQGERGALRIGFVGSATYALLPKLIPAFRAAHPGI
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCE
ELVLHESTTANILDQLEKHRLDAGLVRFPILSSGGYTLTPLESDVFVAAVPADSPHAKEE
EEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCEEEEEECCCCCCCCCC
SIPLKALAAEPFIMHPAAAVPNLHAVSMMLCQQAGFVPRVAQEAVQVQTIISLVESGLGV
CCCHHHHCCCCCEECCHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCE
ALVPSVATRYANRRVRFLPLSSPRPAGRIGIAFAARADDADRQVERFLGAALEAVGG
EEHHHHHHHHHCCEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDLRQLQQFVALAETGNFHRAAERLHMAQPPLSISIRKLEEQLGTALFVRTPRGVRLTQA
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCCCEEEHH
GEAALQDARRALFHAGQARAAAMAAAQGERGALRIGFVGSATYALLPKLIPAFRAAHPGI
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCE
ELVLHESTTANILDQLEKHRLDAGLVRFPILSSGGYTLTPLESDVFVAAVPADSPHAKEE
EEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCEEEEEECCCCCCCCCC
SIPLKALAAEPFIMHPAAAVPNLHAVSMMLCQQAGFVPRVAQEAVQVQTIISLVESGLGV
CCCHHHHCCCCCEECCHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCE
ALVPSVATRYANRRVRFLPLSSPRPAGRIGIAFAARADDADRQVERFLGAALEAVGG
EEHHHHHHHHHCCEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]