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The map label for this gene is hisC2

Identifier: 73542794

GI number: 73542794

Start: 3417146

End: 3418246

Strand: Reverse

Name: hisC2

Synonym: Reut_A3110

Alternate gene names: 73542794

Gene position: 3418246-3417146 (Counterclockwise)

Preceding gene: 73542795

Following gene: 73542793

Centisome position: 89.8

GC content: 65.3

Gene sequence:

>1101_bases
ATGTCAGTCGTAGACCCTTCCCTGATCGAGCGAATCATCCGTGACGACGTGCGCGCCATGGGCGCCTACCACGTGCCGGA
TTCGCATGGTCTGGTGAAGCTCGATGCCATGGAGAACCCGTACCGCCTGCCGCCCGCACTGCGCAGCGAACTGGCGGCGC
GGCTCGGCGAGGTGGCGCTGAACCGTTACCCGGTGCCGAGCAGCGAGGCCTTGCGTGCGAAACTGAAAGAAGTCATGCAG
GTGCCGGCCGGCATGGAAGTGCTGCTCGGCAACGGCTCGGACGAAATCATCAGCATGCTCGCGCTGGCCGCGGCGCGGCC
AGGCGCGAAGGTGATGGCGCCCGTGCCCGGTTTCGTGATGTATGCGATGTCGGCGCAGTTCGCGGGCCTGGAGTTCGTGG
GCGTGCCGCTGCGCGCTGACTTCACGCTGGACCGCGGCGCGATGCTGGCCGCCATGGCCGAGCACCAGCCCGCCATCGTC
TATCTCGCTTATCCGAACAATCCGACCGGCAACCTGTTCGATGCCGCCGACATGGAAGCCATCGTCCGCGCCGCGCAGGG
TAGCGTCTGCCGCAGCCTGGTAGTCGTGGACGAGGCCTATCAGCCGTTTGCGCAGGAAAGCTGGATGTCGCGCCTGACGG
ATTTCGGCAACCTGCTGGTCATGCGCACGGTGTCCAAGCTGGGCCTGGCCGGTATCCGCCTGGGCTATGTGGCTGGCGAC
CCGCAATGGCTCGAGCAGCTCGACAAGGTGCGCCCGCCGTACAACGTCAACGTGCTGACCGAGGCGACCGCGCTGTTCGC
GCTCGAGCACGTCGCGGTGCTCGACGAGCAGGCAGCACAGCTGCGCGCCGAACGTTCGCGTGTGGCGGAAGGCATGGCGG
CCCATGGTGGCGTGACCGTGTTCCCCAGCGCAGCCAATTTCCTGCTCGCGCGTGTGCCGGATGCGGCACAGACGTTCGAT
CGGCTCCTTGCACGCAAGGTACTGATCAAGAACGTGAGTAAAATGCACCCATTGCTGGCCAACTGTCTGCGCGTGACGGT
CAGCACTCCCGAAGAAAACGCGCAGTTCCTTGAGGCATTCGCAGCGTCGCTGCAGGATTAA

Upstream 100 bases:

>100_bases
CGAAGGCCTGCAGGCCCACGCGCGCAGCGCCGAGTACCGTTTCAAGCGTAGTTGAACCCATTGCTGCCGCAGCGTTGCGG
CAGCCCATACAGGAGCATCC

Downstream 100 bases:

>100_bases
CACCATGCGTGTTGCAGAGGTCACCCGCAATACATCGGAAACGCAAATCCGCGTTTCCCTGAATCTCGACGGCACCGGCC
GCCAGAAGCTGGCGTCGGGC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MSVVDPSLIERIIRDDVRAMGAYHVPDSHGLVKLDAMENPYRLPPALRSELAARLGEVALNRYPVPSSEALRAKLKEVMQ
VPAGMEVLLGNGSDEIISMLALAAARPGAKVMAPVPGFVMYAMSAQFAGLEFVGVPLRADFTLDRGAMLAAMAEHQPAIV
YLAYPNNPTGNLFDAADMEAIVRAAQGSVCRSLVVVDEAYQPFAQESWMSRLTDFGNLLVMRTVSKLGLAGIRLGYVAGD
PQWLEQLDKVRPPYNVNVLTEATALFALEHVAVLDEQAAQLRAERSRVAEGMAAHGGVTVFPSAANFLLARVPDAAQTFD
RLLARKVLIKNVSKMHPLLANCLRVTVSTPEENAQFLEAFAASLQD

Sequences:

>Translated_366_residues
MSVVDPSLIERIIRDDVRAMGAYHVPDSHGLVKLDAMENPYRLPPALRSELAARLGEVALNRYPVPSSEALRAKLKEVMQ
VPAGMEVLLGNGSDEIISMLALAAARPGAKVMAPVPGFVMYAMSAQFAGLEFVGVPLRADFTLDRGAMLAAMAEHQPAIV
YLAYPNNPTGNLFDAADMEAIVRAAQGSVCRSLVVVDEAYQPFAQESWMSRLTDFGNLLVMRTVSKLGLAGIRLGYVAGD
PQWLEQLDKVRPPYNVNVLTEATALFALEHVAVLDEQAAQLRAERSRVAEGMAAHGGVTVFPSAANFLLARVPDAAQTFD
RLLARKVLIKNVSKMHPLLANCLRVTVSTPEENAQFLEAFAASLQD
>Mature_365_residues
SVVDPSLIERIIRDDVRAMGAYHVPDSHGLVKLDAMENPYRLPPALRSELAARLGEVALNRYPVPSSEALRAKLKEVMQV
PAGMEVLLGNGSDEIISMLALAAARPGAKVMAPVPGFVMYAMSAQFAGLEFVGVPLRADFTLDRGAMLAAMAEHQPAIVY
LAYPNNPTGNLFDAADMEAIVRAAQGSVCRSLVVVDEAYQPFAQESWMSRLTDFGNLLVMRTVSKLGLAGIRLGYVAGDP
QWLEQLDKVRPPYNVNVLTEATALFALEHVAVLDEQAAQLRAERSRVAEGMAAHGGVTVFPSAANFLLARVPDAAQTFDR
LLARKVLIKNVSKMHPLLANCLRVTVSTPEENAQFLEAFAASLQD

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=363, Percent_Identity=29.7520661157025, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1788722, Length=259, Percent_Identity=25.8687258687259, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=390, Percent_Identity=26.6666666666667, Blast_Score=115, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS82_CUPPJ (Q46WL3)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_297314.1
- PDB:   3EUC
- PDBsum:   3EUC
- ProteinModelPortal:   Q46WL3
- SMR:   Q46WL3
- GeneID:   3609701
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A3110
- NMPDR:   fig|264198.3.peg.3550
- HOGENOM:   HBG646350
- OMA:   MDEAYQP
- ProtClustDB:   PRK04870
- BioCyc:   REUT264198:REUT_A3110-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39607; Mature: 39476

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVDPSLIERIIRDDVRAMGAYHVPDSHGLVKLDAMENPYRLPPALRSELAARLGEVAL
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
NRYPVPSSEALRAKLKEVMQVPAGMEVLLGNGSDEIISMLALAAARPGAKVMAPVPGFVM
HCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEECCCCHHHH
YAMSAQFAGLEFVGVPLRADFTLDRGAMLAAMAEHQPAIVYLAYPNNPTGNLFDAADMEA
HHHHHHHCCCEEEECCEEECCEECCCHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHH
IVRAAQGSVCRSLVVVDEAYQPFAQESWMSRLTDFGNLLVMRTVSKLGLAGIRLGYVAGD
HHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEEECCC
PQWLEQLDKVRPPYNVNVLTEATALFALEHVAVLDEQAAQLRAERSRVAEGMAAHGGVTV
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
FPSAANFLLARVPDAAQTFDRLLARKVLIKNVSKMHPLLANCLRVTVSTPEENAQFLEAF
ECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHH
AASLQD
HHHHCC
>Mature Secondary Structure 
SVVDPSLIERIIRDDVRAMGAYHVPDSHGLVKLDAMENPYRLPPALRSELAARLGEVAL
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
NRYPVPSSEALRAKLKEVMQVPAGMEVLLGNGSDEIISMLALAAARPGAKVMAPVPGFVM
HCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEECCCCHHHH
YAMSAQFAGLEFVGVPLRADFTLDRGAMLAAMAEHQPAIVYLAYPNNPTGNLFDAADMEA
HHHHHHHCCCEEEECCEEECCEECCCHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHH
IVRAAQGSVCRSLVVVDEAYQPFAQESWMSRLTDFGNLLVMRTVSKLGLAGIRLGYVAGD
HHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEEECCC
PQWLEQLDKVRPPYNVNVLTEATALFALEHVAVLDEQAAQLRAERSRVAEGMAAHGGVTV
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
FPSAANFLLARVPDAAQTFDRLLARKVLIKNVSKMHPLLANCLRVTVSTPEENAQFLEAF
ECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHH
AASLQD
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA