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The map label for this gene is kefC [H]

Identifier: 73542897

GI number: 73542897

Start: 3525421

End: 3527229

Strand: Reverse

Name: kefC [H]

Synonym: Reut_A3213

Alternate gene names: 73542897

Gene position: 3527229-3525421 (Counterclockwise)

Preceding gene: 73542898

Following gene: 73542889

Centisome position: 92.66

GC content: 66.67

Gene sequence:

>1809_bases
ATGAACCAGCATGATTTCCTGATTGCACTGGTGGTGTTCCTGGTGGCGGCCGTGGTCGCCGTGCCGCTTGCGCGCCGCAC
CGGGCTTGGCGCGGTGCTGGGGTACCTGCTTGCCGGCGCTGCCATCGGCCCGTTCGCGCTGCGTATGGTGACCAATGTCG
AGTCGATCCTGCATTTTTCGGAATTCGGCGTAGTGCTGATGATGTTCGTGATCGGCCTCGAGCTGGAGCCGCGCAAGCTA
TGGGCGCTGCGGCGGAGCATCTTCGGCTATGGCGGCATCCAGCTGGCGGCGTGCGCGCTGGTGATCGGCATCCTCGCGGC
CCTTGTGGGAGCGCCATGGCCAGTGGCGCTGGTGGCGGGGCTCGGGCTGGCGCTGTCATCCACGGCCATTGCGCTGGCCA
CGCTGGGCGAGCGCAACCTGTTCGGCACGCCTGCGGGTGGGGCGAGCTTCGGCATCCTGCTGTTCCAGGACATCGCGGCG
ATTCCGATGATCGCGCTGCTGCCGCTGCTGGCGGCAGAGAGCGCGGCCGACGCCAGCGGCGGTGGCTGGCAGTCCGCAGC
CAAGGCCGTGGCGGTGATTGCCGCCGTGGTTTTCGGCGGCCGCTACCTCGTCCGTCCGGCCTTGCGCTTCATCGCGCGGA
CCGATATGCGCGAGATGTTCACTGCGTTCGCGCTGCTGCTGGTGGTGGGCATTGCGCTGATGATGGATGCGGTGGGCCTG
TCGATGGCGCTGGGGACTTTCGTCGCCGGCGTGCTGCTGGCCGATTCCGAGTACCGTCATGCGCTCGAGGCCGACCTGGA
ACCGTTCAAGGGCCTGCTGCTCGGCATGTTCTTCATGGCGGTCGGGATGTCCATCGACTTCGCCGTGCTGGCGCGCGCGC
CGGGCACGGTCCTTGGACTGGTGGCTGTGTTCGTAGTCGCCAAGACCGCGGTGCTGATGTTCCTGGGCCGCTATTTCGAG
ATCGCACGCGGACAGCGGCTGCTGTTCGCGCTGCTGATCTCCCAGGGCGGCGAGTTCGCCTTCGTCGTGTTCGGCGTGGC
CGGCACGGCAGGCCTGCTGCCGCGCGAGACCGAGGCGCTGCTGGTGCTGATCGTGGCCTTGTCGATGGTAGCCACGCCCT
TGCTGCTGCTGGCCTATGACCGTCTGGTGGCGCCGCGCCTCGGTGTGACCAAGCGCCGTGCGGATGAGGCCATCACGCCG
CAGGACAACCCCGTGATGATCGCCGGCTTCGGGCGTTTCGGGCAGATCATCGGCCGCTTGCTGTACGCGCAGGGCGTCGG
CGTGACTGTGCTGGACCACGATCCCGACCAGATCGAATTCCTGCGCCAGTACGGCTTCAAGATCTTCTACGGCGACGCCA
CGCGTCTGGACCTGCTCGAAGCAGCGGGCATTGACAAGGCACGCATCCTGATCGTGGCCATCGACGGCATGGACGACAGC
CTGCAACTGATCGACCGCGTGCGCGAGCGCTATCCGGATCTGCAGATCTATGCGCGCGCGCGCCATGTCTCACACATCTA
CCAGCTCAAGGACCGCGGCGTGAACCTGTTCGAACGCGAGATGTTCGAGGGTTCGCTGATGCTGGGCCGCCGCGTACTGG
AAGGGCTGGGCTTCGATCCGGCGGAGGCCCGCAACGTGGCCTTGCGTTTCCGCCGGCACAACATCCAGGCCATCGACCGC
TTCTATCCGCATTACACGGACCAGAAGAAGCTGGTGTCGCTGGCGCGCCAGGCGCGCGACGAACTGCAGGAGATGTTCCG
CCAGGACCGCGAGCAGCGGCGCCAGCGGGAAGAGGCCGAATGGTCCTGA

Upstream 100 bases:

>100_bases
ACACCGACACTCAGGCGCTGGCCGAGCATATTGCGCACGTTTGCAGGCGCATCGGCGCTCATACGGATAGCCCGGTAGCG
GCAGGCGCGGAGGTGCGTGC

Downstream 100 bases:

>100_bases
TGGAGGCGCTGGCCCGCGTTCAGCGCCGCGCCAGCAATTCCGCGGACGCGGCGGCCTTGCCCGGCAGGCCGCCTTCGAGC
AGGTCCACGACCATATCGGC

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MNQHDFLIALVVFLVAAVVAVPLARRTGLGAVLGYLLAGAAIGPFALRMVTNVESILHFSEFGVVLMMFVIGLELEPRKL
WALRRSIFGYGGIQLAACALVIGILAALVGAPWPVALVAGLGLALSSTAIALATLGERNLFGTPAGGASFGILLFQDIAA
IPMIALLPLLAAESAADASGGGWQSAAKAVAVIAAVVFGGRYLVRPALRFIARTDMREMFTAFALLLVVGIALMMDAVGL
SMALGTFVAGVLLADSEYRHALEADLEPFKGLLLGMFFMAVGMSIDFAVLARAPGTVLGLVAVFVVAKTAVLMFLGRYFE
IARGQRLLFALLISQGGEFAFVVFGVAGTAGLLPRETEALLVLIVALSMVATPLLLLAYDRLVAPRLGVTKRRADEAITP
QDNPVMIAGFGRFGQIIGRLLYAQGVGVTVLDHDPDQIEFLRQYGFKIFYGDATRLDLLEAAGIDKARILIVAIDGMDDS
LQLIDRVRERYPDLQIYARARHVSHIYQLKDRGVNLFEREMFEGSLMLGRRVLEGLGFDPAEARNVALRFRRHNIQAIDR
FYPHYTDQKKLVSLARQARDELQEMFRQDREQRRQREEAEWS

Sequences:

>Translated_602_residues
MNQHDFLIALVVFLVAAVVAVPLARRTGLGAVLGYLLAGAAIGPFALRMVTNVESILHFSEFGVVLMMFVIGLELEPRKL
WALRRSIFGYGGIQLAACALVIGILAALVGAPWPVALVAGLGLALSSTAIALATLGERNLFGTPAGGASFGILLFQDIAA
IPMIALLPLLAAESAADASGGGWQSAAKAVAVIAAVVFGGRYLVRPALRFIARTDMREMFTAFALLLVVGIALMMDAVGL
SMALGTFVAGVLLADSEYRHALEADLEPFKGLLLGMFFMAVGMSIDFAVLARAPGTVLGLVAVFVVAKTAVLMFLGRYFE
IARGQRLLFALLISQGGEFAFVVFGVAGTAGLLPRETEALLVLIVALSMVATPLLLLAYDRLVAPRLGVTKRRADEAITP
QDNPVMIAGFGRFGQIIGRLLYAQGVGVTVLDHDPDQIEFLRQYGFKIFYGDATRLDLLEAAGIDKARILIVAIDGMDDS
LQLIDRVRERYPDLQIYARARHVSHIYQLKDRGVNLFEREMFEGSLMLGRRVLEGLGFDPAEARNVALRFRRHNIQAIDR
FYPHYTDQKKLVSLARQARDELQEMFRQDREQRRQREEAEWS
>Mature_602_residues
MNQHDFLIALVVFLVAAVVAVPLARRTGLGAVLGYLLAGAAIGPFALRMVTNVESILHFSEFGVVLMMFVIGLELEPRKL
WALRRSIFGYGGIQLAACALVIGILAALVGAPWPVALVAGLGLALSSTAIALATLGERNLFGTPAGGASFGILLFQDIAA
IPMIALLPLLAAESAADASGGGWQSAAKAVAVIAAVVFGGRYLVRPALRFIARTDMREMFTAFALLLVVGIALMMDAVGL
SMALGTFVAGVLLADSEYRHALEADLEPFKGLLLGMFFMAVGMSIDFAVLARAPGTVLGLVAVFVVAKTAVLMFLGRYFE
IARGQRLLFALLISQGGEFAFVVFGVAGTAGLLPRETEALLVLIVALSMVATPLLLLAYDRLVAPRLGVTKRRADEAITP
QDNPVMIAGFGRFGQIIGRLLYAQGVGVTVLDHDPDQIEFLRQYGFKIFYGDATRLDLLEAAGIDKARILIVAIDGMDDS
LQLIDRVRERYPDLQIYARARHVSHIYQLKDRGVNLFEREMFEGSLMLGRRVLEGLGFDPAEARNVALRFRRHNIQAIDR
FYPHYTDQKKLVSLARQARDELQEMFRQDREQRRQREEAEWS

