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The map label for this gene is hisD

Identifier: 73542795

GI number: 73542795

Start: 3418292

End: 3419629

Strand: Reverse

Name: hisD

Synonym: Reut_A3111

Alternate gene names: 73542795

Gene position: 3419629-3418292 (Counterclockwise)

Preceding gene: 73542796

Following gene: 73542794

Centisome position: 89.84

GC content: 66.89

Gene sequence:

>1338_bases
ATGAACGCAACCGAAATGGAAAACGTGTCGATCCGCCGGCTCGATTCAAGCGATCCGCGCTTCGCGCAAGCGCTGCGCGA
GGTGCTGGCCTTCGAGGCCGGCGAGGACGAGGCCATCGACCGCGCCGTGGCGCAGATCCTGGCCGACGTGAAGGATCGCG
GCGACGCCGCGGTACTCGAATACACGCAGCGGTTTGACCGGGTCGAGGCGGCGTCGATGGGCGCGCTGGAAATCTCGCAA
AGCGAACTCGAAGCTGCGCTCGAAGACCTGGAGCCGAAGCGCCGCGCCGCGCTGGAAGCCGCCGCCGCGCGCGTGCGTGC
CTACCACGAGAAGCAGAAGATCGAATGCGGCAGTCATAGCTGGGAATACACCGAGGCCGATGGCACCATGCTGGGCCAGA
AGGTGACGCCGCTGGACCGCGTCGGCATCTACGTGCCGGGCGGCAAGGCCGCGTACCCGTCGTCGGTGCTGATGAATGCG
ATTCCCGCGCGCGTCGCGGGCGTCAAGGAAATCATCATGGTCGTGCCCACGCCGGGCGGCGTGCGCAATGAACTGGTGCT
GGCGGCTGCGCAGATCGCTGGTGTCGACCGCGTGTTCACCATCGGCGGCGCGCAGGCGGTTGGCGCGCTGGCCTACGGTA
CGGCGACGCTGCCGCAGGTCGACAAGATCGTCGGCCCCGGCAACGCCTATGTGGCCGCAGCCAAGCGCCGCGTGTTCGGC
ACCGTGGGCATCGACATGATCGCCGGCCCGTCGGAGATCCTGGTGATCTGCGACGGTACGACTGATCCGGACTGGGTGGC
GATGGACCTGTTCTCGCAGGCCGAGCACGATGAACTCGCGCAGTCGATCCTGCTGTGCCCGGACGCCGACTACATCGCGC
AGGTCGAGGCAAGTATCCAGCGCCAGCTCGACAGCATGCCACGCCGCGAGGTGATCGCCGCATCGATTTCAGGCCGTGGC
GCGCTGATCAAGGTGCGCGACATGGAAGAAGCTTGCGAGATCGCCAACGCGATCGCGCCCGAGCACCTCGAGATCTCGGC
CGAGAACCCGCGCCAGTGGAGCGAGAAGATCCGCCACGCCGGCGCCATTTTCCTGGGTCGCTATACCAGCGAGTCGCTCG
GCGACTACTGCGCGGGGCCGAACCACGTGCTGCCGACTTCGCGCACCGCTCGCTTCTCGTCGCCGCTGGGCGTGTACGAC
TTCCAGAAGCGTTCAAGCCTGATCGAGGTCAGCGAGGGCGGGGCGCAGATGCTGGGCCAGATCGCGGCCGAACTTGCATA
TGGCGAAGGCCTGCAGGCCCACGCGCGCAGCGCCGAGTACCGTTTCAAGCGTAGTTGA

Upstream 100 bases:

>100_bases
CTGAAGCTCAAGCGCGAACGGCTGACGCCGATTCTCGACGCGTTCGAGAAGGCATCGGCGGCGCTGGCCTGAGGCCTGCG
TCCCAGATAGGAATGGAGTC

Downstream 100 bases:

>100_bases
ACCCATTGCTGCCGCAGCGTTGCGGCAGCCCATACAGGAGCATCCATGTCAGTCGTAGACCCTTCCCTGATCGAGCGAAT
CATCCGTGACGACGTGCGCG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 1

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MNATEMENVSIRRLDSSDPRFAQALREVLAFEAGEDEAIDRAVAQILADVKDRGDAAVLEYTQRFDRVEAASMGALEISQ
SELEAALEDLEPKRRAALEAAAARVRAYHEKQKIECGSHSWEYTEADGTMLGQKVTPLDRVGIYVPGGKAAYPSSVLMNA
IPARVAGVKEIIMVVPTPGGVRNELVLAAAQIAGVDRVFTIGGAQAVGALAYGTATLPQVDKIVGPGNAYVAAAKRRVFG
TVGIDMIAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDADYIAQVEASIQRQLDSMPRREVIAASISGRG
ALIKVRDMEEACEIANAIAPEHLEISAENPRQWSEKIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYD
FQKRSSLIEVSEGGAQMLGQIAAELAYGEGLQAHARSAEYRFKRS

Sequences:

>Translated_445_residues
MNATEMENVSIRRLDSSDPRFAQALREVLAFEAGEDEAIDRAVAQILADVKDRGDAAVLEYTQRFDRVEAASMGALEISQ
SELEAALEDLEPKRRAALEAAAARVRAYHEKQKIECGSHSWEYTEADGTMLGQKVTPLDRVGIYVPGGKAAYPSSVLMNA
IPARVAGVKEIIMVVPTPGGVRNELVLAAAQIAGVDRVFTIGGAQAVGALAYGTATLPQVDKIVGPGNAYVAAAKRRVFG
TVGIDMIAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDADYIAQVEASIQRQLDSMPRREVIAASISGRG
ALIKVRDMEEACEIANAIAPEHLEISAENPRQWSEKIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYD
FQKRSSLIEVSEGGAQMLGQIAAELAYGEGLQAHARSAEYRFKRS
>Mature_445_residues
MNATEMENVSIRRLDSSDPRFAQALREVLAFEAGEDEAIDRAVAQILADVKDRGDAAVLEYTQRFDRVEAASMGALEISQ
SELEAALEDLEPKRRAALEAAAARVRAYHEKQKIECGSHSWEYTEADGTMLGQKVTPLDRVGIYVPGGKAAYPSSVLMNA
IPARVAGVKEIIMVVPTPGGVRNELVLAAAQIAGVDRVFTIGGAQAVGALAYGTATLPQVDKIVGPGNAYVAAAKRRVFG
TVGIDMIAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDADYIAQVEASIQRQLDSMPRREVIAASISGRG
ALIKVRDMEEACEIANAIAPEHLEISAENPRQWSEKIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYD
FQKRSSLIEVSEGGAQMLGQIAAELAYGEGLQAHARSAEYRFKRS

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=410, Percent_Identity=41.9512195121951, Blast_Score=301, Evalue=7e-83,
Organism=Saccharomyces cerevisiae, GI6319819, Length=415, Percent_Identity=36.144578313253, Blast_Score=248, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX1_CUPPJ (Q46WL2)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_297315.1
- ProteinModelPortal:   Q46WL2
- SMR:   Q46WL2
- GeneID:   3611937
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A3111
- NMPDR:   fig|264198.3.peg.3551
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   REUT264198:REUT_A3111-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47889; Mature: 47889

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 341-341 ACT_SITE 342-342 BINDING 144-144 BINDING 205-205 BINDING 228-228 BINDING 251-251 BINDING 273-273 BINDING 276-276 BINDING 342-342 BINDING 375-375 BINDING 429-429 BINDING 434-434

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATEMENVSIRRLDSSDPRFAQALREVLAFEAGEDEAIDRAVAQILADVKDRGDAAVLE
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
YTQRFDRVEAASMGALEISQSELEAALEDLEPKRRAALEAAAARVRAYHEKQKIECGSHS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
WEYTEADGTMLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVAGVKEIIMVVPTPGG
CEEECCCCCCCCCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCC
VRNELVLAAAQIAGVDRVFTIGGAQAVGALAYGTATLPQVDKIVGPGNAYVAAAKRRVFG
CHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHE
TVGIDMIAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDADYIAQVEASIQ
ECCHHEECCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHH
RQLDSMPRREVIAASISGRGALIKVRDMEEACEIANAIAPEHLEISAENPRQWSEKIRHA
HHHHCCCHHHHHEEECCCCCCEEEEECHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHC
GAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSLIEVSEGGAQMLGQ
CEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEECCCHHHHHHH
IAAELAYGEGLQAHARSAEYRFKRS
HHHHHHHCCCHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNATEMENVSIRRLDSSDPRFAQALREVLAFEAGEDEAIDRAVAQILADVKDRGDAAVLE
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
YTQRFDRVEAASMGALEISQSELEAALEDLEPKRRAALEAAAARVRAYHEKQKIECGSHS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
WEYTEADGTMLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVAGVKEIIMVVPTPGG
CEEECCCCCCCCCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCC
VRNELVLAAAQIAGVDRVFTIGGAQAVGALAYGTATLPQVDKIVGPGNAYVAAAKRRVFG
CHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHE
TVGIDMIAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDADYIAQVEASIQ
ECCHHEECCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHH
RQLDSMPRREVIAASISGRGALIKVRDMEEACEIANAIAPEHLEISAENPRQWSEKIRHA
HHHHCCCHHHHHEEECCCCCCEEEEECHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHC
GAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSLIEVSEGGAQMLGQ
CEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEECCCHHHHHHH
IAAELAYGEGLQAHARSAEYRFKRS
HHHHHHHCCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA