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The map label for this gene is guaB [C]

Identifier: 73542360

GI number: 73542360

Start: 2939247

End: 2940386

Strand: Direct

Name: guaB [C]

Synonym: Reut_A2675

Alternate gene names: 73542360

Gene position: 2939247-2940386 (Clockwise)

Preceding gene: 73542358

Following gene: 73542361

Centisome position: 77.22

GC content: 66.84

Gene sequence:

>1140_bases
ATGCCAACCGCCCCCGCCGTCGCTGCGCTCGCACATAGCACTCGTGCCTGGCTGCGCACTTTCGTACCGCTGCCTGTTTC
CGCTAACCGCACCGAGCGCATCAAGAGTTGCCTCGGCGCGCTGCTAGGCCTCTTTCTCACCGAATGGATCAGTCACCAGA
CGCTGGGCGGCTTCAATCCCTGGTTTGTCGCGCCGATGGGCGCCTCGGCCGTGCTGCTGTTCGCGGTGCCTTCGAGTCCG
CTTGCCCAGCCATGGTCGATCATCGGCGGCAATTTATTTGCAGCGCTGGTCGGCGTAGCGTGCGCACGCTGGATTCCGGA
TCAGGGGCTCGCGGCGGCCACGGCCGTCGCAGTCGCCATCGCCGTGATGTTCCAGTTCCGCTGCGTGCACCCGCCCAGCG
GTGCCGTGGCGATCACTGCGGTGTTTGGGGGGCCCGCAGTCAGCGCACTCGGCTTCGGTTTCGTCGCGGTGCCGGTGCTG
TTCAATTCGATGCTGCTGTTGCTGATGGCACTGGCCTTCAACAACCTGTCGCAGCGGCGCTATCCGCATCGCCCACCCGA
GCCGCCGGTACAGCACCATACTGCCGATGCCCCGCCTGGACAGCGCGTCGGCTTCACGCGCGCGGACCTGCATGACGCAT
TGCAGGCTCGCGGCGAATTCCTCGACATCGAAGAAGACGATCTCGAAGCGATCCTAGTGGCCGCCCAACTTCGCGCGTAC
CGGCGCCATTTCGGCAATGTGCTGGTTTCGGAAATCATGTCGCGCGACGTCGTGACGGTGAACCCGAGCCAGCCGGCATC
GGAGGCTTCGCACCTGCTCACGCGGCACCGCATCAAGGCGCTTCCGGTGGTCGACGAACATCGCAAGCTGCTGGGCATCA
TCACCCAGAGCGACTTCTTCGCCGCGCAGCGCGACACGGGGGCGCGGCGCCTGGCCGGCACCGTGCGCGACCTGATGACG
CGCGCCGTGGTCACCGCGCGCGCCGACCAGCCCATGGTCGAACTGGCCCAGGCCTTCAGCGACGGCGGCCTGCACCATGC
GCCAGTCATCGACGACCACCACCGCGTGGTCGGCATGGTGACGCAGTCGGACCTGGTGGCTGCGCTGCTCAAGGACGGCG
TGATGAGCGCCACGGCCTGA

Upstream 100 bases:

>100_bases
CAGCGCGGAACGTCCGTACGACAATGACTCTGCCAGAGGCCGCCAAATATATCACTCCGTGATATATTACGCCGACCATT
CCAACGCGCCCCGCTCCAGA

Downstream 100 bases:

>100_bases
TTTACTTCGGCCTCCTCCCGGGCGTCGCATATCGGGCGCCTGCTACGCCCCTCGAACGCTGGCGCATGTCACATACCTGT
GGCACTGTGGACTCATCCCC

Product: CBS:HPP

Products: H+; Nicotinamide adenine dinucleotide - reduced; Xanthosine 5'-phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MPTAPAVAALAHSTRAWLRTFVPLPVSANRTERIKSCLGALLGLFLTEWISHQTLGGFNPWFVAPMGASAVLLFAVPSSP
LAQPWSIIGGNLFAALVGVACARWIPDQGLAAATAVAVAIAVMFQFRCVHPPSGAVAITAVFGGPAVSALGFGFVAVPVL
FNSMLLLLMALAFNNLSQRRYPHRPPEPPVQHHTADAPPGQRVGFTRADLHDALQARGEFLDIEEDDLEAILVAAQLRAY
RRHFGNVLVSEIMSRDVVTVNPSQPASEASHLLTRHRIKALPVVDEHRKLLGIITQSDFFAAQRDTGARRLAGTVRDLMT
RAVVTARADQPMVELAQAFSDGGLHHAPVIDDHHRVVGMVTQSDLVAALLKDGVMSATA

Sequences:

>Translated_379_residues
MPTAPAVAALAHSTRAWLRTFVPLPVSANRTERIKSCLGALLGLFLTEWISHQTLGGFNPWFVAPMGASAVLLFAVPSSP
LAQPWSIIGGNLFAALVGVACARWIPDQGLAAATAVAVAIAVMFQFRCVHPPSGAVAITAVFGGPAVSALGFGFVAVPVL
FNSMLLLLMALAFNNLSQRRYPHRPPEPPVQHHTADAPPGQRVGFTRADLHDALQARGEFLDIEEDDLEAILVAAQLRAY
RRHFGNVLVSEIMSRDVVTVNPSQPASEASHLLTRHRIKALPVVDEHRKLLGIITQSDFFAAQRDTGARRLAGTVRDLMT
RAVVTARADQPMVELAQAFSDGGLHHAPVIDDHHRVVGMVTQSDLVAALLKDGVMSATA
>Mature_378_residues
PTAPAVAALAHSTRAWLRTFVPLPVSANRTERIKSCLGALLGLFLTEWISHQTLGGFNPWFVAPMGASAVLLFAVPSSPL
AQPWSIIGGNLFAALVGVACARWIPDQGLAAATAVAVAIAVMFQFRCVHPPSGAVAITAVFGGPAVSALGFGFVAVPVLF
NSMLLLLMALAFNNLSQRRYPHRPPEPPVQHHTADAPPGQRVGFTRADLHDALQARGEFLDIEEDDLEAILVAAQLRAYR
RHFGNVLVSEIMSRDVVTVNPSQPASEASHLLTRHRIKALPVVDEHRKLLGIITQSDFFAAQRDTGARRLAGTVRDLMTR
AVVTARADQPMVELAQAFSDGGLHHAPVIDDHHRVVGMVTQSDLVAALLKDGVMSATA

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG3448

COG function: function code T; CBS-domain-containing membrane protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

None

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR002708
- InterPro:   IPR016426
- ProDom:   PD011569 [H]

Pfam domain/function: PF00571 CBS; PF01837 DUF39 [H]

EC number: 1.1.1.205 [C]

Molecular weight: Translated: 40578; Mature: 40447

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTAPAVAALAHSTRAWLRTFVPLPVSANRTERIKSCLGALLGLFLTEWISHQTLGGFNP
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
WFVAPMGASAVLLFAVPSSPLAQPWSIIGGNLFAALVGVACARWIPDQGLAAATAVAVAI
CEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AVMFQFRCVHPPSGAVAITAVFGGPAVSALGFGFVAVPVLFNSMLLLLMALAFNNLSQRR
HHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
YPHRPPEPPVQHHTADAPPGQRVGFTRADLHDALQARGEFLDIEEDDLEAILVAAQLRAY
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
RRHFGNVLVSEIMSRDVVTVNPSQPASEASHLLTRHRIKALPVVDEHRKLLGIITQSDFF
HHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHH
AAQRDTGARRLAGTVRDLMTRAVVTARADQPMVELAQAFSDGGLHHAPVIDDHHRVVGMV
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE
TQSDLVAALLKDGVMSATA
HHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
PTAPAVAALAHSTRAWLRTFVPLPVSANRTERIKSCLGALLGLFLTEWISHQTLGGFNP
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
WFVAPMGASAVLLFAVPSSPLAQPWSIIGGNLFAALVGVACARWIPDQGLAAATAVAVAI
CEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AVMFQFRCVHPPSGAVAITAVFGGPAVSALGFGFVAVPVLFNSMLLLLMALAFNNLSQRR
HHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
YPHRPPEPPVQHHTADAPPGQRVGFTRADLHDALQARGEFLDIEEDDLEAILVAAQLRAY
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
RRHFGNVLVSEIMSRDVVTVNPSQPASEASHLLTRHRIKALPVVDEHRKLLGIITQSDFF
HHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHH
AAQRDTGARRLAGTVRDLMTRAVVTARADQPMVELAQAFSDGGLHHAPVIDDHHRVVGMV
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE
TQSDLVAALLKDGVMSATA
HHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; IMP; Nicotinamide adenine dinucleotide [C]

Specific reaction: H2O + IMP + Nicotinamide adenine dinucleotide --> H+ + Nicotinamide adenine dinucleotide - reduced + Xanthosine 5'-phosphate [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]