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=417, Percent_Identity=24.220623501199, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786232, Length=602, Percent_Identity=51.328903654485, Blast_Score=573, Evalue=1e-164,
Organism=Escherichia coli, GI1789749, Length=597, Percent_Identity=46.0636515912898, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI1786685, Length=536, Percent_Identity=29.4776119402985, Blast_Score=184, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 65492; Mature: 65492

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQHDFLIALVVFLVAAVVAVPLARRTGLGAVLGYLLAGAAIGPFALRMVTNVESILHFS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EFGVVLMMFVIGLELEPRKLWALRRSIFGYGGIQLAACALVIGILAALVGAPWPVALVAG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LGLALSSTAIALATLGERNLFGTPAGGASFGILLFQDIAAIPMIALLPLLAAESAADASG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GGWQSAAKAVAVIAAVVFGGRYLVRPALRFIARTDMREMFTAFALLLVVGIALMMDAVGL
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMALGTFVAGVLLADSEYRHALEADLEPFKGLLLGMFFMAVGMSIDFAVLARAPGTVLGL
HHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHH
VAVFVVAKTAVLMFLGRYFEIARGQRLLFALLISQGGEFAFVVFGVAGTAGLLPRETEAL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHH
LVLIVALSMVATPLLLLAYDRLVAPRLGVTKRRADEAITPQDNPVMIAGFGRFGQIIGRL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCEEEEECCHHHHHHHHH
LYAQGVGVTVLDHDPDQIEFLRQYGFKIFYGDATRLDLLEAAGIDKARILIVAIDGMDDS
HHHCCCCEEEECCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEEEEEECCCCHH
LQLIDRVRERYPDLQIYARARHVSHIYQLKDRGVNLFEREMFEGSLMLGRRVLEGLGFDP
HHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
AEARNVALRFRRHNIQAIDRFYPHYTDQKKLVSLARQARDELQEMFRQDREQRRQREEAE
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WS
CC
>Mature Secondary Structure
MNQHDFLIALVVFLVAAVVAVPLARRTGLGAVLGYLLAGAAIGPFALRMVTNVESILHFS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EFGVVLMMFVIGLELEPRKLWALRRSIFGYGGIQLAACALVIGILAALVGAPWPVALVAG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LGLALSSTAIALATLGERNLFGTPAGGASFGILLFQDIAAIPMIALLPLLAAESAADASG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GGWQSAAKAVAVIAAVVFGGRYLVRPALRFIARTDMREMFTAFALLLVVGIALMMDAVGL
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMALGTFVAGVLLADSEYRHALEADLEPFKGLLLGMFFMAVGMSIDFAVLARAPGTVLGL
HHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHH
VAVFVVAKTAVLMFLGRYFEIARGQRLLFALLISQGGEFAFVVFGVAGTAGLLPRETEAL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHH
LVLIVALSMVATPLLLLAYDRLVAPRLGVTKRRADEAITPQDNPVMIAGFGRFGQIIGRL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCEEEEECCHHHHHHHHH
LYAQGVGVTVLDHDPDQIEFLRQYGFKIFYGDATRLDLLEAAGIDKARILIVAIDGMDDS
HHHCCCCEEEECCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEEEEEECCCCHH
LQLIDRVRERYPDLQIYARARHVSHIYQLKDRGVNLFEREMFEGSLMLGRRVLEGLGFDP
HHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
AEARNVALRFRRHNIQAIDRFYPHYTDQKKLVSLARQARDELQEMFRQDREQRRQREEAE
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA