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The map label for this gene is hisE

Identifier: 73542787

GI number: 73542787

Start: 3412703

End: 3413080

Strand: Reverse

Name: hisE

Synonym: Reut_A3103

Alternate gene names: 73542787

Gene position: 3413080-3412703 (Counterclockwise)

Preceding gene: 73542788

Following gene: 73542786

Centisome position: 89.66

GC content: 65.34

Gene sequence:

>378_bases
ATGACCGAATCCCACTCTGCCGGTACCGACGTGCTGGCGCGCCTGGCTGTGGTGCTGGAGTCGCGCAAGCCTGAGAATGG
CGGCGACCCCGAGAAATCGTACGTCGCTCGCCTGTTCCGCAAGGGTGACGACGCCATCCTCAAGAAGATCGGCGAGGAAG
CCACCGAGACCGTAATGGCGGCCAAGGATGCGCGCGCGGCCGGCAAGACCGGTGCCGACGCCGACAAGATCGTCTATGAA
GTGGCCGACCTGTGGTTCCATACCATGGTGCTGCTGGCCAACTTCGGCCTGACGCCGGCCGATGTCGTCAACGAGCTGGC
GCGCCGCGAAGGCCTGTCCGGCATCGAGGAAAAGGCGAGCCGCAAGGACCAGGGCTGA

Upstream 100 bases:

>100_bases
CGTGCTTCTTCCAGAAGTTCGAAGGTGACGCCGAGAGTGGCGACTGGCAGACCGTCGAGCCTGTGCTCAAGGACCCTTCC
CAAATCTACACGGCCAAACC

Downstream 100 bases:

>100_bases
TACCGCAGCCCGTCGACCAGGGCGCACTGAATCGGGAGGGCCAGCATGGCGAACGACTACACCGGGCAGGTCACGGTCAG
CGACAGCGAGCGGGAGGGCA

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 125; Mature: 124

Protein sequence:

>125_residues
MTESHSAGTDVLARLAVVLESRKPENGGDPEKSYVARLFRKGDDAILKKIGEEATETVMAAKDARAAGKTGADADKIVYE
VADLWFHTMVLLANFGLTPADVVNELARREGLSGIEEKASRKDQG

Sequences:

>Translated_125_residues
MTESHSAGTDVLARLAVVLESRKPENGGDPEKSYVARLFRKGDDAILKKIGEEATETVMAAKDARAAGKTGADADKIVYE
VADLWFHTMVLLANFGLTPADVVNELARREGLSGIEEKASRKDQG
>Mature_124_residues
TESHSAGTDVLARLAVVLESRKPENGGDPEKSYVARLFRKGDDAILKKIGEEATETVMAAKDARAAGKTGADADKIVYEV
ADLWFHTMVLLANFGLTPADVVNELARREGLSGIEEKASRKDQG

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_CUPPJ (Q46WM0)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_297307.1
- ProteinModelPortal:   Q46WM0
- SMR:   Q46WM0
- GeneID:   3609694
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A3103
- NMPDR:   fig|264198.3.peg.2259
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   REUT264198:REUT_A3103-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 13459; Mature: 13328

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESHSAGTDVLARLAVVLESRKPENGGDPEKSYVARLFRKGDDAILKKIGEEATETVMA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AKDARAAGKTGADADKIVYEVADLWFHTMVLLANFGLTPADVVNELARREGLSGIEEKAS
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHH
RKDQG
CCCCC
>Mature Secondary Structure 
TESHSAGTDVLARLAVVLESRKPENGGDPEKSYVARLFRKGDDAILKKIGEEATETVMA
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AKDARAAGKTGADADKIVYEVADLWFHTMVLLANFGLTPADVVNELARREGLSGIEEKAS
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHH
RKDQG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA