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The map label for this gene is serA [H]

Identifier: 73537365

GI number: 73537365

Start: 76223

End: 77161

Strand: Direct

Name: serA [H]

Synonym: Reut_B3530

Alternate gene names: 73537365

Gene position: 76223-77161 (Clockwise)

Preceding gene: 73537364

Following gene: 73537366

Centisome position: 2.8

GC content: 69.12

Gene sequence:

>939_bases
ATGATGAAGCGCATCTGCATCAGCGAGTTCATGGACCCGGCCGCGGTGCAGGCGCTCACGCCCGGCTTCGACGTGCGCTA
CGAGCCGGGCTGGGTGGACCAGCGCGGCGCCTTGCTCGACGCGCTGGCCGGTGCGGATGCGCTGATCGTGCGCAACCGCA
CCCAGGTCGACGCGGCGCTGCTTGAGCGGGCGCCCGCGCTGCGCGTGGTCGGCCGGCTTGGCGTGGGGCTCGACAATATC
GATGTCGCAGCATGCCGTGACCGCGGTATCCGCGTGATTCCGGCGAGTGGCGCAAATGCGCGATCCGTTGCCGAGTACGT
GGTGACCACGGCGGCGCTGCTGCTGCGTGGCGCGTATCTCGGCAGCGCCGAGGTAGCCGGCGGCAAGTGGCCGCGTGCCC
GCTTGTCGGAAGGGCGCGAGGCCTTGGGCAAGACGCTGGGCCTGATTGGCTTCGGCGATATCGGCCGGCAGGCCGCCGCG
CTCGCGCAGGCGTTCGGCATGCGAGTCGTCGCGCATGATCCGATGCTCGCACCAGACGATCCGGTCTGGTCAGCTACCGG
CGTGGTGTGCATGACGCTGGATGCCTTGCTGGCCCAATCCGATGCGGTAAGCCTGCATGTTCCGCTTGTGGCGGCCACAC
GGCACCTGATGAACGCGCAGCGCATTGGCGCGATGAAGCGGGGCGCCGTGCTGATCAACACGGCGCGTGGCGGCGTGGTG
GACGAGGGCGCGCTGGCTGGCGCCTTGCTCGAAGGGCACCTTGCCGGCGCGGCGCTGGACGTGTTCGAGGCAGAGCCGCT
ACCCGCGGACAGCGTGCTCGCAGACGTGCCGAACCTGGTGTTGACTCCGCATATCGGCGGCGTCACGCGTGAGGCCAATG
CGCGCGTGTCGATGATGATTGCCGAGAAGGTGCGGCAAACGCTGGAGGCGCTGCCATGA

Upstream 100 bases:

>100_bases
AGCTGCTCGAGTGCATGCTGGCCACGGCCAACGGGCGCTGGACCGCTGCCGAGGCGCTCGGCCACCGCGAATTCGTGCTG
ACGCGCATCCACGAGTCCGC

Downstream 100 bases:

>100_bases
GCCGTATCCCGATGGAGAAGCTGGAAGTACTGGCCCGATCCGCTTTGCGGAGGGCCGGTGCGAGCCAATTGCAGTCGCAC
GCCACAGCCGCGGCGCTGGT

Product: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MMKRICISEFMDPAAVQALTPGFDVRYEPGWVDQRGALLDALAGADALIVRNRTQVDAALLERAPALRVVGRLGVGLDNI
DVAACRDRGIRVIPASGANARSVAEYVVTTAALLLRGAYLGSAEVAGGKWPRARLSEGREALGKTLGLIGFGDIGRQAAA
LAQAFGMRVVAHDPMLAPDDPVWSATGVVCMTLDALLAQSDAVSLHVPLVAATRHLMNAQRIGAMKRGAVLINTARGGVV
DEGALAGALLEGHLAGAALDVFEAEPLPADSVLADVPNLVLTPHIGGVTREANARVSMMIAEKVRQTLEALP

Sequences:

>Translated_312_residues
MMKRICISEFMDPAAVQALTPGFDVRYEPGWVDQRGALLDALAGADALIVRNRTQVDAALLERAPALRVVGRLGVGLDNI
DVAACRDRGIRVIPASGANARSVAEYVVTTAALLLRGAYLGSAEVAGGKWPRARLSEGREALGKTLGLIGFGDIGRQAAA
LAQAFGMRVVAHDPMLAPDDPVWSATGVVCMTLDALLAQSDAVSLHVPLVAATRHLMNAQRIGAMKRGAVLINTARGGVV
DEGALAGALLEGHLAGAALDVFEAEPLPADSVLADVPNLVLTPHIGGVTREANARVSMMIAEKVRQTLEALP
>Mature_312_residues
MMKRICISEFMDPAAVQALTPGFDVRYEPGWVDQRGALLDALAGADALIVRNRTQVDAALLERAPALRVVGRLGVGLDNI
DVAACRDRGIRVIPASGANARSVAEYVVTTAALLLRGAYLGSAEVAGGKWPRARLSEGREALGKTLGLIGFGDIGRQAAA
LAQAFGMRVVAHDPMLAPDDPVWSATGVVCMTLDALLAQSDAVSLHVPLVAATRHLMNAQRIGAMKRGAVLINTARGGVV
DEGALAGALLEGHLAGAALDVFEAEPLPADSVLADVPNLVLTPHIGGVTREANARVSMMIAEKVRQTLEALP

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=300, Percent_Identity=37.6666666666667, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI145580578, Length=256, Percent_Identity=40.234375, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI4557499, Length=256, Percent_Identity=40.234375, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI145580575, Length=265, Percent_Identity=40, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI61743967, Length=256, Percent_Identity=38.671875, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4557497, Length=256, Percent_Identity=39.0625, Blast_Score=148, Evalue=5e-36,
Organism=Homo sapiens, GI6912396, Length=275, Percent_Identity=31.2727272727273, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1789279, Length=286, Percent_Identity=39.8601398601399, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI87082289, Length=285, Percent_Identity=35.7894736842105, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1787645, Length=256, Percent_Identity=28.515625, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788660, Length=267, Percent_Identity=33.7078651685393, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI87081824, Length=166, Percent_Identity=33.7349397590361, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=273, Percent_Identity=39.9267399267399, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI25147481, Length=276, Percent_Identity=29.7101449275362, Blast_Score=124, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6320925, Length=313, Percent_Identity=33.8658146964856, Blast_Score=159, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322116, Length=294, Percent_Identity=34.6938775510204, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6324055, Length=267, Percent_Identity=32.2097378277154, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=271, Percent_Identity=30.2583025830258, Blast_Score=109, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324980, Length=111, Percent_Identity=36.036036036036, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321253, Length=154, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19921140, Length=307, Percent_Identity=34.5276872964169, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24646446, Length=256, Percent_Identity=39.84375, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24646448, Length=256, Percent_Identity=39.84375, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24646452, Length=256, Percent_Identity=39.84375, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24646450, Length=256, Percent_Identity=39.84375, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI62472511, Length=256, Percent_Identity=39.84375, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24585516, Length=282, Percent_Identity=29.0780141843972, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI28571528, Length=276, Percent_Identity=33.695652173913, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI28574286, Length=282, Percent_Identity=28.7234042553192, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24585514, Length=282, Percent_Identity=28.7234042553192, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574282, Length=282, Percent_Identity=28.7234042553192, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45552429, Length=282, Percent_Identity=28.7234042553192, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28574284, Length=282, Percent_Identity=28.7234042553192, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45551003, Length=282, Percent_Identity=28.7234042553192, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 32522; Mature: 32522

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKRICISEFMDPAAVQALTPGFDVRYEPGWVDQRGALLDALAGADALIVRNRTQVDAAL
CCCHHHHHHCCCHHHHHHCCCCCCCEECCCCCCCCHHHHHHHCCCCEEEEECCHHHHHHH
LERAPALRVVGRLGVGLDNIDVAACRDRGIRVIPASGANARSVAEYVVTTAALLLRGAYL
HHCCHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
GSAEVAGGKWPRARLSEGREALGKTLGLIGFGDIGRQAAALAQAFGMRVVAHDPMLAPDD
CCCCCCCCCCCHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHCCEEEECCCCCCCCC
PVWSATGVVCMTLDALLAQSDAVSLHVPLVAATRHLMNAQRIGAMKRGAVLINTARGGVV
CCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCHHHCCEEEEECCCCCCC
DEGALAGALLEGHLAGAALDVFEAEPLPADSVLADVPNLVLTPHIGGVTREANARVSMMI
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHH
AEKVRQTLEALP
HHHHHHHHHCCC
>Mature Secondary Structure
MMKRICISEFMDPAAVQALTPGFDVRYEPGWVDQRGALLDALAGADALIVRNRTQVDAAL
CCCHHHHHHCCCHHHHHHCCCCCCCEECCCCCCCCHHHHHHHCCCCEEEEECCHHHHHHH
LERAPALRVVGRLGVGLDNIDVAACRDRGIRVIPASGANARSVAEYVVTTAALLLRGAYL
HHCCHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
GSAEVAGGKWPRARLSEGREALGKTLGLIGFGDIGRQAAALAQAFGMRVVAHDPMLAPDD
CCCCCCCCCCCHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHCCEEEECCCCCCCCC
PVWSATGVVCMTLDALLAQSDAVSLHVPLVAATRHLMNAQRIGAMKRGAVLINTARGGVV
CCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCHHHCCEEEEECCCCCCC
DEGALAGALLEGHLAGAALDVFEAEPLPADSVLADVPNLVLTPHIGGVTREANARVSMMI
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHH
AEKVRQTLEALP
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]