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The map label for this gene is zraR [H]

Identifier: 73542317

GI number: 73542317

Start: 2888440

End: 2889813

Strand: Direct

Name: zraR [H]

Synonym: Reut_A2632

Alternate gene names: 73542317

Gene position: 2888440-2889813 (Clockwise)

Preceding gene: 73542316

Following gene: 73542318

Centisome position: 75.88

GC content: 64.34

Gene sequence:

>1374_bases
ATGAGCACTTACGCCAATCGTCCGCTGCTCTATCTGTCCAAGCATCATGACGCCACGCTGTGCAGGGCGTTTTCGCAACG
CGGCTGGAAGATCAGCTTTGCATCGAGCCTGCAAGACCTCGACGCGCTCGCACACAACACGGCCTGTGCCGCTCTGCTCG
ACGTCCATAGCGGATTCAGCGATGCAGAGCTTGAATCCTTCGAGCCCTGGCTGGCCCACCCGTTGCTGGGCTGGATCGGC
ATGGTCACCAGCCGCGAAGAGCTGGGCGACGCGGCGCGCCGCCTTCTCGGCCTCTATTTTATTGACTACTACACCGCGCC
ATTCGACCTGATCCACCTGGCGCATTCGCTCGGCCATGCACAAGGCATGGCGCAGATGCGGCCCGCCGCCCAGCGCACAG
CCGCGAGCAGCGCGCGCCCGGACGGCATGATCGGTAGCTGTGCGGCAATGCAGACGCTCTTTCGCGGTATCGAAAAGGTC
TCGCTCTGGGATACCCCCGTGCTGATCTCCGGCGAATCCGGTACCGGCAAGGAACTGGCTGCGCAGGCCATCCACCGCGC
CAGCGAACGCGCGCAGAAGCCGTTCGTGGCCGTCAACTGCGCCGCGATCCCGCCCACCCTGCTCATGTCGGAACTGTTCG
GCTATGAGCGCGGAGCTTTCACCGGAGCGGCCAAGCGCAAGCTCGGCCGCATCGAGATGGCTCAGGGCGGCACGCTGTTC
CTCGACGAAATCGGCGACATGCCGCTCGAAAGCCAGACCAGCCTGCTGCGCTTCCTGGAAACCGGGCGCATAGAGCGGCT
GGGCGGCACCGAATCCATTGAAGTGGATGTACGCATCATCTCGGCCACGCACGTCGATCTGGAAGCGGCCATCGCAGCCG
AGCGCTTCCGCGGCGACCTGTACCACCGCCTTTGCGTGCTGCGCGTGCGTCAGCCACCGCTGCGCGAACGCGGCAGCGAC
CTCATGCTGCTCGCCGAGCATGTGCTCGCCGGCGTGCGCAAGCAGTCGCCCAACCATATTCGTGGCTTCGCGCCTACCGC
GCTGCGTGCGATTCAACAACACGATTGGCCCGGCAATGTGCGCGAACTCATCAACCGCATCCGCCATGCCGCAGCGATGT
GCGAGGACGGGGTGATCCAGCCCGAGGACCTGGAACTCGCTACTCCGGTGGAGGAACGGCCGCTCACGCTGGCGGCGATC
CGTGAAGCAGCCGAGCAGAATGCCCTCGTGGAAGCGCTGCAGCGCAATCATGAGCGCCTGATCGATGTCGCGGCGGAACT
TGGAATTTCGCGGGTGACGCTGTTCAGGTTGATGCGGGACTACAAGCTGCACGTGAAGAAGGGCGATCTCGGCCTGGTTT
GCGTGCAAGGCTAA

Upstream 100 bases:

>100_bases
AGATCAACCCGCGGCCGGTGCGGGCCTGAAGGCCACCGAATCCGATATCCGGCAACCGCCGGAGTCGGTTTCGTCAAAAA
CAAGAATCCGGGGAAATCTC

Downstream 100 bases:

>100_bases
CCTCACTGCTATCCGAGGAATGGTCCCATGTCCCCTGATGCTTATCTTGAAATGGCCGAGACAGAAGCCGCTCACTGGTG
GTTCCGTGGGCGGCGCGACA

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MSTYANRPLLYLSKHHDATLCRAFSQRGWKISFASSLQDLDALAHNTACAALLDVHSGFSDAELESFEPWLAHPLLGWIG
MVTSREELGDAARRLLGLYFIDYYTAPFDLIHLAHSLGHAQGMAQMRPAAQRTAASSARPDGMIGSCAAMQTLFRGIEKV
SLWDTPVLISGESGTGKELAAQAIHRASERAQKPFVAVNCAAIPPTLLMSELFGYERGAFTGAAKRKLGRIEMAQGGTLF
LDEIGDMPLESQTSLLRFLETGRIERLGGTESIEVDVRIISATHVDLEAAIAAERFRGDLYHRLCVLRVRQPPLRERGSD
LMLLAEHVLAGVRKQSPNHIRGFAPTALRAIQQHDWPGNVRELINRIRHAAAMCEDGVIQPEDLELATPVEERPLTLAAI
REAAEQNALVEALQRNHERLIDVAAELGISRVTLFRLMRDYKLHVKKGDLGLVCVQG

Sequences:

>Translated_457_residues
MSTYANRPLLYLSKHHDATLCRAFSQRGWKISFASSLQDLDALAHNTACAALLDVHSGFSDAELESFEPWLAHPLLGWIG
MVTSREELGDAARRLLGLYFIDYYTAPFDLIHLAHSLGHAQGMAQMRPAAQRTAASSARPDGMIGSCAAMQTLFRGIEKV
SLWDTPVLISGESGTGKELAAQAIHRASERAQKPFVAVNCAAIPPTLLMSELFGYERGAFTGAAKRKLGRIEMAQGGTLF
LDEIGDMPLESQTSLLRFLETGRIERLGGTESIEVDVRIISATHVDLEAAIAAERFRGDLYHRLCVLRVRQPPLRERGSD
LMLLAEHVLAGVRKQSPNHIRGFAPTALRAIQQHDWPGNVRELINRIRHAAAMCEDGVIQPEDLELATPVEERPLTLAAI
REAAEQNALVEALQRNHERLIDVAAELGISRVTLFRLMRDYKLHVKKGDLGLVCVQG
>Mature_456_residues
STYANRPLLYLSKHHDATLCRAFSQRGWKISFASSLQDLDALAHNTACAALLDVHSGFSDAELESFEPWLAHPLLGWIGM
VTSREELGDAARRLLGLYFIDYYTAPFDLIHLAHSLGHAQGMAQMRPAAQRTAASSARPDGMIGSCAAMQTLFRGIEKVS
LWDTPVLISGESGTGKELAAQAIHRASERAQKPFVAVNCAAIPPTLLMSELFGYERGAFTGAAKRKLGRIEMAQGGTLFL
DEIGDMPLESQTSLLRFLETGRIERLGGTESIEVDVRIISATHVDLEAAIAAERFRGDLYHRLCVLRVRQPPLRERGSDL
MLLAEHVLAGVRKQSPNHIRGFAPTALRAIQQHDWPGNVRELINRIRHAAAMCEDGVIQPEDLELATPVEERPLTLAAIR
EAAEQNALVEALQRNHERLIDVAAELGISRVTLFRLMRDYKLHVKKGDLGLVCVQG

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=425, Percent_Identity=38.1176470588235, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI1790299, Length=357, Percent_Identity=42.296918767507, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1788550, Length=356, Percent_Identity=40.7303370786517, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=42.9467084639498, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1789087, Length=302, Percent_Identity=42.0529801324503, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1788905, Length=285, Percent_Identity=44.2105263157895, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87082117, Length=231, Percent_Identity=49.7835497835498, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI87082152, Length=323, Percent_Identity=41.7956656346749, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1786524, Length=316, Percent_Identity=42.0886075949367, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI87081872, Length=320, Percent_Identity=38.4375, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1787583, Length=329, Percent_Identity=35.258358662614, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI87081858, Length=285, Percent_Identity=34.0350877192982, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1789828, Length=311, Percent_Identity=31.8327974276527, Blast_Score=115, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50371; Mature: 50239

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTYANRPLLYLSKHHDATLCRAFSQRGWKISFASSLQDLDALAHNTACAALLDVHSGFS
CCCCCCCCEEEEECCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DAELESFEPWLAHPLLGWIGMVTSREELGDAARRLLGLYFIDYYTAPFDLIHLAHSLGHA
CCCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
QGMAQMRPAAQRTAASSARPDGMIGSCAAMQTLFRGIEKVSLWDTPVLISGESGTGKELA
HHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCEEEECCCCCCHHHH
AQAIHRASERAQKPFVAVNCAAIPPTLLMSELFGYERGAFTGAAKRKLGRIEMAQGGTLF
HHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHCCEEECCCCEEE
LDEIGDMPLESQTSLLRFLETGRIERLGGTESIEVDVRIISATHVDLEAAIAAERFRGDL
HHHHCCCCCCHHHHHHHHHHCCCEEECCCCCEEEEEEEEEEEECCHHHHHHHHHHHHHHH
YHRLCVLRVRQPPLRERGSDLMLLAEHVLAGVRKQSPNHIRGFAPTALRAIQQHDWPGNV
HHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHH
RELINRIRHAAAMCEDGVIQPEDLELATPVEERPLTLAAIREAAEQNALVEALQRNHERL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IDVAAELGISRVTLFRLMRDYKLHVKKGDLGLVCVQG
HHHHHHHCHHHHHHHHHHHHHHEEEEECCEEEEEECC
>Mature Secondary Structure 
STYANRPLLYLSKHHDATLCRAFSQRGWKISFASSLQDLDALAHNTACAALLDVHSGFS
CCCCCCCEEEEECCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DAELESFEPWLAHPLLGWIGMVTSREELGDAARRLLGLYFIDYYTAPFDLIHLAHSLGHA
CCCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
QGMAQMRPAAQRTAASSARPDGMIGSCAAMQTLFRGIEKVSLWDTPVLISGESGTGKELA
HHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCEEEECCCCCCHHHH
AQAIHRASERAQKPFVAVNCAAIPPTLLMSELFGYERGAFTGAAKRKLGRIEMAQGGTLF
HHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHCCEEECCCCEEE
LDEIGDMPLESQTSLLRFLETGRIERLGGTESIEVDVRIISATHVDLEAAIAAERFRGDL
HHHHCCCCCCHHHHHHHHHHCCCEEECCCCCEEEEEEEEEEEECCHHHHHHHHHHHHHHH
YHRLCVLRVRQPPLRERGSDLMLLAEHVLAGVRKQSPNHIRGFAPTALRAIQQHDWPGNV
HHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHH
RELINRIRHAAAMCEDGVIQPEDLELATPVEERPLTLAAIREAAEQNALVEALQRNHERL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IDVAAELGISRVTLFRLMRDYKLHVKKGDLGLVCVQG
HHHHHHHCHHHHHHHHHHHHHHEEEEECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]