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The map label for this gene is allD [C]

Identifier: 73537366

GI number: 73537366

Start: 77158

End: 78174

Strand: Direct

Name: allD [C]

Synonym: Reut_B3531

Alternate gene names: 73537366

Gene position: 77158-78174 (Clockwise)

Preceding gene: 73537365

Following gene: 73537367

Centisome position: 2.83

GC content: 69.32

Gene sequence:

>1017_bases
ATGAGCCGTATCCCGATGGAGAAGCTGGAAGTACTGGCCCGATCCGCTTTGCGGAGGGCCGGTGCGAGCCAATTGCAGTC
GCACGCCACAGCCGCGGCGCTGGTGCGGGCCGATGCCATGGGACTTGCCTCCCATGGCGTATCGCGCGTGCCGATGTATG
TCGGACACCTGAGGCACGATCGCGTGGACGGACAAGCGGTGCCGACCGTGCGCAGTACACGCGCCAGCGCCGTGCTGGTC
GATGCGGCTTGCGGGTTTGCGTTCCCGGCCTGTGAGCTGGCGATCGCCGAGGCCATGCGCCGGGCGCGAGAGACCGGCGT
CGGCGTCGGCGCGGTCACCAACAGCCATCACTTCGGCGCCGCTGGCTTGCCGCTCCATACCGTGGCCCGTGCCGGCATGG
TCGGCATCGCCATGGGCAACTCGCCTGCGGCGATGCCGGCGTGGGGCGGCAAGCGCGCGCTCTTCGGCACCAATCCGATT
GCCGCGGCATTTCCGCGGCAGGGGCGGCTGCCGGTCCTGATCGACCTGTCCCTGTCGGAGGTCGCGCGCGGCAAGATCAT
GGTCGCGGCCAAGCAGGGCAAGCCTATCCCGCCCGGCTGGGCGCTGGACGAGCACGGGCAGCCGACCACCGATGCGCGGG
CGGCGCTGCGCGGCTCGATGCTGCCGGCCGGCGGCGTCAAAGGCGCGATGCTGGCCCTGATGGTCGAACTGCTGGTGACC
ACGCTGGCCGGCGCGCAGTTCGGCGCCGAGGCCGATTCGTTCTTCACGGATGCCGGCAACCGGCCGCGCATCGGGCAACT
GTTCCTCGTGCTCGACCCGGGCGCCTTCGCGGGATCGGACGTATATGGCGAGCGGGTCGAAGCGTTGTTGCAGGTGATGC
TCGACGATACCGGCACGCGGCTACCCGGTGCGCGGCGTTACGCGCTGCAAACCGAGGCGCAGCAACACGGCATTGAAATA
CCGGAAGCGCAGCTTGCAGAACTGCTGTCGCTTGCGGGCGAGGAGGTGAAGGCATAG

Upstream 100 bases:

>100_bases
TGGTGTTGACTCCGCATATCGGCGGCGTCACGCGTGAGGCCAATGCGCGCGTGTCGATGATGATTGCCGAGAAGGTGCGG
CAAACGCTGGAGGCGCTGCC

Downstream 100 bases:

>100_bases
CAGTCATTCCACAACGAAGACGGACCCGCCAGTCGACAAAAAAGGCGGGCCGGCGACCCCAAACGGAGACACACCATGCA
TCGAGGCTTGATTCGCCCGG

Product: (R)-2-hydroxyacid dehydrogenase

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSRIPMEKLEVLARSALRRAGASQLQSHATAAALVRADAMGLASHGVSRVPMYVGHLRHDRVDGQAVPTVRSTRASAVLV
DAACGFAFPACELAIAEAMRRARETGVGVGAVTNSHHFGAAGLPLHTVARAGMVGIAMGNSPAAMPAWGGKRALFGTNPI
AAAFPRQGRLPVLIDLSLSEVARGKIMVAAKQGKPIPPGWALDEHGQPTTDARAALRGSMLPAGGVKGAMLALMVELLVT
TLAGAQFGAEADSFFTDAGNRPRIGQLFLVLDPGAFAGSDVYGERVEALLQVMLDDTGTRLPGARRYALQTEAQQHGIEI
PEAQLAELLSLAGEEVKA

Sequences:

>Translated_338_residues
MSRIPMEKLEVLARSALRRAGASQLQSHATAAALVRADAMGLASHGVSRVPMYVGHLRHDRVDGQAVPTVRSTRASAVLV
DAACGFAFPACELAIAEAMRRARETGVGVGAVTNSHHFGAAGLPLHTVARAGMVGIAMGNSPAAMPAWGGKRALFGTNPI
AAAFPRQGRLPVLIDLSLSEVARGKIMVAAKQGKPIPPGWALDEHGQPTTDARAALRGSMLPAGGVKGAMLALMVELLVT
TLAGAQFGAEADSFFTDAGNRPRIGQLFLVLDPGAFAGSDVYGERVEALLQVMLDDTGTRLPGARRYALQTEAQQHGIEI
PEAQLAELLSLAGEEVKA
>Mature_337_residues
SRIPMEKLEVLARSALRRAGASQLQSHATAAALVRADAMGLASHGVSRVPMYVGHLRHDRVDGQAVPTVRSTRASAVLVD
AACGFAFPACELAIAEAMRRARETGVGVGAVTNSHHFGAAGLPLHTVARAGMVGIAMGNSPAAMPAWGGKRALFGTNPIA
AAFPRQGRLPVLIDLSLSEVARGKIMVAAKQGKPIPPGWALDEHGQPTTDARAALRGSMLPAGGVKGAMLALMVELLVTT
LAGAQFGAEADSFFTDAGNRPRIGQLFLVLDPGAFAGSDVYGERVEALLQVMLDDTGTRLPGARRYALQTEAQQHGIEIP
EAQLAELLSLAGEEVKA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1786727, Length=336, Percent_Identity=29.4642857142857, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1787020, Length=332, Percent_Identity=29.5180722891566, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1790000, Length=341, Percent_Identity=24.633431085044, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17507179, Length=283, Percent_Identity=31.095406360424, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17536633, Length=302, Percent_Identity=29.8013245033113, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24667904, Length=290, Percent_Identity=32.4137931034483, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45553211, Length=263, Percent_Identity=33.0798479087452, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24667912, Length=263, Percent_Identity=33.0798479087452, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24667908, Length=263, Percent_Identity=33.0798479087452, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24658010, Length=301, Percent_Identity=28.9036544850498, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24648360, Length=254, Percent_Identity=27.9527559055118, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 35183; Mature: 35052

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIPMEKLEVLARSALRRAGASQLQSHATAAALVRADAMGLASHGVSRVPMYVGHLRHD
CCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
RVDGQAVPTVRSTRASAVLVDAACGFAFPACELAIAEAMRRARETGVGVGAVTNSHHFGA
CCCCCCCCCHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
AGLPLHTVARAGMVGIAMGNSPAAMPAWGGKRALFGTNPIAAAFPRQGRLPVLIDLSLSE
CCCCHHHHHHCCEEEEEECCCCCCCCCCCCCEEECCCCCHHHCCCCCCCCCEEEECCHHH
VARGKIMVAAKQGKPIPPGWALDEHGQPTTDARAALRGSMLPAGGVKGAMLALMVELLVT
HCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
TLAGAQFGAEADSFFTDAGNRPRIGQLFLVLDPGAFAGSDVYGERVEALLQVMLDDTGTR
HHHCCCCCCCCHHHHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCC
LPGARRYALQTEAQQHGIEIPEAQLAELLSLAGEEVKA
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRIPMEKLEVLARSALRRAGASQLQSHATAAALVRADAMGLASHGVSRVPMYVGHLRHD
CCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
RVDGQAVPTVRSTRASAVLVDAACGFAFPACELAIAEAMRRARETGVGVGAVTNSHHFGA
CCCCCCCCCHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
AGLPLHTVARAGMVGIAMGNSPAAMPAWGGKRALFGTNPIAAAFPRQGRLPVLIDLSLSE
CCCCHHHHHHCCEEEEEECCCCCCCCCCCCCEEECCCCCHHHCCCCCCCCCEEEECCHHH
VARGKIMVAAKQGKPIPPGWALDEHGQPTTDARAALRGSMLPAGGVKGAMLALMVELLVT
HCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
TLAGAQFGAEADSFFTDAGNRPRIGQLFLVLDPGAFAGSDVYGERVEALLQVMLDDTGTR
HHHCCCCCCCCHHHHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCC
LPGARRYALQTEAQQHGIEIPEAQLAELLSLAGEEVKA
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]